Amino acid dipepetide frequency for Apostasia shenzhenica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.414AlaAla: 9.414 ± 0.066	1.468AlaCys: 1.468 ± 0.015	3.542AlaAsp: 3.542 ± 0.024	4.723AlaGlu: 4.723 ± 0.029	3.046AlaPhe: 3.046 ± 0.019	5.782AlaGly: 5.782 ± 0.039	1.433AlaHis: 1.433 ± 0.014	3.952AlaIle: 3.952 ± 0.025	3.77AlaLys: 3.77 ± 0.027	7.278AlaLeu: 7.278 ± 0.039	2.003AlaMet: 2.003 ± 0.023	2.55AlaAsn: 2.55 ± 0.023	3.283AlaPro: 3.283 ± 0.025	2.164AlaGln: 2.164 ± 0.016	4.268AlaArg: 4.268 ± 0.027	6.792AlaSer: 6.792 ± 0.036	3.715AlaThr: 3.715 ± 0.027	5.837AlaVal: 5.837 ± 0.034	0.841AlaTrp: 0.841 ± 0.01	1.869AlaTyr: 1.869 ± 0.015	0.0AlaXaa: 0.0 ± 0.0
Cys	1.208CysAla: 1.208 ± 0.013	0.548CysCys: 0.548 ± 0.01	0.844CysAsp: 0.844 ± 0.011	0.903CysGlu: 0.903 ± 0.012	0.952CysPhe: 0.952 ± 0.012	1.54CysGly: 1.54 ± 0.017	0.501CysHis: 0.501 ± 0.008	0.994CysIle: 0.994 ± 0.012	1.02CysLys: 1.02 ± 0.013	1.941CysLeu: 1.941 ± 0.017	0.484CysMet: 0.484 ± 0.008	0.758CysAsn: 0.758 ± 0.01	0.962CysPro: 0.962 ± 0.013	0.603CysGln: 0.603 ± 0.01	1.394CysArg: 1.394 ± 0.015	2.055CysSer: 2.055 ± 0.019	0.843CysThr: 0.843 ± 0.011	1.016CysVal: 1.016 ± 0.012	0.269CysTrp: 0.269 ± 0.005	0.549CysTyr: 0.549 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.743AspAla: 3.743 ± 0.024	0.962AspCys: 0.962 ± 0.011	3.417AspAsp: 3.417 ± 0.031	3.813AspGlu: 3.813 ± 0.028	2.333AspPhe: 2.333 ± 0.019	3.87AspGly: 3.87 ± 0.027	1.202AspHis: 1.202 ± 0.013	2.759AspIle: 2.759 ± 0.025	2.258AspLys: 2.258 ± 0.017	5.219AspLeu: 5.219 ± 0.029	1.207AspMet: 1.207 ± 0.012	1.717AspAsn: 1.717 ± 0.015	2.636AspPro: 2.636 ± 0.024	1.547AspGln: 1.547 ± 0.015	2.692AspArg: 2.692 ± 0.019	4.046AspSer: 4.046 ± 0.024	1.822AspThr: 1.822 ± 0.018	3.398AspVal: 3.398 ± 0.023	0.673AspTrp: 0.673 ± 0.01	1.42AspTyr: 1.42 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	5.248GluAla: 5.248 ± 0.035	0.873GluCys: 0.873 ± 0.012	3.708GluAsp: 3.708 ± 0.025	6.292GluGlu: 6.292 ± 0.045	2.307GluPhe: 2.307 ± 0.018	3.872GluGly: 3.872 ± 0.028	1.29GluHis: 1.29 ± 0.014	3.663GluIle: 3.663 ± 0.023	4.484GluLys: 4.484 ± 0.034	6.025GluLeu: 6.025 ± 0.035	1.856GluMet: 1.856 ± 0.019	2.715GluAsn: 2.715 ± 0.021	2.137GluPro: 2.137 ± 0.017	2.064GluGln: 2.064 ± 0.017	3.731GluArg: 3.731 ± 0.023	4.315GluSer: 4.315 ± 0.03	2.689GluThr: 2.689 ± 0.022	4.203GluVal: 4.203 ± 0.028	0.725GluTrp: 0.725 ± 0.011	1.48GluTyr: 1.48 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.997PheAla: 2.997 ± 0.029	0.995PheCys: 0.995 ± 0.012	2.364PheAsp: 2.364 ± 0.019	2.255PheGlu: 2.255 ± 0.019	2.209PhePhe: 2.209 ± 0.021	3.031PheGly: 3.031 ± 0.024	1.142PheHis: 1.142 ± 0.012	2.108PheIle: 2.108 ± 0.019	1.847PheLys: 1.847 ± 0.017	4.584PheLeu: 4.584 ± 0.03	0.994PheMet: 0.994 ± 0.014	1.541PheAsn: 1.541 ± 0.016	2.159PhePro: 2.159 ± 0.018	1.479PheGln: 1.479 ± 0.016	2.42PheArg: 2.42 ± 0.018	4.398PheSer: 4.398 ± 0.027	2.168PheThr: 2.168 ± 0.032	2.748PheVal: 2.748 ± 0.023	0.565PheTrp: 0.565 ± 0.01	1.242PheTyr: 1.242 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.444GlyAla: 4.444 ± 0.031	1.362GlyCys: 1.362 ± 0.015	3.609GlyAsp: 3.609 ± 0.023	4.045GlyGlu: 4.045 ± 0.026	3.604GlyPhe: 3.604 ± 0.042	5.888GlyGly: 5.888 ± 0.054	1.546GlyHis: 1.546 ± 0.015	3.652GlyIle: 3.652 ± 0.029	3.819GlyLys: 3.819 ± 0.023	6.221GlyLeu: 6.221 ± 0.041	1.558GlyMet: 1.558 ± 0.014	2.725GlyAsn: 2.725 ± 0.02	2.463GlyPro: 2.463 ± 0.021	1.978GlyGln: 1.978 ± 0.017	4.534GlyArg: 4.534 ± 0.026	5.986GlySer: 5.986 ± 0.036	2.998GlyThr: 2.998 ± 0.026	4.273GlyVal: 4.273 ± 0.036	0.947GlyTrp: 0.947 ± 0.014	2.019GlyTyr: 2.019 ± 0.018	0.001GlyXaa: 0.001 ± 0.0
His	1.591HisAla: 1.591 ± 0.015	0.548HisCys: 0.548 ± 0.007	1.122HisAsp: 1.122 ± 0.011	1.25HisGlu: 1.25 ± 0.016	1.045HisPhe: 1.045 ± 0.01	1.812HisGly: 1.812 ± 0.016	0.877HisHis: 0.877 ± 0.013	1.171HisIle: 1.171 ± 0.012	1.028HisLys: 1.028 ± 0.013	2.545HisLeu: 2.545 ± 0.018	0.522HisMet: 0.522 ± 0.008	0.814HisAsn: 0.814 ± 0.011	1.41HisPro: 1.41 ± 0.015	0.969HisGln: 0.969 ± 0.013	1.619HisArg: 1.619 ± 0.016	1.997HisSer: 1.997 ± 0.017	0.893HisThr: 0.893 ± 0.012	1.53HisVal: 1.53 ± 0.014	0.3HisTrp: 0.3 ± 0.007	0.702HisTyr: 0.702 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.815IleAla: 3.815 ± 0.028	1.152IleCys: 1.152 ± 0.014	2.809IleAsp: 2.809 ± 0.039	3.085IleGlu: 3.085 ± 0.027	2.376IlePhe: 2.376 ± 0.02	3.213IleGly: 3.213 ± 0.025	1.333IleHis: 1.333 ± 0.016	2.712IleIle: 2.712 ± 0.021	2.656IleLys: 2.656 ± 0.019	5.322IleLeu: 5.322 ± 0.028	1.092IleMet: 1.092 ± 0.012	1.989IleAsn: 1.989 ± 0.018	2.861IlePro: 2.861 ± 0.025	1.83IleGln: 1.83 ± 0.019	2.891IleArg: 2.891 ± 0.022	5.036IleSer: 5.036 ± 0.026	2.427IleThr: 2.427 ± 0.015	3.289IleVal: 3.289 ± 0.023	0.693IleTrp: 0.693 ± 0.01	1.503IleTyr: 1.503 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.957LysAla: 3.957 ± 0.025	0.905LysCys: 0.905 ± 0.012	2.805LysAsp: 2.805 ± 0.024	4.278LysGlu: 4.278 ± 0.034	1.973LysPhe: 1.973 ± 0.015	3.362LysGly: 3.362 ± 0.022	1.208LysHis: 1.208 ± 0.014	3.065LysIle: 3.065 ± 0.022	4.309LysLys: 4.309 ± 0.043	5.496LysLeu: 5.496 ± 0.035	1.456LysMet: 1.456 ± 0.015	2.325LysAsn: 2.325 ± 0.019	2.474LysPro: 2.474 ± 0.025	1.963LysGln: 1.963 ± 0.018	3.445LysArg: 3.445 ± 0.024	4.075LysSer: 4.075 ± 0.024	2.419LysThr: 2.419 ± 0.016	3.398LysVal: 3.398 ± 0.023	0.726LysTrp: 0.726 ± 0.01	1.406LysTyr: 1.406 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.264LeuAla: 7.264 ± 0.038	1.976LeuCys: 1.976 ± 0.015	4.828LeuAsp: 4.828 ± 0.027	6.138LeuGlu: 6.138 ± 0.037	4.098LeuPhe: 4.098 ± 0.026	5.841LeuGly: 5.841 ± 0.031	2.805LeuHis: 2.805 ± 0.023	4.71LeuIle: 4.71 ± 0.032	5.669LeuLys: 5.669 ± 0.032	10.991LeuLeu: 10.991 ± 0.055	2.197LeuMet: 2.197 ± 0.015	3.572LeuAsn: 3.572 ± 0.025	5.779LeuPro: 5.779 ± 0.03	4.238LeuGln: 4.238 ± 0.031	6.484LeuArg: 6.484 ± 0.039	8.875LeuSer: 8.875 ± 0.045	4.181LeuThr: 4.181 ± 0.027	6.145LeuVal: 6.145 ± 0.034	1.191LeuTrp: 1.191 ± 0.015	2.411LeuTyr: 2.411 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.354MetAla: 2.354 ± 0.017	0.321MetCys: 0.321 ± 0.006	1.334MetAsp: 1.334 ± 0.013	2.021MetGlu: 2.021 ± 0.017	0.747MetPhe: 0.747 ± 0.009	1.588MetGly: 1.588 ± 0.022	0.516MetHis: 0.516 ± 0.009	1.264MetIle: 1.264 ± 0.013	1.578MetLys: 1.578 ± 0.016	2.233MetLeu: 2.233 ± 0.018	0.674MetMet: 0.674 ± 0.01	0.938MetAsn: 0.938 ± 0.011	1.167MetPro: 1.167 ± 0.015	0.92MetGln: 0.92 ± 0.01	1.384MetArg: 1.384 ± 0.019	1.627MetSer: 1.627 ± 0.014	1.021MetThr: 1.021 ± 0.011	1.638MetVal: 1.638 ± 0.016	0.251MetTrp: 0.251 ± 0.006	0.547MetTyr: 0.547 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.626AsnAla: 2.626 ± 0.02	0.808AsnCys: 0.808 ± 0.011	1.773AsnAsp: 1.773 ± 0.015	2.186AsnGlu: 2.186 ± 0.018	1.759AsnPhe: 1.759 ± 0.015	2.755AsnGly: 2.755 ± 0.02	0.964AsnHis: 0.964 ± 0.013	2.227AsnIle: 2.227 ± 0.017	1.931AsnLys: 1.931 ± 0.019	4.121AsnLeu: 4.121 ± 0.029	0.948AsnMet: 0.948 ± 0.018	1.563AsnAsn: 1.563 ± 0.018	2.193AsnPro: 2.193 ± 0.017	1.419AsnGln: 1.419 ± 0.017	1.987AsnArg: 1.987 ± 0.017	3.491AsnSer: 3.491 ± 0.026	1.596AsnThr: 1.596 ± 0.015	2.4AsnVal: 2.4 ± 0.02	0.511AsnTrp: 0.511 ± 0.007	1.096AsnTyr: 1.096 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.241ProAla: 4.241 ± 0.035	0.838ProCys: 0.838 ± 0.011	2.468ProAsp: 2.468 ± 0.02	3.198ProGlu: 3.198 ± 0.022	2.216ProPhe: 2.216 ± 0.017	2.763ProGly: 2.763 ± 0.022	1.109ProHis: 1.109 ± 0.015	2.323ProIle: 2.323 ± 0.022	2.395ProLys: 2.395 ± 0.019	4.759ProLeu: 4.759 ± 0.029	0.969ProMet: 0.969 ± 0.011	1.968ProAsn: 1.968 ± 0.018	4.613ProPro: 4.613 ± 0.07	1.636ProGln: 1.636 ± 0.017	2.771ProArg: 2.771 ± 0.019	5.491ProSer: 5.491 ± 0.032	2.466ProThr: 2.466 ± 0.017	3.135ProVal: 3.135 ± 0.03	0.646ProTrp: 0.646 ± 0.009	1.242ProTyr: 1.242 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	2.492GlnAla: 2.492 ± 0.021	0.559GlnCys: 0.559 ± 0.009	1.398GlnAsp: 1.398 ± 0.015	2.185GlnGlu: 2.185 ± 0.02	1.265GlnPhe: 1.265 ± 0.012	1.935GlnGly: 1.935 ± 0.019	0.885GlnHis: 0.885 ± 0.011	2.0GlnIle: 2.0 ± 0.017	2.163GlnLys: 2.163 ± 0.018	3.469GlnLeu: 3.469 ± 0.026	0.914GlnMet: 0.914 ± 0.011	1.525GlnAsn: 1.525 ± 0.014	1.738GlnPro: 1.738 ± 0.017	1.781GlnGln: 1.781 ± 0.028	2.259GlnArg: 2.259 ± 0.015	2.602GlnSer: 2.602 ± 0.024	1.501GlnThr: 1.501 ± 0.015	2.129GlnVal: 2.129 ± 0.016	0.459GlnTrp: 0.459 ± 0.008	0.813GlnTyr: 0.813 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	4.033ArgAla: 4.033 ± 0.028	1.2ArgCys: 1.2 ± 0.014	2.738ArgAsp: 2.738 ± 0.022	3.807ArgGlu: 3.807 ± 0.025	2.641ArgPhe: 2.641 ± 0.023	3.894ArgGly: 3.894 ± 0.031	1.459ArgHis: 1.459 ± 0.013	3.16ArgIle: 3.16 ± 0.017	3.853ArgLys: 3.853 ± 0.026	5.77ArgLeu: 5.77 ± 0.03	1.535ArgMet: 1.535 ± 0.015	2.357ArgAsn: 2.357 ± 0.019	2.906ArgPro: 2.906 ± 0.023	2.058ArgGln: 2.058 ± 0.016	5.707ArgArg: 5.707 ± 0.036	5.235ArgSer: 5.235 ± 0.028	2.61ArgThr: 2.61 ± 0.02	3.507ArgVal: 3.507 ± 0.027	0.95ArgTrp: 0.95 ± 0.013	1.515ArgTyr: 1.515 ± 0.015	0.001ArgXaa: 0.001 ± 0.0
Ser	6.436SerAla: 6.436 ± 0.03	1.835SerCys: 1.835 ± 0.017	4.204SerAsp: 4.204 ± 0.028	4.484SerGlu: 4.484 ± 0.028	4.201SerPhe: 4.201 ± 0.027	6.185SerGly: 6.185 ± 0.036	2.035SerHis: 2.035 ± 0.017	4.468SerIle: 4.468 ± 0.031	4.399SerLys: 4.399 ± 0.031	8.934SerLeu: 8.934 ± 0.042	2.082SerMet: 2.082 ± 0.017	3.451SerAsn: 3.451 ± 0.023	5.226SerPro: 5.226 ± 0.035	2.762SerGln: 2.762 ± 0.022	4.961SerArg: 4.961 ± 0.025	11.506SerSer: 11.506 ± 0.056	4.409SerThr: 4.409 ± 0.024	5.063SerVal: 5.063 ± 0.025	1.241SerTrp: 1.241 ± 0.014	2.245SerTyr: 2.245 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	3.839ThrAla: 3.839 ± 0.026	0.848ThrCys: 0.848 ± 0.01	2.072ThrAsp: 2.072 ± 0.019	2.526ThrGlu: 2.526 ± 0.019	1.976ThrPhe: 1.976 ± 0.017	3.275ThrGly: 3.275 ± 0.031	0.93ThrHis: 0.93 ± 0.011	2.461ThrIle: 2.461 ± 0.022	2.234ThrLys: 2.234 ± 0.019	4.265ThrLeu: 4.265 ± 0.023	1.107ThrMet: 1.107 ± 0.012	1.684ThrAsn: 1.684 ± 0.016	2.343ThrPro: 2.343 ± 0.02	1.286ThrGln: 1.286 ± 0.015	2.324ThrArg: 2.324 ± 0.021	4.224ThrSer: 4.224 ± 0.031	2.385ThrThr: 2.385 ± 0.018	3.168ThrVal: 3.168 ± 0.022	0.61ThrTrp: 0.61 ± 0.01	1.262ThrTyr: 1.262 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.281ValAla: 5.281 ± 0.032	1.328ValCys: 1.328 ± 0.023	3.67ValAsp: 3.67 ± 0.026	4.238ValGlu: 4.238 ± 0.025	2.712ValPhe: 2.712 ± 0.021	4.163ValGly: 4.163 ± 0.026	1.485ValHis: 1.485 ± 0.014	3.318ValIle: 3.318 ± 0.027	3.456ValLys: 3.456 ± 0.024	6.344ValLeu: 6.344 ± 0.034	1.515ValMet: 1.515 ± 0.013	2.345ValAsn: 2.345 ± 0.018	3.117ValPro: 3.117 ± 0.023	2.061ValGln: 2.061 ± 0.017	3.481ValArg: 3.481 ± 0.022	5.171ValSer: 5.171 ± 0.028	2.917ValThr: 2.917 ± 0.025	4.779ValVal: 4.779 ± 0.031	0.728ValTrp: 0.728 ± 0.01	2.007ValTyr: 2.007 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.87TrpAla: 0.87 ± 0.011	0.225TrpCys: 0.225 ± 0.006	0.65TrpAsp: 0.65 ± 0.01	0.776TrpGlu: 0.776 ± 0.009	0.536TrpPhe: 0.536 ± 0.008	0.771TrpGly: 0.771 ± 0.012	0.309TrpHis: 0.309 ± 0.007	0.7TrpIle: 0.7 ± 0.009	0.865TrpLys: 0.865 ± 0.011	1.222TrpLeu: 1.222 ± 0.015	0.376TrpMet: 0.376 ± 0.006	0.657TrpAsn: 0.657 ± 0.012	0.599TrpPro: 0.599 ± 0.009	0.447TrpGln: 0.447 ± 0.008	0.996TrpArg: 0.996 ± 0.012	1.023TrpSer: 1.023 ± 0.011	0.596TrpThr: 0.596 ± 0.008	0.781TrpVal: 0.781 ± 0.011	0.235TrpTrp: 0.235 ± 0.006	0.309TrpTyr: 0.309 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.877TyrAla: 1.877 ± 0.02	0.627TyrCys: 0.627 ± 0.009	1.38TyrAsp: 1.38 ± 0.014	1.472TyrGlu: 1.472 ± 0.016	1.249TyrPhe: 1.249 ± 0.014	2.132TyrGly: 2.132 ± 0.028	0.717TyrHis: 0.717 ± 0.01	1.374TyrIle: 1.374 ± 0.014	1.313TyrLys: 1.313 ± 0.015	2.652TyrLeu: 2.652 ± 0.021	0.636TyrMet: 0.636 ± 0.009	1.163TyrAsn: 1.163 ± 0.014	1.181TyrPro: 1.181 ± 0.012	0.868TyrGln: 0.868 ± 0.011	1.588TyrArg: 1.588 ± 0.016	2.183TyrSer: 2.183 ± 0.018	1.164TyrThr: 1.164 ± 0.013	1.677TyrVal: 1.677 ± 0.018	0.383TyrTrp: 0.383 ± 0.008	0.911TyrTyr: 0.911 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.012XaaXaa: 0.012 ± 0.005

Statistics based on 21679 proteins (7935319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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