Amino acid dipepetide frequency for Lettuce chlorosis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.118AlaAla: 3.118 ± 0.464
0.85AlaCys: 0.85 ± 0.383
1.984AlaAsp: 1.984 ± 0.922
1.984AlaGlu: 1.984 ± 0.401
2.977AlaPhe: 2.977 ± 0.458
3.544AlaGly: 3.544 ± 0.584
0.709AlaHis: 0.709 ± 0.238
2.268AlaIle: 2.268 ± 0.995
2.693AlaLys: 2.693 ± 0.353
4.252AlaLeu: 4.252 ± 0.708
1.843AlaMet: 1.843 ± 0.409
2.268AlaAsn: 2.268 ± 0.615
0.567AlaPro: 0.567 ± 0.243
0.85AlaGln: 0.85 ± 0.38
2.41AlaArg: 2.41 ± 0.513
1.984AlaSer: 1.984 ± 0.644
1.276AlaThr: 1.276 ± 0.348
4.536AlaVal: 4.536 ± 1.027
0.283AlaTrp: 0.283 ± 0.128
2.551AlaTyr: 2.551 ± 0.621
0.0AlaXaa: 0.0 ± 0.0
Cys
0.709CysAla: 0.709 ± 0.226
0.142CysCys: 0.142 ± 0.235
1.276CysAsp: 1.276 ± 0.502
1.701CysGlu: 1.701 ± 0.528
0.992CysPhe: 0.992 ± 0.264
0.992CysGly: 0.992 ± 0.366
0.283CysHis: 0.283 ± 0.128
1.134CysIle: 1.134 ± 0.39
1.701CysLys: 1.701 ± 0.516
1.417CysLeu: 1.417 ± 0.262
0.709CysMet: 0.709 ± 0.353
1.701CysAsn: 1.701 ± 0.477
0.567CysPro: 0.567 ± 0.256
1.134CysGln: 1.134 ± 0.283
0.85CysArg: 0.85 ± 0.383
2.41CysSer: 2.41 ± 0.595
0.425CysThr: 0.425 ± 0.444
2.551CysVal: 2.551 ± 0.594
0.567CysTrp: 0.567 ± 0.256
1.559CysTyr: 1.559 ± 0.456
0.0CysXaa: 0.0 ± 0.0
Asp
2.268AspAla: 2.268 ± 0.516
1.559AspCys: 1.559 ± 0.416
3.118AspAsp: 3.118 ± 0.852
4.536AspGlu: 4.536 ± 0.974
4.536AspPhe: 4.536 ± 0.625
3.118AspGly: 3.118 ± 0.366
0.425AspHis: 0.425 ± 0.173
5.67AspIle: 5.67 ± 0.784
4.394AspLys: 4.394 ± 0.623
6.52AspLeu: 6.52 ± 1.494
2.41AspMet: 2.41 ± 0.649
3.827AspAsn: 3.827 ± 0.868
0.85AspPro: 0.85 ± 0.382
1.701AspGln: 1.701 ± 0.408
2.41AspArg: 2.41 ± 0.565
3.685AspSer: 3.685 ± 0.693
2.977AspThr: 2.977 ± 0.842
4.819AspVal: 4.819 ± 0.855
0.709AspTrp: 0.709 ± 0.311
2.835AspTyr: 2.835 ± 0.743
0.0AspXaa: 0.0 ± 0.0
Glu
1.843GluAla: 1.843 ± 0.337
0.992GluCys: 0.992 ± 0.561
4.678GluAsp: 4.678 ± 1.105
2.41GluGlu: 2.41 ± 0.706
2.551GluPhe: 2.551 ± 1.018
2.693GluGly: 2.693 ± 0.551
1.984GluHis: 1.984 ± 0.602
4.394GluIle: 4.394 ± 0.661
4.678GluLys: 4.678 ± 0.43
3.827GluLeu: 3.827 ± 0.739
1.984GluMet: 1.984 ± 0.375
3.118GluAsn: 3.118 ± 0.286
0.567GluPro: 0.567 ± 0.464
0.567GluGln: 0.567 ± 0.375
2.693GluArg: 2.693 ± 0.541
2.977GluSer: 2.977 ± 0.571
3.118GluThr: 3.118 ± 0.911
4.819GluVal: 4.819 ± 0.996
0.85GluTrp: 0.85 ± 0.328
2.977GluTyr: 2.977 ± 0.487
0.0GluXaa: 0.0 ± 0.0
Phe
0.992PheAla: 0.992 ± 0.262
0.992PheCys: 0.992 ± 0.261
4.394PheAsp: 4.394 ± 0.986
2.551PheGlu: 2.551 ± 0.401
1.276PhePhe: 1.276 ± 0.744
2.835PheGly: 2.835 ± 0.932
1.276PheHis: 1.276 ± 0.447
3.26PheIle: 3.26 ± 0.949
4.536PheLys: 4.536 ± 0.688
2.835PheLeu: 2.835 ± 1.084
1.559PheMet: 1.559 ± 0.384
3.544PheAsn: 3.544 ± 0.454
1.417PhePro: 1.417 ± 0.351
1.417PheGln: 1.417 ± 0.608
2.268PheArg: 2.268 ± 0.957
5.386PheSer: 5.386 ± 0.996
3.969PheThr: 3.969 ± 0.847
3.402PheVal: 3.402 ± 0.669
0.283PheTrp: 0.283 ± 0.128
2.835PheTyr: 2.835 ± 0.641
0.0PheXaa: 0.0 ± 0.0
Gly
1.843GlyAla: 1.843 ± 0.467
0.425GlyCys: 0.425 ± 0.421
4.961GlyAsp: 4.961 ± 0.666
3.26GlyGlu: 3.26 ± 0.715
3.118GlyPhe: 3.118 ± 1.136
4.536GlyGly: 4.536 ± 1.394
0.709GlyHis: 0.709 ± 0.24
2.977GlyIle: 2.977 ± 0.73
3.685GlyLys: 3.685 ± 0.354
2.977GlyLeu: 2.977 ± 0.713
1.559GlyMet: 1.559 ± 0.443
2.126GlyAsn: 2.126 ± 0.271
0.85GlyPro: 0.85 ± 0.188
1.701GlyGln: 1.701 ± 0.62
1.701GlyArg: 1.701 ± 0.3
4.961GlySer: 4.961 ± 0.691
2.268GlyThr: 2.268 ± 0.408
4.394GlyVal: 4.394 ± 0.549
0.0GlyTrp: 0.0 ± 0.0
1.984GlyTyr: 1.984 ± 0.629
0.0GlyXaa: 0.0 ± 0.0
His
1.701HisAla: 1.701 ± 0.51
0.425HisCys: 0.425 ± 0.192
1.701HisAsp: 1.701 ± 0.746
0.85HisGlu: 0.85 ± 0.635
2.268HisPhe: 2.268 ± 0.533
0.425HisGly: 0.425 ± 0.468
0.709HisHis: 0.709 ± 0.557
0.85HisIle: 0.85 ± 0.274
1.559HisLys: 1.559 ± 0.319
2.268HisLeu: 2.268 ± 0.776
0.992HisMet: 0.992 ± 0.345
1.134HisAsn: 1.134 ± 0.389
0.85HisPro: 0.85 ± 0.297
0.425HisGln: 0.425 ± 0.276
1.134HisArg: 1.134 ± 0.389
0.567HisSer: 0.567 ± 0.202
1.417HisThr: 1.417 ± 0.367
1.559HisVal: 1.559 ± 0.416
0.142HisTrp: 0.142 ± 0.237
1.276HisTyr: 1.276 ± 0.508
0.0HisXaa: 0.0 ± 0.0
Ile
0.85IleAla: 0.85 ± 0.278
2.268IleCys: 2.268 ± 0.767
2.835IleAsp: 2.835 ± 0.511
2.835IleGlu: 2.835 ± 0.544
2.551IlePhe: 2.551 ± 0.588
2.835IleGly: 2.835 ± 0.754
1.417IleHis: 1.417 ± 0.334
4.536IleIle: 4.536 ± 0.849
6.662IleLys: 6.662 ± 2.041
6.378IleLeu: 6.378 ± 1.31
0.283IleMet: 0.283 ± 0.356
5.811IleAsn: 5.811 ± 1.324
4.252IlePro: 4.252 ± 0.616
2.126IleGln: 2.126 ± 0.906
2.693IleArg: 2.693 ± 0.646
5.103IleSer: 5.103 ± 0.817
3.26IleThr: 3.26 ± 0.572
4.394IleVal: 4.394 ± 1.064
0.567IleTrp: 0.567 ± 0.256
2.977IleTyr: 2.977 ± 0.392
0.0IleXaa: 0.0 ± 0.0
Lys
4.819LysAla: 4.819 ± 0.927
1.134LysCys: 1.134 ± 0.351
3.827LysAsp: 3.827 ± 0.785
3.685LysGlu: 3.685 ± 0.643
4.536LysPhe: 4.536 ± 0.77
2.693LysGly: 2.693 ± 0.762
1.417LysHis: 1.417 ± 0.497
4.111LysIle: 4.111 ± 1.11
5.245LysLys: 5.245 ± 0.616
8.363LysLeu: 8.363 ± 0.936
2.268LysMet: 2.268 ± 0.526
5.811LysAsn: 5.811 ± 0.587
3.827LysPro: 3.827 ± 1.217
3.118LysGln: 3.118 ± 0.838
3.402LysArg: 3.402 ± 0.512
5.386LysSer: 5.386 ± 0.949
5.386LysThr: 5.386 ± 0.858
4.111LysVal: 4.111 ± 0.632
0.85LysTrp: 0.85 ± 0.263
5.386LysTyr: 5.386 ± 0.741
0.0LysXaa: 0.0 ± 0.0
Leu
3.969LeuAla: 3.969 ± 0.819
1.417LeuCys: 1.417 ± 0.492
5.245LeuAsp: 5.245 ± 0.75
4.394LeuGlu: 4.394 ± 0.379
5.528LeuPhe: 5.528 ± 1.539
3.544LeuGly: 3.544 ± 0.49
1.559LeuHis: 1.559 ± 0.348
6.237LeuIle: 6.237 ± 0.987
7.371LeuLys: 7.371 ± 0.736
7.371LeuLeu: 7.371 ± 1.578
2.977LeuMet: 2.977 ± 0.562
5.386LeuAsn: 5.386 ± 1.568
1.559LeuPro: 1.559 ± 1.095
1.559LeuGln: 1.559 ± 0.49
6.378LeuArg: 6.378 ± 0.526
7.087LeuSer: 7.087 ± 0.567
5.811LeuThr: 5.811 ± 1.038
6.945LeuVal: 6.945 ± 0.667
0.425LeuTrp: 0.425 ± 0.192
3.685LeuTyr: 3.685 ± 0.794
0.0LeuXaa: 0.0 ± 0.0
Met
1.417MetAla: 1.417 ± 0.456
1.559MetCys: 1.559 ± 0.559
1.559MetAsp: 1.559 ± 0.262
0.567MetGlu: 0.567 ± 0.547
1.417MetPhe: 1.417 ± 0.394
1.417MetGly: 1.417 ± 0.374
0.283MetHis: 0.283 ± 0.128
1.984MetIle: 1.984 ± 0.846
1.843MetLys: 1.843 ± 0.402
1.417MetLeu: 1.417 ± 0.489
0.567MetMet: 0.567 ± 0.256
2.41MetAsn: 2.41 ± 0.438
1.134MetPro: 1.134 ± 0.324
0.425MetGln: 0.425 ± 0.179
2.41MetArg: 2.41 ± 0.56
2.551MetSer: 2.551 ± 0.372
2.551MetThr: 2.551 ± 0.404
2.126MetVal: 2.126 ± 0.608
0.283MetTrp: 0.283 ± 0.27
1.559MetTyr: 1.559 ± 0.436
0.0MetXaa: 0.0 ± 0.0
Asn
1.701AsnAla: 1.701 ± 0.349
1.417AsnCys: 1.417 ± 0.431
3.969AsnAsp: 3.969 ± 0.883
2.835AsnGlu: 2.835 ± 0.477
2.693AsnPhe: 2.693 ± 0.766
2.977AsnGly: 2.977 ± 0.735
1.417AsnHis: 1.417 ± 0.656
4.961AsnIle: 4.961 ± 0.632
5.245AsnLys: 5.245 ± 0.506
6.52AsnLeu: 6.52 ± 0.945
1.276AsnMet: 1.276 ± 1.007
4.961AsnAsn: 4.961 ± 0.917
2.126AsnPro: 2.126 ± 0.508
2.126AsnGln: 2.126 ± 0.583
2.693AsnArg: 2.693 ± 0.445
4.394AsnSer: 4.394 ± 1.777
2.268AsnThr: 2.268 ± 0.39
4.394AsnVal: 4.394 ± 0.929
1.134AsnTrp: 1.134 ± 0.349
2.977AsnTyr: 2.977 ± 0.642
0.0AsnXaa: 0.0 ± 0.0
Pro
1.843ProAla: 1.843 ± 0.427
0.709ProCys: 0.709 ± 0.263
1.984ProAsp: 1.984 ± 0.408
3.26ProGlu: 3.26 ± 0.652
1.984ProPhe: 1.984 ± 0.851
1.843ProGly: 1.843 ± 0.558
0.709ProHis: 0.709 ± 0.27
2.268ProIle: 2.268 ± 1.154
2.835ProLys: 2.835 ± 0.71
1.984ProLeu: 1.984 ± 0.472
1.276ProMet: 1.276 ± 0.3
2.41ProAsn: 2.41 ± 0.609
1.843ProPro: 1.843 ± 0.758
1.559ProGln: 1.559 ± 0.285
1.276ProArg: 1.276 ± 0.383
1.984ProSer: 1.984 ± 0.443
1.417ProThr: 1.417 ± 0.47
1.417ProVal: 1.417 ± 0.532
0.283ProTrp: 0.283 ± 0.362
0.85ProTyr: 0.85 ± 0.269
0.0ProXaa: 0.0 ± 0.0
Gln
2.126GlnAla: 2.126 ± 0.616
0.992GlnCys: 0.992 ± 0.348
0.425GlnAsp: 0.425 ± 0.244
1.559GlnGlu: 1.559 ± 0.608
1.276GlnPhe: 1.276 ± 0.414
1.984GlnGly: 1.984 ± 0.559
0.709GlnHis: 0.709 ± 0.311
2.268GlnIle: 2.268 ± 0.658
1.843GlnLys: 1.843 ± 0.377
3.685GlnLeu: 3.685 ± 0.714
0.425GlnMet: 0.425 ± 0.269
0.283GlnAsn: 0.283 ± 0.365
1.559GlnPro: 1.559 ± 0.405
0.567GlnGln: 0.567 ± 0.256
2.41GlnArg: 2.41 ± 0.578
2.126GlnSer: 2.126 ± 0.524
1.559GlnThr: 1.559 ± 0.582
1.276GlnVal: 1.276 ± 0.388
0.567GlnTrp: 0.567 ± 0.269
1.276GlnTyr: 1.276 ± 0.453
0.0GlnXaa: 0.0 ± 0.0
Arg
1.559ArgAla: 1.559 ± 0.307
1.417ArgCys: 1.417 ± 0.497
2.41ArgAsp: 2.41 ± 0.715
2.126ArgGlu: 2.126 ± 0.66
2.41ArgPhe: 2.41 ± 0.649
1.843ArgGly: 1.843 ± 0.449
1.417ArgHis: 1.417 ± 0.465
2.693ArgIle: 2.693 ± 0.553
2.551ArgLys: 2.551 ± 0.728
4.252ArgLeu: 4.252 ± 1.064
1.984ArgMet: 1.984 ± 0.433
2.41ArgAsn: 2.41 ± 0.36
1.417ArgPro: 1.417 ± 0.422
1.417ArgGln: 1.417 ± 0.7
2.977ArgArg: 2.977 ± 0.491
5.67ArgSer: 5.67 ± 1.586
1.984ArgThr: 1.984 ± 0.484
5.103ArgVal: 5.103 ± 1.021
0.283ArgTrp: 0.283 ± 0.401
1.843ArgTyr: 1.843 ± 0.511
0.0ArgXaa: 0.0 ± 0.0
Ser
4.252SerAla: 4.252 ± 0.945
2.126SerCys: 2.126 ± 0.713
4.536SerAsp: 4.536 ± 0.749
3.402SerGlu: 3.402 ± 0.702
2.835SerPhe: 2.835 ± 0.912
2.835SerGly: 2.835 ± 0.573
3.969SerHis: 3.969 ± 0.756
4.536SerIle: 4.536 ± 0.823
7.654SerLys: 7.654 ± 1.255
7.087SerLeu: 7.087 ± 1.573
0.992SerMet: 0.992 ± 0.436
5.103SerAsn: 5.103 ± 0.89
2.126SerPro: 2.126 ± 0.69
2.126SerGln: 2.126 ± 0.869
2.977SerArg: 2.977 ± 0.687
4.678SerSer: 4.678 ± 1.095
4.961SerThr: 4.961 ± 0.837
6.52SerVal: 6.52 ± 0.678
0.283SerTrp: 0.283 ± 0.561
2.268SerTyr: 2.268 ± 0.605
0.0SerXaa: 0.0 ± 0.0
Thr
2.268ThrAla: 2.268 ± 0.462
0.992ThrCys: 0.992 ± 0.391
2.835ThrAsp: 2.835 ± 0.665
3.685ThrGlu: 3.685 ± 0.57
2.693ThrPhe: 2.693 ± 0.683
2.693ThrGly: 2.693 ± 0.593
1.134ThrHis: 1.134 ± 0.511
4.678ThrIle: 4.678 ± 0.734
4.111ThrLys: 4.111 ± 1.063
5.245ThrLeu: 5.245 ± 0.887
1.701ThrMet: 1.701 ± 0.645
2.41ThrAsn: 2.41 ± 0.534
3.26ThrPro: 3.26 ± 0.825
2.551ThrGln: 2.551 ± 0.658
1.984ThrArg: 1.984 ± 0.581
3.544ThrSer: 3.544 ± 0.86
2.126ThrThr: 2.126 ± 0.704
3.544ThrVal: 3.544 ± 0.763
0.567ThrTrp: 0.567 ± 0.288
2.41ThrTyr: 2.41 ± 0.885
0.0ThrXaa: 0.0 ± 0.0
Val
3.544ValAla: 3.544 ± 0.645
1.984ValCys: 1.984 ± 0.396
5.811ValAsp: 5.811 ± 0.604
5.386ValGlu: 5.386 ± 0.936
1.984ValPhe: 1.984 ± 0.428
3.402ValGly: 3.402 ± 1.048
1.417ValHis: 1.417 ± 0.384
2.551ValIle: 2.551 ± 0.53
7.371ValLys: 7.371 ± 0.792
5.245ValLeu: 5.245 ± 0.563
2.551ValMet: 2.551 ± 0.534
4.394ValAsn: 4.394 ± 0.836
2.835ValPro: 2.835 ± 0.699
2.126ValGln: 2.126 ± 0.493
2.693ValArg: 2.693 ± 0.507
6.945ValSer: 6.945 ± 0.942
3.685ValThr: 3.685 ± 0.509
4.111ValVal: 4.111 ± 0.787
0.142ValTrp: 0.142 ± 0.187
4.819ValTyr: 4.819 ± 0.899
0.0ValXaa: 0.0 ± 0.0
Trp
0.567TrpAla: 0.567 ± 0.321
0.142TrpCys: 0.142 ± 0.187
0.425TrpAsp: 0.425 ± 0.192
0.425TrpGlu: 0.425 ± 0.171
0.709TrpPhe: 0.709 ± 0.23
0.283TrpGly: 0.283 ± 0.128
0.0TrpHis: 0.0 ± 0.0
0.992TrpIle: 0.992 ± 0.342
0.567TrpLys: 0.567 ± 0.31
1.701TrpLeu: 1.701 ± 0.424
0.283TrpMet: 0.283 ± 0.311
0.0TrpAsn: 0.0 ± 0.0
0.142TrpPro: 0.142 ± 0.28
0.283TrpGln: 0.283 ± 0.128
0.425TrpArg: 0.425 ± 0.58
0.567TrpSer: 0.567 ± 0.253
0.567TrpThr: 0.567 ± 0.256
0.283TrpVal: 0.283 ± 0.27
0.0TrpTrp: 0.0 ± 0.0
0.283TrpTyr: 0.283 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.559TyrAla: 1.559 ± 0.289
1.276TyrCys: 1.276 ± 0.395
4.394TyrAsp: 4.394 ± 0.899
2.268TyrGlu: 2.268 ± 0.524
2.693TyrPhe: 2.693 ± 0.596
3.544TyrGly: 3.544 ± 1.27
0.709TyrHis: 0.709 ± 0.256
2.268TyrIle: 2.268 ± 0.377
2.835TyrLys: 2.835 ± 0.807
5.103TyrLeu: 5.103 ± 0.679
1.701TyrMet: 1.701 ± 0.497
3.118TyrAsn: 3.118 ± 0.683
1.984TyrPro: 1.984 ± 0.593
1.134TyrGln: 1.134 ± 0.648
1.984TyrArg: 1.984 ± 0.414
3.26TyrSer: 3.26 ± 0.77
3.402TyrThr: 3.402 ± 0.796
2.693TyrVal: 2.693 ± 1.112
0.425TyrTrp: 0.425 ± 0.543
2.693TyrTyr: 2.693 ± 0.766
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (7056 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski