Amino acid dipepetide frequency for Blautia hydrogenotrophica CAG:147

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.019AlaAla: 7.019 ± 0.109	1.216AlaCys: 1.216 ± 0.035	3.941AlaAsp: 3.941 ± 0.067	4.723AlaGlu: 4.723 ± 0.089	2.926AlaPhe: 2.926 ± 0.057	6.101AlaGly: 6.101 ± 0.094	1.172AlaHis: 1.172 ± 0.034	4.636AlaIle: 4.636 ± 0.079	4.891AlaLys: 4.891 ± 0.074	6.939AlaLeu: 6.939 ± 0.09	2.361AlaMet: 2.361 ± 0.055	2.302AlaAsn: 2.302 ± 0.055	1.96AlaPro: 1.96 ± 0.045	2.755AlaGln: 2.755 ± 0.061	3.045AlaArg: 3.045 ± 0.06	3.951AlaSer: 3.951 ± 0.067	2.987AlaThr: 2.987 ± 0.052	6.805AlaVal: 6.805 ± 0.106	0.608AlaTrp: 0.608 ± 0.027	2.814AlaTyr: 2.814 ± 0.058	0.002AlaXaa: 0.002 ± 0.002
Cys	1.124CysAla: 1.124 ± 0.036	0.318CysCys: 0.318 ± 0.019	0.844CysAsp: 0.844 ± 0.029	1.13CysGlu: 1.13 ± 0.036	0.641CysPhe: 0.641 ± 0.026	1.667CysGly: 1.667 ± 0.042	0.323CysHis: 0.323 ± 0.02	1.097CysIle: 1.097 ± 0.033	0.834CysLys: 0.834 ± 0.034	1.426CysLeu: 1.426 ± 0.043	0.499CysMet: 0.499 ± 0.026	0.562CysAsn: 0.562 ± 0.022	0.798CysPro: 0.798 ± 0.031	0.612CysGln: 0.612 ± 0.029	0.782CysArg: 0.782 ± 0.03	0.958CysSer: 0.958 ± 0.036	0.794CysThr: 0.794 ± 0.029	1.223CysVal: 1.223 ± 0.036	0.147CysTrp: 0.147 ± 0.011	0.636CysTyr: 0.636 ± 0.027	0.001CysXaa: 0.001 ± 0.001
Asp	3.572AspAla: 3.572 ± 0.07	0.888AspCys: 0.888 ± 0.028	2.21AspAsp: 2.21 ± 0.058	4.231AspGlu: 4.231 ± 0.081	2.464AspPhe: 2.464 ± 0.056	4.123AspGly: 4.123 ± 0.08	0.863AspHis: 0.863 ± 0.039	3.641AspIle: 3.641 ± 0.065	2.859AspLys: 2.859 ± 0.061	4.721AspLeu: 4.721 ± 0.074	1.582AspMet: 1.582 ± 0.043	1.77AspAsn: 1.77 ± 0.044	1.664AspPro: 1.664 ± 0.043	1.606AspGln: 1.606 ± 0.042	2.415AspArg: 2.415 ± 0.055	3.007AspSer: 3.007 ± 0.065	2.784AspThr: 2.784 ± 0.055	3.679AspVal: 3.679 ± 0.063	0.573AspTrp: 0.573 ± 0.024	2.517AspTyr: 2.517 ± 0.058	0.002AspXaa: 0.002 ± 0.001
Glu	5.664GluAla: 5.664 ± 0.079	0.856GluCys: 0.856 ± 0.03	4.303GluAsp: 4.303 ± 0.075	8.115GluGlu: 8.115 ± 0.116	2.653GluPhe: 2.653 ± 0.061	4.892GluGly: 4.892 ± 0.069	1.33GluHis: 1.33 ± 0.049	5.799GluIle: 5.799 ± 0.079	6.978GluLys: 6.978 ± 0.101	7.057GluLeu: 7.057 ± 0.112	2.501GluMet: 2.501 ± 0.046	4.344GluAsn: 4.344 ± 0.072	2.001GluPro: 2.001 ± 0.051	3.084GluGln: 3.084 ± 0.061	3.912GluArg: 3.912 ± 0.076	3.385GluSer: 3.385 ± 0.056	3.6GluThr: 3.6 ± 0.058	4.988GluVal: 4.988 ± 0.089	0.632GluTrp: 0.632 ± 0.027	2.986GluTyr: 2.986 ± 0.06	0.004GluXaa: 0.004 ± 0.002
Phe	2.754PheAla: 2.754 ± 0.056	0.832PheCys: 0.832 ± 0.028	2.115PheAsp: 2.115 ± 0.038	2.622PheGlu: 2.622 ± 0.056	1.867PhePhe: 1.867 ± 0.049	3.077PheGly: 3.077 ± 0.059	0.916PheHis: 0.916 ± 0.032	2.458PheIle: 2.458 ± 0.052	1.576PheLys: 1.576 ± 0.042	4.281PheLeu: 4.281 ± 0.083	1.143PheMet: 1.143 ± 0.04	1.234PheAsn: 1.234 ± 0.037	1.507PhePro: 1.507 ± 0.038	1.814PheGln: 1.814 ± 0.045	1.79PheArg: 1.79 ± 0.047	2.974PheSer: 2.974 ± 0.062	2.126PheThr: 2.126 ± 0.053	2.909PheVal: 2.909 ± 0.058	0.471PheTrp: 0.471 ± 0.022	1.715PheTyr: 1.715 ± 0.051	0.001PheXaa: 0.001 ± 0.001
Gly	5.318GlyAla: 5.318 ± 0.084	1.51GlyCys: 1.51 ± 0.042	3.387GlyAsp: 3.387 ± 0.061	5.375GlyGlu: 5.375 ± 0.086	3.146GlyPhe: 3.146 ± 0.056	5.315GlyGly: 5.315 ± 0.091	1.272GlyHis: 1.272 ± 0.043	6.459GlyIle: 6.459 ± 0.088	5.64GlyLys: 5.64 ± 0.085	6.427GlyLeu: 6.427 ± 0.093	2.651GlyMet: 2.651 ± 0.056	2.982GlyAsn: 2.982 ± 0.059	1.508GlyPro: 1.508 ± 0.057	2.383GlyGln: 2.383 ± 0.055	3.334GlyArg: 3.334 ± 0.066	4.045GlySer: 4.045 ± 0.074	4.261GlyThr: 4.261 ± 0.08	5.485GlyVal: 5.485 ± 0.072	0.794GlyTrp: 0.794 ± 0.041	3.368GlyTyr: 3.368 ± 0.068	0.008GlyXaa: 0.008 ± 0.003
His	1.048HisAla: 1.048 ± 0.039	0.334HisCys: 0.334 ± 0.022	0.81HisAsp: 0.81 ± 0.041	1.075HisGlu: 1.075 ± 0.043	0.767HisPhe: 0.767 ± 0.031	1.402HisGly: 1.402 ± 0.046	0.431HisHis: 0.431 ± 0.038	1.24HisIle: 1.24 ± 0.04	0.93HisLys: 0.93 ± 0.029	1.595HisLeu: 1.595 ± 0.046	0.561HisMet: 0.561 ± 0.024	0.598HisAsn: 0.598 ± 0.026	0.938HisPro: 0.938 ± 0.033	0.557HisGln: 0.557 ± 0.027	0.909HisArg: 0.909 ± 0.027	1.036HisSer: 1.036 ± 0.036	0.932HisThr: 0.932 ± 0.033	1.132HisVal: 1.132 ± 0.034	0.177HisTrp: 0.177 ± 0.015	0.699HisTyr: 0.699 ± 0.028	0.001HisXaa: 0.001 ± 0.001
Ile	5.224IleAla: 5.224 ± 0.089	1.426IleCys: 1.426 ± 0.035	3.36IleAsp: 3.36 ± 0.067	4.464IleGlu: 4.464 ± 0.063	3.092IlePhe: 3.092 ± 0.058	5.187IleGly: 5.187 ± 0.085	1.364IleHis: 1.364 ± 0.041	4.243IleIle: 4.243 ± 0.09	3.379IleLys: 3.379 ± 0.063	7.635IleLeu: 7.635 ± 0.128	1.774IleMet: 1.774 ± 0.051	2.313IleAsn: 2.313 ± 0.051	3.166IlePro: 3.166 ± 0.063	2.858IleGln: 2.858 ± 0.064	3.497IleArg: 3.497 ± 0.065	4.676IleSer: 4.676 ± 0.077	3.71IleThr: 3.71 ± 0.062	4.95IleVal: 4.95 ± 0.084	0.647IleTrp: 0.647 ± 0.027	2.772IleTyr: 2.772 ± 0.049	0.002IleXaa: 0.002 ± 0.001
Lys	4.894LysAla: 4.894 ± 0.078	0.771LysCys: 0.771 ± 0.031	3.477LysAsp: 3.477 ± 0.062	6.655LysGlu: 6.655 ± 0.098	1.931LysPhe: 1.931 ± 0.045	4.103LysGly: 4.103 ± 0.07	0.862LysHis: 0.862 ± 0.029	5.065LysIle: 5.065 ± 0.079	6.014LysLys: 6.014 ± 0.081	5.271LysLeu: 5.271 ± 0.08	2.207LysMet: 2.207 ± 0.046	3.235LysAsn: 3.235 ± 0.056	1.84LysPro: 1.84 ± 0.04	1.983LysGln: 1.983 ± 0.049	3.133LysArg: 3.133 ± 0.054	3.197LysSer: 3.197 ± 0.06	3.593LysThr: 3.593 ± 0.063	4.5LysVal: 4.5 ± 0.077	0.515LysTrp: 0.515 ± 0.027	2.535LysTyr: 2.535 ± 0.061	0.003LysXaa: 0.003 ± 0.002
Leu	7.199LeuAla: 7.199 ± 0.097	1.663LeuCys: 1.663 ± 0.042	4.985LeuAsp: 4.985 ± 0.08	7.226LeuGlu: 7.226 ± 0.093	3.712LeuPhe: 3.712 ± 0.076	6.802LeuGly: 6.802 ± 0.106	1.527LeuHis: 1.527 ± 0.04	6.058LeuIle: 6.058 ± 0.086	6.123LeuLys: 6.123 ± 0.085	9.176LeuLeu: 9.176 ± 0.148	2.74LeuMet: 2.74 ± 0.06	3.767LeuAsn: 3.767 ± 0.068	3.685LeuPro: 3.685 ± 0.066	2.944LeuGln: 2.944 ± 0.068	4.675LeuArg: 4.675 ± 0.079	6.261LeuSer: 6.261 ± 0.095	5.11LeuThr: 5.11 ± 0.072	6.02LeuVal: 6.02 ± 0.102	0.801LeuTrp: 0.801 ± 0.036	3.249LeuTyr: 3.249 ± 0.064	0.003LeuXaa: 0.003 ± 0.002
Met	2.522MetAla: 2.522 ± 0.063	0.387MetCys: 0.387 ± 0.02	1.778MetAsp: 1.778 ± 0.041	2.892MetGlu: 2.892 ± 0.062	0.965MetPhe: 0.965 ± 0.031	2.344MetGly: 2.344 ± 0.047	0.394MetHis: 0.394 ± 0.021	2.086MetIle: 2.086 ± 0.046	2.438MetLys: 2.438 ± 0.051	2.617MetLeu: 2.617 ± 0.052	0.958MetMet: 0.958 ± 0.033	1.418MetAsn: 1.418 ± 0.042	1.104MetPro: 1.104 ± 0.036	0.957MetGln: 0.957 ± 0.029	1.555MetArg: 1.555 ± 0.045	1.762MetSer: 1.762 ± 0.039	1.627MetThr: 1.627 ± 0.044	2.05MetVal: 2.05 ± 0.047	0.205MetTrp: 0.205 ± 0.014	0.816MetTyr: 0.816 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.646AsnAla: 2.646 ± 0.061	0.692AsnCys: 0.692 ± 0.03	1.584AsnAsp: 1.584 ± 0.041	2.406AsnGlu: 2.406 ± 0.054	1.547AsnPhe: 1.547 ± 0.041	3.141AsnGly: 3.141 ± 0.058	0.811AsnHis: 0.811 ± 0.032	2.851AsnIle: 2.851 ± 0.068	2.015AsnLys: 2.015 ± 0.051	3.958AsnLeu: 3.958 ± 0.069	1.241AsnMet: 1.241 ± 0.033	1.369AsnAsn: 1.369 ± 0.042	2.018AsnPro: 2.018 ± 0.045	1.533AsnGln: 1.533 ± 0.041	1.952AsnArg: 1.952 ± 0.047	2.321AsnSer: 2.321 ± 0.048	2.079AsnThr: 2.079 ± 0.049	2.73AsnVal: 2.73 ± 0.058	0.419AsnTrp: 0.419 ± 0.022	1.757AsnTyr: 1.757 ± 0.045	0.003AsnXaa: 0.003 ± 0.002
Pro	2.339ProAla: 2.339 ± 0.059	0.543ProCys: 0.543 ± 0.025	2.113ProAsp: 2.113 ± 0.059	3.104ProGlu: 3.104 ± 0.05	1.531ProPhe: 1.531 ± 0.043	2.54ProGly: 2.54 ± 0.049	0.599ProHis: 0.599 ± 0.03	2.139ProIle: 2.139 ± 0.048	2.074ProLys: 2.074 ± 0.05	2.848ProLeu: 2.848 ± 0.063	0.943ProMet: 0.943 ± 0.035	1.215ProAsn: 1.215 ± 0.034	0.787ProPro: 0.787 ± 0.028	1.318ProGln: 1.318 ± 0.043	1.227ProArg: 1.227 ± 0.036	1.899ProSer: 1.899 ± 0.047	1.752ProThr: 1.752 ± 0.05	3.081ProVal: 3.081 ± 0.061	0.347ProTrp: 0.347 ± 0.019	1.512ProTyr: 1.512 ± 0.04	0.003ProXaa: 0.003 ± 0.002
Gln	2.72GlnAla: 2.72 ± 0.07	0.42GlnCys: 0.42 ± 0.022	1.65GlnAsp: 1.65 ± 0.041	3.665GlnGlu: 3.665 ± 0.082	1.196GlnPhe: 1.196 ± 0.033	2.538GlnGly: 2.538 ± 0.056	0.404GlnHis: 0.404 ± 0.02	2.95GlnIle: 2.95 ± 0.058	3.065GlnLys: 3.065 ± 0.057	2.992GlnLeu: 2.992 ± 0.068	1.241GlnMet: 1.241 ± 0.037	1.589GlnAsn: 1.589 ± 0.043	1.027GlnPro: 1.027 ± 0.031	1.234GlnGln: 1.234 ± 0.043	1.852GlnArg: 1.852 ± 0.049	1.707GlnSer: 1.707 ± 0.042	1.927GlnThr: 1.927 ± 0.049	2.556GlnVal: 2.556 ± 0.055	0.382GlnTrp: 0.382 ± 0.019	1.331GlnTyr: 1.331 ± 0.036	0.002GlnXaa: 0.002 ± 0.002
Arg	2.884ArgAla: 2.884 ± 0.056	0.683ArgCys: 0.683 ± 0.029	2.293ArgAsp: 2.293 ± 0.053	4.685ArgGlu: 4.685 ± 0.088	1.808ArgPhe: 1.808 ± 0.05	3.012ArgGly: 3.012 ± 0.058	0.861ArgHis: 0.861 ± 0.028	3.359ArgIle: 3.359 ± 0.068	3.683ArgLys: 3.683 ± 0.068	4.356ArgLeu: 4.356 ± 0.071	1.647ArgMet: 1.647 ± 0.042	1.94ArgAsn: 1.94 ± 0.046	1.405ArgPro: 1.405 ± 0.04	2.16ArgGln: 2.16 ± 0.052	2.836ArgArg: 2.836 ± 0.066	2.193ArgSer: 2.193 ± 0.048	2.276ArgThr: 2.276 ± 0.044	3.0ArgVal: 3.0 ± 0.057	0.404ArgTrp: 0.404 ± 0.021	1.922ArgTyr: 1.922 ± 0.044	0.004ArgXaa: 0.004 ± 0.002
Ser	3.975SerAla: 3.975 ± 0.067	0.975SerCys: 0.975 ± 0.035	2.908SerAsp: 2.908 ± 0.06	3.952SerGlu: 3.952 ± 0.073	2.508SerPhe: 2.508 ± 0.053	4.953SerGly: 4.953 ± 0.08	1.082SerHis: 1.082 ± 0.035	3.793SerIle: 3.793 ± 0.065	3.2SerLys: 3.2 ± 0.066	5.391SerLeu: 5.391 ± 0.077	1.88SerMet: 1.88 ± 0.047	1.92SerAsn: 1.92 ± 0.043	1.885SerPro: 1.885 ± 0.046	2.359SerGln: 2.359 ± 0.05	2.704SerArg: 2.704 ± 0.052	3.725SerSer: 3.725 ± 0.074	2.798SerThr: 2.798 ± 0.054	4.402SerVal: 4.402 ± 0.073	0.583SerTrp: 0.583 ± 0.026	2.423SerTyr: 2.423 ± 0.052	0.003SerXaa: 0.003 ± 0.002
Thr	4.195ThrAla: 4.195 ± 0.074	0.705ThrCys: 0.705 ± 0.029	2.794ThrAsp: 2.794 ± 0.054	3.633ThrGlu: 3.633 ± 0.066	2.104ThrPhe: 2.104 ± 0.045	4.692ThrGly: 4.692 ± 0.074	0.836ThrHis: 0.836 ± 0.026	3.428ThrIle: 3.428 ± 0.07	2.861ThrLys: 2.861 ± 0.061	4.863ThrLeu: 4.863 ± 0.072	1.426ThrMet: 1.426 ± 0.037	1.784ThrAsn: 1.784 ± 0.053	2.2ThrPro: 2.2 ± 0.044	1.739ThrGln: 1.739 ± 0.043	1.967ThrArg: 1.967 ± 0.045	2.857ThrSer: 2.857 ± 0.052	2.547ThrThr: 2.547 ± 0.054	4.599ThrVal: 4.599 ± 0.077	0.514ThrTrp: 0.514 ± 0.026	1.979ThrTyr: 1.979 ± 0.054	0.003ThrXaa: 0.003 ± 0.002
Val	4.926ValAla: 4.926 ± 0.071	1.385ValCys: 1.385 ± 0.043	3.879ValAsp: 3.879 ± 0.069	5.044ValGlu: 5.044 ± 0.079	3.155ValPhe: 3.155 ± 0.059	4.976ValGly: 4.976 ± 0.079	1.14ValHis: 1.14 ± 0.041	5.321ValIle: 5.321 ± 0.077	4.58ValLys: 4.58 ± 0.075	7.256ValLeu: 7.256 ± 0.092	2.158ValMet: 2.158 ± 0.056	2.815ValAsn: 2.815 ± 0.055	2.641ValPro: 2.641 ± 0.055	2.36ValGln: 2.36 ± 0.059	3.265ValArg: 3.265 ± 0.059	4.778ValSer: 4.778 ± 0.079	4.236ValThr: 4.236 ± 0.077	5.252ValVal: 5.252 ± 0.092	0.636ValTrp: 0.636 ± 0.029	2.787ValTyr: 2.787 ± 0.053	0.005ValXaa: 0.005 ± 0.002
Trp	0.562TrpAla: 0.562 ± 0.024	0.134TrpCys: 0.134 ± 0.012	0.505TrpAsp: 0.505 ± 0.024	0.861TrpGlu: 0.861 ± 0.029	0.365TrpPhe: 0.365 ± 0.02	0.67TrpGly: 0.67 ± 0.027	0.144TrpHis: 0.144 ± 0.012	0.64TrpIle: 0.64 ± 0.028	0.752TrpLys: 0.752 ± 0.032	0.891TrpLeu: 0.891 ± 0.033	0.387TrpMet: 0.387 ± 0.019	0.499TrpAsn: 0.499 ± 0.022	0.235TrpPro: 0.235 ± 0.014	0.354TrpGln: 0.354 ± 0.021	0.408TrpArg: 0.408 ± 0.022	0.442TrpSer: 0.442 ± 0.022	0.446TrpThr: 0.446 ± 0.021	0.598TrpVal: 0.598 ± 0.027	0.095TrpTrp: 0.095 ± 0.011	0.337TrpTyr: 0.337 ± 0.021	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.566TyrAla: 2.566 ± 0.05	0.678TyrCys: 0.678 ± 0.023	2.235TyrAsp: 2.235 ± 0.058	3.226TyrGlu: 3.226 ± 0.066	1.801TyrPhe: 1.801 ± 0.05	3.128TyrGly: 3.128 ± 0.056	0.837TyrHis: 0.837 ± 0.031	2.477TyrIle: 2.477 ± 0.054	1.889TyrLys: 1.889 ± 0.045	4.023TyrLeu: 4.023 ± 0.077	0.976TyrMet: 0.976 ± 0.03	1.414TyrAsn: 1.414 ± 0.04	1.54TyrPro: 1.54 ± 0.038	1.839TyrGln: 1.839 ± 0.05	2.147TyrArg: 2.147 ± 0.045	2.238TyrSer: 2.238 ± 0.048	2.141TyrThr: 2.141 ± 0.064	2.63TyrVal: 2.63 ± 0.051	0.371TyrTrp: 0.371 ± 0.019	1.829TyrTyr: 1.829 ± 0.071	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.003XaaPhe: 0.003 ± 0.002	0.005XaaGly: 0.005 ± 0.002	0.003XaaHis: 0.003 ± 0.002	0.001XaaIle: 0.001 ± 0.001	0.002XaaLys: 0.002 ± 0.002	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.003XaaAsn: 0.003 ± 0.002	0.003XaaPro: 0.003 ± 0.002	0.002XaaGln: 0.002 ± 0.002	0.006XaaArg: 0.006 ± 0.002	0.004XaaSer: 0.004 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.006XaaVal: 0.006 ± 0.002	0.002XaaTrp: 0.002 ± 0.002	0.004XaaTyr: 0.004 ± 0.002	0.07XaaXaa: 0.07 ± 0.012

Statistics based on 3087 proteins (947112 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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