Amino acid dipepetide frequency for Phyllobacterium zundukense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.079AlaAla: 14.079 ± 0.139
0.881AlaCys: 0.881 ± 0.022
6.187AlaAsp: 6.187 ± 0.068
6.824AlaGlu: 6.824 ± 0.073
4.5AlaPhe: 4.5 ± 0.061
9.459AlaGly: 9.459 ± 0.089
2.025AlaHis: 2.025 ± 0.033
6.992AlaIle: 6.992 ± 0.074
4.745AlaLys: 4.745 ± 0.061
11.716AlaLeu: 11.716 ± 0.103
3.249AlaMet: 3.249 ± 0.049
3.241AlaAsn: 3.241 ± 0.045
4.503AlaPro: 4.503 ± 0.064
3.51AlaGln: 3.51 ± 0.052
6.975AlaArg: 6.975 ± 0.071
6.442AlaSer: 6.442 ± 0.064
5.699AlaThr: 5.699 ± 0.063
8.199AlaVal: 8.199 ± 0.085
1.315AlaTrp: 1.315 ± 0.029
2.596AlaTyr: 2.596 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.88CysAla: 0.88 ± 0.024
0.108CysCys: 0.108 ± 0.009
0.479CysAsp: 0.479 ± 0.017
0.444CysGlu: 0.444 ± 0.017
0.326CysPhe: 0.326 ± 0.014
0.833CysGly: 0.833 ± 0.024
0.222CysHis: 0.222 ± 0.011
0.417CysIle: 0.417 ± 0.014
0.233CysLys: 0.233 ± 0.012
0.754CysLeu: 0.754 ± 0.022
0.155CysMet: 0.155 ± 0.008
0.214CysAsn: 0.214 ± 0.01
0.381CysPro: 0.381 ± 0.014
0.232CysGln: 0.232 ± 0.012
0.508CysArg: 0.508 ± 0.019
0.513CysSer: 0.513 ± 0.02
0.432CysThr: 0.432 ± 0.017
0.569CysVal: 0.569 ± 0.017
0.119CysTrp: 0.119 ± 0.009
0.205CysTyr: 0.205 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.159AspAla: 6.159 ± 0.062
0.469AspCys: 0.469 ± 0.019
3.119AspAsp: 3.119 ± 0.052
3.55AspGlu: 3.55 ± 0.052
2.269AspPhe: 2.269 ± 0.041
4.838AspGly: 4.838 ± 0.073
1.327AspHis: 1.327 ± 0.035
3.518AspIle: 3.518 ± 0.051
2.139AspLys: 2.139 ± 0.037
5.632AspLeu: 5.632 ± 0.056
1.369AspMet: 1.369 ± 0.033
1.608AspAsn: 1.608 ± 0.034
3.224AspPro: 3.224 ± 0.048
1.813AspGln: 1.813 ± 0.035
3.97AspArg: 3.97 ± 0.054
2.309AspSer: 2.309 ± 0.038
2.734AspThr: 2.734 ± 0.048
4.21AspVal: 4.21 ± 0.058
0.922AspTrp: 0.922 ± 0.025
1.555AspTyr: 1.555 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.932GluAla: 6.932 ± 0.079
0.363GluCys: 0.363 ± 0.016
2.74GluAsp: 2.74 ± 0.042
3.274GluGlu: 3.274 ± 0.055
1.971GluPhe: 1.971 ± 0.033
4.002GluGly: 4.002 ± 0.047
1.229GluHis: 1.229 ± 0.03
3.876GluIle: 3.876 ± 0.056
2.853GluLys: 2.853 ± 0.042
5.417GluLeu: 5.417 ± 0.058
1.543GluMet: 1.543 ± 0.031
1.977GluAsn: 1.977 ± 0.037
2.687GluPro: 2.687 ± 0.043
2.161GluGln: 2.161 ± 0.04
4.538GluArg: 4.538 ± 0.058
2.571GluSer: 2.571 ± 0.045
3.586GluThr: 3.586 ± 0.054
3.637GluVal: 3.637 ± 0.059
0.705GluTrp: 0.705 ± 0.023
1.181GluTyr: 1.181 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.513PheAla: 4.513 ± 0.059
0.372PheCys: 0.372 ± 0.016
2.786PheAsp: 2.786 ± 0.046
2.291PheGlu: 2.291 ± 0.039
1.665PhePhe: 1.665 ± 0.037
3.763PheGly: 3.763 ± 0.053
0.841PheHis: 0.841 ± 0.024
2.139PheIle: 2.139 ± 0.038
1.25PheLys: 1.25 ± 0.029
3.664PheLeu: 3.664 ± 0.049
0.889PheMet: 0.889 ± 0.019
1.328PheAsn: 1.328 ± 0.027
1.702PhePro: 1.702 ± 0.032
1.114PheGln: 1.114 ± 0.028
2.262PheArg: 2.262 ± 0.037
2.455PheSer: 2.455 ± 0.04
2.06PheThr: 2.06 ± 0.035
3.07PheVal: 3.07 ± 0.043
0.582PheTrp: 0.582 ± 0.021
1.017PheTyr: 1.017 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
7.975GlyAla: 7.975 ± 0.091
0.782GlyCys: 0.782 ± 0.023
4.266GlyAsp: 4.266 ± 0.06
4.496GlyGlu: 4.496 ± 0.053
3.633GlyPhe: 3.633 ± 0.049
6.711GlyGly: 6.711 ± 0.095
1.8GlyHis: 1.8 ± 0.036
5.226GlyIle: 5.226 ± 0.056
3.981GlyLys: 3.981 ± 0.062
8.345GlyLeu: 8.345 ± 0.083
2.173GlyMet: 2.173 ± 0.038
2.525GlyAsn: 2.525 ± 0.046
3.155GlyPro: 3.155 ± 0.044
2.808GlyGln: 2.808 ± 0.044
5.087GlyArg: 5.087 ± 0.051
4.887GlySer: 4.887 ± 0.066
4.737GlyThr: 4.737 ± 0.073
5.815GlyVal: 5.815 ± 0.058
1.237GlyTrp: 1.237 ± 0.029
2.394GlyTyr: 2.394 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.153HisAla: 2.153 ± 0.039
0.231HisCys: 0.231 ± 0.011
1.253HisAsp: 1.253 ± 0.027
1.134HisGlu: 1.134 ± 0.027
0.937HisPhe: 0.937 ± 0.027
1.853HisGly: 1.853 ± 0.039
0.578HisHis: 0.578 ± 0.019
1.118HisIle: 1.118 ± 0.024
0.607HisLys: 0.607 ± 0.019
2.094HisLeu: 2.094 ± 0.04
0.536HisMet: 0.536 ± 0.019
0.563HisAsn: 0.563 ± 0.018
1.311HisPro: 1.311 ± 0.031
0.589HisGln: 0.589 ± 0.021
1.368HisArg: 1.368 ± 0.029
1.069HisSer: 1.069 ± 0.024
0.884HisThr: 0.884 ± 0.022
1.562HisVal: 1.562 ± 0.029
0.317HisTrp: 0.317 ± 0.014
0.61HisTyr: 0.61 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.93IleAla: 7.93 ± 0.073
0.579IleCys: 0.579 ± 0.018
4.035IleAsp: 4.035 ± 0.05
3.972IleGlu: 3.972 ± 0.054
2.197IlePhe: 2.197 ± 0.04
5.436IleGly: 5.436 ± 0.066
1.091IleHis: 1.091 ± 0.023
3.195IleIle: 3.195 ± 0.048
1.95IleLys: 1.95 ± 0.039
5.307IleLeu: 5.307 ± 0.067
1.197IleMet: 1.197 ± 0.025
1.873IleAsn: 1.873 ± 0.032
2.562IlePro: 2.562 ± 0.041
1.49IleGln: 1.49 ± 0.03
3.451IleArg: 3.451 ± 0.049
3.674IleSer: 3.674 ± 0.047
3.142IleThr: 3.142 ± 0.043
4.805IleVal: 4.805 ± 0.058
0.667IleTrp: 0.667 ± 0.022
1.346IleTyr: 1.346 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.764LysAla: 4.764 ± 0.067
0.201LysCys: 0.201 ± 0.011
2.153LysAsp: 2.153 ± 0.039
2.084LysGlu: 2.084 ± 0.037
1.226LysPhe: 1.226 ± 0.029
3.06LysGly: 3.06 ± 0.053
0.764LysHis: 0.764 ± 0.022
2.343LysIle: 2.343 ± 0.041
1.815LysLys: 1.815 ± 0.04
3.917LysLeu: 3.917 ± 0.05
0.945LysMet: 0.945 ± 0.025
1.274LysAsn: 1.274 ± 0.024
2.442LysPro: 2.442 ± 0.038
1.352LysGln: 1.352 ± 0.028
2.702LysArg: 2.702 ± 0.041
2.433LysSer: 2.433 ± 0.036
2.476LysThr: 2.476 ± 0.037
2.817LysVal: 2.817 ± 0.048
0.453LysTrp: 0.453 ± 0.016
0.797LysTyr: 0.797 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
12.005LeuAla: 12.005 ± 0.101
0.866LeuCys: 0.866 ± 0.022
5.753LeuAsp: 5.753 ± 0.065
5.329LeuGlu: 5.329 ± 0.062
3.788LeuPhe: 3.788 ± 0.054
7.969LeuGly: 7.969 ± 0.074
1.86LeuHis: 1.86 ± 0.037
5.682LeuIle: 5.682 ± 0.069
4.19LeuLys: 4.19 ± 0.048
9.115LeuLeu: 9.115 ± 0.097
2.4LeuMet: 2.4 ± 0.043
2.914LeuAsn: 2.914 ± 0.039
5.124LeuPro: 5.124 ± 0.056
2.919LeuGln: 2.919 ± 0.045
5.988LeuArg: 5.988 ± 0.065
6.674LeuSer: 6.674 ± 0.073
5.569LeuThr: 5.569 ± 0.053
7.263LeuVal: 7.263 ± 0.072
1.082LeuTrp: 1.082 ± 0.03
2.213LeuTyr: 2.213 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.877MetAla: 2.877 ± 0.045
0.151MetCys: 0.151 ± 0.009
1.17MetAsp: 1.17 ± 0.027
1.147MetGlu: 1.147 ± 0.027
0.766MetPhe: 0.766 ± 0.025
1.75MetGly: 1.75 ± 0.034
0.483MetHis: 0.483 ± 0.018
1.571MetIle: 1.571 ± 0.032
1.133MetLys: 1.133 ± 0.028
2.494MetLeu: 2.494 ± 0.042
0.679MetMet: 0.679 ± 0.02
0.927MetAsn: 0.927 ± 0.02
1.422MetPro: 1.422 ± 0.033
0.876MetGln: 0.876 ± 0.019
1.782MetArg: 1.782 ± 0.037
1.722MetSer: 1.722 ± 0.031
1.907MetThr: 1.907 ± 0.029
1.71MetVal: 1.71 ± 0.033
0.216MetTrp: 0.216 ± 0.013
0.328MetTyr: 0.328 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.371AsnAla: 3.371 ± 0.04
0.268AsnCys: 0.268 ± 0.014
1.784AsnAsp: 1.784 ± 0.036
1.593AsnGlu: 1.593 ± 0.031
1.156AsnPhe: 1.156 ± 0.027
2.797AsnGly: 2.797 ± 0.057
0.606AsnHis: 0.606 ± 0.018
1.755AsnIle: 1.755 ± 0.028
0.936AsnLys: 0.936 ± 0.026
2.953AsnLeu: 2.953 ± 0.041
0.728AsnMet: 0.728 ± 0.024
0.919AsnAsn: 0.919 ± 0.022
2.044AsnPro: 2.044 ± 0.037
0.907AsnGln: 0.907 ± 0.028
2.05AsnArg: 2.05 ± 0.035
1.673AsnSer: 1.673 ± 0.034
1.498AsnThr: 1.498 ± 0.03
2.317AsnVal: 2.317 ± 0.037
0.53AsnTrp: 0.53 ± 0.018
0.837AsnTyr: 0.837 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.307ProAla: 5.307 ± 0.062
0.289ProCys: 0.289 ± 0.015
3.429ProAsp: 3.429 ± 0.046
3.521ProGlu: 3.521 ± 0.057
2.017ProPhe: 2.017 ± 0.038
3.879ProGly: 3.879 ± 0.048
1.087ProHis: 1.087 ± 0.028
2.506ProIle: 2.506 ± 0.036
2.003ProLys: 2.003 ± 0.036
4.6ProLeu: 4.6 ± 0.055
1.088ProMet: 1.088 ± 0.029
1.459ProAsn: 1.459 ± 0.026
1.982ProPro: 1.982 ± 0.039
1.597ProGln: 1.597 ± 0.031
2.456ProArg: 2.456 ± 0.041
2.783ProSer: 2.783 ± 0.046
2.416ProThr: 2.416 ± 0.035
4.157ProVal: 4.157 ± 0.056
0.64ProTrp: 0.64 ± 0.019
1.2ProTyr: 1.2 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.632GlnAla: 3.632 ± 0.05
0.199GlnCys: 0.199 ± 0.011
1.464GlnAsp: 1.464 ± 0.033
1.541GlnGlu: 1.541 ± 0.034
1.193GlnPhe: 1.193 ± 0.025
2.292GlnGly: 2.292 ± 0.038
0.636GlnHis: 0.636 ± 0.019
2.094GlnIle: 2.094 ± 0.037
1.338GlnLys: 1.338 ± 0.034
3.072GlnLeu: 3.072 ± 0.049
0.909GlnMet: 0.909 ± 0.025
1.034GlnAsn: 1.034 ± 0.027
1.633GlnPro: 1.633 ± 0.033
1.259GlnGln: 1.259 ± 0.031
2.298GlnArg: 2.298 ± 0.042
2.06GlnSer: 2.06 ± 0.034
1.842GlnThr: 1.842 ± 0.037
2.088GlnVal: 2.088 ± 0.037
0.409GlnTrp: 0.409 ± 0.017
0.681GlnTyr: 0.681 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
6.366ArgAla: 6.366 ± 0.067
0.441ArgCys: 0.441 ± 0.017
3.665ArgAsp: 3.665 ± 0.051
3.835ArgGlu: 3.835 ± 0.054
2.881ArgPhe: 2.881 ± 0.043
4.114ArgGly: 4.114 ± 0.054
1.577ArgHis: 1.577 ± 0.031
4.077ArgIle: 4.077 ± 0.052
2.621ArgLys: 2.621 ± 0.042
6.875ArgLeu: 6.875 ± 0.077
1.738ArgMet: 1.738 ± 0.035
2.123ArgAsn: 2.123 ± 0.034
2.921ArgPro: 2.921 ± 0.049
2.453ArgGln: 2.453 ± 0.042
4.562ArgArg: 4.562 ± 0.065
3.698ArgSer: 3.698 ± 0.051
3.287ArgThr: 3.287 ± 0.045
4.242ArgVal: 4.242 ± 0.05
0.842ArgTrp: 0.842 ± 0.023
1.704ArgTyr: 1.704 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.186SerAla: 6.186 ± 0.06
0.419SerCys: 0.419 ± 0.017
3.255SerAsp: 3.255 ± 0.048
3.098SerGlu: 3.098 ± 0.04
2.486SerPhe: 2.486 ± 0.038
5.758SerGly: 5.758 ± 0.066
1.201SerHis: 1.201 ± 0.029
3.483SerIle: 3.483 ± 0.055
2.143SerLys: 2.143 ± 0.042
5.726SerLeu: 5.726 ± 0.065
1.5SerMet: 1.5 ± 0.032
1.792SerAsn: 1.792 ± 0.037
2.822SerPro: 2.822 ± 0.039
1.779SerGln: 1.779 ± 0.032
3.617SerArg: 3.617 ± 0.044
3.457SerSer: 3.457 ± 0.051
3.054SerThr: 3.054 ± 0.049
4.363SerVal: 4.363 ± 0.055
0.825SerTrp: 0.825 ± 0.024
1.442SerTyr: 1.442 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.014ThrAla: 6.014 ± 0.059
0.42ThrCys: 0.42 ± 0.017
2.899ThrAsp: 2.899 ± 0.04
2.776ThrGlu: 2.776 ± 0.04
2.21ThrPhe: 2.21 ± 0.035
5.12ThrGly: 5.12 ± 0.058
1.124ThrHis: 1.124 ± 0.024
3.6ThrIle: 3.6 ± 0.049
1.972ThrLys: 1.972 ± 0.032
5.7ThrLeu: 5.7 ± 0.056
1.28ThrMet: 1.28 ± 0.027
1.548ThrAsn: 1.548 ± 0.034
3.105ThrPro: 3.105 ± 0.041
1.434ThrGln: 1.434 ± 0.029
3.151ThrArg: 3.151 ± 0.039
3.123ThrSer: 3.123 ± 0.047
3.082ThrThr: 3.082 ± 0.064
4.385ThrVal: 4.385 ± 0.061
0.643ThrTrp: 0.643 ± 0.019
1.324ThrTyr: 1.324 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
8.385ValAla: 8.385 ± 0.077
0.621ValCys: 0.621 ± 0.021
4.119ValAsp: 4.119 ± 0.057
4.4ValGlu: 4.4 ± 0.059
2.963ValPhe: 2.963 ± 0.045
5.369ValGly: 5.369 ± 0.069
1.449ValHis: 1.449 ± 0.029
4.497ValIle: 4.497 ± 0.057
2.763ValLys: 2.763 ± 0.041
7.307ValLeu: 7.307 ± 0.075
1.878ValMet: 1.878 ± 0.033
2.199ValAsn: 2.199 ± 0.038
3.552ValPro: 3.552 ± 0.046
2.026ValGln: 2.026 ± 0.037
4.528ValArg: 4.528 ± 0.049
4.627ValSer: 4.627 ± 0.059
4.534ValThr: 4.534 ± 0.058
5.749ValVal: 5.749 ± 0.068
0.856ValTrp: 0.856 ± 0.023
1.59ValTyr: 1.59 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.105TrpAla: 1.105 ± 0.028
0.122TrpCys: 0.122 ± 0.008
0.631TrpAsp: 0.631 ± 0.021
0.579TrpGlu: 0.579 ± 0.019
0.538TrpPhe: 0.538 ± 0.018
0.844TrpGly: 0.844 ± 0.022
0.336TrpHis: 0.336 ± 0.014
0.711TrpIle: 0.711 ± 0.026
0.536TrpLys: 0.536 ± 0.019
1.567TrpLeu: 1.567 ± 0.035
0.359TrpMet: 0.359 ± 0.016
0.501TrpAsn: 0.501 ± 0.016
0.668TrpPro: 0.668 ± 0.022
0.584TrpGln: 0.584 ± 0.018
0.968TrpArg: 0.968 ± 0.023
0.832TrpSer: 0.832 ± 0.021
0.77TrpThr: 0.77 ± 0.023
0.769TrpVal: 0.769 ± 0.023
0.216TrpTrp: 0.216 ± 0.013
0.336TrpTyr: 0.336 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.503TyrAla: 2.503 ± 0.038
0.242TyrCys: 0.242 ± 0.011
1.551TyrAsp: 1.551 ± 0.03
1.356TyrGlu: 1.356 ± 0.031
1.04TyrPhe: 1.04 ± 0.023
2.186TyrGly: 2.186 ± 0.037
0.532TyrHis: 0.532 ± 0.018
1.102TyrIle: 1.102 ± 0.028
0.806TyrLys: 0.806 ± 0.025
2.448TyrLeu: 2.448 ± 0.044
0.495TyrMet: 0.495 ± 0.018
0.703TyrAsn: 0.703 ± 0.019
1.176TyrPro: 1.176 ± 0.026
0.77TyrGln: 0.77 ± 0.023
1.763TyrArg: 1.763 ± 0.036
1.399TyrSer: 1.399 ± 0.031
1.199TyrThr: 1.199 ± 0.027
1.685TyrVal: 1.685 ± 0.033
0.397TyrTrp: 0.397 ± 0.016
0.676TyrTyr: 0.676 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5605 proteins (1679408 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski