Amino acid dipepetide frequency for Akabane virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.347AlaAla: 3.347 ± 4.21
1.545AlaCys: 1.545 ± 1.068
2.317AlaAsp: 2.317 ± 0.559
3.605AlaGlu: 3.605 ± 4.061
2.832AlaPhe: 2.832 ± 3.263
1.287AlaGly: 1.287 ± 1.702
0.257AlaHis: 0.257 ± 0.158
5.407AlaIle: 5.407 ± 1.476
3.347AlaLys: 3.347 ± 1.675
4.892AlaLeu: 4.892 ± 1.267
1.802AlaMet: 1.802 ± 0.574
4.377AlaAsn: 4.377 ± 1.986
0.772AlaPro: 0.772 ± 0.94
2.06AlaGln: 2.06 ± 1.548
2.06AlaArg: 2.06 ± 2.462
2.832AlaSer: 2.832 ± 0.699
4.377AlaThr: 4.377 ± 1.583
3.347AlaVal: 3.347 ± 0.939
0.257AlaTrp: 0.257 ± 0.158
2.06AlaTyr: 2.06 ± 0.469
0.0AlaXaa: 0.0 ± 0.0
Cys
1.802CysAla: 1.802 ± 0.422
0.772CysCys: 0.772 ± 0.186
0.772CysAsp: 0.772 ± 0.361
0.515CysGlu: 0.515 ± 0.477
1.287CysPhe: 1.287 ± 1.192
2.317CysGly: 2.317 ± 1.082
0.257CysHis: 0.257 ± 0.238
3.347CysIle: 3.347 ± 1.348
1.802CysLys: 1.802 ± 1.184
2.575CysLeu: 2.575 ± 0.99
0.772CysMet: 0.772 ± 0.186
1.287CysAsn: 1.287 ± 0.495
1.287CysPro: 1.287 ± 0.495
0.772CysGln: 0.772 ± 0.361
1.802CysArg: 1.802 ± 0.633
1.03CysSer: 1.03 ± 0.954
2.06CysThr: 2.06 ± 1.369
1.287CysVal: 1.287 ± 1.192
0.257CysTrp: 0.257 ± 0.158
2.317CysTyr: 2.317 ± 0.774
0.0CysXaa: 0.0 ± 0.0
Asp
2.317AspAla: 2.317 ± 1.542
1.287AspCys: 1.287 ± 0.831
4.377AspAsp: 4.377 ± 1.689
2.06AspGlu: 2.06 ± 0.629
4.119AspPhe: 4.119 ± 2.185
2.317AspGly: 2.317 ± 1.435
1.545AspHis: 1.545 ± 0.373
5.922AspIle: 5.922 ± 1.532
4.892AspLys: 4.892 ± 1.229
7.209AspLeu: 7.209 ± 0.679
1.287AspMet: 1.287 ± 0.706
2.832AspAsn: 2.832 ± 0.699
1.802AspPro: 1.802 ± 0.769
1.802AspGln: 1.802 ± 0.492
2.06AspArg: 2.06 ± 1.266
2.06AspSer: 2.06 ± 0.469
2.832AspThr: 2.832 ± 0.76
4.377AspVal: 4.377 ± 1.147
0.0AspTrp: 0.0 ± 0.0
2.832AspTyr: 2.832 ± 1.075
0.0AspXaa: 0.0 ± 0.0
Glu
1.545GluAla: 1.545 ± 0.759
1.802GluCys: 1.802 ± 0.954
2.317GluAsp: 2.317 ± 1.082
3.605GluGlu: 3.605 ± 0.158
5.664GluPhe: 5.664 ± 0.847
1.802GluGly: 1.802 ± 0.422
1.802GluHis: 1.802 ± 0.492
5.407GluIle: 5.407 ± 1.304
3.09GluLys: 3.09 ± 0.943
3.862GluLeu: 3.862 ± 1.118
2.06GluMet: 2.06 ± 0.802
2.317GluAsn: 2.317 ± 0.559
2.06GluPro: 2.06 ± 0.469
2.317GluGln: 2.317 ± 0.581
2.832GluArg: 2.832 ± 1.075
4.634GluSer: 4.634 ± 1.118
2.317GluThr: 2.317 ± 0.889
2.317GluVal: 2.317 ± 1.211
0.515GluTrp: 0.515 ± 0.898
2.317GluTyr: 2.317 ± 0.559
0.0GluXaa: 0.0 ± 0.0
Phe
2.575PheAla: 2.575 ± 2.523
1.287PheCys: 1.287 ± 0.495
3.347PheAsp: 3.347 ± 1.058
3.605PheGlu: 3.605 ± 1.135
1.03PhePhe: 1.03 ± 0.743
1.802PheGly: 1.802 ± 1.683
0.257PheHis: 0.257 ± 0.158
4.119PheIle: 4.119 ± 1.125
4.892PheLys: 4.892 ± 1.696
4.892PheLeu: 4.892 ± 2.137
1.287PheMet: 1.287 ± 0.726
2.317PheAsn: 2.317 ± 1.441
0.257PhePro: 0.257 ± 0.918
1.287PheGln: 1.287 ± 0.462
1.802PheArg: 1.802 ± 0.954
3.605PheSer: 3.605 ± 0.158
3.862PheThr: 3.862 ± 2.057
2.832PheVal: 2.832 ± 0.651
0.257PheTrp: 0.257 ± 0.158
2.317PheTyr: 2.317 ± 0.45
0.0PheXaa: 0.0 ± 0.0
Gly
1.287GlyAla: 1.287 ± 0.706
1.802GlyCys: 1.802 ± 0.871
2.832GlyAsp: 2.832 ± 0.804
2.575GlyGlu: 2.575 ± 0.674
1.287GlyPhe: 1.287 ± 1.702
1.802GlyGly: 1.802 ± 0.954
0.515GlyHis: 0.515 ± 0.477
3.09GlyIle: 3.09 ± 0.529
2.832GlyLys: 2.832 ± 0.651
3.605GlyLeu: 3.605 ± 0.835
1.802GlyMet: 1.802 ± 0.634
2.317GlyAsn: 2.317 ± 0.559
2.06GlyPro: 2.06 ± 0.629
1.287GlyGln: 1.287 ± 1.702
1.802GlyArg: 1.802 ± 0.492
2.06GlySer: 2.06 ± 1.726
2.317GlyThr: 2.317 ± 1.082
1.545GlyVal: 1.545 ± 1.022
0.515GlyTrp: 0.515 ± 0.144
1.802GlyTyr: 1.802 ± 2.532
0.0GlyXaa: 0.0 ± 0.0
His
1.545HisAla: 1.545 ± 0.432
0.257HisCys: 0.257 ± 0.238
1.03HisAsp: 1.03 ± 0.633
2.06HisGlu: 2.06 ± 0.854
1.287HisPhe: 1.287 ± 0.706
1.802HisGly: 1.802 ± 0.769
0.772HisHis: 0.772 ± 0.186
1.03HisIle: 1.03 ± 0.288
2.575HisLys: 2.575 ± 0.449
1.545HisLeu: 1.545 ± 0.432
0.515HisMet: 0.515 ± 0.144
2.06HisAsn: 2.06 ± 0.629
0.515HisPro: 0.515 ± 0.144
0.257HisGln: 0.257 ± 0.158
1.287HisArg: 1.287 ± 1.823
2.317HisSer: 2.317 ± 0.559
1.287HisThr: 1.287 ± 0.293
1.545HisVal: 1.545 ± 0.432
0.0HisTrp: 0.0 ± 0.0
1.03HisTyr: 1.03 ± 0.288
0.0HisXaa: 0.0 ± 0.0
Ile
5.149IleAla: 5.149 ± 1.44
3.347IleCys: 3.347 ± 1.348
5.407IleAsp: 5.407 ± 1.42
4.892IleGlu: 4.892 ± 1.432
2.832IlePhe: 2.832 ± 0.76
2.575IleGly: 2.575 ± 0.72
3.605IleHis: 3.605 ± 0.835
5.664IleIle: 5.664 ± 1.584
8.754IleLys: 8.754 ± 0.485
7.467IleLeu: 7.467 ± 1.698
1.802IleMet: 1.802 ± 0.257
5.149IleAsn: 5.149 ± 1.44
2.832IlePro: 2.832 ± 0.651
3.862IleGln: 3.862 ± 0.169
4.119IleArg: 4.119 ± 1.152
7.981IleSer: 7.981 ± 1.428
6.437IleThr: 6.437 ± 1.465
3.605IleVal: 3.605 ± 0.158
0.515IleTrp: 0.515 ± 0.317
2.832IleTyr: 2.832 ± 1.397
0.0IleXaa: 0.0 ± 0.0
Lys
4.377LysAla: 4.377 ± 2.28
1.287LysCys: 1.287 ± 0.495
4.377LysAsp: 4.377 ± 0.056
4.119LysGlu: 4.119 ± 1.152
4.119LysPhe: 4.119 ± 1.333
4.377LysGly: 4.377 ± 0.431
1.03LysHis: 1.03 ± 0.314
6.179LysIle: 6.179 ± 1.886
6.179LysLys: 6.179 ± 0.43
7.981LysLeu: 7.981 ± 1.029
2.317LysMet: 2.317 ± 0.663
5.149LysAsn: 5.149 ± 1.44
2.832LysPro: 2.832 ± 0.651
2.575LysGln: 2.575 ± 0.674
2.317LysArg: 2.317 ± 0.774
5.149LysSer: 5.149 ± 1.037
6.694LysThr: 6.694 ± 0.749
3.862LysVal: 3.862 ± 0.261
1.03LysTrp: 1.03 ± 0.314
3.09LysTyr: 3.09 ± 0.736
0.0LysXaa: 0.0 ± 0.0
Leu
5.407LeuAla: 5.407 ± 2.339
2.832LeuCys: 2.832 ± 1.214
6.952LeuAsp: 6.952 ± 1.995
5.922LeuGlu: 5.922 ± 0.668
4.119LeuPhe: 4.119 ± 1.536
1.802LeuGly: 1.802 ± 0.871
3.09LeuHis: 3.09 ± 1.34
4.377LeuIle: 4.377 ± 2.268
6.694LeuLys: 6.694 ± 1.577
7.724LeuLeu: 7.724 ± 1.825
2.832LeuMet: 2.832 ± 1.075
4.634LeuAsn: 4.634 ± 0.9
3.605LeuPro: 3.605 ± 0.845
2.317LeuGln: 2.317 ± 0.774
3.347LeuArg: 3.347 ± 1.001
7.724LeuSer: 7.724 ± 1.772
5.664LeuThr: 5.664 ± 0.903
5.407LeuVal: 5.407 ± 0.364
0.772LeuTrp: 0.772 ± 0.361
5.149LeuTyr: 5.149 ± 1.257
0.0LeuXaa: 0.0 ± 0.0
Met
1.03MetAla: 1.03 ± 0.743
1.03MetCys: 1.03 ± 0.288
2.317MetAsp: 2.317 ± 1.231
0.257MetGlu: 0.257 ± 0.158
0.515MetPhe: 0.515 ± 0.898
1.287MetGly: 1.287 ± 0.791
0.772MetHis: 0.772 ± 0.842
3.347MetIle: 3.347 ± 0.76
1.802MetLys: 1.802 ± 0.492
2.575MetLeu: 2.575 ± 0.674
0.257MetMet: 0.257 ± 0.158
2.06MetAsn: 2.06 ± 1.266
2.06MetPro: 2.06 ± 0.526
1.287MetGln: 1.287 ± 0.462
0.772MetArg: 0.772 ± 0.842
2.317MetSer: 2.317 ± 0.774
2.317MetThr: 2.317 ± 0.595
2.06MetVal: 2.06 ± 1.027
0.257MetTrp: 0.257 ± 0.158
0.515MetTyr: 0.515 ± 0.867
0.0MetXaa: 0.0 ± 0.0
Asn
2.06AsnAla: 2.06 ± 0.563
1.03AsnCys: 1.03 ± 0.954
4.119AsnAsp: 4.119 ± 0.103
3.09AsnGlu: 3.09 ± 0.713
2.575AsnPhe: 2.575 ± 1.413
2.06AsnGly: 2.06 ± 0.854
2.832AsnHis: 2.832 ± 0.341
4.377AsnIle: 4.377 ± 1.166
3.347AsnLys: 3.347 ± 0.84
5.407AsnLeu: 5.407 ± 1.304
2.317AsnMet: 2.317 ± 0.774
5.922AsnAsn: 5.922 ± 0.41
2.832AsnPro: 2.832 ± 1.333
3.09AsnGln: 3.09 ± 2.276
2.317AsnArg: 2.317 ± 0.774
3.862AsnSer: 3.862 ± 0.879
3.09AsnThr: 3.09 ± 0.713
3.09AsnVal: 3.09 ± 1.127
1.287AsnTrp: 1.287 ± 0.293
2.06AsnTyr: 2.06 ± 0.629
0.0AsnXaa: 0.0 ± 0.0
Pro
2.832ProAla: 2.832 ± 0.561
0.257ProCys: 0.257 ± 0.238
2.575ProAsp: 2.575 ± 0.664
2.317ProGlu: 2.317 ± 0.559
1.287ProPhe: 1.287 ± 0.293
2.06ProGly: 2.06 ± 0.563
0.772ProHis: 0.772 ± 0.186
3.862ProIle: 3.862 ± 1.118
1.545ProLys: 1.545 ± 0.721
2.575ProLeu: 2.575 ± 1.79
1.03ProMet: 1.03 ± 0.594
2.317ProAsn: 2.317 ± 1.082
1.03ProPro: 1.03 ± 0.314
1.802ProGln: 1.802 ± 2.521
0.515ProArg: 0.515 ± 0.144
2.575ProSer: 2.575 ± 0.664
1.545ProThr: 1.545 ± 0.432
2.317ProVal: 2.317 ± 0.45
0.515ProTrp: 0.515 ± 0.317
0.772ProTyr: 0.772 ± 0.186
0.0ProXaa: 0.0 ± 0.0
Gln
1.287GlnAla: 1.287 ± 0.293
1.802GlnCys: 1.802 ± 0.871
2.575GlnAsp: 2.575 ± 0.586
1.545GlnGlu: 1.545 ± 0.432
1.287GlnPhe: 1.287 ± 1.659
1.287GlnGly: 1.287 ± 0.293
0.772GlnHis: 0.772 ± 0.715
4.377GlnIle: 4.377 ± 2.28
2.832GlnLys: 2.832 ± 0.341
2.832GlnLeu: 2.832 ± 1.315
0.772GlnMet: 0.772 ± 0.475
2.317GlnAsn: 2.317 ± 0.774
1.03GlnPro: 1.03 ± 0.743
0.772GlnGln: 0.772 ± 0.809
2.832GlnArg: 2.832 ± 1.402
1.287GlnSer: 1.287 ± 0.293
2.06GlnThr: 2.06 ± 0.469
1.802GlnVal: 1.802 ± 0.769
0.515GlnTrp: 0.515 ± 0.317
1.802GlnTyr: 1.802 ± 0.574
0.0GlnXaa: 0.0 ± 0.0
Arg
2.832ArgAla: 2.832 ± 0.341
1.287ArgCys: 1.287 ± 0.495
2.317ArgAsp: 2.317 ± 0.559
3.862ArgGlu: 3.862 ± 0.879
2.317ArgPhe: 2.317 ± 0.774
1.287ArgGly: 1.287 ± 0.293
1.287ArgHis: 1.287 ± 0.791
3.605ArgIle: 3.605 ± 0.763
2.575ArgLys: 2.575 ± 0.449
3.605ArgLeu: 3.605 ± 1.235
0.772ArgMet: 0.772 ± 0.475
1.802ArgAsn: 1.802 ± 0.738
1.545ArgPro: 1.545 ± 0.721
1.802ArgGln: 1.802 ± 0.634
0.772ArgArg: 0.772 ± 0.186
3.09ArgSer: 3.09 ± 1.229
0.257ArgThr: 0.257 ± 0.158
2.06ArgVal: 2.06 ± 1.517
0.515ArgTrp: 0.515 ± 0.867
2.575ArgTyr: 2.575 ± 0.422
0.0ArgXaa: 0.0 ± 0.0
Ser
3.605SerAla: 3.605 ± 1.267
2.575SerCys: 2.575 ± 1.314
3.09SerAsp: 3.09 ± 1.41
3.347SerGlu: 3.347 ± 0.858
1.802SerPhe: 1.802 ± 0.633
1.287SerGly: 1.287 ± 1.659
1.545SerHis: 1.545 ± 0.432
9.269SerIle: 9.269 ± 2.391
6.952SerLys: 6.952 ± 1.763
5.922SerLeu: 5.922 ± 1.391
1.802SerMet: 1.802 ± 0.492
3.09SerAsn: 3.09 ± 0.745
2.317SerPro: 2.317 ± 0.581
2.575SerGln: 2.575 ± 0.674
5.664SerArg: 5.664 ± 1.861
5.407SerSer: 5.407 ± 1.229
5.922SerThr: 5.922 ± 1.553
2.832SerVal: 2.832 ± 1.652
0.772SerTrp: 0.772 ± 0.809
2.06SerTyr: 2.06 ± 0.576
0.0SerXaa: 0.0 ± 0.0
Thr
3.862ThrAla: 3.862 ± 2.119
2.317ThrCys: 2.317 ± 1.425
2.575ThrAsp: 2.575 ± 0.586
2.06ThrGlu: 2.06 ± 0.629
4.119ThrPhe: 4.119 ± 1.993
2.832ThrGly: 2.832 ± 1.548
0.772ThrHis: 0.772 ± 0.186
5.407ThrIle: 5.407 ± 0.908
4.892ThrLys: 4.892 ± 1.229
4.377ThrLeu: 4.377 ± 0.704
1.545ThrMet: 1.545 ± 0.373
3.605ThrAsn: 3.605 ± 0.845
3.09ThrPro: 3.09 ± 0.284
1.545ThrGln: 1.545 ± 0.614
1.03ThrArg: 1.03 ± 0.288
7.209ThrSer: 7.209 ± 1.128
1.802ThrThr: 1.802 ± 0.492
2.575ThrVal: 2.575 ± 1.424
1.545ThrTrp: 1.545 ± 0.627
2.832ThrTyr: 2.832 ± 0.651
0.0ThrXaa: 0.0 ± 0.0
Val
4.634ValAla: 4.634 ± 2.871
0.257ValCys: 0.257 ± 0.158
2.575ValAsp: 2.575 ± 0.449
2.06ValGlu: 2.06 ± 0.469
2.06ValPhe: 2.06 ± 0.526
1.802ValGly: 1.802 ± 0.492
1.802ValHis: 1.802 ± 1.306
4.892ValIle: 4.892 ± 1.586
5.149ValLys: 5.149 ± 2.764
6.437ValLeu: 6.437 ± 0.973
2.317ValMet: 2.317 ± 0.889
2.575ValAsn: 2.575 ± 1.413
1.03ValPro: 1.03 ± 0.848
2.317ValGln: 2.317 ± 1.082
1.802ValArg: 1.802 ± 0.422
3.862ValSer: 3.862 ± 0.261
1.545ValThr: 1.545 ± 0.373
1.545ValVal: 1.545 ± 1.022
0.257ValTrp: 0.257 ± 0.158
2.575ValTyr: 2.575 ± 1.314
0.0ValXaa: 0.0 ± 0.0
Trp
0.257TrpAla: 0.257 ± 0.918
0.257TrpCys: 0.257 ± 0.158
0.257TrpAsp: 0.257 ± 0.158
0.515TrpGlu: 0.515 ± 0.317
1.287TrpPhe: 1.287 ± 0.293
0.772TrpGly: 0.772 ± 0.715
0.0TrpHis: 0.0 ± 0.0
1.03TrpIle: 1.03 ± 0.633
0.257TrpLys: 0.257 ± 0.238
1.545TrpLeu: 1.545 ± 0.373
0.257TrpMet: 0.257 ± 0.918
0.772TrpAsn: 0.772 ± 0.186
0.0TrpPro: 0.0 ± 0.0
0.515TrpGln: 0.515 ± 0.317
0.0TrpArg: 0.0 ± 0.0
1.545TrpSer: 1.545 ± 0.705
0.0TrpThr: 0.0 ± 0.0
0.772TrpVal: 0.772 ± 0.842
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.03TyrAla: 1.03 ± 0.743
1.287TyrCys: 1.287 ± 0.495
1.802TyrAsp: 1.802 ± 1.108
2.575TyrGlu: 2.575 ± 0.923
1.802TyrPhe: 1.802 ± 0.769
2.575TyrGly: 2.575 ± 1.424
1.03TyrHis: 1.03 ± 0.314
4.377TyrIle: 4.377 ± 1.343
4.634TyrLys: 4.634 ± 1.118
3.347TyrLeu: 3.347 ± 1.192
1.03TyrMet: 1.03 ± 0.633
3.862TyrAsn: 3.862 ± 0.879
1.545TyrPro: 1.545 ± 1.022
1.545TyrGln: 1.545 ± 0.721
1.03TyrArg: 1.03 ± 0.314
1.287TyrSer: 1.287 ± 0.495
3.605TyrThr: 3.605 ± 0.4
2.317TyrVal: 2.317 ± 0.581
0.257TyrTrp: 0.257 ± 0.158
2.317TyrTyr: 2.317 ± 0.774
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3885 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski