Amino acid dipepetide frequency for Micropruina glycogenica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.189AlaAla: 19.189 ± 0.169	1.09AlaCys: 1.09 ± 0.036	8.583AlaAsp: 8.583 ± 0.105	7.918AlaGlu: 7.918 ± 0.126	3.406AlaPhe: 3.406 ± 0.068	12.069AlaGly: 12.069 ± 0.103	2.556AlaHis: 2.556 ± 0.049	5.068AlaIle: 5.068 ± 0.066	3.154AlaLys: 3.154 ± 0.069	13.684AlaLeu: 13.684 ± 0.13	2.91AlaMet: 2.91 ± 0.053	2.551AlaAsn: 2.551 ± 0.049	5.806AlaPro: 5.806 ± 0.085	4.237AlaGln: 4.237 ± 0.07	8.918AlaArg: 8.918 ± 0.1	6.494AlaSer: 6.494 ± 0.079	7.689AlaThr: 7.689 ± 0.101	11.093AlaVal: 11.093 ± 0.11	2.092AlaTrp: 2.092 ± 0.045	2.24AlaTyr: 2.24 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.942CysAla: 0.942 ± 0.028	0.13CysCys: 0.13 ± 0.012	0.46CysAsp: 0.46 ± 0.022	0.379CysGlu: 0.379 ± 0.019	0.23CysPhe: 0.23 ± 0.014	0.879CysGly: 0.879 ± 0.028	0.204CysHis: 0.204 ± 0.013	0.205CysIle: 0.205 ± 0.014	0.104CysLys: 0.104 ± 0.009	0.749CysLeu: 0.749 ± 0.025	0.132CysMet: 0.132 ± 0.01	0.157CysAsn: 0.157 ± 0.011	0.528CysPro: 0.528 ± 0.025	0.195CysGln: 0.195 ± 0.015	0.703CysArg: 0.703 ± 0.025	0.492CysSer: 0.492 ± 0.023	0.529CysThr: 0.529 ± 0.03	0.608CysVal: 0.608 ± 0.021	0.144CysTrp: 0.144 ± 0.011	0.192CysTyr: 0.192 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.854AspAla: 7.854 ± 0.091	0.369AspCys: 0.369 ± 0.018	4.693AspAsp: 4.693 ± 0.072	4.117AspGlu: 4.117 ± 0.07	1.724AspPhe: 1.724 ± 0.04	5.622AspGly: 5.622 ± 0.074	1.409AspHis: 1.409 ± 0.037	1.849AspIle: 1.849 ± 0.043	1.134AspLys: 1.134 ± 0.035	6.78AspLeu: 6.78 ± 0.089	0.795AspMet: 0.795 ± 0.025	1.017AspAsn: 1.017 ± 0.03	4.279AspPro: 4.279 ± 0.063	2.091AspGln: 2.091 ± 0.039	4.522AspArg: 4.522 ± 0.063	2.58AspSer: 2.58 ± 0.055	2.839AspThr: 2.839 ± 0.055	5.145AspVal: 5.145 ± 0.071	1.072AspTrp: 1.072 ± 0.03	1.241AspTyr: 1.241 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.736GluAla: 6.736 ± 0.092	0.306GluCys: 0.306 ± 0.017	1.819GluAsp: 1.819 ± 0.045	1.826GluGlu: 1.826 ± 0.056	1.528GluPhe: 1.528 ± 0.039	3.565GluGly: 3.565 ± 0.054	1.352GluHis: 1.352 ± 0.036	2.032GluIle: 2.032 ± 0.047	1.11GluLys: 1.11 ± 0.037	6.541GluLeu: 6.541 ± 0.092	0.852GluMet: 0.852 ± 0.026	0.986GluAsn: 0.986 ± 0.031	3.245GluPro: 3.245 ± 0.065	2.446GluGln: 2.446 ± 0.057	4.634GluArg: 4.634 ± 0.082	2.505GluSer: 2.505 ± 0.048	2.424GluThr: 2.424 ± 0.046	4.734GluVal: 4.734 ± 0.071	0.762GluTrp: 0.762 ± 0.029	0.967GluTyr: 0.967 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.95PheAla: 3.95 ± 0.061	0.284PheCys: 0.284 ± 0.016	2.252PheAsp: 2.252 ± 0.048	1.578PheGlu: 1.578 ± 0.043	0.936PhePhe: 0.936 ± 0.033	3.248PheGly: 3.248 ± 0.058	0.57PheHis: 0.57 ± 0.021	0.991PheIle: 0.991 ± 0.035	0.553PheLys: 0.553 ± 0.025	2.434PheLeu: 2.434 ± 0.055	0.477PheMet: 0.477 ± 0.022	0.719PheAsn: 0.719 ± 0.027	1.26PhePro: 1.26 ± 0.037	0.663PheGln: 0.663 ± 0.025	1.66PheArg: 1.66 ± 0.036	1.601PheSer: 1.601 ± 0.04	2.096PheThr: 2.096 ± 0.044	2.637PheVal: 2.637 ± 0.053	0.44PheTrp: 0.44 ± 0.019	0.608PheTyr: 0.608 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.406GlyAla: 9.406 ± 0.085	0.865GlyCys: 0.865 ± 0.028	5.128GlyAsp: 5.128 ± 0.076	4.477GlyGlu: 4.477 ± 0.065	3.053GlyPhe: 3.053 ± 0.051	7.268GlyGly: 7.268 ± 0.093	2.021GlyHis: 2.021 ± 0.045	3.555GlyIle: 3.555 ± 0.066	2.209GlyLys: 2.209 ± 0.051	9.487GlyLeu: 9.487 ± 0.109	2.012GlyMet: 2.012 ± 0.042	1.803GlyAsn: 1.803 ± 0.04	4.069GlyPro: 4.069 ± 0.056	2.885GlyGln: 2.885 ± 0.06	6.909GlyArg: 6.909 ± 0.097	5.293GlySer: 5.293 ± 0.077	5.418GlyThr: 5.418 ± 0.094	8.115GlyVal: 8.115 ± 0.09	2.007GlyTrp: 2.007 ± 0.044	2.37GlyTyr: 2.37 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.463HisAla: 2.463 ± 0.054	0.209HisCys: 0.209 ± 0.014	1.526HisAsp: 1.526 ± 0.035	1.236HisGlu: 1.236 ± 0.038	0.551HisPhe: 0.551 ± 0.02	2.017HisGly: 2.017 ± 0.05	0.709HisHis: 0.709 ± 0.025	0.682HisIle: 0.682 ± 0.028	0.338HisLys: 0.338 ± 0.017	2.388HisLeu: 2.388 ± 0.047	0.311HisMet: 0.311 ± 0.016	0.457HisAsn: 0.457 ± 0.02	1.693HisPro: 1.693 ± 0.04	0.721HisGln: 0.721 ± 0.025	1.921HisArg: 1.921 ± 0.046	1.033HisSer: 1.033 ± 0.028	1.137HisThr: 1.137 ± 0.035	1.696HisVal: 1.696 ± 0.037	0.388HisTrp: 0.388 ± 0.017	0.493HisTyr: 0.493 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.667IleAla: 5.667 ± 0.076	0.378IleCys: 0.378 ± 0.019	3.166IleAsp: 3.166 ± 0.055	2.605IleGlu: 2.605 ± 0.057	0.977IlePhe: 0.977 ± 0.036	4.172IleGly: 4.172 ± 0.068	0.629IleHis: 0.629 ± 0.025	1.275IleIle: 1.275 ± 0.036	0.911IleLys: 0.911 ± 0.03	2.596IleLeu: 2.596 ± 0.056	0.601IleMet: 0.601 ± 0.026	0.986IleAsn: 0.986 ± 0.031	1.843IlePro: 1.843 ± 0.04	0.791IleGln: 0.791 ± 0.028	2.246IleArg: 2.246 ± 0.048	2.066IleSer: 2.066 ± 0.042	2.782IleThr: 2.782 ± 0.052	3.723IleVal: 3.723 ± 0.055	0.482IleTrp: 0.482 ± 0.023	0.721IleTyr: 0.721 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.061LysAla: 3.061 ± 0.071	0.105LysCys: 0.105 ± 0.01	1.025LysAsp: 1.025 ± 0.035	0.85LysGlu: 0.85 ± 0.032	0.528LysPhe: 0.528 ± 0.022	1.831LysGly: 1.831 ± 0.042	0.439LysHis: 0.439 ± 0.022	0.809LysIle: 0.809 ± 0.032	0.812LysLys: 0.812 ± 0.038	2.255LysLeu: 2.255 ± 0.051	0.4LysMet: 0.4 ± 0.019	0.57LysAsn: 0.57 ± 0.024	1.396LysPro: 1.396 ± 0.038	0.824LysGln: 0.824 ± 0.031	1.617LysArg: 1.617 ± 0.039	1.194LysSer: 1.194 ± 0.035	1.346LysThr: 1.346 ± 0.04	2.028LysVal: 2.028 ± 0.047	0.27LysTrp: 0.27 ± 0.014	0.48LysTyr: 0.48 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.682LeuAla: 15.682 ± 0.144	0.744LeuCys: 0.744 ± 0.026	6.742LeuAsp: 6.742 ± 0.088	4.236LeuGlu: 4.236 ± 0.067	2.764LeuPhe: 2.764 ± 0.053	9.341LeuGly: 9.341 ± 0.107	2.164LeuHis: 2.164 ± 0.047	4.439LeuIle: 4.439 ± 0.072	2.051LeuLys: 2.051 ± 0.049	10.595LeuLeu: 10.595 ± 0.129	1.838LeuMet: 1.838 ± 0.036	2.207LeuAsn: 2.207 ± 0.045	6.075LeuPro: 6.075 ± 0.081	2.876LeuGln: 2.876 ± 0.053	7.593LeuArg: 7.593 ± 0.099	5.607LeuSer: 5.607 ± 0.077	6.917LeuThr: 6.917 ± 0.077	9.456LeuVal: 9.456 ± 0.123	1.362LeuTrp: 1.362 ± 0.04	1.717LeuTyr: 1.717 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.495MetAla: 2.495 ± 0.047	0.141MetCys: 0.141 ± 0.01	0.809MetAsp: 0.809 ± 0.028	0.612MetGlu: 0.612 ± 0.024	0.532MetPhe: 0.532 ± 0.024	1.408MetGly: 1.408 ± 0.034	0.397MetHis: 0.397 ± 0.02	0.858MetIle: 0.858 ± 0.031	0.502MetLys: 0.502 ± 0.022	1.972MetLeu: 1.972 ± 0.045	0.387MetMet: 0.387 ± 0.022	0.55MetAsn: 0.55 ± 0.025	1.205MetPro: 1.205 ± 0.034	0.57MetGln: 0.57 ± 0.024	1.44MetArg: 1.44 ± 0.032	1.382MetSer: 1.382 ± 0.038	1.704MetThr: 1.704 ± 0.038	1.585MetVal: 1.585 ± 0.039	0.224MetTrp: 0.224 ± 0.013	0.275MetTyr: 0.275 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.668AsnAla: 2.668 ± 0.049	0.159AsnCys: 0.159 ± 0.012	1.308AsnAsp: 1.308 ± 0.037	1.009AsnGlu: 1.009 ± 0.026	0.581AsnPhe: 0.581 ± 0.022	1.974AsnGly: 1.974 ± 0.04	0.496AsnHis: 0.496 ± 0.02	0.689AsnIle: 0.689 ± 0.027	0.472AsnLys: 0.472 ± 0.022	2.18AsnLeu: 2.18 ± 0.044	0.357AsnMet: 0.357 ± 0.018	0.541AsnAsn: 0.541 ± 0.024	1.782AsnPro: 1.782 ± 0.045	0.759AsnGln: 0.759 ± 0.026	1.534AsnArg: 1.534 ± 0.038	1.049AsnSer: 1.049 ± 0.032	1.243AsnThr: 1.243 ± 0.034	1.618AsnVal: 1.618 ± 0.042	0.394AsnTrp: 0.394 ± 0.016	0.476AsnTyr: 0.476 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.302ProAla: 7.302 ± 0.088	0.358ProCys: 0.358 ± 0.019	4.37ProAsp: 4.37 ± 0.073	3.373ProGlu: 3.373 ± 0.055	1.593ProPhe: 1.593 ± 0.035	5.455ProGly: 5.455 ± 0.071	1.233ProHis: 1.233 ± 0.036	2.01ProIle: 2.01 ± 0.043	1.21ProLys: 1.21 ± 0.035	5.124ProLeu: 5.124 ± 0.069	1.05ProMet: 1.05 ± 0.029	1.242ProAsn: 1.242 ± 0.036	2.984ProPro: 2.984 ± 0.063	1.873ProGln: 1.873 ± 0.046	3.555ProArg: 3.555 ± 0.059	3.726ProSer: 3.726 ± 0.07	3.768ProThr: 3.768 ± 0.064	4.899ProVal: 4.899 ± 0.068	1.017ProTrp: 1.017 ± 0.031	1.135ProTyr: 1.135 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.38GlnAla: 4.38 ± 0.072	0.201GlnCys: 0.201 ± 0.015	1.011GlnAsp: 1.011 ± 0.032	0.994GlnGlu: 0.994 ± 0.032	0.86GlnPhe: 0.86 ± 0.032	2.435GlnGly: 2.435 ± 0.051	0.812GlnHis: 0.812 ± 0.027	1.263GlnIle: 1.263 ± 0.032	0.62GlnLys: 0.62 ± 0.027	3.76GlnLeu: 3.76 ± 0.07	0.561GlnMet: 0.561 ± 0.026	0.664GlnAsn: 0.664 ± 0.025	2.384GlnPro: 2.384 ± 0.061	1.654GlnGln: 1.654 ± 0.054	2.877GlnArg: 2.877 ± 0.055	1.672GlnSer: 1.672 ± 0.048	1.638GlnThr: 1.638 ± 0.042	3.108GlnVal: 3.108 ± 0.055	0.589GlnTrp: 0.589 ± 0.02	0.665GlnTyr: 0.665 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.686ArgAla: 8.686 ± 0.112	0.593ArgCys: 0.593 ± 0.027	4.051ArgAsp: 4.051 ± 0.061	3.582ArgGlu: 3.582 ± 0.063	2.416ArgPhe: 2.416 ± 0.045	5.247ArgGly: 5.247 ± 0.07	1.889ArgHis: 1.889 ± 0.051	2.928ArgIle: 2.928 ± 0.05	1.509ArgLys: 1.509 ± 0.044	8.493ArgLeu: 8.493 ± 0.102	1.647ArgMet: 1.647 ± 0.042	1.509ArgAsn: 1.509 ± 0.032	4.614ArgPro: 4.614 ± 0.059	2.46ArgGln: 2.46 ± 0.042	7.241ArgArg: 7.241 ± 0.123	4.093ArgSer: 4.093 ± 0.062	4.519ArgThr: 4.519 ± 0.07	6.052ArgVal: 6.052 ± 0.078	1.428ArgTrp: 1.428 ± 0.038	1.66ArgTyr: 1.66 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.725SerAla: 6.725 ± 0.094	0.43SerCys: 0.43 ± 0.022	3.05SerAsp: 3.05 ± 0.057	2.407SerGlu: 2.407 ± 0.049	1.659SerPhe: 1.659 ± 0.035	5.621SerGly: 5.621 ± 0.075	1.081SerHis: 1.081 ± 0.031	2.209SerIle: 2.209 ± 0.049	1.197SerLys: 1.197 ± 0.034	5.08SerLeu: 5.08 ± 0.067	1.333SerMet: 1.333 ± 0.032	1.156SerAsn: 1.156 ± 0.035	3.236SerPro: 3.236 ± 0.059	1.537SerGln: 1.537 ± 0.041	3.873SerArg: 3.873 ± 0.06	3.408SerSer: 3.408 ± 0.07	3.558SerThr: 3.558 ± 0.067	4.624SerVal: 4.624 ± 0.069	0.967SerTrp: 0.967 ± 0.03	1.229SerTyr: 1.229 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.617ThrAla: 7.617 ± 0.101	0.507ThrCys: 0.507 ± 0.02	3.791ThrAsp: 3.791 ± 0.056	2.912ThrGlu: 2.912 ± 0.053	1.827ThrPhe: 1.827 ± 0.046	5.796ThrGly: 5.796 ± 0.088	1.309ThrHis: 1.309 ± 0.037	2.66ThrIle: 2.66 ± 0.05	1.456ThrLys: 1.456 ± 0.039	6.171ThrLeu: 6.171 ± 0.085	1.232ThrMet: 1.232 ± 0.031	1.39ThrAsn: 1.39 ± 0.048	3.988ThrPro: 3.988 ± 0.068	1.662ThrGln: 1.662 ± 0.038	3.914ThrArg: 3.914 ± 0.065	3.519ThrSer: 3.519 ± 0.067	4.074ThrThr: 4.074 ± 0.088	5.693ThrVal: 5.693 ± 0.08	1.099ThrTrp: 1.099 ± 0.037	1.279ThrTyr: 1.279 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.587ValAla: 11.587 ± 0.101	0.711ValCys: 0.711 ± 0.025	5.34ValAsp: 5.34 ± 0.07	4.786ValGlu: 4.786 ± 0.069	2.523ValPhe: 2.523 ± 0.049	7.347ValGly: 7.347 ± 0.098	1.863ValHis: 1.863 ± 0.042	3.93ValIle: 3.93 ± 0.061	1.855ValLys: 1.855 ± 0.053	9.582ValLeu: 9.582 ± 0.115	1.644ValMet: 1.644 ± 0.037	1.882ValAsn: 1.882 ± 0.04	4.895ValPro: 4.895 ± 0.063	2.461ValGln: 2.461 ± 0.046	6.299ValArg: 6.299 ± 0.076	4.554ValSer: 4.554 ± 0.059	5.985ValThr: 5.985 ± 0.08	8.507ValVal: 8.507 ± 0.111	1.254ValTrp: 1.254 ± 0.034	1.328ValTyr: 1.328 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.849TrpAla: 1.849 ± 0.043	0.173TrpCys: 0.173 ± 0.014	0.674TrpAsp: 0.674 ± 0.025	0.481TrpGlu: 0.481 ± 0.021	0.606TrpPhe: 0.606 ± 0.023	1.137TrpGly: 1.137 ± 0.03	0.428TrpHis: 0.428 ± 0.02	0.643TrpIle: 0.643 ± 0.024	0.306TrpLys: 0.306 ± 0.018	2.253TrpLeu: 2.253 ± 0.053	0.292TrpMet: 0.292 ± 0.015	0.473TrpAsn: 0.473 ± 0.021	0.914TrpPro: 0.914 ± 0.03	0.762TrpGln: 0.762 ± 0.025	1.435TrpArg: 1.435 ± 0.035	1.059TrpSer: 1.059 ± 0.027	1.094TrpThr: 1.094 ± 0.032	1.442TrpVal: 1.442 ± 0.04	0.442TrpTrp: 0.442 ± 0.023	0.331TrpTyr: 0.331 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.487TyrAla: 2.487 ± 0.049	0.211TyrCys: 0.211 ± 0.013	1.333TyrAsp: 1.333 ± 0.037	0.992TyrGlu: 0.992 ± 0.034	0.662TyrPhe: 0.662 ± 0.024	1.919TyrGly: 1.919 ± 0.051	0.405TyrHis: 0.405 ± 0.019	0.526TyrIle: 0.526 ± 0.021	0.34TyrLys: 0.34 ± 0.019	2.281TyrLeu: 2.281 ± 0.046	0.217TyrMet: 0.217 ± 0.013	0.431TyrAsn: 0.431 ± 0.021	1.081TyrPro: 1.081 ± 0.032	0.679TyrGln: 0.679 ± 0.027	1.723TyrArg: 1.723 ± 0.039	1.054TyrSer: 1.054 ± 0.032	1.135TyrThr: 1.135 ± 0.038	1.572TyrVal: 1.572 ± 0.034	0.36TyrTrp: 0.36 ± 0.019	0.465TyrTyr: 0.465 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3901 proteins (1158705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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