Amino acid dipepetide frequency for Klebsiella phage 5 LV-2017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.858AlaAla: 11.858 ± 1.328
1.169AlaCys: 1.169 ± 0.306
6.263AlaAsp: 6.263 ± 0.611
7.432AlaGlu: 7.432 ± 0.969
2.171AlaPhe: 2.171 ± 0.353
9.937AlaGly: 9.937 ± 1.073
1.002AlaHis: 1.002 ± 0.263
5.428AlaIle: 5.428 ± 0.565
5.177AlaLys: 5.177 ± 0.547
9.687AlaLeu: 9.687 ± 1.003
3.507AlaMet: 3.507 ± 0.536
4.927AlaAsn: 4.927 ± 0.679
3.424AlaPro: 3.424 ± 0.61
6.681AlaGln: 6.681 ± 1.225
6.18AlaArg: 6.18 ± 0.702
5.762AlaSer: 5.762 ± 0.626
6.347AlaThr: 6.347 ± 0.8
6.764AlaVal: 6.764 ± 0.693
2.088AlaTrp: 2.088 ± 0.382
2.422AlaTyr: 2.422 ± 0.468
0.0AlaXaa: 0.0 ± 0.0
Cys
0.501CysAla: 0.501 ± 0.201
0.418CysCys: 0.418 ± 0.183
0.501CysAsp: 0.501 ± 0.25
0.919CysGlu: 0.919 ± 0.312
0.334CysPhe: 0.334 ± 0.237
0.835CysGly: 0.835 ± 0.282
0.334CysHis: 0.334 ± 0.195
0.668CysIle: 0.668 ± 0.217
0.585CysLys: 0.585 ± 0.217
1.002CysLeu: 1.002 ± 0.326
0.251CysMet: 0.251 ± 0.15
0.668CysAsn: 0.668 ± 0.24
0.585CysPro: 0.585 ± 0.172
0.251CysGln: 0.251 ± 0.143
1.503CysArg: 1.503 ± 0.363
0.418CysSer: 0.418 ± 0.253
0.084CysThr: 0.084 ± 0.073
0.418CysVal: 0.418 ± 0.202
0.084CysTrp: 0.084 ± 0.073
0.251CysTyr: 0.251 ± 0.145
0.0CysXaa: 0.0 ± 0.0
Asp
6.931AspAla: 6.931 ± 0.781
0.668AspCys: 0.668 ± 0.277
3.507AspAsp: 3.507 ± 0.791
4.593AspGlu: 4.593 ± 0.565
1.837AspPhe: 1.837 ± 0.412
4.426AspGly: 4.426 ± 0.639
0.835AspHis: 0.835 ± 0.316
3.591AspIle: 3.591 ± 0.494
2.672AspLys: 2.672 ± 0.515
4.509AspLeu: 4.509 ± 0.604
1.587AspMet: 1.587 ± 0.374
2.839AspAsn: 2.839 ± 0.474
3.257AspPro: 3.257 ± 0.675
2.672AspGln: 2.672 ± 0.551
2.338AspArg: 2.338 ± 0.429
4.008AspSer: 4.008 ± 0.61
2.255AspThr: 2.255 ± 0.45
3.925AspVal: 3.925 ± 0.635
1.086AspTrp: 1.086 ± 0.308
2.422AspTyr: 2.422 ± 0.404
0.0AspXaa: 0.0 ± 0.0
Glu
7.098GluAla: 7.098 ± 0.937
0.585GluCys: 0.585 ± 0.253
2.923GluAsp: 2.923 ± 0.543
4.259GluGlu: 4.259 ± 0.545
2.004GluPhe: 2.004 ± 0.34
3.34GluGly: 3.34 ± 0.65
0.835GluHis: 0.835 ± 0.218
4.509GluIle: 4.509 ± 0.486
3.507GluLys: 3.507 ± 0.694
6.764GluLeu: 6.764 ± 0.664
1.921GluMet: 1.921 ± 0.409
3.424GluAsn: 3.424 ± 0.433
2.589GluPro: 2.589 ± 0.468
4.509GluGln: 4.509 ± 1.61
3.841GluArg: 3.841 ± 0.498
3.758GluSer: 3.758 ± 0.588
3.34GluThr: 3.34 ± 0.592
4.008GluVal: 4.008 ± 0.577
2.088GluTrp: 2.088 ± 0.43
2.255GluTyr: 2.255 ± 0.467
0.0GluXaa: 0.0 ± 0.0
Phe
3.507PheAla: 3.507 ± 0.448
0.334PheCys: 0.334 ± 0.135
2.839PheAsp: 2.839 ± 0.453
1.67PheGlu: 1.67 ± 0.346
0.501PhePhe: 0.501 ± 0.168
2.338PheGly: 2.338 ± 0.259
0.251PheHis: 0.251 ± 0.134
1.169PheIle: 1.169 ± 0.271
1.587PheLys: 1.587 ± 0.349
2.004PheLeu: 2.004 ± 0.401
0.835PheMet: 0.835 ± 0.242
1.587PheAsn: 1.587 ± 0.291
2.004PhePro: 2.004 ± 0.385
1.42PheGln: 1.42 ± 0.35
1.754PheArg: 1.754 ± 0.441
2.422PheSer: 2.422 ± 0.445
2.171PheThr: 2.171 ± 0.525
1.002PheVal: 1.002 ± 0.238
0.334PheTrp: 0.334 ± 0.152
0.919PheTyr: 0.919 ± 0.318
0.0PheXaa: 0.0 ± 0.0
Gly
4.843GlyAla: 4.843 ± 0.646
0.334GlyCys: 0.334 ± 0.144
4.259GlyAsp: 4.259 ± 0.827
4.76GlyGlu: 4.76 ± 0.508
3.09GlyPhe: 3.09 ± 0.469
5.428GlyGly: 5.428 ± 1.067
1.42GlyHis: 1.42 ± 0.41
4.092GlyIle: 4.092 ± 0.543
4.843GlyLys: 4.843 ± 0.641
6.681GlyLeu: 6.681 ± 0.839
2.004GlyMet: 2.004 ± 0.345
2.839GlyAsn: 2.839 ± 0.429
1.754GlyPro: 1.754 ± 0.388
3.09GlyGln: 3.09 ± 0.495
4.092GlyArg: 4.092 ± 0.538
4.426GlySer: 4.426 ± 0.701
4.927GlyThr: 4.927 ± 0.804
5.428GlyVal: 5.428 ± 0.668
1.086GlyTrp: 1.086 ± 0.253
2.422GlyTyr: 2.422 ± 0.373
0.0GlyXaa: 0.0 ± 0.0
His
1.503HisAla: 1.503 ± 0.312
0.084HisCys: 0.084 ± 0.089
0.835HisAsp: 0.835 ± 0.254
0.752HisGlu: 0.752 ± 0.256
1.002HisPhe: 1.002 ± 0.24
1.086HisGly: 1.086 ± 0.351
0.501HisHis: 0.501 ± 0.191
0.668HisIle: 0.668 ± 0.199
1.002HisLys: 1.002 ± 0.283
1.253HisLeu: 1.253 ± 0.307
0.251HisMet: 0.251 ± 0.146
0.251HisAsn: 0.251 ± 0.147
1.086HisPro: 1.086 ± 0.318
0.752HisGln: 0.752 ± 0.226
1.002HisArg: 1.002 ± 0.299
0.835HisSer: 0.835 ± 0.259
1.002HisThr: 1.002 ± 0.297
1.086HisVal: 1.086 ± 0.299
0.251HisTrp: 0.251 ± 0.122
1.002HisTyr: 1.002 ± 0.285
0.0HisXaa: 0.0 ± 0.0
Ile
6.43IleAla: 6.43 ± 0.618
0.752IleCys: 0.752 ± 0.233
4.175IleAsp: 4.175 ± 0.57
2.923IleGlu: 2.923 ± 0.466
0.752IlePhe: 0.752 ± 0.223
3.173IleGly: 3.173 ± 0.532
0.752IleHis: 0.752 ± 0.18
2.505IleIle: 2.505 ± 0.373
3.006IleLys: 3.006 ± 0.449
3.34IleLeu: 3.34 ± 0.528
0.501IleMet: 0.501 ± 0.21
2.338IleAsn: 2.338 ± 0.46
1.67IlePro: 1.67 ± 0.34
1.754IleGln: 1.754 ± 0.35
3.34IleArg: 3.34 ± 0.531
3.841IleSer: 3.841 ± 0.543
5.094IleThr: 5.094 ± 0.777
2.756IleVal: 2.756 ± 0.481
0.418IleTrp: 0.418 ± 0.159
1.336IleTyr: 1.336 ± 0.425
0.0IleXaa: 0.0 ± 0.0
Lys
6.43LysAla: 6.43 ± 0.797
0.752LysCys: 0.752 ± 0.233
2.255LysAsp: 2.255 ± 0.446
3.591LysGlu: 3.591 ± 0.553
1.587LysPhe: 1.587 ± 0.39
2.505LysGly: 2.505 ± 0.458
1.169LysHis: 1.169 ± 0.355
3.09LysIle: 3.09 ± 0.69
3.591LysLys: 3.591 ± 0.512
5.344LysLeu: 5.344 ± 0.577
1.169LysMet: 1.169 ± 0.275
1.336LysAsn: 1.336 ± 0.299
3.173LysPro: 3.173 ± 0.677
2.839LysGln: 2.839 ± 0.455
3.173LysArg: 3.173 ± 0.362
3.674LysSer: 3.674 ± 0.644
3.674LysThr: 3.674 ± 0.546
3.507LysVal: 3.507 ± 0.485
0.835LysTrp: 0.835 ± 0.246
1.587LysTyr: 1.587 ± 0.376
0.0LysXaa: 0.0 ± 0.0
Leu
9.019LeuAla: 9.019 ± 0.969
1.002LeuCys: 1.002 ± 0.393
6.263LeuAsp: 6.263 ± 0.788
5.511LeuGlu: 5.511 ± 0.699
2.088LeuPhe: 2.088 ± 0.364
4.927LeuGly: 4.927 ± 0.566
1.169LeuHis: 1.169 ± 0.273
2.923LeuIle: 2.923 ± 0.543
4.593LeuLys: 4.593 ± 0.539
5.678LeuLeu: 5.678 ± 0.623
2.088LeuMet: 2.088 ± 0.523
4.509LeuAsn: 4.509 ± 0.652
4.008LeuPro: 4.008 ± 0.433
4.342LeuGln: 4.342 ± 0.82
5.511LeuArg: 5.511 ± 0.595
6.18LeuSer: 6.18 ± 0.897
5.511LeuThr: 5.511 ± 0.673
5.177LeuVal: 5.177 ± 0.662
0.668LeuTrp: 0.668 ± 0.25
1.921LeuTyr: 1.921 ± 0.463
0.0LeuXaa: 0.0 ± 0.0
Met
3.34MetAla: 3.34 ± 0.407
0.251MetCys: 0.251 ± 0.186
1.169MetAsp: 1.169 ± 0.262
1.169MetGlu: 1.169 ± 0.242
0.752MetPhe: 0.752 ± 0.235
1.002MetGly: 1.002 ± 0.254
0.334MetHis: 0.334 ± 0.185
0.752MetIle: 0.752 ± 0.233
1.754MetLys: 1.754 ± 0.3
1.754MetLeu: 1.754 ± 0.418
0.501MetMet: 0.501 ± 0.209
0.668MetAsn: 0.668 ± 0.191
1.42MetPro: 1.42 ± 0.347
1.169MetGln: 1.169 ± 0.366
1.754MetArg: 1.754 ± 0.359
1.754MetSer: 1.754 ± 0.427
1.42MetThr: 1.42 ± 0.239
1.67MetVal: 1.67 ± 0.361
0.418MetTrp: 0.418 ± 0.16
0.585MetTyr: 0.585 ± 0.184
0.0MetXaa: 0.0 ± 0.0
Asn
5.177AsnAla: 5.177 ± 0.587
0.167AsnCys: 0.167 ± 0.098
2.505AsnAsp: 2.505 ± 0.449
3.34AsnGlu: 3.34 ± 0.54
0.919AsnPhe: 0.919 ± 0.236
4.509AsnGly: 4.509 ± 0.646
0.585AsnHis: 0.585 ± 0.271
2.422AsnIle: 2.422 ± 0.494
2.422AsnLys: 2.422 ± 0.481
2.422AsnLeu: 2.422 ± 0.388
0.334AsnMet: 0.334 ± 0.14
1.169AsnAsn: 1.169 ± 0.401
1.921AsnPro: 1.921 ± 0.379
1.754AsnGln: 1.754 ± 0.437
1.67AsnArg: 1.67 ± 0.439
2.422AsnSer: 2.422 ± 0.644
2.338AsnThr: 2.338 ± 0.5
2.255AsnVal: 2.255 ± 0.468
0.334AsnTrp: 0.334 ± 0.144
1.253AsnTyr: 1.253 ± 0.363
0.0AsnXaa: 0.0 ± 0.0
Pro
5.929ProAla: 5.929 ± 0.706
0.334ProCys: 0.334 ± 0.199
4.175ProAsp: 4.175 ± 0.606
4.426ProGlu: 4.426 ± 0.584
1.587ProPhe: 1.587 ± 0.265
3.006ProGly: 3.006 ± 0.599
0.835ProHis: 0.835 ± 0.288
1.169ProIle: 1.169 ± 0.272
2.088ProLys: 2.088 ± 0.412
2.839ProLeu: 2.839 ± 0.511
0.835ProMet: 0.835 ± 0.181
1.42ProAsn: 1.42 ± 0.37
1.336ProPro: 1.336 ± 0.366
1.086ProGln: 1.086 ± 0.315
2.171ProArg: 2.171 ± 0.453
1.587ProSer: 1.587 ± 0.323
2.589ProThr: 2.589 ± 0.455
4.092ProVal: 4.092 ± 0.678
0.418ProTrp: 0.418 ± 0.177
0.835ProTyr: 0.835 ± 0.272
0.0ProXaa: 0.0 ± 0.0
Gln
5.177GlnAla: 5.177 ± 0.732
0.334GlnCys: 0.334 ± 0.153
2.505GlnAsp: 2.505 ± 0.423
3.674GlnGlu: 3.674 ± 1.427
1.336GlnPhe: 1.336 ± 0.365
2.923GlnGly: 2.923 ± 0.355
0.585GlnHis: 0.585 ± 0.199
2.672GlnIle: 2.672 ± 0.491
3.674GlnLys: 3.674 ± 0.735
5.094GlnLeu: 5.094 ± 0.685
1.086GlnMet: 1.086 ± 0.2
1.253GlnAsn: 1.253 ± 0.354
1.67GlnPro: 1.67 ± 0.37
5.261GlnGln: 5.261 ± 1.784
3.006GlnArg: 3.006 ± 0.574
2.338GlnSer: 2.338 ± 0.545
3.006GlnThr: 3.006 ± 0.489
2.505GlnVal: 2.505 ± 0.375
0.752GlnTrp: 0.752 ± 0.276
2.004GlnTyr: 2.004 ± 0.316
0.0GlnXaa: 0.0 ± 0.0
Arg
6.347ArgAla: 6.347 ± 0.918
1.169ArgCys: 1.169 ± 0.323
2.756ArgAsp: 2.756 ± 0.57
4.259ArgGlu: 4.259 ± 0.519
1.921ArgPhe: 1.921 ± 0.4
4.092ArgGly: 4.092 ± 0.603
1.42ArgHis: 1.42 ± 0.333
2.756ArgIle: 2.756 ± 0.282
3.173ArgLys: 3.173 ± 0.562
6.096ArgLeu: 6.096 ± 0.8
1.503ArgMet: 1.503 ± 0.374
2.255ArgAsn: 2.255 ± 0.388
1.587ArgPro: 1.587 ± 0.591
3.758ArgGln: 3.758 ± 0.715
5.01ArgArg: 5.01 ± 0.783
2.255ArgSer: 2.255 ± 0.366
2.923ArgThr: 2.923 ± 0.474
3.34ArgVal: 3.34 ± 0.63
0.919ArgTrp: 0.919 ± 0.262
2.422ArgTyr: 2.422 ± 0.449
0.0ArgXaa: 0.0 ± 0.0
Ser
6.347SerAla: 6.347 ± 0.874
0.501SerCys: 0.501 ± 0.195
3.257SerAsp: 3.257 ± 0.441
3.424SerGlu: 3.424 ± 0.578
2.171SerPhe: 2.171 ± 0.567
4.593SerGly: 4.593 ± 0.917
1.169SerHis: 1.169 ± 0.261
3.424SerIle: 3.424 ± 0.604
3.006SerLys: 3.006 ± 0.571
4.676SerLeu: 4.676 ± 0.631
1.754SerMet: 1.754 ± 0.387
2.004SerAsn: 2.004 ± 0.323
2.422SerPro: 2.422 ± 0.469
2.589SerGln: 2.589 ± 0.595
3.674SerArg: 3.674 ± 0.471
4.259SerSer: 4.259 ± 0.756
4.008SerThr: 4.008 ± 0.691
4.092SerVal: 4.092 ± 0.5
1.002SerTrp: 1.002 ± 0.277
1.587SerTyr: 1.587 ± 0.296
0.0SerXaa: 0.0 ± 0.0
Thr
7.683ThrAla: 7.683 ± 0.887
0.501ThrCys: 0.501 ± 0.2
3.424ThrAsp: 3.424 ± 0.494
3.758ThrGlu: 3.758 ± 0.561
2.672ThrPhe: 2.672 ± 0.775
6.263ThrGly: 6.263 ± 0.759
1.086ThrHis: 1.086 ± 0.227
3.674ThrIle: 3.674 ± 0.57
2.756ThrLys: 2.756 ± 0.453
5.929ThrLeu: 5.929 ± 0.671
1.086ThrMet: 1.086 ± 0.206
2.088ThrAsn: 2.088 ± 0.261
3.257ThrPro: 3.257 ± 0.587
2.338ThrGln: 2.338 ± 0.598
2.672ThrArg: 2.672 ± 0.389
3.173ThrSer: 3.173 ± 0.488
3.758ThrThr: 3.758 ± 0.642
4.175ThrVal: 4.175 ± 0.716
0.919ThrTrp: 0.919 ± 0.317
1.587ThrTyr: 1.587 ± 0.37
0.0ThrXaa: 0.0 ± 0.0
Val
6.18ValAla: 6.18 ± 0.753
0.251ValCys: 0.251 ± 0.134
4.092ValAsp: 4.092 ± 0.72
4.76ValGlu: 4.76 ± 0.761
1.67ValPhe: 1.67 ± 0.35
4.843ValGly: 4.843 ± 0.797
0.919ValHis: 0.919 ± 0.223
2.839ValIle: 2.839 ± 0.457
3.591ValLys: 3.591 ± 0.506
4.927ValLeu: 4.927 ± 0.604
1.587ValMet: 1.587 ± 0.41
2.338ValAsn: 2.338 ± 0.412
2.756ValPro: 2.756 ± 0.465
2.255ValGln: 2.255 ± 0.567
3.674ValArg: 3.674 ± 0.638
4.259ValSer: 4.259 ± 0.553
5.177ValThr: 5.177 ± 0.781
3.34ValVal: 3.34 ± 0.621
0.919ValTrp: 0.919 ± 0.258
1.503ValTyr: 1.503 ± 0.25
0.0ValXaa: 0.0 ± 0.0
Trp
1.587TrpAla: 1.587 ± 0.42
0.334TrpCys: 0.334 ± 0.145
0.585TrpAsp: 0.585 ± 0.181
1.253TrpGlu: 1.253 ± 0.385
1.169TrpPhe: 1.169 ± 0.417
1.002TrpGly: 1.002 ± 0.285
0.167TrpHis: 0.167 ± 0.127
0.752TrpIle: 0.752 ± 0.312
0.835TrpLys: 0.835 ± 0.251
1.42TrpLeu: 1.42 ± 0.296
0.251TrpMet: 0.251 ± 0.169
0.752TrpAsn: 0.752 ± 0.241
1.086TrpPro: 1.086 ± 0.252
0.668TrpGln: 0.668 ± 0.235
1.002TrpArg: 1.002 ± 0.262
0.585TrpSer: 0.585 ± 0.197
0.752TrpThr: 0.752 ± 0.203
0.752TrpVal: 0.752 ± 0.254
0.084TrpTrp: 0.084 ± 0.079
0.251TrpTyr: 0.251 ± 0.137
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.338TyrAla: 2.338 ± 0.464
0.668TyrCys: 0.668 ± 0.217
1.67TyrAsp: 1.67 ± 0.412
1.086TyrGlu: 1.086 ± 0.226
1.086TyrPhe: 1.086 ± 0.345
1.587TyrGly: 1.587 ± 0.356
0.835TyrHis: 0.835 ± 0.333
1.754TyrIle: 1.754 ± 0.312
1.42TyrLys: 1.42 ± 0.415
1.67TyrLeu: 1.67 ± 0.345
0.501TyrMet: 0.501 ± 0.221
1.253TyrAsn: 1.253 ± 0.253
1.837TyrPro: 1.837 ± 0.522
1.67TyrGln: 1.67 ± 0.393
2.589TyrArg: 2.589 ± 0.52
2.004TyrSer: 2.004 ± 0.469
2.422TyrThr: 2.422 ± 0.373
1.587TyrVal: 1.587 ± 0.309
0.585TyrTrp: 0.585 ± 0.2
0.167TyrTyr: 0.167 ± 0.111
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 41 proteins (11976 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski