Amino acid dipepetide frequency for Nonomuraea sp. C10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.702AlaAla: 20.702 ± 0.154
1.198AlaCys: 1.198 ± 0.024
7.762AlaAsp: 7.762 ± 0.065
8.767AlaGlu: 8.767 ± 0.076
3.789AlaPhe: 3.789 ± 0.045
13.815AlaGly: 13.815 ± 0.09
2.607AlaHis: 2.607 ± 0.032
4.206AlaIle: 4.206 ± 0.044
2.571AlaLys: 2.571 ± 0.045
14.269AlaLeu: 14.269 ± 0.109
2.78AlaMet: 2.78 ± 0.029
1.878AlaAsn: 1.878 ± 0.03
6.103AlaPro: 6.103 ± 0.054
3.287AlaGln: 3.287 ± 0.036
10.622AlaArg: 10.622 ± 0.082
5.464AlaSer: 5.464 ± 0.042
6.681AlaThr: 6.681 ± 0.056
11.82AlaVal: 11.82 ± 0.081
1.969AlaTrp: 1.969 ± 0.029
2.764AlaTyr: 2.764 ± 0.028
0.0AlaXaa: 0.0 ± 0.0
Cys
1.022CysAla: 1.022 ± 0.019
0.102CysCys: 0.102 ± 0.007
0.505CysAsp: 0.505 ± 0.015
0.426CysGlu: 0.426 ± 0.015
0.238CysPhe: 0.238 ± 0.01
0.971CysGly: 0.971 ± 0.022
0.219CysHis: 0.219 ± 0.01
0.122CysIle: 0.122 ± 0.007
0.1CysLys: 0.1 ± 0.007
0.769CysLeu: 0.769 ± 0.017
0.119CysMet: 0.119 ± 0.006
0.124CysAsn: 0.124 ± 0.006
0.487CysPro: 0.487 ± 0.015
0.183CysGln: 0.183 ± 0.008
0.625CysArg: 0.625 ± 0.016
0.429CysSer: 0.429 ± 0.013
0.428CysThr: 0.428 ± 0.013
0.709CysVal: 0.709 ± 0.016
0.119CysTrp: 0.119 ± 0.006
0.175CysTyr: 0.175 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
6.807AspAla: 6.807 ± 0.064
0.37AspCys: 0.37 ± 0.012
3.641AspAsp: 3.641 ± 0.041
3.858AspGlu: 3.858 ± 0.036
1.534AspPhe: 1.534 ± 0.026
6.079AspGly: 6.079 ± 0.06
1.409AspHis: 1.409 ± 0.023
1.747AspIle: 1.747 ± 0.026
1.031AspLys: 1.031 ± 0.023
6.601AspLeu: 6.601 ± 0.055
0.85AspMet: 0.85 ± 0.018
0.849AspAsn: 0.849 ± 0.018
4.548AspPro: 4.548 ± 0.049
1.577AspGln: 1.577 ± 0.025
5.044AspArg: 5.044 ± 0.052
2.151AspSer: 2.151 ± 0.029
2.663AspThr: 2.663 ± 0.036
5.038AspVal: 5.038 ± 0.046
0.926AspTrp: 0.926 ± 0.021
1.206AspTyr: 1.206 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
7.287GluAla: 7.287 ± 0.065
0.358GluCys: 0.358 ± 0.012
2.58GluAsp: 2.58 ± 0.034
3.742GluGlu: 3.742 ± 0.052
1.511GluPhe: 1.511 ± 0.027
4.192GluGly: 4.192 ± 0.04
1.592GluHis: 1.592 ± 0.026
2.537GluIle: 2.537 ± 0.038
1.244GluLys: 1.244 ± 0.025
7.318GluLeu: 7.318 ± 0.052
0.944GluMet: 0.944 ± 0.017
0.938GluAsn: 0.938 ± 0.022
3.692GluPro: 3.692 ± 0.036
2.136GluGln: 2.136 ± 0.028
5.91GluArg: 5.91 ± 0.053
2.691GluSer: 2.691 ± 0.032
2.93GluThr: 2.93 ± 0.033
4.956GluVal: 4.956 ± 0.046
0.831GluTrp: 0.831 ± 0.017
1.024GluTyr: 1.024 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
3.876PheAla: 3.876 ± 0.042
0.27PheCys: 0.27 ± 0.01
2.035PheAsp: 2.035 ± 0.03
1.501PheGlu: 1.501 ± 0.025
0.891PhePhe: 0.891 ± 0.02
3.133PheGly: 3.133 ± 0.042
0.638PheHis: 0.638 ± 0.016
0.748PheIle: 0.748 ± 0.019
0.497PheLys: 0.497 ± 0.014
2.737PheLeu: 2.737 ± 0.038
0.468PheMet: 0.468 ± 0.013
0.555PheAsn: 0.555 ± 0.018
1.486PhePro: 1.486 ± 0.025
0.737PheGln: 0.737 ± 0.014
1.95PheArg: 1.95 ± 0.029
1.425PheSer: 1.425 ± 0.026
2.012PheThr: 2.012 ± 0.028
2.401PheVal: 2.401 ± 0.037
0.458PheTrp: 0.458 ± 0.015
0.654PheTyr: 0.654 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
10.607GlyAla: 10.607 ± 0.078
0.84GlyCys: 0.84 ± 0.02
5.499GlyAsp: 5.499 ± 0.047
5.685GlyGlu: 5.685 ± 0.053
3.046GlyPhe: 3.046 ± 0.036
9.01GlyGly: 9.01 ± 0.077
2.297GlyHis: 2.297 ± 0.033
3.26GlyIle: 3.26 ± 0.041
2.295GlyLys: 2.295 ± 0.037
9.977GlyLeu: 9.977 ± 0.071
2.164GlyMet: 2.164 ± 0.032
1.647GlyAsn: 1.647 ± 0.03
5.127GlyPro: 5.127 ± 0.052
2.728GlyGln: 2.728 ± 0.04
8.17GlyArg: 8.17 ± 0.056
4.866GlySer: 4.866 ± 0.052
5.509GlyThr: 5.509 ± 0.054
8.271GlyVal: 8.271 ± 0.061
1.816GlyTrp: 1.816 ± 0.029
2.434GlyTyr: 2.434 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
2.73HisAla: 2.73 ± 0.035
0.205HisCys: 0.205 ± 0.01
1.391HisAsp: 1.391 ± 0.024
1.204HisGlu: 1.204 ± 0.02
0.59HisPhe: 0.59 ± 0.013
2.287HisGly: 2.287 ± 0.029
0.649HisHis: 0.649 ± 0.018
0.62HisIle: 0.62 ± 0.015
0.302HisLys: 0.302 ± 0.011
2.452HisLeu: 2.452 ± 0.034
0.337HisMet: 0.337 ± 0.01
0.374HisAsn: 0.374 ± 0.011
1.717HisPro: 1.717 ± 0.027
0.608HisGln: 0.608 ± 0.014
2.009HisArg: 2.009 ± 0.029
0.853HisSer: 0.853 ± 0.02
1.076HisThr: 1.076 ± 0.021
1.931HisVal: 1.931 ± 0.028
0.356HisTrp: 0.356 ± 0.014
0.467HisTyr: 0.467 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
4.933IleAla: 4.933 ± 0.045
0.316IleCys: 0.316 ± 0.011
2.29IleAsp: 2.29 ± 0.031
2.156IleGlu: 2.156 ± 0.028
0.879IlePhe: 0.879 ± 0.02
3.733IleGly: 3.733 ± 0.042
0.632IleHis: 0.632 ± 0.014
1.046IleIle: 1.046 ± 0.019
0.798IleLys: 0.798 ± 0.021
2.764IleLeu: 2.764 ± 0.037
0.636IleMet: 0.636 ± 0.016
0.692IleAsn: 0.692 ± 0.018
1.863IlePro: 1.863 ± 0.03
0.779IleGln: 0.779 ± 0.016
2.521IleArg: 2.521 ± 0.034
1.828IleSer: 1.828 ± 0.027
2.345IleThr: 2.345 ± 0.033
3.151IleVal: 3.151 ± 0.04
0.45IleTrp: 0.45 ± 0.012
0.624IleTyr: 0.624 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
2.553LysAla: 2.553 ± 0.037
0.117LysCys: 0.117 ± 0.008
1.083LysAsp: 1.083 ± 0.02
1.144LysGlu: 1.144 ± 0.021
0.408LysPhe: 0.408 ± 0.015
1.616LysGly: 1.616 ± 0.03
0.412LysHis: 0.412 ± 0.013
0.915LysIle: 0.915 ± 0.022
0.651LysLys: 0.651 ± 0.021
2.026LysLeu: 2.026 ± 0.031
0.357LysMet: 0.357 ± 0.013
0.426LysAsn: 0.426 ± 0.016
1.281LysPro: 1.281 ± 0.022
0.626LysGln: 0.626 ± 0.018
1.434LysArg: 1.434 ± 0.028
0.982LysSer: 0.982 ± 0.022
1.175LysThr: 1.175 ± 0.022
1.917LysVal: 1.917 ± 0.031
0.251LysTrp: 0.251 ± 0.01
0.395LysTyr: 0.395 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
16.09LeuAla: 16.09 ± 0.108
0.778LeuCys: 0.778 ± 0.018
6.83LeuAsp: 6.83 ± 0.046
5.081LeuGlu: 5.081 ± 0.047
2.758LeuPhe: 2.758 ± 0.033
9.746LeuGly: 9.746 ± 0.069
2.138LeuHis: 2.138 ± 0.031
3.738LeuIle: 3.738 ± 0.043
1.911LeuLys: 1.911 ± 0.033
11.313LeuLeu: 11.313 ± 0.103
1.85LeuMet: 1.85 ± 0.03
1.655LeuAsn: 1.655 ± 0.027
6.458LeuPro: 6.458 ± 0.046
2.028LeuGln: 2.028 ± 0.032
9.147LeuArg: 9.147 ± 0.066
5.533LeuSer: 5.533 ± 0.045
6.605LeuThr: 6.605 ± 0.048
9.431LeuVal: 9.431 ± 0.072
1.35LeuTrp: 1.35 ± 0.027
1.93LeuTyr: 1.93 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
2.545MetAla: 2.545 ± 0.033
0.13MetCys: 0.13 ± 0.007
0.929MetAsp: 0.929 ± 0.019
0.851MetGlu: 0.851 ± 0.02
0.544MetPhe: 0.544 ± 0.014
1.417MetGly: 1.417 ± 0.02
0.342MetHis: 0.342 ± 0.011
0.863MetIle: 0.863 ± 0.021
0.444MetLys: 0.444 ± 0.014
2.051MetLeu: 2.051 ± 0.03
0.365MetMet: 0.365 ± 0.013
0.448MetAsn: 0.448 ± 0.013
1.189MetPro: 1.189 ± 0.022
0.392MetGln: 0.392 ± 0.012
1.769MetArg: 1.769 ± 0.023
1.326MetSer: 1.326 ± 0.021
1.618MetThr: 1.618 ± 0.024
1.453MetVal: 1.453 ± 0.024
0.228MetTrp: 0.228 ± 0.009
0.313MetTyr: 0.313 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.062AsnAla: 2.062 ± 0.034
0.158AsnCys: 0.158 ± 0.008
0.881AsnAsp: 0.881 ± 0.021
0.804AsnGlu: 0.804 ± 0.017
0.464AsnPhe: 0.464 ± 0.014
1.762AsnGly: 1.762 ± 0.036
0.383AsnHis: 0.383 ± 0.013
0.583AsnIle: 0.583 ± 0.016
0.342AsnLys: 0.342 ± 0.012
1.787AsnLeu: 1.787 ± 0.027
0.28AsnMet: 0.28 ± 0.01
0.371AsnAsn: 0.371 ± 0.013
1.352AsnPro: 1.352 ± 0.025
0.508AsnGln: 0.508 ± 0.015
1.302AsnArg: 1.302 ± 0.021
0.75AsnSer: 0.75 ± 0.019
0.931AsnThr: 0.931 ± 0.023
1.489AsnVal: 1.489 ± 0.026
0.285AsnTrp: 0.285 ± 0.01
0.381AsnTyr: 0.381 ± 0.011
0.0AsnXaa: 0.0 ± 0.0
Pro
8.249ProAla: 8.249 ± 0.064
0.351ProCys: 0.351 ± 0.013
4.261ProAsp: 4.261 ± 0.044
4.383ProGlu: 4.383 ± 0.039
1.629ProPhe: 1.629 ± 0.022
6.92ProGly: 6.92 ± 0.058
1.312ProHis: 1.312 ± 0.025
1.703ProIle: 1.703 ± 0.026
1.067ProLys: 1.067 ± 0.021
5.322ProLeu: 5.322 ± 0.04
1.146ProMet: 1.146 ± 0.022
0.864ProAsn: 0.864 ± 0.018
3.867ProPro: 3.867 ± 0.047
1.437ProGln: 1.437 ± 0.03
4.035ProArg: 4.035 ± 0.038
3.116ProSer: 3.116 ± 0.04
2.753ProThr: 2.753 ± 0.039
5.413ProVal: 5.413 ± 0.049
0.954ProTrp: 0.954 ± 0.02
1.498ProTyr: 1.498 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.754GlnAla: 3.754 ± 0.042
0.159GlnCys: 0.159 ± 0.007
1.228GlnAsp: 1.228 ± 0.027
1.515GlnGlu: 1.515 ± 0.026
0.627GlnPhe: 0.627 ± 0.015
2.135GlnGly: 2.135 ± 0.028
0.538GlnHis: 0.538 ± 0.014
1.134GlnIle: 1.134 ± 0.021
0.501GlnLys: 0.501 ± 0.015
2.681GlnLeu: 2.681 ± 0.035
0.459GlnMet: 0.459 ± 0.013
0.458GlnAsn: 0.458 ± 0.013
1.61GlnPro: 1.61 ± 0.034
0.969GlnGln: 0.969 ± 0.029
2.284GlnArg: 2.284 ± 0.03
1.096GlnSer: 1.096 ± 0.023
1.205GlnThr: 1.205 ± 0.021
2.568GlnVal: 2.568 ± 0.028
0.458GlnTrp: 0.458 ± 0.014
0.52GlnTyr: 0.52 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
10.168ArgAla: 10.168 ± 0.077
0.592ArgCys: 0.592 ± 0.013
4.686ArgAsp: 4.686 ± 0.042
5.168ArgGlu: 5.168 ± 0.046
2.514ArgPhe: 2.514 ± 0.031
6.103ArgGly: 6.103 ± 0.056
2.204ArgHis: 2.204 ± 0.028
3.095ArgIle: 3.095 ± 0.031
1.639ArgLys: 1.639 ± 0.025
9.874ArgLeu: 9.874 ± 0.08
1.986ArgMet: 1.986 ± 0.026
1.353ArgAsn: 1.353 ± 0.024
5.175ArgPro: 5.175 ± 0.055
2.386ArgGln: 2.386 ± 0.033
8.212ArgArg: 8.212 ± 0.08
3.916ArgSer: 3.916 ± 0.036
4.612ArgThr: 4.612 ± 0.048
6.689ArgVal: 6.689 ± 0.053
1.483ArgTrp: 1.483 ± 0.027
1.891ArgTyr: 1.891 ± 0.027
0.0ArgXaa: 0.0 ± 0.0
Ser
6.068SerAla: 6.068 ± 0.044
0.414SerCys: 0.414 ± 0.015
2.421SerAsp: 2.421 ± 0.032
2.281SerGlu: 2.281 ± 0.033
1.59SerPhe: 1.59 ± 0.026
5.903SerGly: 5.903 ± 0.064
0.98SerHis: 0.98 ± 0.019
1.62SerIle: 1.62 ± 0.027
0.888SerLys: 0.888 ± 0.02
4.708SerLeu: 4.708 ± 0.045
1.191SerMet: 1.191 ± 0.019
0.758SerAsn: 0.758 ± 0.018
3.184SerPro: 3.184 ± 0.039
1.18SerGln: 1.18 ± 0.027
3.863SerArg: 3.863 ± 0.04
2.64SerSer: 2.64 ± 0.034
2.65SerThr: 2.65 ± 0.036
3.974SerVal: 3.974 ± 0.042
0.938SerTrp: 0.938 ± 0.018
1.207SerTyr: 1.207 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
7.529ThrAla: 7.529 ± 0.064
0.447ThrCys: 0.447 ± 0.013
2.866ThrAsp: 2.866 ± 0.035
2.747ThrGlu: 2.747 ± 0.032
1.703ThrPhe: 1.703 ± 0.027
6.458ThrGly: 6.458 ± 0.05
1.064ThrHis: 1.064 ± 0.019
1.974ThrIle: 1.974 ± 0.024
0.996ThrLys: 0.996 ± 0.019
5.827ThrLeu: 5.827 ± 0.048
1.107ThrMet: 1.107 ± 0.022
0.917ThrAsn: 0.917 ± 0.021
3.836ThrPro: 3.836 ± 0.048
1.211ThrGln: 1.211 ± 0.022
4.039ThrArg: 4.039 ± 0.044
2.934ThrSer: 2.934 ± 0.039
3.391ThrThr: 3.391 ± 0.042
5.547ThrVal: 5.547 ± 0.051
0.95ThrTrp: 0.95 ± 0.02
1.237ThrTyr: 1.237 ± 0.018
0.0ThrXaa: 0.0 ± 0.0
Val
11.669ValAla: 11.669 ± 0.076
0.725ValCys: 0.725 ± 0.017
4.801ValAsp: 4.801 ± 0.044
5.015ValGlu: 5.015 ± 0.045
2.605ValPhe: 2.605 ± 0.034
6.539ValGly: 6.539 ± 0.059
1.888ValHis: 1.888 ± 0.029
3.405ValIle: 3.405 ± 0.041
1.807ValLys: 1.807 ± 0.029
9.72ValLeu: 9.72 ± 0.08
1.586ValMet: 1.586 ± 0.027
1.762ValAsn: 1.762 ± 0.029
5.302ValPro: 5.302 ± 0.047
1.909ValGln: 1.909 ± 0.025
7.418ValArg: 7.418 ± 0.061
4.599ValSer: 4.599 ± 0.041
6.0ValThr: 6.0 ± 0.054
8.404ValVal: 8.404 ± 0.07
1.176ValTrp: 1.176 ± 0.021
1.712ValTyr: 1.712 ± 0.025
0.0ValXaa: 0.0 ± 0.0
Trp
1.703TrpAla: 1.703 ± 0.024
0.154TrpCys: 0.154 ± 0.007
0.823TrpAsp: 0.823 ± 0.019
0.76TrpGlu: 0.76 ± 0.019
0.517TrpPhe: 0.517 ± 0.014
1.094TrpGly: 1.094 ± 0.021
0.407TrpHis: 0.407 ± 0.014
0.61TrpIle: 0.61 ± 0.017
0.329TrpLys: 0.329 ± 0.013
1.89TrpLeu: 1.89 ± 0.027
0.324TrpMet: 0.324 ± 0.011
0.413TrpAsn: 0.413 ± 0.013
0.899TrpPro: 0.899 ± 0.02
0.58TrpGln: 0.58 ± 0.015
1.495TrpArg: 1.495 ± 0.025
0.929TrpSer: 0.929 ± 0.019
1.012TrpThr: 1.012 ± 0.022
1.05TrpVal: 1.05 ± 0.02
0.365TrpTrp: 0.365 ± 0.013
0.366TrpTyr: 0.366 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.698TyrAla: 2.698 ± 0.029
0.189TyrCys: 0.189 ± 0.009
1.416TyrAsp: 1.416 ± 0.027
1.323TyrGlu: 1.323 ± 0.024
0.632TyrPhe: 0.632 ± 0.015
2.338TyrGly: 2.338 ± 0.033
0.448TyrHis: 0.448 ± 0.013
0.51TyrIle: 0.51 ± 0.014
0.356TyrLys: 0.356 ± 0.013
2.286TyrLeu: 2.286 ± 0.028
0.267TyrMet: 0.267 ± 0.01
0.393TyrAsn: 0.393 ± 0.013
1.107TyrPro: 1.107 ± 0.021
0.638TyrGln: 0.638 ± 0.016
1.897TyrArg: 1.897 ± 0.03
0.928TyrSer: 0.928 ± 0.021
1.181TyrThr: 1.181 ± 0.022
1.83TyrVal: 1.83 ± 0.028
0.358TyrTrp: 0.358 ± 0.012
0.468TyrTyr: 0.468 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8383 proteins (2740636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski