Amino acid dipepetide frequency for Lysobacter lacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.015AlaAla: 18.015 ± 0.209	1.315AlaCys: 1.315 ± 0.04	7.268AlaAsp: 7.268 ± 0.083	6.237AlaGlu: 6.237 ± 0.13	4.368AlaPhe: 4.368 ± 0.086	11.094AlaGly: 11.094 ± 0.124	2.958AlaHis: 2.958 ± 0.062	5.648AlaIle: 5.648 ± 0.088	3.533AlaLys: 3.533 ± 0.089	15.003AlaLeu: 15.003 ± 0.155	3.652AlaMet: 3.652 ± 0.065	2.982AlaAsn: 2.982 ± 0.078	6.679AlaPro: 6.679 ± 0.116	4.949AlaGln: 4.949 ± 0.092	10.917AlaArg: 10.917 ± 0.146	7.355AlaSer: 7.355 ± 0.104	6.885AlaThr: 6.885 ± 0.109	9.424AlaVal: 9.424 ± 0.122	1.998AlaTrp: 1.998 ± 0.058	2.626AlaTyr: 2.626 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	1.091CysAla: 1.091 ± 0.038	0.109CysCys: 0.109 ± 0.012	0.567CysAsp: 0.567 ± 0.026	0.51CysGlu: 0.51 ± 0.027	0.258CysPhe: 0.258 ± 0.018	0.903CysGly: 0.903 ± 0.036	0.244CysHis: 0.244 ± 0.02	0.367CysIle: 0.367 ± 0.022	0.179CysLys: 0.179 ± 0.016	0.704CysLeu: 0.704 ± 0.031	0.151CysMet: 0.151 ± 0.013	0.21CysAsn: 0.21 ± 0.018	0.429CysPro: 0.429 ± 0.027	0.197CysGln: 0.197 ± 0.015	0.643CysArg: 0.643 ± 0.032	0.483CysSer: 0.483 ± 0.023	0.489CysThr: 0.489 ± 0.024	0.743CysVal: 0.743 ± 0.03	0.122CysTrp: 0.122 ± 0.014	0.204CysTyr: 0.204 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	9.786AspAla: 9.786 ± 0.134	0.442AspCys: 0.442 ± 0.027	3.564AspAsp: 3.564 ± 0.064	3.617AspGlu: 3.617 ± 0.07	2.082AspPhe: 2.082 ± 0.051	5.851AspGly: 5.851 ± 0.089	1.137AspHis: 1.137 ± 0.041	2.501AspIle: 2.501 ± 0.051	1.246AspLys: 1.246 ± 0.047	5.479AspLeu: 5.479 ± 0.092	1.205AspMet: 1.205 ± 0.038	1.119AspAsn: 1.119 ± 0.038	3.56AspPro: 3.56 ± 0.066	1.374AspGln: 1.374 ± 0.042	4.772AspArg: 4.772 ± 0.082	2.471AspSer: 2.471 ± 0.058	2.952AspThr: 2.952 ± 0.067	5.317AspVal: 5.317 ± 0.097	1.014AspTrp: 1.014 ± 0.036	1.564AspTyr: 1.564 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.557GluAla: 6.557 ± 0.113	0.395GluCys: 0.395 ± 0.022	2.213GluAsp: 2.213 ± 0.055	2.088GluGlu: 2.088 ± 0.064	1.803GluPhe: 1.803 ± 0.046	3.788GluGly: 3.788 ± 0.072	1.424GluHis: 1.424 ± 0.043	2.463GluIle: 2.463 ± 0.055	1.442GluLys: 1.442 ± 0.048	5.863GluLeu: 5.863 ± 0.094	1.13GluMet: 1.13 ± 0.041	1.175GluAsn: 1.175 ± 0.04	2.634GluPro: 2.634 ± 0.062	2.199GluGln: 2.199 ± 0.062	5.367GluArg: 5.367 ± 0.101	2.78GluSer: 2.78 ± 0.058	2.563GluThr: 2.563 ± 0.056	3.752GluVal: 3.752 ± 0.07	0.632GluTrp: 0.632 ± 0.025	1.012GluTyr: 1.012 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.44PheAla: 4.44 ± 0.083	0.326PheCys: 0.326 ± 0.02	2.953PheAsp: 2.953 ± 0.063	2.024PheGlu: 2.024 ± 0.046	1.162PhePhe: 1.162 ± 0.041	3.419PheGly: 3.419 ± 0.078	0.78PheHis: 0.78 ± 0.034	1.246PheIle: 1.246 ± 0.045	0.834PheLys: 0.834 ± 0.034	2.856PheLeu: 2.856 ± 0.062	0.656PheMet: 0.656 ± 0.026	1.001PheAsn: 1.001 ± 0.035	1.374PhePro: 1.374 ± 0.041	0.876PheGln: 0.876 ± 0.031	2.213PheArg: 2.213 ± 0.05	1.811PheSer: 1.811 ± 0.045	1.683PheThr: 1.683 ± 0.049	2.917PheVal: 2.917 ± 0.078	0.455PheTrp: 0.455 ± 0.029	0.786PheTyr: 0.786 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.996GlyAla: 9.996 ± 0.137	0.895GlyCys: 0.895 ± 0.038	5.201GlyAsp: 5.201 ± 0.091	4.616GlyGlu: 4.616 ± 0.077	3.283GlyPhe: 3.283 ± 0.068	7.244GlyGly: 7.244 ± 0.129	2.231GlyHis: 2.231 ± 0.052	3.996GlyIle: 3.996 ± 0.075	2.61GlyLys: 2.61 ± 0.068	8.553GlyLeu: 8.553 ± 0.103	2.374GlyMet: 2.374 ± 0.055	2.212GlyAsn: 2.212 ± 0.067	3.222GlyPro: 3.222 ± 0.057	2.716GlyGln: 2.716 ± 0.058	6.84GlyArg: 6.84 ± 0.091	4.613GlySer: 4.613 ± 0.099	4.544GlyThr: 4.544 ± 0.092	6.802GlyVal: 6.802 ± 0.095	1.553GlyTrp: 1.553 ± 0.042	2.338GlyTyr: 2.338 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	3.42HisAla: 3.42 ± 0.066	0.268HisCys: 0.268 ± 0.018	1.424HisAsp: 1.424 ± 0.043	1.204HisGlu: 1.204 ± 0.041	0.877HisPhe: 0.877 ± 0.032	2.415HisGly: 2.415 ± 0.058	0.576HisHis: 0.576 ± 0.027	0.768HisIle: 0.768 ± 0.03	0.392HisLys: 0.392 ± 0.026	2.118HisLeu: 2.118 ± 0.051	0.511HisMet: 0.511 ± 0.023	0.422HisAsn: 0.422 ± 0.022	1.47HisPro: 1.47 ± 0.042	0.56HisGln: 0.56 ± 0.027	1.908HisArg: 1.908 ± 0.049	1.03HisSer: 1.03 ± 0.036	0.935HisThr: 0.935 ± 0.034	2.07HisVal: 2.07 ± 0.049	0.405HisTrp: 0.405 ± 0.023	0.61HisTyr: 0.61 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.836IleAla: 6.836 ± 0.096	0.357IleCys: 0.357 ± 0.02	3.58IleAsp: 3.58 ± 0.069	3.001IleGlu: 3.001 ± 0.07	1.024IlePhe: 1.024 ± 0.042	4.249IleGly: 4.249 ± 0.073	0.788IleHis: 0.788 ± 0.029	1.297IleIle: 1.297 ± 0.05	1.043IleLys: 1.043 ± 0.039	2.756IleLeu: 2.756 ± 0.063	0.49IleMet: 0.49 ± 0.025	1.087IleAsn: 1.087 ± 0.039	1.985IlePro: 1.985 ± 0.048	0.97IleGln: 0.97 ± 0.036	2.752IleArg: 2.752 ± 0.058	1.988IleSer: 1.988 ± 0.046	2.119IleThr: 2.119 ± 0.052	3.557IleVal: 3.557 ± 0.073	0.385IleTrp: 0.385 ± 0.025	0.822IleTyr: 0.822 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.146LysAla: 3.146 ± 0.084	0.162LysCys: 0.162 ± 0.015	1.365LysAsp: 1.365 ± 0.045	0.997LysGlu: 0.997 ± 0.041	0.724LysPhe: 0.724 ± 0.031	1.917LysGly: 1.917 ± 0.06	0.567LysHis: 0.567 ± 0.03	1.049LysIle: 1.049 ± 0.041	0.894LysLys: 0.894 ± 0.057	2.741LysLeu: 2.741 ± 0.066	0.555LysMet: 0.555 ± 0.028	0.598LysAsn: 0.598 ± 0.032	1.73LysPro: 1.73 ± 0.049	1.028LysGln: 1.028 ± 0.039	2.031LysArg: 2.031 ± 0.053	1.457LysSer: 1.457 ± 0.043	1.393LysThr: 1.393 ± 0.05	2.031LysVal: 2.031 ± 0.055	0.285LysTrp: 0.285 ± 0.019	0.616LysTyr: 0.616 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	14.904LeuAla: 14.904 ± 0.171	0.882LeuCys: 0.882 ± 0.037	7.036LeuAsp: 7.036 ± 0.091	5.142LeuGlu: 5.142 ± 0.098	3.224LeuPhe: 3.224 ± 0.077	8.708LeuGly: 8.708 ± 0.095	2.574LeuHis: 2.574 ± 0.064	3.532LeuIle: 3.532 ± 0.066	2.63LeuLys: 2.63 ± 0.061	10.848LeuLeu: 10.848 ± 0.161	2.239LeuMet: 2.239 ± 0.053	2.049LeuAsn: 2.049 ± 0.055	5.939LeuPro: 5.939 ± 0.086	3.465LeuGln: 3.465 ± 0.067	8.868LeuArg: 8.868 ± 0.122	5.416LeuSer: 5.416 ± 0.078	4.687LeuThr: 4.687 ± 0.084	8.358LeuVal: 8.358 ± 0.121	1.29LeuTrp: 1.29 ± 0.042	1.947LeuTyr: 1.947 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.679MetAla: 2.679 ± 0.051	0.149MetCys: 0.149 ± 0.013	1.135MetAsp: 1.135 ± 0.043	0.895MetGlu: 0.895 ± 0.036	0.695MetPhe: 0.695 ± 0.035	1.589MetGly: 1.589 ± 0.047	0.62MetHis: 0.62 ± 0.027	0.843MetIle: 0.843 ± 0.034	0.786MetLys: 0.786 ± 0.031	2.676MetLeu: 2.676 ± 0.055	0.411MetMet: 0.411 ± 0.024	0.664MetAsn: 0.664 ± 0.03	1.607MetPro: 1.607 ± 0.044	0.945MetGln: 0.945 ± 0.04	2.18MetArg: 2.18 ± 0.051	1.529MetSer: 1.529 ± 0.041	1.516MetThr: 1.516 ± 0.04	1.468MetVal: 1.468 ± 0.041	0.205MetTrp: 0.205 ± 0.014	0.392MetTyr: 0.392 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.297AsnAla: 3.297 ± 0.08	0.228AsnCys: 0.228 ± 0.017	1.395AsnAsp: 1.395 ± 0.045	1.097AsnGlu: 1.097 ± 0.036	0.872AsnPhe: 0.872 ± 0.034	2.241AsnGly: 2.241 ± 0.066	0.431AsnHis: 0.431 ± 0.023	0.975AsnIle: 0.975 ± 0.035	0.51AsnLys: 0.51 ± 0.031	2.185AsnLeu: 2.185 ± 0.051	0.383AsnMet: 0.383 ± 0.025	0.597AsnAsn: 0.597 ± 0.041	1.713AsnPro: 1.713 ± 0.046	0.622AsnGln: 0.622 ± 0.032	1.738AsnArg: 1.738 ± 0.046	1.089AsnSer: 1.089 ± 0.051	1.193AsnThr: 1.193 ± 0.056	1.878AsnVal: 1.878 ± 0.056	0.314AsnTrp: 0.314 ± 0.019	0.576AsnTyr: 0.576 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.264ProAla: 7.264 ± 0.113	0.331ProCys: 0.331 ± 0.02	3.619ProAsp: 3.619 ± 0.065	2.899ProGlu: 2.899 ± 0.061	1.657ProPhe: 1.657 ± 0.043	4.91ProGly: 4.91 ± 0.094	1.186ProHis: 1.186 ± 0.045	1.901ProIle: 1.901 ± 0.046	1.382ProLys: 1.382 ± 0.05	5.085ProLeu: 5.085 ± 0.084	1.363ProMet: 1.363 ± 0.039	1.255ProAsn: 1.255 ± 0.043	2.927ProPro: 2.927 ± 0.082	1.819ProGln: 1.819 ± 0.043	3.742ProArg: 3.742 ± 0.079	2.897ProSer: 2.897 ± 0.06	2.734ProThr: 2.734 ± 0.053	4.579ProVal: 4.579 ± 0.074	0.748ProTrp: 0.748 ± 0.034	1.185ProTyr: 1.185 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.6GlnAla: 4.6 ± 0.08	0.244GlnCys: 0.244 ± 0.018	1.39GlnAsp: 1.39 ± 0.041	1.175GlnGlu: 1.175 ± 0.045	1.051GlnPhe: 1.051 ± 0.034	2.462GlnGly: 2.462 ± 0.062	0.841GlnHis: 0.841 ± 0.031	1.34GlnIle: 1.34 ± 0.044	0.898GlnLys: 0.898 ± 0.033	3.929GlnLeu: 3.929 ± 0.076	0.819GlnMet: 0.819 ± 0.035	0.659GlnAsn: 0.659 ± 0.032	1.923GlnPro: 1.923 ± 0.05	1.523GlnGln: 1.523 ± 0.06	3.219GlnArg: 3.219 ± 0.076	1.73GlnSer: 1.73 ± 0.045	1.429GlnThr: 1.429 ± 0.042	2.747GlnVal: 2.747 ± 0.065	0.512GlnTrp: 0.512 ± 0.026	0.736GlnTyr: 0.736 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	9.823ArgAla: 9.823 ± 0.12	0.616ArgCys: 0.616 ± 0.027	5.31ArgAsp: 5.31 ± 0.088	4.904ArgGlu: 4.904 ± 0.086	3.108ArgPhe: 3.108 ± 0.058	5.944ArgGly: 5.944 ± 0.088	2.027ArgHis: 2.027 ± 0.058	4.107ArgIle: 4.107 ± 0.066	1.878ArgLys: 1.878 ± 0.06	8.806ArgLeu: 8.806 ± 0.145	2.237ArgMet: 2.237 ± 0.052	1.866ArgAsn: 1.866 ± 0.042	3.881ArgPro: 3.881 ± 0.067	2.639ArgGln: 2.639 ± 0.066	6.789ArgArg: 6.789 ± 0.127	3.881ArgSer: 3.881 ± 0.071	3.747ArgThr: 3.747 ± 0.06	6.351ArgVal: 6.351 ± 0.116	1.401ArgTrp: 1.401 ± 0.046	2.172ArgTyr: 2.172 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	6.32SerAla: 6.32 ± 0.115	0.409SerCys: 0.409 ± 0.024	2.82SerAsp: 2.82 ± 0.054	2.432SerGlu: 2.432 ± 0.061	1.792SerPhe: 1.792 ± 0.044	4.987SerGly: 4.987 ± 0.075	1.169SerHis: 1.169 ± 0.038	2.272SerIle: 2.272 ± 0.053	1.414SerLys: 1.414 ± 0.053	5.472SerLeu: 5.472 ± 0.08	1.341SerMet: 1.341 ± 0.038	1.347SerAsn: 1.347 ± 0.051	2.91SerPro: 2.91 ± 0.064	1.805SerGln: 1.805 ± 0.051	4.091SerArg: 4.091 ± 0.077	2.879SerSer: 2.879 ± 0.085	3.001SerThr: 3.001 ± 0.071	3.904SerVal: 3.904 ± 0.065	0.664SerTrp: 0.664 ± 0.03	1.144SerTyr: 1.144 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.14ThrAla: 6.14 ± 0.125	0.468ThrCys: 0.468 ± 0.023	2.776ThrAsp: 2.776 ± 0.059	2.118ThrGlu: 2.118 ± 0.053	1.66ThrPhe: 1.66 ± 0.053	4.917ThrGly: 4.917 ± 0.077	1.198ThrHis: 1.198 ± 0.036	2.025ThrIle: 2.025 ± 0.051	1.055ThrLys: 1.055 ± 0.042	5.841ThrLeu: 5.841 ± 0.089	0.959ThrMet: 0.959 ± 0.039	1.026ThrAsn: 1.026 ± 0.041	3.391ThrPro: 3.391 ± 0.067	1.691ThrGln: 1.691 ± 0.049	3.98ThrArg: 3.98 ± 0.067	2.654ThrSer: 2.654 ± 0.06	2.683ThrThr: 2.683 ± 0.066	3.978ThrVal: 3.978 ± 0.07	0.718ThrTrp: 0.718 ± 0.031	1.167ThrTyr: 1.167 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	10.556ValAla: 10.556 ± 0.131	0.667ValCys: 0.667 ± 0.028	5.463ValAsp: 5.463 ± 0.081	4.761ValGlu: 4.761 ± 0.084	2.714ValPhe: 2.714 ± 0.061	6.247ValGly: 6.247 ± 0.092	1.853ValHis: 1.853 ± 0.046	3.299ValIle: 3.299 ± 0.073	1.674ValLys: 1.674 ± 0.049	8.628ValLeu: 8.628 ± 0.112	1.709ValMet: 1.709 ± 0.045	1.995ValAsn: 1.995 ± 0.058	4.226ValPro: 4.226 ± 0.071	2.487ValGln: 2.487 ± 0.061	6.03ValArg: 6.03 ± 0.092	4.014ValSer: 4.014 ± 0.078	3.999ValThr: 3.999 ± 0.071	6.818ValVal: 6.818 ± 0.106	0.854ValTrp: 0.854 ± 0.038	1.472ValTyr: 1.472 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.259TrpAla: 1.259 ± 0.041	0.139TrpCys: 0.139 ± 0.014	0.634TrpAsp: 0.634 ± 0.028	0.477TrpGlu: 0.477 ± 0.023	0.595TrpPhe: 0.595 ± 0.031	0.853TrpGly: 0.853 ± 0.03	0.348TrpHis: 0.348 ± 0.022	0.727TrpIle: 0.727 ± 0.031	0.413TrpLys: 0.413 ± 0.025	2.07TrpLeu: 2.07 ± 0.059	0.415TrpMet: 0.415 ± 0.023	0.486TrpAsn: 0.486 ± 0.025	0.705TrpPro: 0.705 ± 0.031	0.606TrpGln: 0.606 ± 0.032	1.319TrpArg: 1.319 ± 0.044	0.877TrpSer: 0.877 ± 0.032	0.76TrpThr: 0.76 ± 0.031	0.927TrpVal: 0.927 ± 0.037	0.289TrpTrp: 0.289 ± 0.018	0.308TrpTyr: 0.308 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.775TyrAla: 2.775 ± 0.063	0.199TyrCys: 0.199 ± 0.013	1.339TyrAsp: 1.339 ± 0.045	1.087TyrGlu: 1.087 ± 0.036	0.862TyrPhe: 0.862 ± 0.034	2.1TyrGly: 2.1 ± 0.059	0.43TyrHis: 0.43 ± 0.022	0.73TyrIle: 0.73 ± 0.031	0.477TyrLys: 0.477 ± 0.029	2.126TyrLeu: 2.126 ± 0.046	0.382TyrMet: 0.382 ± 0.023	0.583TyrAsn: 0.583 ± 0.031	1.18TyrPro: 1.18 ± 0.038	0.757TyrGln: 0.757 ± 0.033	2.087TyrArg: 2.087 ± 0.048	1.222TyrSer: 1.222 ± 0.043	1.134TyrThr: 1.134 ± 0.043	1.846TyrVal: 1.846 ± 0.043	0.36TyrTrp: 0.36 ± 0.019	0.53TyrTyr: 0.53 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2756 proteins (837149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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