Amino acid dipepetide frequency for Phaeocystidibacter marisrubri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.334AlaAla: 5.334 ± 0.101	0.613AlaCys: 0.613 ± 0.024	3.939AlaAsp: 3.939 ± 0.065	4.751AlaGlu: 4.751 ± 0.083	3.444AlaPhe: 3.444 ± 0.059	5.075AlaGly: 5.075 ± 0.097	1.423AlaHis: 1.423 ± 0.039	5.096AlaIle: 5.096 ± 0.081	3.643AlaLys: 3.643 ± 0.075	7.134AlaLeu: 7.134 ± 0.108	2.032AlaMet: 2.032 ± 0.047	3.553AlaAsn: 3.553 ± 0.08	2.502AlaPro: 2.502 ± 0.057	2.784AlaGln: 2.784 ± 0.058	3.002AlaArg: 3.002 ± 0.06	4.967AlaSer: 4.967 ± 0.101	4.049AlaThr: 4.049 ± 0.089	4.955AlaVal: 4.955 ± 0.074	0.935AlaTrp: 0.935 ± 0.035	2.864AlaTyr: 2.864 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.557CysAla: 0.557 ± 0.026	0.091CysCys: 0.091 ± 0.01	0.516CysAsp: 0.516 ± 0.029	0.474CysGlu: 0.474 ± 0.021	0.359CysPhe: 0.359 ± 0.032	0.706CysGly: 0.706 ± 0.031	0.186CysHis: 0.186 ± 0.016	0.489CysIle: 0.489 ± 0.024	0.302CysLys: 0.302 ± 0.018	0.551CysLeu: 0.551 ± 0.024	0.174CysMet: 0.174 ± 0.014	0.375CysAsn: 0.375 ± 0.022	0.38CysPro: 0.38 ± 0.021	0.232CysGln: 0.232 ± 0.018	0.263CysArg: 0.263 ± 0.017	0.621CysSer: 0.621 ± 0.033	0.547CysThr: 0.547 ± 0.031	0.476CysVal: 0.476 ± 0.025	0.086CysTrp: 0.086 ± 0.013	0.284CysTyr: 0.284 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.072AspAla: 4.072 ± 0.074	0.447AspCys: 0.447 ± 0.024	2.927AspAsp: 2.927 ± 0.062	4.107AspGlu: 4.107 ± 0.081	2.969AspPhe: 2.969 ± 0.057	4.276AspGly: 4.276 ± 0.09	1.268AspHis: 1.268 ± 0.035	3.893AspIle: 3.893 ± 0.063	2.597AspLys: 2.597 ± 0.062	5.522AspLeu: 5.522 ± 0.07	1.299AspMet: 1.299 ± 0.042	2.416AspAsn: 2.416 ± 0.064	2.457AspPro: 2.457 ± 0.056	1.947AspGln: 1.947 ± 0.049	2.733AspArg: 2.733 ± 0.056	4.073AspSer: 4.073 ± 0.079	3.258AspThr: 3.258 ± 0.09	4.107AspVal: 4.107 ± 0.076	0.933AspTrp: 0.933 ± 0.032	2.418AspTyr: 2.418 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.915GluAla: 4.915 ± 0.08	0.412GluCys: 0.412 ± 0.021	3.718GluAsp: 3.718 ± 0.072	5.256GluGlu: 5.256 ± 0.097	2.907GluPhe: 2.907 ± 0.056	4.417GluGly: 4.417 ± 0.072	1.349GluHis: 1.349 ± 0.035	4.511GluIle: 4.511 ± 0.08	3.854GluLys: 3.854 ± 0.085	6.351GluLeu: 6.351 ± 0.092	1.956GluMet: 1.956 ± 0.051	3.384GluAsn: 3.384 ± 0.062	1.892GluPro: 1.892 ± 0.039	2.095GluGln: 2.095 ± 0.054	3.539GluArg: 3.539 ± 0.068	4.051GluSer: 4.051 ± 0.066	3.208GluThr: 3.208 ± 0.062	5.037GluVal: 5.037 ± 0.083	0.984GluTrp: 0.984 ± 0.033	2.552GluTyr: 2.552 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.329PheAla: 3.329 ± 0.065	0.358PheCys: 0.358 ± 0.02	3.019PheAsp: 3.019 ± 0.05	3.072PheGlu: 3.072 ± 0.065	2.111PhePhe: 2.111 ± 0.057	3.675PheGly: 3.675 ± 0.065	0.959PheHis: 0.959 ± 0.034	3.103PheIle: 3.103 ± 0.062	2.118PheLys: 2.118 ± 0.05	3.785PheLeu: 3.785 ± 0.078	1.12PheMet: 1.12 ± 0.04	2.45PheAsn: 2.45 ± 0.057	1.775PhePro: 1.775 ± 0.041	1.537PheGln: 1.537 ± 0.04	2.053PheArg: 2.053 ± 0.045	3.544PheSer: 3.544 ± 0.057	3.109PheThr: 3.109 ± 0.059	3.145PheVal: 3.145 ± 0.064	0.615PheTrp: 0.615 ± 0.027	1.874PheTyr: 1.874 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	5.026GlyAla: 5.026 ± 0.091	0.701GlyCys: 0.701 ± 0.057	4.175GlyAsp: 4.175 ± 0.072	4.45GlyGlu: 4.45 ± 0.067	3.355GlyPhe: 3.355 ± 0.063	5.567GlyGly: 5.567 ± 0.126	1.365GlyHis: 1.365 ± 0.04	4.918GlyIle: 4.918 ± 0.071	3.728GlyLys: 3.728 ± 0.065	6.49GlyLeu: 6.49 ± 0.089	2.081GlyMet: 2.081 ± 0.047	3.388GlyAsn: 3.388 ± 0.083	1.912GlyPro: 1.912 ± 0.055	2.589GlyGln: 2.589 ± 0.066	3.027GlyArg: 3.027 ± 0.058	4.907GlySer: 4.907 ± 0.107	4.662GlyThr: 4.662 ± 0.143	5.362GlyVal: 5.362 ± 0.083	1.07GlyTrp: 1.07 ± 0.037	3.148GlyTyr: 3.148 ± 0.078	0.0GlyXaa: 0.0 ± 0.0
His	1.304HisAla: 1.304 ± 0.04	0.198HisCys: 0.198 ± 0.015	0.969HisAsp: 0.969 ± 0.031	1.259HisGlu: 1.259 ± 0.036	1.231HisPhe: 1.231 ± 0.037	1.35HisGly: 1.35 ± 0.035	0.608HisHis: 0.608 ± 0.026	1.386HisIle: 1.386 ± 0.037	0.982HisLys: 0.982 ± 0.029	2.131HisLeu: 2.131 ± 0.051	0.54HisMet: 0.54 ± 0.025	0.882HisAsn: 0.882 ± 0.031	1.248HisPro: 1.248 ± 0.04	0.833HisGln: 0.833 ± 0.03	1.054HisArg: 1.054 ± 0.036	1.383HisSer: 1.383 ± 0.041	1.157HisThr: 1.157 ± 0.029	1.348HisVal: 1.348 ± 0.045	0.325HisTrp: 0.325 ± 0.02	0.966HisTyr: 0.966 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.137IleAla: 5.137 ± 0.076	0.542IleCys: 0.542 ± 0.025	4.333IleAsp: 4.333 ± 0.073	4.709IleGlu: 4.709 ± 0.089	2.751IlePhe: 2.751 ± 0.068	4.747IleGly: 4.747 ± 0.074	1.65IleHis: 1.65 ± 0.043	3.707IleIle: 3.707 ± 0.069	2.655IleLys: 2.655 ± 0.061	5.934IleLeu: 5.934 ± 0.105	1.229IleMet: 1.229 ± 0.036	2.97IleAsn: 2.97 ± 0.063	3.084IlePro: 3.084 ± 0.057	2.671IleGln: 2.671 ± 0.05	3.359IleArg: 3.359 ± 0.064	4.836IleSer: 4.836 ± 0.079	4.066IleThr: 4.066 ± 0.085	4.351IleVal: 4.351 ± 0.068	0.763IleTrp: 0.763 ± 0.03	2.294IleTyr: 2.294 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	3.878LysAla: 3.878 ± 0.083	0.296LysCys: 0.296 ± 0.017	2.781LysAsp: 2.781 ± 0.065	3.459LysGlu: 3.459 ± 0.078	1.906LysPhe: 1.906 ± 0.048	3.404LysGly: 3.404 ± 0.072	1.025LysHis: 1.025 ± 0.035	3.027LysIle: 3.027 ± 0.061	3.195LysLys: 3.195 ± 0.073	4.452LysLeu: 4.452 ± 0.078	1.548LysMet: 1.548 ± 0.041	2.333LysAsn: 2.333 ± 0.053	1.853LysPro: 1.853 ± 0.056	1.449LysGln: 1.449 ± 0.047	2.686LysArg: 2.686 ± 0.059	3.51LysSer: 3.51 ± 0.07	2.666LysThr: 2.666 ± 0.056	3.651LysVal: 3.651 ± 0.075	0.802LysTrp: 0.802 ± 0.028	2.091LysTyr: 2.091 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.704LeuAla: 6.704 ± 0.094	0.646LeuCys: 0.646 ± 0.026	5.332LeuAsp: 5.332 ± 0.075	6.07LeuGlu: 6.07 ± 0.099	4.302LeuPhe: 4.302 ± 0.071	6.188LeuGly: 6.188 ± 0.087	2.004LeuHis: 2.004 ± 0.046	5.84LeuIle: 5.84 ± 0.095	5.062LeuLys: 5.062 ± 0.094	8.553LeuLeu: 8.553 ± 0.144	2.144LeuMet: 2.144 ± 0.054	4.831LeuAsn: 4.831 ± 0.081	3.973LeuPro: 3.973 ± 0.062	3.208LeuGln: 3.208 ± 0.055	4.211LeuArg: 4.211 ± 0.072	7.337LeuSer: 7.337 ± 0.101	5.361LeuThr: 5.361 ± 0.084	5.554LeuVal: 5.554 ± 0.082	1.073LeuTrp: 1.073 ± 0.033	3.288LeuTyr: 3.288 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.95MetAla: 1.95 ± 0.047	0.139MetCys: 0.139 ± 0.011	1.569MetAsp: 1.569 ± 0.038	1.768MetGlu: 1.768 ± 0.045	0.83MetPhe: 0.83 ± 0.029	1.841MetGly: 1.841 ± 0.047	0.468MetHis: 0.468 ± 0.022	1.483MetIle: 1.483 ± 0.044	1.983MetLys: 1.983 ± 0.046	2.058MetLeu: 2.058 ± 0.055	0.782MetMet: 0.782 ± 0.031	1.421MetAsn: 1.421 ± 0.042	0.982MetPro: 0.982 ± 0.032	0.778MetGln: 0.778 ± 0.028	1.371MetArg: 1.371 ± 0.039	1.79MetSer: 1.79 ± 0.042	1.445MetThr: 1.445 ± 0.036	1.599MetVal: 1.599 ± 0.036	0.215MetTrp: 0.215 ± 0.014	0.794MetTyr: 0.794 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.739AsnAla: 3.739 ± 0.068	0.419AsnCys: 0.419 ± 0.03	2.791AsnAsp: 2.791 ± 0.051	2.838AsnGlu: 2.838 ± 0.058	2.115AsnPhe: 2.115 ± 0.055	4.382AsnGly: 4.382 ± 0.121	1.064AsnHis: 1.064 ± 0.037	2.95AsnIle: 2.95 ± 0.056	1.945AsnLys: 1.945 ± 0.047	4.313AsnLeu: 4.313 ± 0.069	1.055AsnMet: 1.055 ± 0.033	2.329AsnAsn: 2.329 ± 0.063	2.781AsnPro: 2.781 ± 0.062	1.722AsnGln: 1.722 ± 0.049	2.491AsnArg: 2.491 ± 0.049	3.467AsnSer: 3.467 ± 0.074	2.97AsnThr: 2.97 ± 0.066	3.337AsnVal: 3.337 ± 0.07	0.8AsnTrp: 0.8 ± 0.034	1.959AsnTyr: 1.959 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.682ProAla: 2.682 ± 0.057	0.301ProCys: 0.301 ± 0.021	2.488ProAsp: 2.488 ± 0.055	2.984ProGlu: 2.984 ± 0.059	1.963ProPhe: 1.963 ± 0.047	2.699ProGly: 2.699 ± 0.059	0.835ProHis: 0.835 ± 0.027	2.698ProIle: 2.698 ± 0.055	1.9ProLys: 1.9 ± 0.055	3.368ProLeu: 3.368 ± 0.063	0.947ProMet: 0.947 ± 0.034	2.304ProAsn: 2.304 ± 0.053	1.144ProPro: 1.144 ± 0.04	1.268ProGln: 1.268 ± 0.036	1.304ProArg: 1.304 ± 0.036	3.074ProSer: 3.074 ± 0.076	2.482ProThr: 2.482 ± 0.057	2.885ProVal: 2.885 ± 0.056	0.493ProTrp: 0.493 ± 0.024	1.547ProTyr: 1.547 ± 0.058	0.0ProXaa: 0.0 ± 0.0
Gln	2.362GlnAla: 2.362 ± 0.05	0.223GlnCys: 0.223 ± 0.014	1.578GlnAsp: 1.578 ± 0.039	1.925GlnGlu: 1.925 ± 0.048	1.709GlnPhe: 1.709 ± 0.041	1.839GlnGly: 1.839 ± 0.049	0.732GlnHis: 0.732 ± 0.027	2.369GlnIle: 2.369 ± 0.049	1.815GlnLys: 1.815 ± 0.046	3.658GlnLeu: 3.658 ± 0.065	1.049GlnMet: 1.049 ± 0.032	1.787GlnAsn: 1.787 ± 0.045	1.4GlnPro: 1.4 ± 0.045	1.282GlnGln: 1.282 ± 0.042	1.762GlnArg: 1.762 ± 0.039	2.477GlnSer: 2.477 ± 0.052	1.92GlnThr: 1.92 ± 0.051	2.387GlnVal: 2.387 ± 0.047	0.521GlnTrp: 0.521 ± 0.024	1.397GlnTyr: 1.397 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.069ArgAla: 3.069 ± 0.068	0.276ArgCys: 0.276 ± 0.019	2.39ArgAsp: 2.39 ± 0.059	3.275ArgGlu: 3.275 ± 0.066	2.381ArgPhe: 2.381 ± 0.054	2.769ArgGly: 2.769 ± 0.059	0.865ArgHis: 0.865 ± 0.033	3.522ArgIle: 3.522 ± 0.058	2.676ArgLys: 2.676 ± 0.065	4.329ArgLeu: 4.329 ± 0.065	1.454ArgMet: 1.454 ± 0.041	2.203ArgAsn: 2.203 ± 0.051	1.674ArgPro: 1.674 ± 0.047	1.544ArgGln: 1.544 ± 0.046	2.24ArgArg: 2.24 ± 0.052	2.978ArgSer: 2.978 ± 0.061	2.458ArgThr: 2.458 ± 0.054	3.393ArgVal: 3.393 ± 0.064	0.701ArgTrp: 0.701 ± 0.028	1.965ArgTyr: 1.965 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.24SerAla: 5.24 ± 0.111	0.659SerCys: 0.659 ± 0.036	4.201SerAsp: 4.201 ± 0.062	4.511SerGlu: 4.511 ± 0.074	3.677SerPhe: 3.677 ± 0.069	5.739SerGly: 5.739 ± 0.116	1.342SerHis: 1.342 ± 0.042	5.093SerIle: 5.093 ± 0.071	3.24SerLys: 3.24 ± 0.069	6.286SerLeu: 6.286 ± 0.097	1.762SerMet: 1.762 ± 0.045	3.649SerAsn: 3.649 ± 0.09	2.813SerPro: 2.813 ± 0.064	2.212SerGln: 2.212 ± 0.05	2.797SerArg: 2.797 ± 0.053	5.762SerSer: 5.762 ± 0.137	4.711SerThr: 4.711 ± 0.1	4.794SerVal: 4.794 ± 0.075	1.003SerTrp: 1.003 ± 0.035	2.777SerTyr: 2.777 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	4.379ThrAla: 4.379 ± 0.108	0.438ThrCys: 0.438 ± 0.027	3.315ThrAsp: 3.315 ± 0.094	3.454ThrGlu: 3.454 ± 0.062	2.881ThrPhe: 2.881 ± 0.061	4.799ThrGly: 4.799 ± 0.117	1.225ThrHis: 1.225 ± 0.032	3.863ThrIle: 3.863 ± 0.082	2.311ThrLys: 2.311 ± 0.053	5.737ThrLeu: 5.737 ± 0.1	1.12ThrMet: 1.12 ± 0.037	2.659ThrAsn: 2.659 ± 0.066	2.816ThrPro: 2.816 ± 0.065	1.871ThrGln: 1.871 ± 0.054	2.23ThrArg: 2.23 ± 0.044	4.475ThrSer: 4.475 ± 0.099	3.761ThrThr: 3.761 ± 0.08	4.276ThrVal: 4.276 ± 0.113	0.809ThrTrp: 0.809 ± 0.033	2.556ThrTyr: 2.556 ± 0.071	0.0ThrXaa: 0.0 ± 0.0
Val	4.835ValAla: 4.835 ± 0.078	0.493ValCys: 0.493 ± 0.023	4.456ValAsp: 4.456 ± 0.075	5.005ValGlu: 5.005 ± 0.085	3.267ValPhe: 3.267 ± 0.066	4.652ValGly: 4.652 ± 0.08	1.436ValHis: 1.436 ± 0.04	4.641ValIle: 4.641 ± 0.081	3.409ValLys: 3.409 ± 0.066	6.3ValLeu: 6.3 ± 0.087	1.61ValMet: 1.61 ± 0.047	3.598ValAsn: 3.598 ± 0.06	2.594ValPro: 2.594 ± 0.052	2.305ValGln: 2.305 ± 0.052	3.275ValArg: 3.275 ± 0.059	4.953ValSer: 4.953 ± 0.087	3.772ValThr: 3.772 ± 0.122	5.37ValVal: 5.37 ± 0.095	0.794ValTrp: 0.794 ± 0.028	2.791ValTyr: 2.791 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.844TrpAla: 0.844 ± 0.034	0.099TrpCys: 0.099 ± 0.009	0.802TrpAsp: 0.802 ± 0.026	0.786TrpGlu: 0.786 ± 0.029	0.553TrpPhe: 0.553 ± 0.024	0.896TrpGly: 0.896 ± 0.036	0.313TrpHis: 0.313 ± 0.019	0.919TrpIle: 0.919 ± 0.037	0.936TrpLys: 0.936 ± 0.032	1.189TrpLeu: 1.189 ± 0.038	0.514TrpMet: 0.514 ± 0.026	0.875TrpAsn: 0.875 ± 0.029	0.371TrpPro: 0.371 ± 0.021	0.431TrpGln: 0.431 ± 0.024	0.598TrpArg: 0.598 ± 0.025	1.022TrpSer: 1.022 ± 0.046	0.872TrpThr: 0.872 ± 0.034	0.959TrpVal: 0.959 ± 0.028	0.223TrpTrp: 0.223 ± 0.016	0.512TrpTyr: 0.512 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.741TyrAla: 2.741 ± 0.058	0.318TyrCys: 0.318 ± 0.018	2.421TyrAsp: 2.421 ± 0.056	2.236TyrGlu: 2.236 ± 0.051	2.041TyrPhe: 2.041 ± 0.049	2.902TyrGly: 2.902 ± 0.07	1.037TyrHis: 1.037 ± 0.036	2.276TyrIle: 2.276 ± 0.053	1.662TyrLys: 1.662 ± 0.049	3.538TyrLeu: 3.538 ± 0.062	0.847TyrMet: 0.847 ± 0.025	2.059TyrAsn: 2.059 ± 0.054	1.714TyrPro: 1.714 ± 0.044	1.435TyrGln: 1.435 ± 0.042	2.168TyrArg: 2.168 ± 0.05	3.041TyrSer: 3.041 ± 0.066	2.502TyrThr: 2.502 ± 0.074	2.571TyrVal: 2.571 ± 0.052	0.568TyrTrp: 0.568 ± 0.026	1.767TyrTyr: 1.767 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2884 proteins (1015842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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