Amino acid dipepetide frequency for Erwinia phage vB_EamM_Special G

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.402AlaAla: 7.402 ± 0.505
0.66AlaCys: 0.66 ± 0.089
5.151AlaAsp: 5.151 ± 0.243
4.609AlaGlu: 4.609 ± 0.274
3.076AlaPhe: 3.076 ± 0.194
5.728AlaGly: 5.728 ± 0.337
1.556AlaHis: 1.556 ± 0.151
5.139AlaIle: 5.139 ± 0.249
4.809AlaLys: 4.809 ± 0.294
7.614AlaLeu: 7.614 ± 0.319
2.746AlaMet: 2.746 ± 0.193
4.125AlaAsn: 4.125 ± 0.199
2.994AlaPro: 2.994 ± 0.212
3.123AlaGln: 3.123 ± 0.284
3.713AlaArg: 3.713 ± 0.213
4.373AlaSer: 4.373 ± 0.267
4.998AlaThr: 4.998 ± 0.264
6.035AlaVal: 6.035 ± 0.274
1.096AlaTrp: 1.096 ± 0.114
2.64AlaTyr: 2.64 ± 0.178
0.0AlaXaa: 0.0 ± 0.0
Cys
0.636CysAla: 0.636 ± 0.089
0.083CysCys: 0.083 ± 0.035
0.566CysAsp: 0.566 ± 0.09
0.413CysGlu: 0.413 ± 0.066
0.389CysPhe: 0.389 ± 0.062
0.589CysGly: 0.589 ± 0.082
0.283CysHis: 0.283 ± 0.062
0.495CysIle: 0.495 ± 0.086
0.46CysLys: 0.46 ± 0.074
0.896CysLeu: 0.896 ± 0.1
0.318CysMet: 0.318 ± 0.07
0.471CysAsn: 0.471 ± 0.068
0.389CysPro: 0.389 ± 0.072
0.318CysGln: 0.318 ± 0.06
0.66CysArg: 0.66 ± 0.09
0.471CysSer: 0.471 ± 0.084
0.507CysThr: 0.507 ± 0.066
0.601CysVal: 0.601 ± 0.099
0.118CysTrp: 0.118 ± 0.036
0.377CysTyr: 0.377 ± 0.071
0.0CysXaa: 0.0 ± 0.0
Asp
5.269AspAla: 5.269 ± 0.303
0.471AspCys: 0.471 ± 0.083
3.937AspAsp: 3.937 ± 0.289
4.055AspGlu: 4.055 ± 0.26
2.381AspPhe: 2.381 ± 0.162
4.137AspGly: 4.137 ± 0.278
1.367AspHis: 1.367 ± 0.127
4.149AspIle: 4.149 ± 0.234
3.477AspLys: 3.477 ± 0.274
5.587AspLeu: 5.587 ± 0.236
1.674AspMet: 1.674 ± 0.119
3.065AspAsn: 3.065 ± 0.154
2.711AspPro: 2.711 ± 0.213
2.463AspGln: 2.463 ± 0.206
3.218AspArg: 3.218 ± 0.216
3.23AspSer: 3.23 ± 0.215
3.395AspThr: 3.395 ± 0.25
4.514AspVal: 4.514 ± 0.254
0.743AspTrp: 0.743 ± 0.079
2.676AspTyr: 2.676 ± 0.171
0.0AspXaa: 0.0 ± 0.0
Glu
4.821GluAla: 4.821 ± 0.28
0.519GluCys: 0.519 ± 0.09
3.182GluAsp: 3.182 ± 0.201
3.63GluGlu: 3.63 ± 0.257
2.322GluPhe: 2.322 ± 0.153
3.336GluGly: 3.336 ± 0.22
1.379GluHis: 1.379 ± 0.13
3.395GluIle: 3.395 ± 0.181
3.041GluLys: 3.041 ± 0.195
6.471GluLeu: 6.471 ± 0.311
1.803GluMet: 1.803 ± 0.152
2.228GluAsn: 2.228 ± 0.165
1.909GluPro: 1.909 ± 0.148
2.746GluGln: 2.746 ± 0.175
3.359GluArg: 3.359 ± 0.228
3.123GluSer: 3.123 ± 0.183
2.805GluThr: 2.805 ± 0.177
4.243GluVal: 4.243 ± 0.212
0.99GluTrp: 0.99 ± 0.106
2.074GluTyr: 2.074 ± 0.162
0.0GluXaa: 0.0 ± 0.0
Phe
2.605PheAla: 2.605 ± 0.136
0.377PheCys: 0.377 ± 0.076
2.829PheAsp: 2.829 ± 0.182
2.145PheGlu: 2.145 ± 0.167
1.19PhePhe: 1.19 ± 0.12
2.239PheGly: 2.239 ± 0.166
0.719PheHis: 0.719 ± 0.107
2.369PheIle: 2.369 ± 0.162
2.275PheLys: 2.275 ± 0.159
2.534PheLeu: 2.534 ± 0.171
1.002PheMet: 1.002 ± 0.093
2.687PheAsn: 2.687 ± 0.161
1.308PhePro: 1.308 ± 0.131
0.978PheGln: 0.978 ± 0.1
1.462PheArg: 1.462 ± 0.128
2.086PheSer: 2.086 ± 0.172
2.793PheThr: 2.793 ± 0.186
2.711PheVal: 2.711 ± 0.193
0.295PheTrp: 0.295 ± 0.07
1.367PheTyr: 1.367 ± 0.155
0.0PheXaa: 0.0 ± 0.0
Gly
5.245GlyAla: 5.245 ± 0.43
0.436GlyCys: 0.436 ± 0.069
4.903GlyAsp: 4.903 ± 0.71
4.007GlyGlu: 4.007 ± 0.253
2.251GlyPhe: 2.251 ± 0.166
5.811GlyGly: 5.811 ± 0.711
1.108GlyHis: 1.108 ± 0.106
3.972GlyIle: 3.972 ± 0.204
3.795GlyLys: 3.795 ± 0.242
5.646GlyLeu: 5.646 ± 0.288
2.404GlyMet: 2.404 ± 0.189
3.571GlyAsn: 3.571 ± 0.253
1.568GlyPro: 1.568 ± 0.19
2.487GlyGln: 2.487 ± 0.205
2.947GlyArg: 2.947 ± 0.235
4.444GlySer: 4.444 ± 0.216
4.055GlyThr: 4.055 ± 0.261
4.632GlyVal: 4.632 ± 0.257
1.096GlyTrp: 1.096 ± 0.146
3.265GlyTyr: 3.265 ± 0.197
0.0GlyXaa: 0.0 ± 0.0
His
1.485HisAla: 1.485 ± 0.157
0.295HisCys: 0.295 ± 0.069
1.473HisAsp: 1.473 ± 0.131
1.285HisGlu: 1.285 ± 0.118
0.813HisPhe: 0.813 ± 0.107
1.473HisGly: 1.473 ± 0.154
0.695HisHis: 0.695 ± 0.093
1.568HisIle: 1.568 ± 0.137
0.801HisLys: 0.801 ± 0.092
1.874HisLeu: 1.874 ± 0.158
0.707HisMet: 0.707 ± 0.095
0.955HisAsn: 0.955 ± 0.126
0.978HisPro: 0.978 ± 0.109
0.99HisGln: 0.99 ± 0.115
1.297HisArg: 1.297 ± 0.135
0.955HisSer: 0.955 ± 0.136
1.202HisThr: 1.202 ± 0.119
1.603HisVal: 1.603 ± 0.141
0.365HisTrp: 0.365 ± 0.065
1.014HisTyr: 1.014 ± 0.115
0.0HisXaa: 0.0 ± 0.0
Ile
5.21IleAla: 5.21 ± 0.285
0.424IleCys: 0.424 ± 0.078
4.337IleAsp: 4.337 ± 0.268
3.972IleGlu: 3.972 ± 0.228
1.65IlePhe: 1.65 ± 0.144
3.689IleGly: 3.689 ± 0.192
1.084IleHis: 1.084 ± 0.125
3.123IleIle: 3.123 ± 0.215
3.442IleLys: 3.442 ± 0.199
4.172IleLeu: 4.172 ± 0.256
1.45IleMet: 1.45 ± 0.148
3.654IleAsn: 3.654 ± 0.212
3.006IlePro: 3.006 ± 0.204
2.004IleGln: 2.004 ± 0.148
2.947IleArg: 2.947 ± 0.189
3.748IleSer: 3.748 ± 0.202
4.88IleThr: 4.88 ± 0.28
3.654IleVal: 3.654 ± 0.245
0.507IleTrp: 0.507 ± 0.068
1.839IleTyr: 1.839 ± 0.169
0.0IleXaa: 0.0 ± 0.0
Lys
5.163LysAla: 5.163 ± 0.297
0.365LysCys: 0.365 ± 0.074
3.23LysAsp: 3.23 ± 0.222
3.501LysGlu: 3.501 ± 0.252
1.874LysPhe: 1.874 ± 0.164
4.208LysGly: 4.208 ± 0.699
1.332LysHis: 1.332 ± 0.144
2.758LysIle: 2.758 ± 0.186
2.64LysLys: 2.64 ± 0.219
4.797LysLeu: 4.797 ± 0.242
1.497LysMet: 1.497 ± 0.129
2.074LysAsn: 2.074 ± 0.202
2.393LysPro: 2.393 ± 0.204
2.346LysGln: 2.346 ± 0.2
2.852LysArg: 2.852 ± 0.186
2.817LysSer: 2.817 ± 0.186
2.923LysThr: 2.923 ± 0.197
3.501LysVal: 3.501 ± 0.201
0.707LysTrp: 0.707 ± 0.101
2.181LysTyr: 2.181 ± 0.159
0.0LysXaa: 0.0 ± 0.0
Leu
7.001LeuAla: 7.001 ± 0.28
1.249LeuCys: 1.249 ± 0.122
5.328LeuAsp: 5.328 ± 0.283
4.915LeuGlu: 4.915 ± 0.242
3.041LeuPhe: 3.041 ± 0.17
5.634LeuGly: 5.634 ± 0.236
1.697LeuHis: 1.697 ± 0.139
4.833LeuIle: 4.833 ± 0.286
4.703LeuLys: 4.703 ± 0.244
7.178LeuLeu: 7.178 ± 0.31
2.499LeuMet: 2.499 ± 0.171
4.809LeuAsn: 4.809 ± 0.229
4.102LeuPro: 4.102 ± 0.227
3.63LeuGln: 3.63 ± 0.208
4.797LeuArg: 4.797 ± 0.224
6.754LeuSer: 6.754 ± 0.307
6.011LeuThr: 6.011 ± 0.246
6.506LeuVal: 6.506 ± 0.336
0.908LeuTrp: 0.908 ± 0.1
3.265LeuTyr: 3.265 ± 0.225
0.0LeuXaa: 0.0 ± 0.0
Met
2.44MetAla: 2.44 ± 0.168
0.177MetCys: 0.177 ± 0.045
1.485MetAsp: 1.485 ± 0.132
1.355MetGlu: 1.355 ± 0.133
1.167MetPhe: 1.167 ± 0.125
1.756MetGly: 1.756 ± 0.17
0.613MetHis: 0.613 ± 0.076
1.544MetIle: 1.544 ± 0.143
1.544MetLys: 1.544 ± 0.15
2.746MetLeu: 2.746 ± 0.188
1.049MetMet: 1.049 ± 0.14
1.426MetAsn: 1.426 ± 0.112
1.355MetPro: 1.355 ± 0.14
1.379MetGln: 1.379 ± 0.147
1.379MetArg: 1.379 ± 0.122
2.581MetSer: 2.581 ± 0.157
2.628MetThr: 2.628 ± 0.188
1.957MetVal: 1.957 ± 0.162
0.224MetTrp: 0.224 ± 0.052
1.12MetTyr: 1.12 ± 0.116
0.0MetXaa: 0.0 ± 0.0
Asn
4.078AsnAla: 4.078 ± 0.253
0.401AsnCys: 0.401 ± 0.056
2.935AsnAsp: 2.935 ± 0.206
2.64AsnGlu: 2.64 ± 0.153
1.579AsnPhe: 1.579 ± 0.147
4.031AsnGly: 4.031 ± 0.211
1.155AsnHis: 1.155 ± 0.111
2.947AsnIle: 2.947 ± 0.211
2.911AsnLys: 2.911 ± 0.197
4.161AsnLeu: 4.161 ± 0.215
1.52AsnMet: 1.52 ± 0.171
2.64AsnAsn: 2.64 ± 0.166
3.159AsnPro: 3.159 ± 0.194
1.957AsnGln: 1.957 ± 0.144
2.628AsnArg: 2.628 ± 0.177
2.746AsnSer: 2.746 ± 0.183
3.595AsnThr: 3.595 ± 0.209
3.512AsnVal: 3.512 ± 0.191
0.554AsnTrp: 0.554 ± 0.082
1.768AsnTyr: 1.768 ± 0.131
0.0AsnXaa: 0.0 ± 0.0
Pro
3.831ProAla: 3.831 ± 0.243
0.236ProCys: 0.236 ± 0.05
3.041ProAsp: 3.041 ± 0.229
2.958ProGlu: 2.958 ± 0.166
1.52ProPhe: 1.52 ± 0.148
2.723ProGly: 2.723 ± 0.178
0.884ProHis: 0.884 ± 0.123
2.511ProIle: 2.511 ± 0.19
2.051ProLys: 2.051 ± 0.17
3.548ProLeu: 3.548 ± 0.204
1.132ProMet: 1.132 ± 0.13
1.898ProAsn: 1.898 ± 0.152
1.65ProPro: 1.65 ± 0.174
2.004ProGln: 2.004 ± 0.278
1.685ProArg: 1.685 ± 0.139
2.522ProSer: 2.522 ± 0.173
2.97ProThr: 2.97 ± 0.194
3.63ProVal: 3.63 ± 0.229
0.519ProTrp: 0.519 ± 0.072
1.603ProTyr: 1.603 ± 0.154
0.0ProXaa: 0.0 ± 0.0
Gln
3.595GlnAla: 3.595 ± 0.259
0.389GlnCys: 0.389 ± 0.073
1.756GlnAsp: 1.756 ± 0.149
1.898GlnGlu: 1.898 ± 0.187
1.65GlnPhe: 1.65 ± 0.155
2.475GlnGly: 2.475 ± 0.294
1.214GlnHis: 1.214 ± 0.12
2.11GlnIle: 2.11 ± 0.144
1.603GlnLys: 1.603 ± 0.147
4.208GlnLeu: 4.208 ± 0.225
1.355GlnMet: 1.355 ± 0.197
1.65GlnAsn: 1.65 ± 0.163
2.133GlnPro: 2.133 ± 0.182
2.805GlnGln: 2.805 ± 0.451
2.192GlnArg: 2.192 ± 0.148
2.016GlnSer: 2.016 ± 0.159
2.393GlnThr: 2.393 ± 0.163
2.793GlnVal: 2.793 ± 0.194
0.601GlnTrp: 0.601 ± 0.096
1.862GlnTyr: 1.862 ± 0.138
0.0GlnXaa: 0.0 ± 0.0
Arg
3.666ArgAla: 3.666 ± 0.228
0.53ArgCys: 0.53 ± 0.078
2.864ArgAsp: 2.864 ± 0.197
3.112ArgGlu: 3.112 ± 0.198
2.357ArgPhe: 2.357 ± 0.158
2.817ArgGly: 2.817 ± 0.185
1.143ArgHis: 1.143 ± 0.129
3.147ArgIle: 3.147 ± 0.178
2.546ArgLys: 2.546 ± 0.172
5.163ArgLeu: 5.163 ± 0.277
1.52ArgMet: 1.52 ± 0.149
2.935ArgAsn: 2.935 ± 0.175
1.803ArgPro: 1.803 ± 0.157
2.063ArgGln: 2.063 ± 0.153
2.734ArgArg: 2.734 ± 0.197
2.852ArgSer: 2.852 ± 0.2
2.746ArgThr: 2.746 ± 0.163
3.359ArgVal: 3.359 ± 0.222
0.601ArgTrp: 0.601 ± 0.089
2.404ArgTyr: 2.404 ± 0.196
0.0ArgXaa: 0.0 ± 0.0
Ser
4.361SerAla: 4.361 ± 0.255
0.613SerCys: 0.613 ± 0.086
3.666SerAsp: 3.666 ± 0.205
3.088SerGlu: 3.088 ± 0.179
2.204SerPhe: 2.204 ± 0.139
4.184SerGly: 4.184 ± 0.295
1.19SerHis: 1.19 ± 0.121
3.701SerIle: 3.701 ± 0.207
3.135SerLys: 3.135 ± 0.215
5.434SerLeu: 5.434 ± 0.273
1.862SerMet: 1.862 ± 0.144
3.112SerAsn: 3.112 ± 0.196
2.511SerPro: 2.511 ± 0.157
2.322SerGln: 2.322 ± 0.187
2.852SerArg: 2.852 ± 0.161
3.583SerSer: 3.583 ± 0.299
4.267SerThr: 4.267 ± 0.25
4.597SerVal: 4.597 ± 0.23
0.648SerTrp: 0.648 ± 0.089
2.016SerTyr: 2.016 ± 0.143
0.0SerXaa: 0.0 ± 0.0
Thr
5.563ThrAla: 5.563 ± 0.262
0.413ThrCys: 0.413 ± 0.064
4.231ThrAsp: 4.231 ± 0.204
3.277ThrGlu: 3.277 ± 0.175
2.263ThrPhe: 2.263 ± 0.171
4.962ThrGly: 4.962 ± 0.386
1.568ThrHis: 1.568 ± 0.138
3.56ThrIle: 3.56 ± 0.2
3.088ThrLys: 3.088 ± 0.182
5.681ThrLeu: 5.681 ± 0.273
1.615ThrMet: 1.615 ± 0.142
3.123ThrAsn: 3.123 ± 0.225
3.854ThrPro: 3.854 ± 0.205
2.581ThrGln: 2.581 ± 0.177
3.194ThrArg: 3.194 ± 0.187
3.595ThrSer: 3.595 ± 0.216
4.502ThrThr: 4.502 ± 0.201
4.821ThrVal: 4.821 ± 0.271
0.672ThrTrp: 0.672 ± 0.088
2.699ThrTyr: 2.699 ± 0.189
0.0ThrXaa: 0.0 ± 0.0
Val
5.469ValAla: 5.469 ± 0.252
0.825ValCys: 0.825 ± 0.1
4.314ValAsp: 4.314 ± 0.236
3.972ValGlu: 3.972 ± 0.209
2.511ValPhe: 2.511 ± 0.154
4.597ValGly: 4.597 ± 0.272
1.367ValHis: 1.367 ± 0.13
4.833ValIle: 4.833 ± 0.28
4.396ValLys: 4.396 ± 0.232
5.775ValLeu: 5.775 ± 0.288
2.452ValMet: 2.452 ± 0.157
3.925ValAsn: 3.925 ± 0.229
2.817ValPro: 2.817 ± 0.181
2.275ValGln: 2.275 ± 0.156
3.501ValArg: 3.501 ± 0.216
4.691ValSer: 4.691 ± 0.233
5.257ValThr: 5.257 ± 0.276
6.412ValVal: 6.412 ± 0.343
0.754ValTrp: 0.754 ± 0.102
2.558ValTyr: 2.558 ± 0.167
0.0ValXaa: 0.0 ± 0.0
Trp
0.837TrpAla: 0.837 ± 0.092
0.071TrpCys: 0.071 ± 0.028
0.766TrpAsp: 0.766 ± 0.099
0.578TrpGlu: 0.578 ± 0.084
0.589TrpPhe: 0.589 ± 0.091
0.601TrpGly: 0.601 ± 0.084
0.365TrpHis: 0.365 ± 0.077
0.625TrpIle: 0.625 ± 0.09
0.519TrpLys: 0.519 ± 0.083
1.568TrpLeu: 1.568 ± 0.163
0.519TrpMet: 0.519 ± 0.076
0.495TrpAsn: 0.495 ± 0.067
0.318TrpPro: 0.318 ± 0.054
0.401TrpGln: 0.401 ± 0.069
0.707TrpArg: 0.707 ± 0.081
0.707TrpSer: 0.707 ± 0.079
0.837TrpThr: 0.837 ± 0.098
0.931TrpVal: 0.931 ± 0.102
0.189TrpTrp: 0.189 ± 0.048
0.554TrpTyr: 0.554 ± 0.08
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.911TyrAla: 2.911 ± 0.201
0.507TyrCys: 0.507 ± 0.077
2.522TyrAsp: 2.522 ± 0.194
1.98TyrGlu: 1.98 ± 0.15
1.143TyrPhe: 1.143 ± 0.125
2.652TyrGly: 2.652 ± 0.175
1.108TyrHis: 1.108 ± 0.121
2.016TyrIle: 2.016 ± 0.172
1.921TyrLys: 1.921 ± 0.147
3.807TyrLeu: 3.807 ± 0.223
0.79TyrMet: 0.79 ± 0.094
2.074TyrAsn: 2.074 ± 0.195
1.957TyrPro: 1.957 ± 0.16
1.827TyrGln: 1.827 ± 0.135
2.239TyrArg: 2.239 ± 0.141
2.051TyrSer: 2.051 ± 0.154
2.499TyrThr: 2.499 ± 0.169
2.687TyrVal: 2.687 ± 0.208
0.589TyrTrp: 0.589 ± 0.081
1.638TyrTyr: 1.638 ± 0.154
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 321 proteins (84843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski