Amino acid dipepetide frequency for Salipiger aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.083AlaAla: 17.083 ± 0.188	1.255AlaCys: 1.255 ± 0.032	7.314AlaAsp: 7.314 ± 0.075	7.379AlaGlu: 7.379 ± 0.085	4.242AlaPhe: 4.242 ± 0.056	10.995AlaGly: 10.995 ± 0.1	2.45AlaHis: 2.45 ± 0.046	5.616AlaIle: 5.616 ± 0.077	2.967AlaLys: 2.967 ± 0.056	14.69AlaLeu: 14.69 ± 0.153	3.813AlaMet: 3.813 ± 0.05	2.529AlaAsn: 2.529 ± 0.044	6.671AlaPro: 6.671 ± 0.084	4.828AlaGln: 4.828 ± 0.069	10.625AlaArg: 10.625 ± 0.135	5.8AlaSer: 5.8 ± 0.072	6.151AlaThr: 6.151 ± 0.07	8.573AlaVal: 8.573 ± 0.092	1.66AlaTrp: 1.66 ± 0.035	2.371AlaTyr: 2.371 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.285CysAla: 1.285 ± 0.029	0.136CysCys: 0.136 ± 0.01	0.697CysAsp: 0.697 ± 0.025	0.444CysGlu: 0.444 ± 0.019	0.335CysPhe: 0.335 ± 0.015	0.991CysGly: 0.991 ± 0.028	0.287CysHis: 0.287 ± 0.015	0.438CysIle: 0.438 ± 0.015	0.213CysLys: 0.213 ± 0.013	0.875CysLeu: 0.875 ± 0.028	0.192CysMet: 0.192 ± 0.011	0.236CysAsn: 0.236 ± 0.014	0.57CysPro: 0.57 ± 0.022	0.219CysGln: 0.219 ± 0.014	0.647CysArg: 0.647 ± 0.021	0.452CysSer: 0.452 ± 0.018	0.496CysThr: 0.496 ± 0.019	0.642CysVal: 0.642 ± 0.024	0.123CysTrp: 0.123 ± 0.01	0.205CysTyr: 0.205 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.186AspAla: 8.186 ± 0.087	0.579AspCys: 0.579 ± 0.02	3.815AspAsp: 3.815 ± 0.071	3.445AspGlu: 3.445 ± 0.058	2.346AspPhe: 2.346 ± 0.041	5.898AspGly: 5.898 ± 0.085	1.437AspHis: 1.437 ± 0.037	3.133AspIle: 3.133 ± 0.052	1.623AspLys: 1.623 ± 0.038	6.627AspLeu: 6.627 ± 0.075	1.843AspMet: 1.843 ± 0.039	1.268AspAsn: 1.268 ± 0.035	3.934AspPro: 3.934 ± 0.06	1.725AspGln: 1.725 ± 0.036	4.849AspArg: 4.849 ± 0.062	2.517AspSer: 2.517 ± 0.051	3.352AspThr: 3.352 ± 0.057	4.259AspVal: 4.259 ± 0.06	1.234AspTrp: 1.234 ± 0.034	1.485AspTyr: 1.485 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.057GluAla: 7.057 ± 0.085	0.356GluCys: 0.356 ± 0.018	3.154GluAsp: 3.154 ± 0.05	2.757GluGlu: 2.757 ± 0.058	1.571GluPhe: 1.571 ± 0.033	4.131GluGly: 4.131 ± 0.053	1.079GluHis: 1.079 ± 0.033	3.424GluIle: 3.424 ± 0.056	1.827GluLys: 1.827 ± 0.044	4.735GluLeu: 4.735 ± 0.072	1.689GluMet: 1.689 ± 0.038	1.588GluAsn: 1.588 ± 0.034	2.397GluPro: 2.397 ± 0.041	1.964GluGln: 1.964 ± 0.041	4.012GluArg: 4.012 ± 0.059	2.25GluSer: 2.25 ± 0.045	3.865GluThr: 3.865 ± 0.061	3.74GluVal: 3.74 ± 0.049	0.617GluTrp: 0.617 ± 0.021	1.024GluTyr: 1.024 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.456PheAla: 4.456 ± 0.063	0.427PheCys: 0.427 ± 0.016	2.951PheAsp: 2.951 ± 0.046	2.012PheGlu: 2.012 ± 0.045	1.331PhePhe: 1.331 ± 0.037	3.608PheGly: 3.608 ± 0.054	0.749PheHis: 0.749 ± 0.026	1.494PheIle: 1.494 ± 0.037	0.771PheLys: 0.771 ± 0.026	3.24PheLeu: 3.24 ± 0.052	0.835PheMet: 0.835 ± 0.028	0.926PheAsn: 0.926 ± 0.03	1.537PhePro: 1.537 ± 0.034	0.984PheGln: 0.984 ± 0.027	2.292PheArg: 2.292 ± 0.049	2.035PheSer: 2.035 ± 0.042	1.939PheThr: 1.939 ± 0.042	2.674PheVal: 2.674 ± 0.049	0.546PheTrp: 0.546 ± 0.021	0.864PheTyr: 0.864 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.027GlyAla: 11.027 ± 0.114	0.899GlyCys: 0.899 ± 0.026	5.127GlyAsp: 5.127 ± 0.078	4.322GlyGlu: 4.322 ± 0.072	3.567GlyPhe: 3.567 ± 0.048	7.686GlyGly: 7.686 ± 0.1	2.025GlyHis: 2.025 ± 0.041	4.546GlyIle: 4.546 ± 0.06	2.871GlyLys: 2.871 ± 0.047	9.44GlyLeu: 9.44 ± 0.093	2.647GlyMet: 2.647 ± 0.049	2.063GlyAsn: 2.063 ± 0.053	3.907GlyPro: 3.907 ± 0.055	3.059GlyGln: 3.059 ± 0.041	6.229GlyArg: 6.229 ± 0.076	4.293GlySer: 4.293 ± 0.065	4.893GlyThr: 4.893 ± 0.071	6.548GlyVal: 6.548 ± 0.068	1.597GlyTrp: 1.597 ± 0.041	2.323GlyTyr: 2.323 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.475HisAla: 2.475 ± 0.039	0.251HisCys: 0.251 ± 0.013	1.436HisAsp: 1.436 ± 0.032	1.016HisGlu: 1.016 ± 0.025	0.812HisPhe: 0.812 ± 0.024	2.075HisGly: 2.075 ± 0.04	0.594HisHis: 0.594 ± 0.022	0.9HisIle: 0.9 ± 0.026	0.491HisLys: 0.491 ± 0.018	2.151HisLeu: 2.151 ± 0.038	0.579HisMet: 0.579 ± 0.02	0.456HisAsn: 0.456 ± 0.019	1.415HisPro: 1.415 ± 0.036	0.554HisGln: 0.554 ± 0.02	1.527HisArg: 1.527 ± 0.034	0.937HisSer: 0.937 ± 0.027	0.846HisThr: 0.846 ± 0.028	1.54HisVal: 1.54 ± 0.034	0.358HisTrp: 0.358 ± 0.015	0.504HisTyr: 0.504 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.038IleAla: 7.038 ± 0.071	0.621IleCys: 0.621 ± 0.024	3.525IleAsp: 3.525 ± 0.06	3.316IleGlu: 3.316 ± 0.053	1.617IlePhe: 1.617 ± 0.04	4.657IleGly: 4.657 ± 0.063	0.908IleHis: 0.908 ± 0.026	1.87IleIle: 1.87 ± 0.04	1.197IleLys: 1.197 ± 0.031	4.407IleLeu: 4.407 ± 0.067	1.002IleMet: 1.002 ± 0.029	1.151IleAsn: 1.151 ± 0.03	2.354IlePro: 2.354 ± 0.038	1.117IleGln: 1.117 ± 0.028	3.219IleArg: 3.219 ± 0.053	2.735IleSer: 2.735 ± 0.051	2.671IleThr: 2.671 ± 0.053	3.713IleVal: 3.713 ± 0.059	0.703IleTrp: 0.703 ± 0.024	1.057IleTyr: 1.057 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.37LysAla: 3.37 ± 0.051	0.172LysCys: 0.172 ± 0.013	1.516LysAsp: 1.516 ± 0.039	1.204LysGlu: 1.204 ± 0.03	0.777LysPhe: 0.777 ± 0.027	2.311LysGly: 2.311 ± 0.045	0.563LysHis: 0.563 ± 0.02	1.4LysIle: 1.4 ± 0.036	1.01LysLys: 1.01 ± 0.035	2.749LysLeu: 2.749 ± 0.048	0.735LysMet: 0.735 ± 0.024	0.623LysAsn: 0.623 ± 0.02	1.713LysPro: 1.713 ± 0.04	0.768LysGln: 0.768 ± 0.029	2.12LysArg: 2.12 ± 0.045	1.562LysSer: 1.562 ± 0.036	1.772LysThr: 1.772 ± 0.038	2.065LysVal: 2.065 ± 0.041	0.338LysTrp: 0.338 ± 0.016	0.572LysTyr: 0.572 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.374LeuAla: 13.374 ± 0.133	1.117LeuCys: 1.117 ± 0.027	6.375LeuAsp: 6.375 ± 0.076	4.819LeuGlu: 4.819 ± 0.066	3.467LeuPhe: 3.467 ± 0.06	8.924LeuGly: 8.924 ± 0.087	2.019LeuHis: 2.019 ± 0.038	4.661LeuIle: 4.661 ± 0.07	2.799LeuLys: 2.799 ± 0.053	9.071LeuLeu: 9.071 ± 0.117	2.686LeuMet: 2.686 ± 0.05	2.471LeuAsn: 2.471 ± 0.04	5.73LeuPro: 5.73 ± 0.071	2.515LeuGln: 2.515 ± 0.048	7.842LeuArg: 7.842 ± 0.085	6.688LeuSer: 6.688 ± 0.077	6.095LeuThr: 6.095 ± 0.07	7.078LeuVal: 7.078 ± 0.087	1.354LeuTrp: 1.354 ± 0.033	1.974LeuTyr: 1.974 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.464MetAla: 3.464 ± 0.053	0.188MetCys: 0.188 ± 0.011	1.48MetAsp: 1.48 ± 0.034	1.122MetGlu: 1.122 ± 0.032	0.82MetPhe: 0.82 ± 0.023	2.272MetGly: 2.272 ± 0.046	0.511MetHis: 0.511 ± 0.022	1.495MetIle: 1.495 ± 0.033	0.983MetLys: 0.983 ± 0.026	2.695MetLeu: 2.695 ± 0.049	0.789MetMet: 0.789 ± 0.028	0.776MetAsn: 0.776 ± 0.025	1.623MetPro: 1.623 ± 0.037	1.012MetGln: 1.012 ± 0.023	2.033MetArg: 2.033 ± 0.038	1.742MetSer: 1.742 ± 0.04	2.311MetThr: 2.311 ± 0.038	1.861MetVal: 1.861 ± 0.04	0.238MetTrp: 0.238 ± 0.015	0.361MetTyr: 0.361 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.094AsnAla: 3.094 ± 0.048	0.248AsnCys: 0.248 ± 0.016	1.446AsnAsp: 1.446 ± 0.044	1.055AsnGlu: 1.055 ± 0.026	0.834AsnPhe: 0.834 ± 0.028	2.359AsnGly: 2.359 ± 0.053	0.476AsnHis: 0.476 ± 0.019	1.201AsnIle: 1.201 ± 0.035	0.587AsnLys: 0.587 ± 0.022	2.341AsnLeu: 2.341 ± 0.047	0.653AsnMet: 0.653 ± 0.024	0.559AsnAsn: 0.559 ± 0.025	1.669AsnPro: 1.669 ± 0.041	0.608AsnGln: 0.608 ± 0.021	1.733AsnArg: 1.733 ± 0.033	1.021AsnSer: 1.021 ± 0.026	1.321AsnThr: 1.321 ± 0.037	1.673AsnVal: 1.673 ± 0.038	0.385AsnTrp: 0.385 ± 0.017	0.571AsnTyr: 0.571 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.199ProAla: 6.199 ± 0.096	0.438ProCys: 0.438 ± 0.017	4.432ProAsp: 4.432 ± 0.064	3.982ProGlu: 3.982 ± 0.056	1.905ProPhe: 1.905 ± 0.038	5.043ProGly: 5.043 ± 0.07	1.101ProHis: 1.101 ± 0.03	2.109ProIle: 2.109 ± 0.039	1.374ProLys: 1.374 ± 0.034	4.847ProLeu: 4.847 ± 0.071	1.37ProMet: 1.37 ± 0.027	1.147ProAsn: 1.147 ± 0.033	2.586ProPro: 2.586 ± 0.054	1.802ProGln: 1.802 ± 0.035	3.387ProArg: 3.387 ± 0.05	2.541ProSer: 2.541 ± 0.045	2.387ProThr: 2.387 ± 0.046	4.498ProVal: 4.498 ± 0.056	0.708ProTrp: 0.708 ± 0.026	1.118ProTyr: 1.118 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.154GlnAla: 4.154 ± 0.06	0.212GlnCys: 0.212 ± 0.012	1.847GlnAsp: 1.847 ± 0.036	1.376GlnGlu: 1.376 ± 0.033	1.005GlnPhe: 1.005 ± 0.027	2.791GlnGly: 2.791 ± 0.049	0.607GlnHis: 0.607 ± 0.021	1.912GlnIle: 1.912 ± 0.038	0.952GlnLys: 0.952 ± 0.029	2.772GlnLeu: 2.772 ± 0.041	1.032GlnMet: 1.032 ± 0.03	0.803GlnAsn: 0.803 ± 0.028	1.576GlnPro: 1.576 ± 0.031	1.054GlnGln: 1.054 ± 0.032	2.211GlnArg: 2.211 ± 0.045	1.746GlnSer: 1.746 ± 0.037	1.87GlnThr: 1.87 ± 0.037	2.367GlnVal: 2.367 ± 0.044	0.369GlnTrp: 0.369 ± 0.016	0.571GlnTyr: 0.571 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.296ArgAla: 9.296 ± 0.105	0.574ArgCys: 0.574 ± 0.022	4.957ArgAsp: 4.957 ± 0.066	3.741ArgGlu: 3.741 ± 0.061	2.845ArgPhe: 2.845 ± 0.05	5.388ArgGly: 5.388 ± 0.07	1.758ArgHis: 1.758 ± 0.041	4.174ArgIle: 4.174 ± 0.058	2.335ArgLys: 2.335 ± 0.047	7.996ArgLeu: 7.996 ± 0.098	2.175ArgMet: 2.175 ± 0.046	1.904ArgAsn: 1.904 ± 0.038	3.648ArgPro: 3.648 ± 0.051	2.418ArgGln: 2.418 ± 0.048	5.827ArgArg: 5.827 ± 0.083	3.451ArgSer: 3.451 ± 0.048	3.263ArgThr: 3.263 ± 0.052	4.939ArgVal: 4.939 ± 0.068	1.038ArgTrp: 1.038 ± 0.029	1.613ArgTyr: 1.613 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.016SerAla: 6.016 ± 0.068	0.45SerCys: 0.45 ± 0.021	3.459SerAsp: 3.459 ± 0.062	2.729SerGlu: 2.729 ± 0.046	2.179SerPhe: 2.179 ± 0.034	5.565SerGly: 5.565 ± 0.075	1.091SerHis: 1.091 ± 0.025	2.329SerIle: 2.329 ± 0.046	1.295SerLys: 1.295 ± 0.032	4.8SerLeu: 4.8 ± 0.062	1.404SerMet: 1.404 ± 0.031	1.243SerAsn: 1.243 ± 0.036	2.589SerPro: 2.589 ± 0.042	1.591SerGln: 1.591 ± 0.034	3.536SerArg: 3.536 ± 0.059	2.582SerSer: 2.582 ± 0.05	2.461SerThr: 2.461 ± 0.047	3.851SerVal: 3.851 ± 0.063	0.747SerTrp: 0.747 ± 0.025	1.339SerTyr: 1.339 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.474ThrAla: 6.474 ± 0.082	0.48ThrCys: 0.48 ± 0.021	3.404ThrAsp: 3.404 ± 0.058	2.898ThrGlu: 2.898 ± 0.047	1.859ThrPhe: 1.859 ± 0.04	5.884ThrGly: 5.884 ± 0.065	1.092ThrHis: 1.092 ± 0.028	2.508ThrIle: 2.508 ± 0.047	1.177ThrLys: 1.177 ± 0.033	6.202ThrLeu: 6.202 ± 0.071	1.277ThrMet: 1.277 ± 0.031	1.219ThrAsn: 1.219 ± 0.03	3.566ThrPro: 3.566 ± 0.05	1.628ThrGln: 1.628 ± 0.036	3.929ThrArg: 3.929 ± 0.058	2.648ThrSer: 2.648 ± 0.052	2.82ThrThr: 2.82 ± 0.053	4.404ThrVal: 4.404 ± 0.067	0.743ThrTrp: 0.743 ± 0.024	1.15ThrTyr: 1.15 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.963ValAla: 8.963 ± 0.103	0.712ValCys: 0.712 ± 0.026	4.17ValAsp: 4.17 ± 0.06	3.864ValGlu: 3.864 ± 0.053	2.797ValPhe: 2.797 ± 0.052	5.292ValGly: 5.292 ± 0.071	1.315ValHis: 1.315 ± 0.035	4.091ValIle: 4.091 ± 0.055	1.881ValLys: 1.881 ± 0.044	7.534ValLeu: 7.534 ± 0.087	2.155ValMet: 2.155 ± 0.042	1.892ValAsn: 1.892 ± 0.043	3.728ValPro: 3.728 ± 0.063	2.146ValGln: 2.146 ± 0.042	4.564ValArg: 4.564 ± 0.056	4.424ValSer: 4.424 ± 0.056	4.877ValThr: 4.877 ± 0.064	5.527ValVal: 5.527 ± 0.068	0.942ValTrp: 0.942 ± 0.028	1.454ValTyr: 1.454 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.428TrpAla: 1.428 ± 0.031	0.142TrpCys: 0.142 ± 0.01	0.823TrpAsp: 0.823 ± 0.03	0.562TrpGlu: 0.562 ± 0.02	0.553TrpPhe: 0.553 ± 0.022	1.108TrpGly: 1.108 ± 0.027	0.346TrpHis: 0.346 ± 0.018	0.703TrpIle: 0.703 ± 0.022	0.482TrpLys: 0.482 ± 0.021	1.725TrpLeu: 1.725 ± 0.036	0.422TrpMet: 0.422 ± 0.017	0.428TrpAsn: 0.428 ± 0.019	0.718TrpPro: 0.718 ± 0.025	0.614TrpGln: 0.614 ± 0.023	1.222TrpArg: 1.222 ± 0.035	0.775TrpSer: 0.775 ± 0.028	0.812TrpThr: 0.812 ± 0.027	0.891TrpVal: 0.891 ± 0.028	0.227TrpTrp: 0.227 ± 0.013	0.296TrpTyr: 0.296 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.049	0.224TyrCys: 0.224 ± 0.012	1.631TyrAsp: 1.631 ± 0.04	1.194TyrGlu: 1.194 ± 0.032	0.808TyrPhe: 0.808 ± 0.024	2.092TyrGly: 2.092 ± 0.043	0.51TyrHis: 0.51 ± 0.021	0.874TyrIle: 0.874 ± 0.023	0.504TyrLys: 0.504 ± 0.022	2.162TyrLeu: 2.162 ± 0.039	0.476TyrMet: 0.476 ± 0.019	0.552TyrAsn: 0.552 ± 0.022	1.046TyrPro: 1.046 ± 0.028	0.619TyrGln: 0.619 ± 0.022	1.534TyrArg: 1.534 ± 0.031	1.058TyrSer: 1.058 ± 0.027	1.158TyrThr: 1.158 ± 0.035	1.486TyrVal: 1.486 ± 0.037	0.35TyrTrp: 0.35 ± 0.019	0.552TyrTyr: 0.552 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4452 proteins (1363853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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