Amino acid dipepetide frequency for Pectobacterium phage Jarilo

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.664AlaAla: 10.664 ± 1.226
0.738AlaCys: 0.738 ± 0.26
6.07AlaAsp: 6.07 ± 0.685
6.07AlaGlu: 6.07 ± 0.728
3.937AlaPhe: 3.937 ± 0.484
6.89AlaGly: 6.89 ± 0.702
1.641AlaHis: 1.641 ± 0.311
4.758AlaIle: 4.758 ± 0.651
5.332AlaLys: 5.332 ± 0.584
8.777AlaLeu: 8.777 ± 0.895
3.035AlaMet: 3.035 ± 0.528
5.168AlaAsn: 5.168 ± 0.601
2.871AlaPro: 2.871 ± 0.545
4.101AlaGln: 4.101 ± 0.627
5.004AlaArg: 5.004 ± 0.701
6.398AlaSer: 6.398 ± 1.061
5.742AlaThr: 5.742 ± 0.658
5.66AlaVal: 5.66 ± 0.476
1.148AlaTrp: 1.148 ± 0.343
2.625AlaTyr: 2.625 ± 0.591
0.0AlaXaa: 0.0 ± 0.0
Cys
0.738CysAla: 0.738 ± 0.262
0.328CysCys: 0.328 ± 0.184
0.656CysAsp: 0.656 ± 0.288
0.164CysGlu: 0.164 ± 0.123
0.656CysPhe: 0.656 ± 0.243
0.574CysGly: 0.574 ± 0.277
0.41CysHis: 0.41 ± 0.254
0.574CysIle: 0.574 ± 0.216
0.492CysLys: 0.492 ± 0.291
0.41CysLeu: 0.41 ± 0.181
0.328CysMet: 0.328 ± 0.173
0.246CysAsn: 0.246 ± 0.171
0.574CysPro: 0.574 ± 0.226
0.246CysGln: 0.246 ± 0.149
0.574CysArg: 0.574 ± 0.254
0.492CysSer: 0.492 ± 0.224
0.164CysThr: 0.164 ± 0.111
0.656CysVal: 0.656 ± 0.204
0.082CysTrp: 0.082 ± 0.077
0.164CysTyr: 0.164 ± 0.123
0.0CysXaa: 0.0 ± 0.0
Asp
5.906AspAla: 5.906 ± 0.528
0.902AspCys: 0.902 ± 0.344
5.168AspAsp: 5.168 ± 0.678
3.281AspGlu: 3.281 ± 0.391
2.707AspPhe: 2.707 ± 0.392
5.086AspGly: 5.086 ± 0.575
1.476AspHis: 1.476 ± 0.459
3.937AspIle: 3.937 ± 0.38
3.855AspLys: 3.855 ± 0.586
3.937AspLeu: 3.937 ± 0.451
1.805AspMet: 1.805 ± 0.342
2.379AspAsn: 2.379 ± 0.371
3.117AspPro: 3.117 ± 0.567
2.297AspGln: 2.297 ± 0.495
3.035AspArg: 3.035 ± 0.429
4.429AspSer: 4.429 ± 0.608
3.363AspThr: 3.363 ± 0.498
4.512AspVal: 4.512 ± 0.593
0.656AspTrp: 0.656 ± 0.215
2.051AspTyr: 2.051 ± 0.368
0.0AspXaa: 0.0 ± 0.0
Glu
8.121GluAla: 8.121 ± 0.803
0.738GluCys: 0.738 ± 0.206
3.281GluAsp: 3.281 ± 0.518
4.429GluGlu: 4.429 ± 0.883
2.379GluPhe: 2.379 ± 0.405
4.594GluGly: 4.594 ± 0.612
0.984GluHis: 0.984 ± 0.239
2.871GluIle: 2.871 ± 0.515
1.969GluLys: 1.969 ± 0.323
5.496GluLeu: 5.496 ± 0.6
2.379GluMet: 2.379 ± 0.575
1.969GluAsn: 1.969 ± 0.388
1.805GluPro: 1.805 ± 0.337
2.297GluGln: 2.297 ± 0.613
3.445GluArg: 3.445 ± 0.533
3.773GluSer: 3.773 ± 0.481
3.117GluThr: 3.117 ± 0.522
3.691GluVal: 3.691 ± 0.745
1.148GluTrp: 1.148 ± 0.311
2.297GluTyr: 2.297 ± 0.413
0.0GluXaa: 0.0 ± 0.0
Phe
2.625PheAla: 2.625 ± 0.408
0.246PheCys: 0.246 ± 0.161
2.543PheAsp: 2.543 ± 0.476
1.723PheGlu: 1.723 ± 0.318
0.738PhePhe: 0.738 ± 0.285
2.953PheGly: 2.953 ± 0.637
0.574PheHis: 0.574 ± 0.269
1.641PheIle: 1.641 ± 0.435
3.035PheLys: 3.035 ± 0.561
3.117PheLeu: 3.117 ± 0.483
1.476PheMet: 1.476 ± 0.426
2.215PheAsn: 2.215 ± 0.491
2.051PhePro: 2.051 ± 0.471
1.148PheGln: 1.148 ± 0.259
1.969PheArg: 1.969 ± 0.482
2.461PheSer: 2.461 ± 0.311
2.789PheThr: 2.789 ± 0.609
1.805PheVal: 1.805 ± 0.391
0.328PheTrp: 0.328 ± 0.162
0.984PheTyr: 0.984 ± 0.319
0.0PheXaa: 0.0 ± 0.0
Gly
6.07GlyAla: 6.07 ± 0.909
0.492GlyCys: 0.492 ± 0.289
5.168GlyAsp: 5.168 ± 0.662
4.347GlyGlu: 4.347 ± 0.537
2.789GlyPhe: 2.789 ± 0.457
4.758GlyGly: 4.758 ± 0.762
1.312GlyHis: 1.312 ± 0.415
4.676GlyIle: 4.676 ± 0.844
5.578GlyLys: 5.578 ± 0.875
7.136GlyLeu: 7.136 ± 0.761
1.394GlyMet: 1.394 ± 0.317
3.117GlyAsn: 3.117 ± 0.457
0.82GlyPro: 0.82 ± 0.351
3.609GlyGln: 3.609 ± 0.78
3.445GlyArg: 3.445 ± 0.441
5.414GlySer: 5.414 ± 0.799
4.183GlyThr: 4.183 ± 0.749
4.101GlyVal: 4.101 ± 0.672
1.476GlyTrp: 1.476 ± 0.367
3.035GlyTyr: 3.035 ± 0.505
0.0GlyXaa: 0.0 ± 0.0
His
1.559HisAla: 1.559 ± 0.455
0.328HisCys: 0.328 ± 0.153
1.312HisAsp: 1.312 ± 0.38
1.312HisGlu: 1.312 ± 0.415
0.656HisPhe: 0.656 ± 0.205
1.066HisGly: 1.066 ± 0.254
0.574HisHis: 0.574 ± 0.267
0.902HisIle: 0.902 ± 0.279
1.394HisLys: 1.394 ± 0.402
2.133HisLeu: 2.133 ± 0.465
0.574HisMet: 0.574 ± 0.193
1.23HisAsn: 1.23 ± 0.395
0.574HisPro: 0.574 ± 0.204
0.246HisGln: 0.246 ± 0.131
0.492HisArg: 0.492 ± 0.161
1.23HisSer: 1.23 ± 0.308
0.492HisThr: 0.492 ± 0.25
1.312HisVal: 1.312 ± 0.283
0.492HisTrp: 0.492 ± 0.189
0.902HisTyr: 0.902 ± 0.246
0.0HisXaa: 0.0 ± 0.0
Ile
4.429IleAla: 4.429 ± 0.701
0.41IleCys: 0.41 ± 0.258
4.429IleAsp: 4.429 ± 0.577
3.527IleGlu: 3.527 ± 0.434
1.148IlePhe: 1.148 ± 0.32
4.183IleGly: 4.183 ± 0.542
1.23IleHis: 1.23 ± 0.272
2.543IleIle: 2.543 ± 0.524
3.281IleLys: 3.281 ± 0.547
3.117IleLeu: 3.117 ± 0.51
1.641IleMet: 1.641 ± 0.324
2.133IleAsn: 2.133 ± 0.416
2.379IlePro: 2.379 ± 0.475
2.133IleGln: 2.133 ± 0.426
2.707IleArg: 2.707 ± 0.58
2.953IleSer: 2.953 ± 0.415
3.035IleThr: 3.035 ± 0.398
3.199IleVal: 3.199 ± 0.541
0.656IleTrp: 0.656 ± 0.214
1.641IleTyr: 1.641 ± 0.408
0.0IleXaa: 0.0 ± 0.0
Lys
8.777LysAla: 8.777 ± 0.959
0.738LysCys: 0.738 ± 0.235
3.445LysAsp: 3.445 ± 0.575
3.363LysGlu: 3.363 ± 0.815
2.051LysPhe: 2.051 ± 0.367
4.84LysGly: 4.84 ± 0.643
1.23LysHis: 1.23 ± 0.323
1.969LysIle: 1.969 ± 0.429
2.625LysLys: 2.625 ± 0.527
5.496LysLeu: 5.496 ± 0.82
1.641LysMet: 1.641 ± 0.323
1.805LysAsn: 1.805 ± 0.351
2.625LysPro: 2.625 ± 0.493
3.035LysGln: 3.035 ± 0.576
3.527LysArg: 3.527 ± 0.674
4.265LysSer: 4.265 ± 0.45
3.445LysThr: 3.445 ± 0.433
4.758LysVal: 4.758 ± 0.575
0.656LysTrp: 0.656 ± 0.211
1.805LysTyr: 1.805 ± 0.351
0.0LysXaa: 0.0 ± 0.0
Leu
7.629LeuAla: 7.629 ± 1.093
0.574LeuCys: 0.574 ± 0.234
4.922LeuAsp: 4.922 ± 0.698
5.332LeuGlu: 5.332 ± 0.848
2.543LeuPhe: 2.543 ± 0.378
4.84LeuGly: 4.84 ± 0.666
0.82LeuHis: 0.82 ± 0.245
4.019LeuIle: 4.019 ± 0.59
7.547LeuLys: 7.547 ± 0.887
5.496LeuLeu: 5.496 ± 0.924
2.625LeuMet: 2.625 ± 0.5
5.004LeuAsn: 5.004 ± 0.64
3.281LeuPro: 3.281 ± 0.511
3.609LeuGln: 3.609 ± 0.645
4.183LeuArg: 4.183 ± 0.563
4.594LeuSer: 4.594 ± 0.509
6.48LeuThr: 6.48 ± 0.788
6.562LeuVal: 6.562 ± 0.535
1.641LeuTrp: 1.641 ± 0.435
2.379LeuTyr: 2.379 ± 0.467
0.0LeuXaa: 0.0 ± 0.0
Met
2.707MetAla: 2.707 ± 0.466
0.164MetCys: 0.164 ± 0.111
2.379MetAsp: 2.379 ± 0.521
1.394MetGlu: 1.394 ± 0.3
0.82MetPhe: 0.82 ± 0.229
1.805MetGly: 1.805 ± 0.452
0.328MetHis: 0.328 ± 0.157
1.148MetIle: 1.148 ± 0.237
1.148MetLys: 1.148 ± 0.372
3.117MetLeu: 3.117 ± 0.464
0.82MetMet: 0.82 ± 0.299
1.312MetAsn: 1.312 ± 0.26
1.312MetPro: 1.312 ± 0.316
1.559MetGln: 1.559 ± 0.333
1.312MetArg: 1.312 ± 0.341
2.133MetSer: 2.133 ± 0.381
2.051MetThr: 2.051 ± 0.364
1.805MetVal: 1.805 ± 0.399
0.082MetTrp: 0.082 ± 0.079
0.41MetTyr: 0.41 ± 0.191
0.0MetXaa: 0.0 ± 0.0
Asn
4.512AsnAla: 4.512 ± 0.398
0.246AsnCys: 0.246 ± 0.13
2.215AsnAsp: 2.215 ± 0.373
2.133AsnGlu: 2.133 ± 0.334
1.148AsnPhe: 1.148 ± 0.253
4.512AsnGly: 4.512 ± 0.756
0.984AsnHis: 0.984 ± 0.341
2.379AsnIle: 2.379 ± 0.493
2.297AsnLys: 2.297 ± 0.405
3.445AsnLeu: 3.445 ± 0.556
0.984AsnMet: 0.984 ± 0.286
1.476AsnAsn: 1.476 ± 0.33
2.871AsnPro: 2.871 ± 0.524
1.476AsnGln: 1.476 ± 0.399
2.707AsnArg: 2.707 ± 0.514
2.133AsnSer: 2.133 ± 0.629
2.461AsnThr: 2.461 ± 0.446
3.773AsnVal: 3.773 ± 0.799
0.492AsnTrp: 0.492 ± 0.152
2.051AsnTyr: 2.051 ± 0.415
0.0AsnXaa: 0.0 ± 0.0
Pro
3.363ProAla: 3.363 ± 0.455
0.328ProCys: 0.328 ± 0.161
2.707ProAsp: 2.707 ± 0.397
3.281ProGlu: 3.281 ± 0.561
1.641ProPhe: 1.641 ± 0.294
1.312ProGly: 1.312 ± 0.305
0.492ProHis: 0.492 ± 0.219
1.066ProIle: 1.066 ± 0.276
2.871ProLys: 2.871 ± 0.709
2.953ProLeu: 2.953 ± 0.521
0.984ProMet: 0.984 ± 0.332
2.133ProAsn: 2.133 ± 0.521
0.574ProPro: 0.574 ± 0.214
1.723ProGln: 1.723 ± 0.36
1.723ProArg: 1.723 ± 0.286
2.871ProSer: 2.871 ± 0.379
2.379ProThr: 2.379 ± 0.547
2.707ProVal: 2.707 ± 0.344
0.738ProTrp: 0.738 ± 0.163
1.559ProTyr: 1.559 ± 0.472
0.0ProXaa: 0.0 ± 0.0
Gln
4.758GlnAla: 4.758 ± 0.656
0.082GlnCys: 0.082 ± 0.081
2.871GlnAsp: 2.871 ± 0.456
2.871GlnGlu: 2.871 ± 0.626
2.215GlnPhe: 2.215 ± 0.428
3.117GlnGly: 3.117 ± 0.497
0.738GlnHis: 0.738 ± 0.262
2.379GlnIle: 2.379 ± 0.359
1.394GlnLys: 1.394 ± 0.321
4.019GlnLeu: 4.019 ± 0.558
0.902GlnMet: 0.902 ± 0.29
0.984GlnAsn: 0.984 ± 0.317
1.23GlnPro: 1.23 ± 0.376
3.609GlnGln: 3.609 ± 0.725
2.461GlnArg: 2.461 ± 0.549
2.789GlnSer: 2.789 ± 0.563
2.379GlnThr: 2.379 ± 0.518
3.281GlnVal: 3.281 ± 0.537
1.066GlnTrp: 1.066 ± 0.322
1.394GlnTyr: 1.394 ± 0.499
0.0GlnXaa: 0.0 ± 0.0
Arg
4.183ArgAla: 4.183 ± 0.571
0.738ArgCys: 0.738 ± 0.21
3.117ArgAsp: 3.117 ± 0.52
3.363ArgGlu: 3.363 ± 0.536
1.887ArgPhe: 1.887 ± 0.534
3.855ArgGly: 3.855 ± 0.55
1.066ArgHis: 1.066 ± 0.311
2.461ArgIle: 2.461 ± 0.489
3.691ArgLys: 3.691 ± 0.472
5.25ArgLeu: 5.25 ± 0.65
1.148ArgMet: 1.148 ± 0.192
2.379ArgAsn: 2.379 ± 0.473
2.297ArgPro: 2.297 ± 0.368
2.379ArgGln: 2.379 ± 0.424
2.543ArgArg: 2.543 ± 0.458
3.281ArgSer: 3.281 ± 0.635
2.707ArgThr: 2.707 ± 0.452
3.363ArgVal: 3.363 ± 0.536
0.574ArgTrp: 0.574 ± 0.316
1.641ArgTyr: 1.641 ± 0.265
0.0ArgXaa: 0.0 ± 0.0
Ser
5.742SerAla: 5.742 ± 0.787
0.164SerCys: 0.164 ± 0.102
3.937SerAsp: 3.937 ± 0.588
3.445SerGlu: 3.445 ± 0.541
2.953SerPhe: 2.953 ± 0.462
4.922SerGly: 4.922 ± 0.633
1.23SerHis: 1.23 ± 0.316
3.609SerIle: 3.609 ± 0.499
4.676SerLys: 4.676 ± 0.773
4.594SerLeu: 4.594 ± 0.683
1.312SerMet: 1.312 ± 0.325
2.543SerAsn: 2.543 ± 0.417
2.297SerPro: 2.297 ± 0.43
3.199SerGln: 3.199 ± 0.549
3.609SerArg: 3.609 ± 0.517
4.183SerSer: 4.183 ± 0.954
3.691SerThr: 3.691 ± 0.458
4.183SerVal: 4.183 ± 0.575
0.902SerTrp: 0.902 ± 0.226
2.871SerTyr: 2.871 ± 0.73
0.0SerXaa: 0.0 ± 0.0
Thr
4.84ThrAla: 4.84 ± 0.804
0.41ThrCys: 0.41 ± 0.211
3.199ThrAsp: 3.199 ± 0.464
3.117ThrGlu: 3.117 ± 0.497
2.297ThrPhe: 2.297 ± 0.599
5.742ThrGly: 5.742 ± 0.64
1.312ThrHis: 1.312 ± 0.293
4.265ThrIle: 4.265 ± 0.534
4.101ThrLys: 4.101 ± 0.537
6.07ThrLeu: 6.07 ± 0.653
1.641ThrMet: 1.641 ± 0.32
2.461ThrAsn: 2.461 ± 0.559
2.871ThrPro: 2.871 ± 0.46
2.871ThrGln: 2.871 ± 0.46
2.215ThrArg: 2.215 ± 0.378
3.773ThrSer: 3.773 ± 0.71
4.101ThrThr: 4.101 ± 0.655
3.117ThrVal: 3.117 ± 0.673
0.82ThrTrp: 0.82 ± 0.304
1.723ThrTyr: 1.723 ± 0.375
0.0ThrXaa: 0.0 ± 0.0
Val
6.562ValAla: 6.562 ± 0.794
0.164ValCys: 0.164 ± 0.109
3.609ValAsp: 3.609 ± 0.579
4.512ValGlu: 4.512 ± 0.512
2.543ValPhe: 2.543 ± 0.537
4.676ValGly: 4.676 ± 0.601
1.148ValHis: 1.148 ± 0.447
2.953ValIle: 2.953 ± 0.511
3.855ValLys: 3.855 ± 0.58
6.07ValLeu: 6.07 ± 0.709
1.641ValMet: 1.641 ± 0.439
2.871ValAsn: 2.871 ± 0.612
2.543ValPro: 2.543 ± 0.511
2.461ValGln: 2.461 ± 0.428
3.773ValArg: 3.773 ± 0.567
4.265ValSer: 4.265 ± 0.52
5.086ValThr: 5.086 ± 0.552
5.578ValVal: 5.578 ± 0.616
0.82ValTrp: 0.82 ± 0.29
1.969ValTyr: 1.969 ± 0.388
0.0ValXaa: 0.0 ± 0.0
Trp
0.82TrpAla: 0.82 ± 0.236
0.164TrpCys: 0.164 ± 0.111
0.574TrpAsp: 0.574 ± 0.179
0.82TrpGlu: 0.82 ± 0.262
0.328TrpPhe: 0.328 ± 0.154
0.902TrpGly: 0.902 ± 0.366
0.574TrpHis: 0.574 ± 0.255
0.656TrpIle: 0.656 ± 0.279
1.476TrpLys: 1.476 ± 0.381
1.312TrpLeu: 1.312 ± 0.289
0.328TrpMet: 0.328 ± 0.167
0.984TrpAsn: 0.984 ± 0.337
0.164TrpPro: 0.164 ± 0.108
0.656TrpGln: 0.656 ± 0.202
1.148TrpArg: 1.148 ± 0.279
0.82TrpSer: 0.82 ± 0.269
0.902TrpThr: 0.902 ± 0.299
0.984TrpVal: 0.984 ± 0.348
0.492TrpTrp: 0.492 ± 0.292
0.492TrpTyr: 0.492 ± 0.22
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.625TyrAla: 2.625 ± 0.441
0.574TyrCys: 0.574 ± 0.204
2.297TyrAsp: 2.297 ± 0.445
2.297TyrGlu: 2.297 ± 0.38
0.984TyrPhe: 0.984 ± 0.297
2.297TyrGly: 2.297 ± 0.451
0.656TyrHis: 0.656 ± 0.218
1.969TyrIle: 1.969 ± 0.447
1.559TyrLys: 1.559 ± 0.402
2.133TyrLeu: 2.133 ± 0.478
1.066TyrMet: 1.066 ± 0.276
1.887TyrAsn: 1.887 ± 0.41
1.148TyrPro: 1.148 ± 0.327
1.887TyrGln: 1.887 ± 0.488
2.051TyrArg: 2.051 ± 0.406
1.805TyrSer: 1.805 ± 0.369
2.379TyrThr: 2.379 ± 0.476
2.051TyrVal: 2.051 ± 0.341
0.328TyrTrp: 0.328 ± 0.173
0.41TyrTyr: 0.41 ± 0.149
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (12192 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski