Amino acid dipepetide frequency for Zhengella mangrovi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.535AlaAla: 17.535 ± 0.151	1.181AlaCys: 1.181 ± 0.031	7.469AlaAsp: 7.469 ± 0.074	7.335AlaGlu: 7.335 ± 0.091	4.737AlaPhe: 4.737 ± 0.055	12.449AlaGly: 12.449 ± 0.097	2.268AlaHis: 2.268 ± 0.038	6.86AlaIle: 6.86 ± 0.072	3.586AlaLys: 3.586 ± 0.053	12.829AlaLeu: 12.829 ± 0.116	4.339AlaMet: 4.339 ± 0.065	2.988AlaAsn: 2.988 ± 0.05	5.281AlaPro: 5.281 ± 0.074	3.344AlaGln: 3.344 ± 0.053	9.285AlaArg: 9.285 ± 0.09	6.508AlaSer: 6.508 ± 0.075	5.984AlaThr: 5.984 ± 0.078	9.163AlaVal: 9.163 ± 0.089	1.627AlaTrp: 1.627 ± 0.037	2.652AlaTyr: 2.652 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.028	0.107CysCys: 0.107 ± 0.009	0.567CysAsp: 0.567 ± 0.022	0.436CysGlu: 0.436 ± 0.019	0.338CysPhe: 0.338 ± 0.013	0.995CysGly: 0.995 ± 0.027	0.263CysHis: 0.263 ± 0.015	0.393CysIle: 0.393 ± 0.015	0.206CysLys: 0.206 ± 0.012	0.843CysLeu: 0.843 ± 0.023	0.191CysMet: 0.191 ± 0.011	0.207CysAsn: 0.207 ± 0.013	0.489CysPro: 0.489 ± 0.02	0.239CysGln: 0.239 ± 0.013	0.648CysArg: 0.648 ± 0.024	0.441CysSer: 0.441 ± 0.019	0.415CysThr: 0.415 ± 0.018	0.567CysVal: 0.567 ± 0.019	0.112CysTrp: 0.112 ± 0.01	0.182CysTyr: 0.182 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.13AspAla: 7.13 ± 0.07	0.523AspCys: 0.523 ± 0.02	3.42AspAsp: 3.42 ± 0.062	3.6AspGlu: 3.6 ± 0.061	2.281AspPhe: 2.281 ± 0.033	5.741AspGly: 5.741 ± 0.063	1.404AspHis: 1.404 ± 0.038	3.246AspIle: 3.246 ± 0.054	1.761AspLys: 1.761 ± 0.042	6.188AspLeu: 6.188 ± 0.064	1.725AspMet: 1.725 ± 0.033	1.407AspAsn: 1.407 ± 0.034	3.539AspPro: 3.539 ± 0.051	1.561AspGln: 1.561 ± 0.035	4.688AspArg: 4.688 ± 0.07	2.165AspSer: 2.165 ± 0.039	2.757AspThr: 2.757 ± 0.046	4.115AspVal: 4.115 ± 0.06	1.012AspTrp: 1.012 ± 0.028	1.531AspTyr: 1.531 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.895GluAla: 7.895 ± 0.09	0.375GluCys: 0.375 ± 0.017	2.996GluAsp: 2.996 ± 0.049	3.196GluGlu: 3.196 ± 0.054	1.73GluPhe: 1.73 ± 0.034	4.429GluGly: 4.429 ± 0.053	1.128GluHis: 1.128 ± 0.029	3.472GluIle: 3.472 ± 0.046	2.457GluLys: 2.457 ± 0.048	4.466GluLeu: 4.466 ± 0.061	1.631GluMet: 1.631 ± 0.033	1.7GluAsn: 1.7 ± 0.029	2.793GluPro: 2.793 ± 0.064	1.934GluGln: 1.934 ± 0.043	4.733GluArg: 4.733 ± 0.069	2.288GluSer: 2.288 ± 0.044	4.077GluThr: 4.077 ± 0.056	3.523GluVal: 3.523 ± 0.051	0.678GluTrp: 0.678 ± 0.021	0.91GluTyr: 0.91 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.704PheAla: 4.704 ± 0.065	0.422PheCys: 0.422 ± 0.016	2.658PheAsp: 2.658 ± 0.046	2.148PheGlu: 2.148 ± 0.045	1.512PhePhe: 1.512 ± 0.041	3.743PheGly: 3.743 ± 0.051	0.79PheHis: 0.79 ± 0.022	1.76PheIle: 1.76 ± 0.037	0.96PheLys: 0.96 ± 0.026	3.64PheLeu: 3.64 ± 0.059	0.956PheMet: 0.956 ± 0.028	1.025PheAsn: 1.025 ± 0.028	1.642PhePro: 1.642 ± 0.032	1.0PheGln: 1.0 ± 0.028	2.411PheArg: 2.411 ± 0.04	2.416PheSer: 2.416 ± 0.045	2.038PheThr: 2.038 ± 0.037	2.783PheVal: 2.783 ± 0.042	0.559PheTrp: 0.559 ± 0.02	0.913PheTyr: 0.913 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.505GlyAla: 9.505 ± 0.089	0.867GlyCys: 0.867 ± 0.028	4.862GlyAsp: 4.862 ± 0.063	5.091GlyGlu: 5.091 ± 0.052	3.842GlyPhe: 3.842 ± 0.058	7.627GlyGly: 7.627 ± 0.097	2.101GlyHis: 2.101 ± 0.04	4.918GlyIle: 4.918 ± 0.062	3.457GlyLys: 3.457 ± 0.053	9.163GlyLeu: 9.163 ± 0.092	2.806GlyMet: 2.806 ± 0.045	2.343GlyAsn: 2.343 ± 0.046	3.683GlyPro: 3.683 ± 0.049	2.982GlyGln: 2.982 ± 0.046	6.357GlyArg: 6.357 ± 0.075	4.756GlySer: 4.756 ± 0.064	4.859GlyThr: 4.859 ± 0.066	6.013GlyVal: 6.013 ± 0.074	1.42GlyTrp: 1.42 ± 0.034	2.435GlyTyr: 2.435 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.451HisAla: 2.451 ± 0.045	0.267HisCys: 0.267 ± 0.014	1.368HisAsp: 1.368 ± 0.031	1.092HisGlu: 1.092 ± 0.026	0.934HisPhe: 0.934 ± 0.027	2.179HisGly: 2.179 ± 0.044	0.619HisHis: 0.619 ± 0.026	0.864HisIle: 0.864 ± 0.025	0.458HisLys: 0.458 ± 0.016	1.936HisLeu: 1.936 ± 0.038	0.531HisMet: 0.531 ± 0.021	0.424HisAsn: 0.424 ± 0.016	1.309HisPro: 1.309 ± 0.034	0.526HisGln: 0.526 ± 0.02	1.38HisArg: 1.38 ± 0.029	0.862HisSer: 0.862 ± 0.027	0.791HisThr: 0.791 ± 0.026	1.728HisVal: 1.728 ± 0.034	0.331HisTrp: 0.331 ± 0.015	0.522HisTyr: 0.522 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.565IleAla: 7.565 ± 0.076	0.504IleCys: 0.504 ± 0.017	3.616IleAsp: 3.616 ± 0.045	3.343IleGlu: 3.343 ± 0.052	1.668IlePhe: 1.668 ± 0.044	5.021IleGly: 5.021 ± 0.064	0.988IleHis: 0.988 ± 0.027	2.394IleIle: 2.394 ± 0.053	1.303IleLys: 1.303 ± 0.033	4.643IleLeu: 4.643 ± 0.061	1.1IleMet: 1.1 ± 0.027	1.442IleAsn: 1.442 ± 0.031	2.374IlePro: 2.374 ± 0.043	1.13IleGln: 1.13 ± 0.032	3.681IleArg: 3.681 ± 0.047	2.822IleSer: 2.822 ± 0.04	2.603IleThr: 2.603 ± 0.039	4.217IleVal: 4.217 ± 0.067	0.552IleTrp: 0.552 ± 0.019	1.081IleTyr: 1.081 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.612LysAla: 4.612 ± 0.06	0.172LysCys: 0.172 ± 0.01	1.85LysAsp: 1.85 ± 0.039	1.587LysGlu: 1.587 ± 0.035	0.811LysPhe: 0.811 ± 0.021	2.796LysGly: 2.796 ± 0.047	0.547LysHis: 0.547 ± 0.02	1.579LysIle: 1.579 ± 0.042	1.241LysLys: 1.241 ± 0.034	2.942LysLeu: 2.942 ± 0.045	0.743LysMet: 0.743 ± 0.023	0.784LysAsn: 0.784 ± 0.026	2.117LysPro: 2.117 ± 0.043	0.945LysGln: 0.945 ± 0.028	2.343LysArg: 2.343 ± 0.045	1.718LysSer: 1.718 ± 0.035	2.013LysThr: 2.013 ± 0.039	2.271LysVal: 2.271 ± 0.039	0.368LysTrp: 0.368 ± 0.015	0.613LysTyr: 0.613 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.979LeuAla: 13.979 ± 0.134	0.815LeuCys: 0.815 ± 0.023	6.049LeuAsp: 6.049 ± 0.072	5.271LeuGlu: 5.271 ± 0.07	3.8LeuPhe: 3.8 ± 0.057	7.896LeuGly: 7.896 ± 0.091	1.729LeuHis: 1.729 ± 0.033	4.449LeuIle: 4.449 ± 0.068	3.613LeuLys: 3.613 ± 0.055	8.803LeuLeu: 8.803 ± 0.112	2.372LeuMet: 2.372 ± 0.045	2.447LeuAsn: 2.447 ± 0.04	5.2LeuPro: 5.2 ± 0.07	2.507LeuGln: 2.507 ± 0.04	6.028LeuArg: 6.028 ± 0.071	6.111LeuSer: 6.111 ± 0.073	5.337LeuThr: 5.337 ± 0.062	7.536LeuVal: 7.536 ± 0.08	1.043LeuTrp: 1.043 ± 0.026	1.977LeuTyr: 1.977 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.928MetAla: 3.928 ± 0.055	0.168MetCys: 0.168 ± 0.01	1.464MetAsp: 1.464 ± 0.028	1.408MetGlu: 1.408 ± 0.031	0.753MetPhe: 0.753 ± 0.023	2.019MetGly: 2.019 ± 0.039	0.498MetHis: 0.498 ± 0.017	1.58MetIle: 1.58 ± 0.037	1.177MetLys: 1.177 ± 0.029	2.587MetLeu: 2.587 ± 0.047	0.821MetMet: 0.821 ± 0.027	0.921MetAsn: 0.921 ± 0.023	1.616MetPro: 1.616 ± 0.034	0.87MetGln: 0.87 ± 0.026	1.971MetArg: 1.971 ± 0.037	1.625MetSer: 1.625 ± 0.035	2.149MetThr: 2.149 ± 0.039	1.879MetVal: 1.879 ± 0.035	0.215MetTrp: 0.215 ± 0.013	0.312MetTyr: 0.312 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.201AsnAla: 3.201 ± 0.048	0.22AsnCys: 0.22 ± 0.013	1.466AsnAsp: 1.466 ± 0.03	1.263AsnGlu: 1.263 ± 0.035	0.928AsnPhe: 0.928 ± 0.028	2.646AsnGly: 2.646 ± 0.053	0.523AsnHis: 0.523 ± 0.019	1.368AsnIle: 1.368 ± 0.031	0.69AsnLys: 0.69 ± 0.024	2.449AsnLeu: 2.449 ± 0.041	0.668AsnMet: 0.668 ± 0.024	0.647AsnAsn: 0.647 ± 0.024	1.879AsnPro: 1.879 ± 0.039	0.702AsnGln: 0.702 ± 0.023	1.998AsnArg: 1.998 ± 0.039	1.156AsnSer: 1.156 ± 0.03	1.276AsnThr: 1.276 ± 0.032	1.805AsnVal: 1.805 ± 0.04	0.411AsnTrp: 0.411 ± 0.02	0.609AsnTyr: 0.609 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.651ProAla: 6.651 ± 0.082	0.318ProCys: 0.318 ± 0.016	4.074ProAsp: 4.074 ± 0.062	3.635ProGlu: 3.635 ± 0.064	1.995ProPhe: 1.995 ± 0.04	4.874ProGly: 4.874 ± 0.069	1.014ProHis: 1.014 ± 0.026	1.877ProIle: 1.877 ± 0.034	1.505ProLys: 1.505 ± 0.035	4.494ProLeu: 4.494 ± 0.058	1.254ProMet: 1.254 ± 0.029	1.16ProAsn: 1.16 ± 0.027	2.188ProPro: 2.188 ± 0.051	1.472ProGln: 1.472 ± 0.028	2.833ProArg: 2.833 ± 0.044	2.542ProSer: 2.542 ± 0.041	1.942ProThr: 1.942 ± 0.036	4.935ProVal: 4.935 ± 0.057	0.68ProTrp: 0.68 ± 0.022	1.124ProTyr: 1.124 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.158GlnAla: 4.158 ± 0.063	0.217GlnCys: 0.217 ± 0.014	1.498GlnAsp: 1.498 ± 0.032	1.403GlnGlu: 1.403 ± 0.03	1.006GlnPhe: 1.006 ± 0.024	2.283GlnGly: 2.283 ± 0.037	0.522GlnHis: 0.522 ± 0.02	1.614GlnIle: 1.614 ± 0.031	1.02GlnLys: 1.02 ± 0.026	2.357GlnLeu: 2.357 ± 0.045	0.887GlnMet: 0.887 ± 0.025	0.77GlnAsn: 0.77 ± 0.024	1.593GlnPro: 1.593 ± 0.042	1.032GlnGln: 1.032 ± 0.033	2.043GlnArg: 2.043 ± 0.04	1.601GlnSer: 1.601 ± 0.034	1.604GlnThr: 1.604 ± 0.035	2.196GlnVal: 2.196 ± 0.039	0.374GlnTrp: 0.374 ± 0.016	0.53GlnTyr: 0.53 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.706ArgAla: 7.706 ± 0.091	0.499ArgCys: 0.499 ± 0.019	4.38ArgAsp: 4.38 ± 0.059	4.222ArgGlu: 4.222 ± 0.058	3.112ArgPhe: 3.112 ± 0.047	4.701ArgGly: 4.701 ± 0.062	1.846ArgHis: 1.846 ± 0.037	4.148ArgIle: 4.148 ± 0.055	2.508ArgLys: 2.508 ± 0.042	7.762ArgLeu: 7.762 ± 0.083	2.117ArgMet: 2.117 ± 0.036	1.899ArgAsn: 1.899 ± 0.038	3.541ArgPro: 3.541 ± 0.051	2.64ArgGln: 2.64 ± 0.051	5.587ArgArg: 5.587 ± 0.076	3.673ArgSer: 3.673 ± 0.053	3.467ArgThr: 3.467 ± 0.055	4.599ArgVal: 4.599 ± 0.06	0.912ArgTrp: 0.912 ± 0.024	1.659ArgTyr: 1.659 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.141SerAla: 6.141 ± 0.074	0.42SerCys: 0.42 ± 0.016	3.033SerAsp: 3.033 ± 0.052	2.712SerGlu: 2.712 ± 0.048	2.117SerPhe: 2.117 ± 0.04	5.775SerGly: 5.775 ± 0.069	1.076SerHis: 1.076 ± 0.025	2.752SerIle: 2.752 ± 0.044	1.507SerLys: 1.507 ± 0.035	5.189SerLeu: 5.189 ± 0.068	1.539SerMet: 1.539 ± 0.029	1.337SerAsn: 1.337 ± 0.035	2.636SerPro: 2.636 ± 0.043	1.543SerGln: 1.543 ± 0.028	3.672SerArg: 3.672 ± 0.055	2.737SerSer: 2.737 ± 0.056	2.565SerThr: 2.565 ± 0.05	4.042SerVal: 4.042 ± 0.057	0.726SerTrp: 0.726 ± 0.022	1.131SerTyr: 1.131 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	6.555ThrAla: 6.555 ± 0.08	0.471ThrCys: 0.471 ± 0.02	2.859ThrAsp: 2.859 ± 0.047	2.587ThrGlu: 2.587 ± 0.046	2.011ThrPhe: 2.011 ± 0.04	5.962ThrGly: 5.962 ± 0.055	0.967ThrHis: 0.967 ± 0.024	2.955ThrIle: 2.955 ± 0.047	1.236ThrLys: 1.236 ± 0.03	5.39ThrLeu: 5.39 ± 0.065	1.383ThrMet: 1.383 ± 0.03	1.296ThrAsn: 1.296 ± 0.038	3.107ThrPro: 3.107 ± 0.046	1.268ThrGln: 1.268 ± 0.026	3.437ThrArg: 3.437 ± 0.05	2.616ThrSer: 2.616 ± 0.044	2.703ThrThr: 2.703 ± 0.049	4.526ThrVal: 4.526 ± 0.058	0.738ThrTrp: 0.738 ± 0.024	1.22ThrTyr: 1.22 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.146ValAla: 9.146 ± 0.08	0.65ValCys: 0.65 ± 0.023	4.086ValAsp: 4.086 ± 0.057	4.347ValGlu: 4.347 ± 0.057	2.987ValPhe: 2.987 ± 0.051	4.902ValGly: 4.902 ± 0.063	1.49ValHis: 1.49 ± 0.032	4.277ValIle: 4.277 ± 0.063	2.265ValLys: 2.265 ± 0.04	7.44ValLeu: 7.44 ± 0.09	2.017ValMet: 2.017 ± 0.035	2.089ValAsn: 2.089 ± 0.038	3.796ValPro: 3.796 ± 0.049	1.815ValGln: 1.815 ± 0.043	5.051ValArg: 5.051 ± 0.057	4.616ValSer: 4.616 ± 0.057	4.839ValThr: 4.839 ± 0.059	5.549ValVal: 5.549 ± 0.078	0.967ValTrp: 0.967 ± 0.026	1.51ValTyr: 1.51 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.192TrpAla: 1.192 ± 0.029	0.139TrpCys: 0.139 ± 0.01	0.642TrpAsp: 0.642 ± 0.021	0.544TrpGlu: 0.544 ± 0.02	0.565TrpPhe: 0.565 ± 0.019	0.921TrpGly: 0.921 ± 0.027	0.32TrpHis: 0.32 ± 0.014	0.673TrpIle: 0.673 ± 0.023	0.517TrpLys: 0.517 ± 0.019	1.665TrpLeu: 1.665 ± 0.043	0.398TrpMet: 0.398 ± 0.015	0.444TrpAsn: 0.444 ± 0.018	0.711TrpPro: 0.711 ± 0.022	0.546TrpGln: 0.546 ± 0.017	1.117TrpArg: 1.117 ± 0.027	0.805TrpSer: 0.805 ± 0.027	0.81TrpThr: 0.81 ± 0.028	0.788TrpVal: 0.788 ± 0.027	0.234TrpTrp: 0.234 ± 0.014	0.299TrpTyr: 0.299 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.401TyrAla: 2.401 ± 0.037	0.271TyrCys: 0.271 ± 0.013	1.435TyrAsp: 1.435 ± 0.035	1.192TyrGlu: 1.192 ± 0.026	0.952TyrPhe: 0.952 ± 0.027	2.127TyrGly: 2.127 ± 0.034	0.479TyrHis: 0.479 ± 0.019	0.869TyrIle: 0.869 ± 0.025	0.587TyrLys: 0.587 ± 0.02	2.172TyrLeu: 2.172 ± 0.04	0.483TyrMet: 0.483 ± 0.018	0.579TyrAsn: 0.579 ± 0.019	1.074TyrPro: 1.074 ± 0.026	0.65TyrGln: 0.65 ± 0.021	1.715TyrArg: 1.715 ± 0.036	1.193TyrSer: 1.193 ± 0.027	1.055TyrThr: 1.055 ± 0.027	1.604TyrVal: 1.604 ± 0.031	0.373TyrTrp: 0.373 ± 0.017	0.547TyrTyr: 0.547 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4686 proteins (1491495 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---