Amino acid dipepetide frequency for Nitrospira lenta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.213AlaAla: 11.213 ± 0.144	1.076AlaCys: 1.076 ± 0.033	4.928AlaAsp: 4.928 ± 0.073	5.816AlaGlu: 5.816 ± 0.089	3.286AlaPhe: 3.286 ± 0.054	8.362AlaGly: 8.362 ± 0.098	2.19AlaHis: 2.19 ± 0.042	5.581AlaIle: 5.581 ± 0.073	4.433AlaLys: 4.433 ± 0.073	10.808AlaLeu: 10.808 ± 0.121	2.801AlaMet: 2.801 ± 0.048	2.409AlaAsn: 2.409 ± 0.05	4.55AlaPro: 4.55 ± 0.067	4.039AlaGln: 4.039 ± 0.069	6.062AlaArg: 6.062 ± 0.075	5.63AlaSer: 5.63 ± 0.089	5.619AlaThr: 5.619 ± 0.086	8.045AlaVal: 8.045 ± 0.097	1.355AlaTrp: 1.355 ± 0.038	2.414AlaTyr: 2.414 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.969CysAla: 0.969 ± 0.035	0.162CysCys: 0.162 ± 0.011	0.471CysAsp: 0.471 ± 0.021	0.491CysGlu: 0.491 ± 0.023	0.334CysPhe: 0.334 ± 0.017	0.977CysGly: 0.977 ± 0.035	0.356CysHis: 0.356 ± 0.021	0.39CysIle: 0.39 ± 0.02	0.314CysLys: 0.314 ± 0.017	1.104CysLeu: 1.104 ± 0.031	0.202CysMet: 0.202 ± 0.011	0.228CysAsn: 0.228 ± 0.012	0.577CysPro: 0.577 ± 0.023	0.398CysGln: 0.398 ± 0.017	0.793CysArg: 0.793 ± 0.027	0.601CysSer: 0.601 ± 0.023	0.501CysThr: 0.501 ± 0.023	0.795CysVal: 0.795 ± 0.026	0.109CysTrp: 0.109 ± 0.009	0.285CysTyr: 0.285 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.989AspAla: 4.989 ± 0.067	0.5AspCys: 0.5 ± 0.021	2.352AspAsp: 2.352 ± 0.056	3.164AspGlu: 3.164 ± 0.06	1.691AspPhe: 1.691 ± 0.038	4.033AspGly: 4.033 ± 0.077	1.305AspHis: 1.305 ± 0.038	2.672AspIle: 2.672 ± 0.045	1.715AspLys: 1.715 ± 0.043	5.885AspLeu: 5.885 ± 0.072	1.071AspMet: 1.071 ± 0.03	1.112AspAsn: 1.112 ± 0.034	3.118AspPro: 3.118 ± 0.057	2.233AspGln: 2.233 ± 0.047	4.202AspArg: 4.202 ± 0.068	2.564AspSer: 2.564 ± 0.048	2.413AspThr: 2.413 ± 0.049	3.97AspVal: 3.97 ± 0.058	0.745AspTrp: 0.745 ± 0.026	1.406AspTyr: 1.406 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.161GluAla: 6.161 ± 0.087	0.44GluCys: 0.44 ± 0.02	2.594GluAsp: 2.594 ± 0.049	3.637GluGlu: 3.637 ± 0.066	2.008GluPhe: 2.008 ± 0.045	4.119GluGly: 4.119 ± 0.06	1.386GluHis: 1.386 ± 0.036	3.138GluIle: 3.138 ± 0.061	2.54GluLys: 2.54 ± 0.056	5.921GluLeu: 5.921 ± 0.09	1.475GluMet: 1.475 ± 0.033	1.251GluAsn: 1.251 ± 0.031	2.489GluPro: 2.489 ± 0.048	3.173GluGln: 3.173 ± 0.056	4.726GluArg: 4.726 ± 0.066	3.577GluSer: 3.577 ± 0.057	3.121GluThr: 3.121 ± 0.057	4.075GluVal: 4.075 ± 0.065	0.888GluTrp: 0.888 ± 0.028	1.4GluTyr: 1.4 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.164PheAla: 3.164 ± 0.045	0.426PheCys: 0.426 ± 0.02	2.127PheAsp: 2.127 ± 0.047	1.975PheGlu: 1.975 ± 0.036	1.394PhePhe: 1.394 ± 0.04	3.049PheGly: 3.049 ± 0.055	0.896PheHis: 0.896 ± 0.031	1.679PheIle: 1.679 ± 0.041	1.198PheLys: 1.198 ± 0.034	3.773PheLeu: 3.773 ± 0.066	0.835PheMet: 0.835 ± 0.026	1.08PheAsn: 1.08 ± 0.032	1.752PhePro: 1.752 ± 0.043	1.292PheGln: 1.292 ± 0.034	2.216PheArg: 2.216 ± 0.049	2.408PheSer: 2.408 ± 0.045	2.146PheThr: 2.146 ± 0.046	2.554PheVal: 2.554 ± 0.052	0.519PheTrp: 0.519 ± 0.019	0.98PheTyr: 0.98 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.898GlyAla: 6.898 ± 0.1	1.006GlyCys: 1.006 ± 0.034	3.661GlyAsp: 3.661 ± 0.067	4.261GlyGlu: 4.261 ± 0.06	3.122GlyPhe: 3.122 ± 0.054	6.246GlyGly: 6.246 ± 0.113	1.904GlyHis: 1.904 ± 0.046	4.488GlyIle: 4.488 ± 0.066	3.722GlyLys: 3.722 ± 0.067	8.483GlyLeu: 8.483 ± 0.103	2.164GlyMet: 2.164 ± 0.04	2.155GlyAsn: 2.155 ± 0.058	3.016GlyPro: 3.016 ± 0.052	3.27GlyGln: 3.27 ± 0.056	5.146GlyArg: 5.146 ± 0.078	4.708GlySer: 4.708 ± 0.076	5.028GlyThr: 5.028 ± 0.098	5.844GlyVal: 5.844 ± 0.087	1.248GlyTrp: 1.248 ± 0.038	2.377GlyTyr: 2.377 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.302HisAla: 2.302 ± 0.054	0.307HisCys: 0.307 ± 0.016	1.291HisAsp: 1.291 ± 0.036	1.432HisGlu: 1.432 ± 0.034	0.824HisPhe: 0.824 ± 0.026	1.851HisGly: 1.851 ± 0.042	0.793HisHis: 0.793 ± 0.031	1.128HisIle: 1.128 ± 0.032	0.656HisLys: 0.656 ± 0.022	2.61HisLeu: 2.61 ± 0.056	0.531HisMet: 0.531 ± 0.023	0.575HisAsn: 0.575 ± 0.026	1.549HisPro: 1.549 ± 0.036	0.953HisGln: 0.953 ± 0.029	1.86HisArg: 1.86 ± 0.038	1.209HisSer: 1.209 ± 0.032	1.208HisThr: 1.208 ± 0.038	1.68HisVal: 1.68 ± 0.041	0.334HisTrp: 0.334 ± 0.018	0.677HisTyr: 0.677 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.459IleAla: 5.459 ± 0.071	0.467IleCys: 0.467 ± 0.021	3.112IleAsp: 3.112 ± 0.044	3.57IleGlu: 3.57 ± 0.069	1.578IlePhe: 1.578 ± 0.037	4.744IleGly: 4.744 ± 0.078	1.253IleHis: 1.253 ± 0.036	2.291IleIle: 2.291 ± 0.051	2.055IleLys: 2.055 ± 0.046	5.081IleLeu: 5.081 ± 0.078	0.999IleMet: 0.999 ± 0.029	1.453IleAsn: 1.453 ± 0.038	3.026IlePro: 3.026 ± 0.055	2.017IleGln: 2.017 ± 0.042	3.619IleArg: 3.619 ± 0.058	2.809IleSer: 2.809 ± 0.055	2.954IleThr: 2.954 ± 0.06	4.239IleVal: 4.239 ± 0.062	0.569IleTrp: 0.569 ± 0.026	1.134IleTyr: 1.134 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.168LysAla: 4.168 ± 0.067	0.246LysCys: 0.246 ± 0.015	2.33LysAsp: 2.33 ± 0.049	2.789LysGlu: 2.789 ± 0.057	1.094LysPhe: 1.094 ± 0.035	3.033LysGly: 3.033 ± 0.054	0.842LysHis: 0.842 ± 0.027	2.18LysIle: 2.18 ± 0.044	2.184LysLys: 2.184 ± 0.055	3.642LysLeu: 3.642 ± 0.069	1.047LysMet: 1.047 ± 0.036	1.186LysAsn: 1.186 ± 0.037	2.227LysPro: 2.227 ± 0.046	1.853LysGln: 1.853 ± 0.039	2.666LysArg: 2.666 ± 0.056	2.284LysSer: 2.284 ± 0.052	2.523LysThr: 2.523 ± 0.054	2.859LysVal: 2.859 ± 0.055	0.38LysTrp: 0.38 ± 0.017	0.836LysTyr: 0.836 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.322LeuAla: 11.322 ± 0.124	1.175LeuCys: 1.175 ± 0.033	5.578LeuAsp: 5.578 ± 0.069	5.585LeuGlu: 5.585 ± 0.07	3.868LeuPhe: 3.868 ± 0.066	7.673LeuGly: 7.673 ± 0.09	2.432LeuHis: 2.432 ± 0.045	5.238LeuIle: 5.238 ± 0.071	4.473LeuLys: 4.473 ± 0.066	11.039LeuLeu: 11.039 ± 0.128	2.383LeuMet: 2.383 ± 0.047	3.001LeuAsn: 3.001 ± 0.06	5.528LeuPro: 5.528 ± 0.077	3.791LeuGln: 3.791 ± 0.06	6.995LeuArg: 6.995 ± 0.083	7.073LeuSer: 7.073 ± 0.085	6.677LeuThr: 6.677 ± 0.096	7.923LeuVal: 7.923 ± 0.086	1.228LeuTrp: 1.228 ± 0.04	2.541LeuTyr: 2.541 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.788MetAla: 2.788 ± 0.054	0.171MetCys: 0.171 ± 0.011	1.178MetAsp: 1.178 ± 0.03	1.298MetGlu: 1.298 ± 0.033	0.687MetPhe: 0.687 ± 0.023	1.961MetGly: 1.961 ± 0.049	0.509MetHis: 0.509 ± 0.021	1.277MetIle: 1.277 ± 0.033	1.424MetLys: 1.424 ± 0.037	2.278MetLeu: 2.278 ± 0.049	0.659MetMet: 0.659 ± 0.025	0.821MetAsn: 0.821 ± 0.028	1.433MetPro: 1.433 ± 0.037	0.924MetGln: 0.924 ± 0.029	1.507MetArg: 1.507 ± 0.043	1.501MetSer: 1.501 ± 0.036	1.779MetThr: 1.779 ± 0.037	1.855MetVal: 1.855 ± 0.041	0.229MetTrp: 0.229 ± 0.015	0.429MetTyr: 0.429 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.339AsnAla: 2.339 ± 0.047	0.272AsnCys: 0.272 ± 0.019	1.251AsnAsp: 1.251 ± 0.037	1.321AsnGlu: 1.321 ± 0.036	0.948AsnPhe: 0.948 ± 0.035	2.267AsnGly: 2.267 ± 0.056	0.622AsnHis: 0.622 ± 0.023	1.304AsnIle: 1.304 ± 0.038	0.883AsnLys: 0.883 ± 0.031	2.916AsnLeu: 2.916 ± 0.051	0.576AsnMet: 0.576 ± 0.026	0.73AsnAsn: 0.73 ± 0.029	1.973AsnPro: 1.973 ± 0.043	1.191AsnGln: 1.191 ± 0.038	1.916AsnArg: 1.916 ± 0.044	1.351AsnSer: 1.351 ± 0.038	1.361AsnThr: 1.361 ± 0.039	1.967AsnVal: 1.967 ± 0.051	0.378AsnTrp: 0.378 ± 0.019	0.732AsnTyr: 0.732 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.475ProAla: 5.475 ± 0.082	0.438ProCys: 0.438 ± 0.021	3.19ProAsp: 3.19 ± 0.054	3.234ProGlu: 3.234 ± 0.056	1.981ProPhe: 1.981 ± 0.044	3.952ProGly: 3.952 ± 0.057	1.226ProHis: 1.226 ± 0.032	2.662ProIle: 2.662 ± 0.049	1.915ProLys: 1.915 ± 0.039	5.093ProLeu: 5.093 ± 0.069	1.299ProMet: 1.299 ± 0.035	1.41ProAsn: 1.41 ± 0.033	2.731ProPro: 2.731 ± 0.067	1.9ProGln: 1.9 ± 0.043	2.572ProArg: 2.572 ± 0.049	3.411ProSer: 3.411 ± 0.063	2.934ProThr: 2.934 ± 0.056	4.215ProVal: 4.215 ± 0.068	0.682ProTrp: 0.682 ± 0.029	1.267ProTyr: 1.267 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.902GlnAla: 4.902 ± 0.065	0.305GlnCys: 0.305 ± 0.018	2.033GlnAsp: 2.033 ± 0.038	2.507GlnGlu: 2.507 ± 0.046	1.5GlnPhe: 1.5 ± 0.038	2.974GlnGly: 2.974 ± 0.053	0.996GlnHis: 0.996 ± 0.027	2.066GlnIle: 2.066 ± 0.044	1.446GlnLys: 1.446 ± 0.041	4.106GlnLeu: 4.106 ± 0.06	0.941GlnMet: 0.941 ± 0.027	0.888GlnAsn: 0.888 ± 0.032	2.068GlnPro: 2.068 ± 0.046	2.063GlnGln: 2.063 ± 0.049	2.95GlnArg: 2.95 ± 0.058	2.478GlnSer: 2.478 ± 0.047	2.212GlnThr: 2.212 ± 0.044	2.995GlnVal: 2.995 ± 0.057	0.615GlnTrp: 0.615 ± 0.025	0.97GlnTyr: 0.97 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.06ArgAla: 6.06 ± 0.087	0.7ArgCys: 0.7 ± 0.026	3.402ArgAsp: 3.402 ± 0.058	4.321ArgGlu: 4.321 ± 0.072	2.624ArgPhe: 2.624 ± 0.042	4.161ArgGly: 4.161 ± 0.058	1.739ArgHis: 1.739 ± 0.037	3.873ArgIle: 3.873 ± 0.067	2.468ArgLys: 2.468 ± 0.053	7.639ArgLeu: 7.639 ± 0.089	1.926ArgMet: 1.926 ± 0.047	1.657ArgAsn: 1.657 ± 0.037	3.068ArgPro: 3.068 ± 0.061	3.085ArgGln: 3.085 ± 0.053	4.897ArgArg: 4.897 ± 0.078	3.786ArgSer: 3.786 ± 0.055	3.784ArgThr: 3.784 ± 0.059	5.044ArgVal: 5.044 ± 0.065	1.045ArgTrp: 1.045 ± 0.03	2.045ArgTyr: 2.045 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.731SerAla: 5.731 ± 0.077	0.601SerCys: 0.601 ± 0.023	2.966SerAsp: 2.966 ± 0.056	3.023SerGlu: 3.023 ± 0.061	2.277SerPhe: 2.277 ± 0.048	5.377SerGly: 5.377 ± 0.097	1.392SerHis: 1.392 ± 0.039	3.014SerIle: 3.014 ± 0.056	2.035SerLys: 2.035 ± 0.045	6.571SerLeu: 6.571 ± 0.08	1.55SerMet: 1.55 ± 0.044	1.538SerAsn: 1.538 ± 0.04	3.415SerPro: 3.415 ± 0.065	2.294SerGln: 2.294 ± 0.049	3.872SerArg: 3.872 ± 0.058	3.987SerSer: 3.987 ± 0.078	3.333SerThr: 3.333 ± 0.056	4.363SerVal: 4.363 ± 0.068	0.821SerTrp: 0.821 ± 0.027	1.395SerTyr: 1.395 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.751ThrAla: 5.751 ± 0.085	0.515ThrCys: 0.515 ± 0.024	2.853ThrAsp: 2.853 ± 0.053	2.923ThrGlu: 2.923 ± 0.055	2.082ThrPhe: 2.082 ± 0.039	5.062ThrGly: 5.062 ± 0.088	1.346ThrHis: 1.346 ± 0.034	3.503ThrIle: 3.503 ± 0.063	2.252ThrLys: 2.252 ± 0.044	6.172ThrLeu: 6.172 ± 0.089	1.386ThrMet: 1.386 ± 0.042	1.532ThrAsn: 1.532 ± 0.045	3.424ThrPro: 3.424 ± 0.071	2.023ThrGln: 2.023 ± 0.038	3.204ThrArg: 3.204 ± 0.051	3.174ThrSer: 3.174 ± 0.056	3.496ThrThr: 3.496 ± 0.077	5.192ThrVal: 5.192 ± 0.075	0.728ThrTrp: 0.728 ± 0.027	1.386ThrTyr: 1.386 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.574ValAla: 7.574 ± 0.095	0.795ValCys: 0.795 ± 0.026	3.723ValAsp: 3.723 ± 0.059	4.558ValGlu: 4.558 ± 0.051	2.587ValPhe: 2.587 ± 0.046	5.956ValGly: 5.956 ± 0.081	1.562ValHis: 1.562 ± 0.036	4.204ValIle: 4.204 ± 0.064	3.194ValLys: 3.194 ± 0.059	8.176ValLeu: 8.176 ± 0.097	2.013ValMet: 2.013 ± 0.045	2.09ValAsn: 2.09 ± 0.048	3.75ValPro: 3.75 ± 0.058	2.815ValGln: 2.815 ± 0.05	5.067ValArg: 5.067 ± 0.071	4.829ValSer: 4.829 ± 0.075	4.954ValThr: 4.954 ± 0.075	6.389ValVal: 6.389 ± 0.1	0.915ValTrp: 0.915 ± 0.031	1.621ValTyr: 1.621 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.106TrpAla: 1.106 ± 0.035	0.163TrpCys: 0.163 ± 0.011	0.634TrpAsp: 0.634 ± 0.025	0.754TrpGlu: 0.754 ± 0.026	0.558TrpPhe: 0.558 ± 0.023	0.91TrpGly: 0.91 ± 0.032	0.353TrpHis: 0.353 ± 0.016	0.757TrpIle: 0.757 ± 0.031	0.636TrpLys: 0.636 ± 0.024	1.5TrpLeu: 1.5 ± 0.044	0.398TrpMet: 0.398 ± 0.02	0.466TrpAsn: 0.466 ± 0.021	0.603TrpPro: 0.603 ± 0.024	0.593TrpGln: 0.593 ± 0.023	0.852TrpArg: 0.852 ± 0.03	0.813TrpSer: 0.813 ± 0.031	0.763TrpThr: 0.763 ± 0.026	0.936TrpVal: 0.936 ± 0.031	0.272TrpTrp: 0.272 ± 0.018	0.382TrpTyr: 0.382 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.244TyrAla: 2.244 ± 0.051	0.291TyrCys: 0.291 ± 0.016	1.467TyrAsp: 1.467 ± 0.046	1.459TyrGlu: 1.459 ± 0.035	1.02TyrPhe: 1.02 ± 0.033	2.039TyrGly: 2.039 ± 0.051	0.667TyrHis: 0.667 ± 0.026	0.983TyrIle: 0.983 ± 0.033	0.826TyrLys: 0.826 ± 0.03	2.726TyrLeu: 2.726 ± 0.05	0.453TyrMet: 0.453 ± 0.023	0.716TyrAsn: 0.716 ± 0.026	1.288TyrPro: 1.288 ± 0.036	1.111TyrGln: 1.111 ± 0.031	2.202TyrArg: 2.202 ± 0.047	1.362TyrSer: 1.362 ± 0.036	1.198TyrThr: 1.198 ± 0.036	1.834TyrVal: 1.834 ± 0.045	0.389TyrTrp: 0.389 ± 0.018	0.772TyrTyr: 0.772 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3885 proteins (1139029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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