Amino acid dipepetide frequency for Brachyspira catarrhinii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.012AlaAla: 3.012 ± 0.083	0.652AlaCys: 0.652 ± 0.032	2.958AlaAsp: 2.958 ± 0.071	3.21AlaGlu: 3.21 ± 0.075	2.631AlaPhe: 2.631 ± 0.059	3.609AlaGly: 3.609 ± 0.078	0.674AlaHis: 0.674 ± 0.038	5.974AlaIle: 5.974 ± 0.094	4.748AlaLys: 4.748 ± 0.092	5.631AlaLeu: 5.631 ± 0.106	1.433AlaMet: 1.433 ± 0.048	3.399AlaAsn: 3.399 ± 0.069	1.226AlaPro: 1.226 ± 0.048	1.291AlaGln: 1.291 ± 0.046	1.99AlaArg: 1.99 ± 0.058	3.699AlaSer: 3.699 ± 0.076	2.569AlaThr: 2.569 ± 0.066	3.511AlaVal: 3.511 ± 0.077	0.399AlaTrp: 0.399 ± 0.025	2.184AlaTyr: 2.184 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.567CysAla: 0.567 ± 0.028	0.109CysCys: 0.109 ± 0.015	0.568CysAsp: 0.568 ± 0.029	0.676CysGlu: 0.676 ± 0.034	0.508CysPhe: 0.508 ± 0.025	0.794CysGly: 0.794 ± 0.036	0.191CysHis: 0.191 ± 0.014	0.858CysIle: 0.858 ± 0.031	0.914CysLys: 0.914 ± 0.034	0.791CysLeu: 0.791 ± 0.035	0.212CysMet: 0.212 ± 0.015	0.532CysAsn: 0.532 ± 0.028	0.388CysPro: 0.388 ± 0.025	0.177CysGln: 0.177 ± 0.016	0.319CysArg: 0.319 ± 0.021	0.647CysSer: 0.647 ± 0.035	0.237CysThr: 0.237 ± 0.017	0.551CysVal: 0.551 ± 0.032	0.056CysTrp: 0.056 ± 0.008	0.455CysTyr: 0.455 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	2.847AspAla: 2.847 ± 0.069	0.495AspCys: 0.495 ± 0.025	2.68AspAsp: 2.68 ± 0.059	3.683AspGlu: 3.683 ± 0.08	3.534AspPhe: 3.534 ± 0.077	3.02AspGly: 3.02 ± 0.077	0.312AspHis: 0.312 ± 0.022	7.459AspIle: 7.459 ± 0.11	5.967AspLys: 5.967 ± 0.1	5.02AspLeu: 5.02 ± 0.077	1.522AspMet: 1.522 ± 0.042	4.525AspAsn: 4.525 ± 0.1	1.002AspPro: 1.002 ± 0.037	0.41AspGln: 0.41 ± 0.025	1.922AspArg: 1.922 ± 0.052	3.488AspSer: 3.488 ± 0.083	2.46AspThr: 2.46 ± 0.059	2.229AspVal: 2.229 ± 0.056	0.44AspTrp: 0.44 ± 0.03	3.436AspTyr: 3.436 ± 0.074	0.0AspXaa: 0.0 ± 0.0
Glu	4.065GluAla: 4.065 ± 0.08	0.546GluCys: 0.546 ± 0.027	4.208GluAsp: 4.208 ± 0.094	6.874GluGlu: 6.874 ± 0.153	2.906GluPhe: 2.906 ± 0.066	3.216GluGly: 3.216 ± 0.073	0.952GluHis: 0.952 ± 0.041	7.589GluIle: 7.589 ± 0.122	7.453GluLys: 7.453 ± 0.126	5.982GluLeu: 5.982 ± 0.123	1.559GluMet: 1.559 ± 0.052	7.145GluAsn: 7.145 ± 0.117	1.397GluPro: 1.397 ± 0.041	1.393GluGln: 1.393 ± 0.049	2.719GluArg: 2.719 ± 0.088	4.047GluSer: 4.047 ± 0.08	3.396GluThr: 3.396 ± 0.066	3.466GluVal: 3.466 ± 0.07	0.475GluTrp: 0.475 ± 0.026	3.777GluTyr: 3.777 ± 0.086	0.0GluXaa: 0.0 ± 0.0
Phe	2.791PheAla: 2.791 ± 0.069	0.566PheCys: 0.566 ± 0.027	3.206PheAsp: 3.206 ± 0.071	3.578PheGlu: 3.578 ± 0.07	2.659PhePhe: 2.659 ± 0.071	3.132PheGly: 3.132 ± 0.072	0.65PheHis: 0.65 ± 0.026	5.469PheIle: 5.469 ± 0.107	3.787PheLys: 3.787 ± 0.077	4.476PheLeu: 4.476 ± 0.091	1.143PheMet: 1.143 ± 0.04	3.781PheAsn: 3.781 ± 0.083	1.342PhePro: 1.342 ± 0.045	0.948PheGln: 0.948 ± 0.035	1.565PheArg: 1.565 ± 0.043	3.789PheSer: 3.789 ± 0.09	2.311PheThr: 2.311 ± 0.061	2.695PheVal: 2.695 ± 0.066	0.335PheTrp: 0.335 ± 0.024	2.537PheTyr: 2.537 ± 0.067	0.0PheXaa: 0.0 ± 0.0
Gly	3.634GlyAla: 3.634 ± 0.092	0.652GlyCys: 0.652 ± 0.031	3.095GlyAsp: 3.095 ± 0.062	3.742GlyGlu: 3.742 ± 0.075	3.026GlyPhe: 3.026 ± 0.073	4.101GlyGly: 4.101 ± 0.111	0.851GlyHis: 0.851 ± 0.041	5.964GlyIle: 5.964 ± 0.111	4.732GlyLys: 4.732 ± 0.084	4.422GlyLeu: 4.422 ± 0.089	1.357GlyMet: 1.357 ± 0.044	3.531GlyAsn: 3.531 ± 0.077	0.868GlyPro: 0.868 ± 0.038	1.139GlyGln: 1.139 ± 0.042	1.986GlyArg: 1.986 ± 0.061	3.376GlySer: 3.376 ± 0.085	2.695GlyThr: 2.695 ± 0.073	3.448GlyVal: 3.448 ± 0.078	0.423GlyTrp: 0.423 ± 0.026	2.86GlyTyr: 2.86 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.686HisAla: 0.686 ± 0.028	0.157HisCys: 0.157 ± 0.015	0.595HisAsp: 0.595 ± 0.03	0.67HisGlu: 0.67 ± 0.03	0.684HisPhe: 0.684 ± 0.03	0.8HisGly: 0.8 ± 0.033	0.232HisHis: 0.232 ± 0.02	1.389HisIle: 1.389 ± 0.042	0.997HisLys: 0.997 ± 0.036	1.074HisLeu: 1.074 ± 0.038	0.197HisMet: 0.197 ± 0.016	0.911HisAsn: 0.911 ± 0.038	0.543HisPro: 0.543 ± 0.027	0.228HisGln: 0.228 ± 0.018	0.492HisArg: 0.492 ± 0.025	0.916HisSer: 0.916 ± 0.035	0.634HisThr: 0.634 ± 0.029	0.556HisVal: 0.556 ± 0.028	0.112HisTrp: 0.112 ± 0.013	0.672HisTyr: 0.672 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.946IleAla: 5.946 ± 0.102	1.066IleCys: 1.066 ± 0.045	6.438IleAsp: 6.438 ± 0.098	8.328IleGlu: 8.328 ± 0.144	5.8IlePhe: 5.8 ± 0.116	5.578IleGly: 5.578 ± 0.101	1.155IleHis: 1.155 ± 0.043	11.219IleIle: 11.219 ± 0.183	10.411IleLys: 10.411 ± 0.139	9.54IleLeu: 9.54 ± 0.139	2.273IleMet: 2.273 ± 0.058	7.836IleAsn: 7.836 ± 0.125	3.54IlePro: 3.54 ± 0.073	1.85IleGln: 1.85 ± 0.05	3.184IleArg: 3.184 ± 0.065	7.122IleSer: 7.122 ± 0.114	5.131IleThr: 5.131 ± 0.078	5.562IleVal: 5.562 ± 0.084	0.571IleTrp: 0.571 ± 0.027	4.529IleTyr: 4.529 ± 0.085	0.0IleXaa: 0.0 ± 0.0
Lys	4.374LysAla: 4.374 ± 0.095	0.696LysCys: 0.696 ± 0.038	5.892LysAsp: 5.892 ± 0.106	9.352LysGlu: 9.352 ± 0.167	3.579LysPhe: 3.579 ± 0.077	3.738LysGly: 3.738 ± 0.082	1.105LysHis: 1.105 ± 0.039	9.608LysIle: 9.608 ± 0.142	9.298LysLys: 9.298 ± 0.14	7.579LysLeu: 7.579 ± 0.141	2.13LysMet: 2.13 ± 0.051	8.977LysAsn: 8.977 ± 0.15	2.053LysPro: 2.053 ± 0.047	1.658LysGln: 1.658 ± 0.05	3.275LysArg: 3.275 ± 0.066	5.714LysSer: 5.714 ± 0.107	4.377LysThr: 4.377 ± 0.082	4.378LysVal: 4.378 ± 0.084	0.574LysTrp: 0.574 ± 0.026	4.837LysTyr: 4.837 ± 0.1	0.0LysXaa: 0.0 ± 0.0
Leu	4.588LeuAla: 4.588 ± 0.104	0.882LeuCys: 0.882 ± 0.034	4.685LeuAsp: 4.685 ± 0.085	6.219LeuGlu: 6.219 ± 0.11	4.661LeuPhe: 4.661 ± 0.107	4.967LeuGly: 4.967 ± 0.078	1.049LeuHis: 1.049 ± 0.04	8.542LeuIle: 8.542 ± 0.127	8.754LeuLys: 8.754 ± 0.131	7.264LeuLeu: 7.264 ± 0.119	1.986LeuMet: 1.986 ± 0.066	6.778LeuAsn: 6.778 ± 0.116	2.62LeuPro: 2.62 ± 0.069	1.88LeuGln: 1.88 ± 0.051	2.679LeuArg: 2.679 ± 0.074	6.782LeuSer: 6.782 ± 0.121	4.334LeuThr: 4.334 ± 0.089	3.79LeuVal: 3.79 ± 0.08	0.559LeuTrp: 0.559 ± 0.028	3.925LeuTyr: 3.925 ± 0.081	0.0LeuXaa: 0.0 ± 0.0
Met	1.521MetAla: 1.521 ± 0.052	0.156MetCys: 0.156 ± 0.013	1.213MetAsp: 1.213 ± 0.042	1.682MetGlu: 1.682 ± 0.055	1.087MetPhe: 1.087 ± 0.045	1.407MetGly: 1.407 ± 0.047	0.39MetHis: 0.39 ± 0.021	2.176MetIle: 2.176 ± 0.053	2.357MetLys: 2.357 ± 0.066	1.828MetLeu: 1.828 ± 0.054	0.539MetMet: 0.539 ± 0.027	1.638MetAsn: 1.638 ± 0.05	1.014MetPro: 1.014 ± 0.033	0.735MetGln: 0.735 ± 0.03	0.936MetArg: 0.936 ± 0.04	1.636MetSer: 1.636 ± 0.048	1.115MetThr: 1.115 ± 0.04	1.217MetVal: 1.217 ± 0.044	0.132MetTrp: 0.132 ± 0.011	0.774MetTyr: 0.774 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.649AsnAla: 3.649 ± 0.072	0.636AsnCys: 0.636 ± 0.03	4.113AsnAsp: 4.113 ± 0.081	5.285AsnGlu: 5.285 ± 0.102	3.543AsnPhe: 3.543 ± 0.082	4.001AsnGly: 4.001 ± 0.092	0.763AsnHis: 0.763 ± 0.032	10.361AsnIle: 10.361 ± 0.165	7.784AsnLys: 7.784 ± 0.134	6.478AsnLeu: 6.478 ± 0.125	1.866AsnMet: 1.866 ± 0.05	7.021AsnAsn: 7.021 ± 0.167	2.368AsnPro: 2.368 ± 0.061	1.602AsnGln: 1.602 ± 0.046	2.432AsnArg: 2.432 ± 0.061	4.873AsnSer: 4.873 ± 0.09	2.915AsnThr: 2.915 ± 0.068	3.292AsnVal: 3.292 ± 0.07	0.516AsnTrp: 0.516 ± 0.03	3.847AsnTyr: 3.847 ± 0.091	0.0AsnXaa: 0.0 ± 0.0
Pro	1.511ProAla: 1.511 ± 0.054	0.247ProCys: 0.247 ± 0.018	1.326ProAsp: 1.326 ± 0.041	1.926ProGlu: 1.926 ± 0.051	1.579ProPhe: 1.579 ± 0.05	0.956ProGly: 0.956 ± 0.039	0.411ProHis: 0.411 ± 0.024	2.891ProIle: 2.891 ± 0.071	2.361ProLys: 2.361 ± 0.059	2.396ProLeu: 2.396 ± 0.064	0.648ProMet: 0.648 ± 0.032	1.929ProAsn: 1.929 ± 0.051	0.794ProPro: 0.794 ± 0.033	0.736ProGln: 0.736 ± 0.035	0.787ProArg: 0.787 ± 0.035	1.761ProSer: 1.761 ± 0.048	1.405ProThr: 1.405 ± 0.045	1.571ProVal: 1.571 ± 0.044	0.128ProTrp: 0.128 ± 0.014	1.419ProTyr: 1.419 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	1.266GlnAla: 1.266 ± 0.049	0.18GlnCys: 0.18 ± 0.015	0.859GlnAsp: 0.859 ± 0.033	1.103GlnGlu: 1.103 ± 0.038	0.923GlnPhe: 0.923 ± 0.035	1.09GlnGly: 1.09 ± 0.044	0.264GlnHis: 0.264 ± 0.019	2.178GlnIle: 2.178 ± 0.057	2.042GlnLys: 2.042 ± 0.052	1.531GlnLeu: 1.531 ± 0.044	0.608GlnMet: 0.608 ± 0.029	1.822GlnAsn: 1.822 ± 0.056	0.456GlnPro: 0.456 ± 0.027	0.442GlnGln: 0.442 ± 0.027	0.758GlnArg: 0.758 ± 0.034	1.326GlnSer: 1.326 ± 0.045	1.138GlnThr: 1.138 ± 0.047	1.001GlnVal: 1.001 ± 0.037	0.156GlnTrp: 0.156 ± 0.016	1.025GlnTyr: 1.025 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	1.981ArgAla: 1.981 ± 0.063	0.267ArgCys: 0.267 ± 0.02	2.06ArgAsp: 2.06 ± 0.054	2.947ArgGlu: 2.947 ± 0.069	1.825ArgPhe: 1.825 ± 0.057	1.94ArgGly: 1.94 ± 0.057	0.526ArgHis: 0.526 ± 0.027	3.403ArgIle: 3.403 ± 0.079	2.824ArgLys: 2.824 ± 0.066	2.947ArgLeu: 2.947 ± 0.072	0.931ArgMet: 0.931 ± 0.038	2.367ArgAsn: 2.367 ± 0.062	0.728ArgPro: 0.728 ± 0.033	0.77ArgGln: 0.77 ± 0.034	1.473ArgArg: 1.473 ± 0.052	1.407ArgSer: 1.407 ± 0.051	1.429ArgThr: 1.429 ± 0.044	1.972ArgVal: 1.972 ± 0.054	0.228ArgTrp: 0.228 ± 0.02	1.74ArgTyr: 1.74 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	3.629SerAla: 3.629 ± 0.068	0.708SerCys: 0.708 ± 0.032	3.799SerAsp: 3.799 ± 0.076	4.368SerGlu: 4.368 ± 0.093	3.69SerPhe: 3.69 ± 0.072	4.25SerGly: 4.25 ± 0.092	0.954SerHis: 0.954 ± 0.037	6.809SerIle: 6.809 ± 0.118	5.908SerLys: 5.908 ± 0.106	6.209SerLeu: 6.209 ± 0.097	1.624SerMet: 1.624 ± 0.049	4.017SerAsn: 4.017 ± 0.083	1.74SerPro: 1.74 ± 0.053	1.569SerGln: 1.569 ± 0.041	1.961SerArg: 1.961 ± 0.055	4.58SerSer: 4.58 ± 0.107	2.532SerThr: 2.532 ± 0.061	4.047SerVal: 4.047 ± 0.071	0.462SerTrp: 0.462 ± 0.025	3.116SerTyr: 3.116 ± 0.079	0.0SerXaa: 0.0 ± 0.0
Thr	2.903ThrAla: 2.903 ± 0.067	0.364ThrCys: 0.364 ± 0.021	2.409ThrAsp: 2.409 ± 0.053	2.943ThrGlu: 2.943 ± 0.069	2.275ThrPhe: 2.275 ± 0.062	2.813ThrGly: 2.813 ± 0.071	0.638ThrHis: 0.638 ± 0.034	4.891ThrIle: 4.891 ± 0.092	3.519ThrLys: 3.519 ± 0.069	4.304ThrLeu: 4.304 ± 0.09	0.977ThrMet: 0.977 ± 0.032	3.272ThrAsn: 3.272 ± 0.095	1.613ThrPro: 1.613 ± 0.054	0.954ThrGln: 0.954 ± 0.039	1.321ThrArg: 1.321 ± 0.046	2.776ThrSer: 2.776 ± 0.064	2.292ThrThr: 2.292 ± 0.06	2.938ThrVal: 2.938 ± 0.075	0.344ThrTrp: 0.344 ± 0.023	1.833ThrTyr: 1.833 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	3.127ValAla: 3.127 ± 0.069	0.587ValCys: 0.587 ± 0.028	2.986ValAsp: 2.986 ± 0.065	3.331ValGlu: 3.331 ± 0.079	2.68ValPhe: 2.68 ± 0.072	3.347ValGly: 3.347 ± 0.083	0.66ValHis: 0.66 ± 0.034	4.768ValIle: 4.768 ± 0.087	4.288ValLys: 4.288 ± 0.084	4.632ValLeu: 4.632 ± 0.094	1.246ValMet: 1.246 ± 0.04	3.372ValAsn: 3.372 ± 0.061	1.583ValPro: 1.583 ± 0.057	1.083ValGln: 1.083 ± 0.039	1.945ValArg: 1.945 ± 0.047	4.155ValSer: 4.155 ± 0.077	1.885ValThr: 1.885 ± 0.061	2.952ValVal: 2.952 ± 0.071	0.398ValTrp: 0.398 ± 0.023	2.389ValTyr: 2.389 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.431TrpAla: 0.431 ± 0.026	0.068TrpCys: 0.068 ± 0.01	0.376TrpAsp: 0.376 ± 0.025	0.427TrpGlu: 0.427 ± 0.022	0.354TrpPhe: 0.354 ± 0.022	0.463TrpGly: 0.463 ± 0.026	0.136TrpHis: 0.136 ± 0.014	0.626TrpIle: 0.626 ± 0.03	0.538TrpLys: 0.538 ± 0.027	0.554TrpLeu: 0.554 ± 0.033	0.172TrpMet: 0.172 ± 0.017	0.504TrpAsn: 0.504 ± 0.028	0.084TrpPro: 0.084 ± 0.011	0.26TrpGln: 0.26 ± 0.022	0.287TrpArg: 0.287 ± 0.017	0.336TrpSer: 0.336 ± 0.022	0.379TrpThr: 0.379 ± 0.022	0.366TrpVal: 0.366 ± 0.022	0.121TrpTrp: 0.121 ± 0.012	0.305TrpTyr: 0.305 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.273TyrAla: 2.273 ± 0.05	0.516TyrCys: 0.516 ± 0.027	2.987TyrAsp: 2.987 ± 0.066	2.82TyrGlu: 2.82 ± 0.066	2.815TyrPhe: 2.815 ± 0.068	2.681TyrGly: 2.681 ± 0.068	0.635TyrHis: 0.635 ± 0.032	4.908TyrIle: 4.908 ± 0.092	4.512TyrLys: 4.512 ± 0.086	4.288TyrLeu: 4.288 ± 0.089	1.126TyrMet: 1.126 ± 0.041	3.989TyrAsn: 3.989 ± 0.086	1.425TyrPro: 1.425 ± 0.043	1.043TyrGln: 1.043 ± 0.038	1.732TyrArg: 1.732 ± 0.053	3.538TyrSer: 3.538 ± 0.08	2.144TyrThr: 2.144 ± 0.048	1.873TyrVal: 1.873 ± 0.051	0.358TyrTrp: 0.358 ± 0.026	2.785TyrTyr: 2.785 ± 0.08	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2664 proteins (749613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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