Amino acid dipepetide frequency for Phormidium willei BDU 130791

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.669AlaAla: 9.669 ± 0.151
0.891AlaCys: 0.891 ± 0.026
4.647AlaAsp: 4.647 ± 0.068
6.179AlaGlu: 6.179 ± 0.1
2.903AlaPhe: 2.903 ± 0.052
6.282AlaGly: 6.282 ± 0.103
1.494AlaHis: 1.494 ± 0.034
6.874AlaIle: 6.874 ± 0.079
3.077AlaLys: 3.077 ± 0.055
10.091AlaLeu: 10.091 ± 0.119
1.879AlaMet: 1.879 ± 0.039
3.131AlaAsn: 3.131 ± 0.066
3.567AlaPro: 3.567 ± 0.072
5.065AlaGln: 5.065 ± 0.092
5.004AlaArg: 5.004 ± 0.079
4.878AlaSer: 4.878 ± 0.064
4.504AlaThr: 4.504 ± 0.073
6.169AlaVal: 6.169 ± 0.081
1.271AlaTrp: 1.271 ± 0.035
2.344AlaTyr: 2.344 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.681CysAla: 0.681 ± 0.022
0.165CysCys: 0.165 ± 0.01
0.812CysAsp: 0.812 ± 0.025
0.529CysGlu: 0.529 ± 0.021
0.403CysPhe: 0.403 ± 0.02
0.84CysGly: 0.84 ± 0.03
0.311CysHis: 0.311 ± 0.015
0.45CysIle: 0.45 ± 0.018
0.208CysLys: 0.208 ± 0.011
1.163CysLeu: 1.163 ± 0.031
0.133CysMet: 0.133 ± 0.01
0.297CysAsn: 0.297 ± 0.017
0.659CysPro: 0.659 ± 0.025
0.685CysGln: 0.685 ± 0.027
0.636CysArg: 0.636 ± 0.024
0.581CysSer: 0.581 ± 0.023
0.434CysThr: 0.434 ± 0.018
0.558CysVal: 0.558 ± 0.021
0.148CysTrp: 0.148 ± 0.012
0.332CysTyr: 0.332 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.397AspAla: 4.397 ± 0.066
0.677AspCys: 0.677 ± 0.022
3.24AspAsp: 3.24 ± 0.092
3.7AspGlu: 3.7 ± 0.069
2.253AspPhe: 2.253 ± 0.05
4.139AspGly: 4.139 ± 0.074
1.098AspHis: 1.098 ± 0.03
3.122AspIle: 3.122 ± 0.05
1.474AspLys: 1.474 ± 0.033
6.693AspLeu: 6.693 ± 0.092
0.856AspMet: 0.856 ± 0.025
1.832AspAsn: 1.832 ± 0.044
3.172AspPro: 3.172 ± 0.051
1.742AspGln: 1.742 ± 0.041
5.627AspArg: 5.627 ± 0.075
3.403AspSer: 3.403 ± 0.06
2.477AspThr: 2.477 ± 0.049
3.603AspVal: 3.603 ± 0.058
1.229AspTrp: 1.229 ± 0.036
1.997AspTyr: 1.997 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
7.096GluAla: 7.096 ± 0.101
0.376GluCys: 0.376 ± 0.016
3.334GluAsp: 3.334 ± 0.067
4.187GluGlu: 4.187 ± 0.074
2.439GluPhe: 2.439 ± 0.049
4.001GluGly: 4.001 ± 0.061
1.035GluHis: 1.035 ± 0.029
4.156GluIle: 4.156 ± 0.068
2.106GluLys: 2.106 ± 0.054
7.117GluLeu: 7.117 ± 0.089
1.482GluMet: 1.482 ± 0.037
2.134GluAsn: 2.134 ± 0.048
2.798GluPro: 2.798 ± 0.063
3.455GluGln: 3.455 ± 0.06
4.556GluArg: 4.556 ± 0.067
3.787GluSer: 3.787 ± 0.062
4.385GluThr: 4.385 ± 0.07
4.357GluVal: 4.357 ± 0.073
0.656GluTrp: 0.656 ± 0.025
1.447GluTyr: 1.447 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.269PheAla: 3.269 ± 0.049
0.533PheCys: 0.533 ± 0.02
2.271PheAsp: 2.271 ± 0.051
2.47PheGlu: 2.47 ± 0.047
1.507PhePhe: 1.507 ± 0.034
2.922PheGly: 2.922 ± 0.066
0.687PheHis: 0.687 ± 0.024
1.751PheIle: 1.751 ± 0.035
1.094PheLys: 1.094 ± 0.031
3.852PheLeu: 3.852 ± 0.066
0.637PheMet: 0.637 ± 0.021
1.434PheAsn: 1.434 ± 0.033
1.869PhePro: 1.869 ± 0.038
1.568PheGln: 1.568 ± 0.04
1.97PheArg: 1.97 ± 0.042
2.527PheSer: 2.527 ± 0.05
1.796PheThr: 1.796 ± 0.039
2.403PheVal: 2.403 ± 0.044
0.686PheTrp: 0.686 ± 0.029
1.2PheTyr: 1.2 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.805GlyAla: 5.805 ± 0.098
0.861GlyCys: 0.861 ± 0.025
4.771GlyAsp: 4.771 ± 0.074
4.668GlyGlu: 4.668 ± 0.065
3.078GlyPhe: 3.078 ± 0.051
5.485GlyGly: 5.485 ± 0.097
1.487GlyHis: 1.487 ± 0.04
4.329GlyIle: 4.329 ± 0.067
2.636GlyLys: 2.636 ± 0.048
8.113GlyLeu: 8.113 ± 0.101
1.641GlyMet: 1.641 ± 0.041
2.511GlyAsn: 2.511 ± 0.063
1.968GlyPro: 1.968 ± 0.043
3.689GlyGln: 3.689 ± 0.054
4.296GlyArg: 4.296 ± 0.072
4.173GlySer: 4.173 ± 0.069
3.988GlyThr: 3.988 ± 0.064
5.387GlyVal: 5.387 ± 0.08
1.288GlyTrp: 1.288 ± 0.038
2.405GlyTyr: 2.405 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.22HisAla: 1.22 ± 0.033
0.344HisCys: 0.344 ± 0.018
0.958HisAsp: 0.958 ± 0.034
1.045HisGlu: 1.045 ± 0.032
0.815HisPhe: 0.815 ± 0.028
1.329HisGly: 1.329 ± 0.032
0.83HisHis: 0.83 ± 0.032
0.938HisIle: 0.938 ± 0.028
0.514HisLys: 0.514 ± 0.02
2.818HisLeu: 2.818 ± 0.059
0.25HisMet: 0.25 ± 0.014
0.573HisAsn: 0.573 ± 0.021
1.75HisPro: 1.75 ± 0.04
1.294HisGln: 1.294 ± 0.039
1.561HisArg: 1.561 ± 0.039
1.141HisSer: 1.141 ± 0.032
0.725HisThr: 0.725 ± 0.023
0.957HisVal: 0.957 ± 0.03
0.477HisTrp: 0.477 ± 0.018
0.757HisTyr: 0.757 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.414IleAla: 6.414 ± 0.079
0.632IleCys: 0.632 ± 0.022
3.172IleAsp: 3.172 ± 0.055
3.946IleGlu: 3.946 ± 0.065
1.975IlePhe: 1.975 ± 0.041
3.917IleGly: 3.917 ± 0.071
1.099IleHis: 1.099 ± 0.027
2.434IleIle: 2.434 ± 0.055
1.477IleLys: 1.477 ± 0.042
5.948IleLeu: 5.948 ± 0.073
0.644IleMet: 0.644 ± 0.026
1.694IleAsn: 1.694 ± 0.04
3.227IlePro: 3.227 ± 0.051
2.362IleGln: 2.362 ± 0.054
3.23IleArg: 3.23 ± 0.061
3.439IleSer: 3.439 ± 0.058
2.711IleThr: 2.711 ± 0.049
3.591IleVal: 3.591 ± 0.064
0.858IleTrp: 0.858 ± 0.028
1.486IleTyr: 1.486 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
2.837LysAla: 2.837 ± 0.057
0.198LysCys: 0.198 ± 0.014
1.436LysAsp: 1.436 ± 0.039
1.561LysGlu: 1.561 ± 0.044
1.025LysPhe: 1.025 ± 0.034
1.948LysGly: 1.948 ± 0.038
0.588LysHis: 0.588 ± 0.023
1.873LysIle: 1.873 ± 0.045
1.234LysLys: 1.234 ± 0.041
3.589LysLeu: 3.589 ± 0.07
0.571LysMet: 0.571 ± 0.02
1.025LysAsn: 1.025 ± 0.036
1.964LysPro: 1.964 ± 0.038
1.757LysGln: 1.757 ± 0.042
2.076LysArg: 2.076 ± 0.04
1.938LysSer: 1.938 ± 0.045
2.241LysThr: 2.241 ± 0.048
1.959LysVal: 1.959 ± 0.045
0.317LysTrp: 0.317 ± 0.018
0.75LysTyr: 0.75 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
11.245LeuAla: 11.245 ± 0.121
1.075LeuCys: 1.075 ± 0.032
6.993LeuAsp: 6.993 ± 0.081
7.842LeuGlu: 7.842 ± 0.094
3.671LeuPhe: 3.671 ± 0.064
8.851LeuGly: 8.851 ± 0.11
2.053LeuHis: 2.053 ± 0.04
5.622LeuIle: 5.622 ± 0.079
4.261LeuLys: 4.261 ± 0.067
12.026LeuLeu: 12.026 ± 0.14
2.234LeuMet: 2.234 ± 0.044
4.323LeuAsn: 4.323 ± 0.067
5.989LeuPro: 5.989 ± 0.073
5.804LeuGln: 5.804 ± 0.088
7.165LeuArg: 7.165 ± 0.095
8.04LeuSer: 8.04 ± 0.103
6.411LeuThr: 6.411 ± 0.07
7.426LeuVal: 7.426 ± 0.08
1.597LeuTrp: 1.597 ± 0.044
2.806LeuTyr: 2.806 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.108MetAla: 2.108 ± 0.044
0.111MetCys: 0.111 ± 0.009
0.827MetAsp: 0.827 ± 0.026
1.036MetGlu: 1.036 ± 0.033
0.524MetPhe: 0.524 ± 0.02
1.467MetGly: 1.467 ± 0.034
0.266MetHis: 0.266 ± 0.015
0.9MetIle: 0.9 ± 0.028
0.738MetLys: 0.738 ± 0.026
1.851MetLeu: 1.851 ± 0.042
0.5MetMet: 0.5 ± 0.02
0.672MetAsn: 0.672 ± 0.023
0.942MetPro: 0.942 ± 0.028
0.796MetGln: 0.796 ± 0.026
1.021MetArg: 1.021 ± 0.029
1.451MetSer: 1.451 ± 0.031
1.581MetThr: 1.581 ± 0.036
1.369MetVal: 1.369 ± 0.035
0.154MetTrp: 0.154 ± 0.012
0.341MetTyr: 0.341 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.764AsnAla: 2.764 ± 0.053
0.387AsnCys: 0.387 ± 0.018
1.562AsnAsp: 1.562 ± 0.044
1.454AsnGlu: 1.454 ± 0.036
1.311AsnPhe: 1.311 ± 0.038
2.15AsnGly: 2.15 ± 0.049
0.756AsnHis: 0.756 ± 0.026
1.61AsnIle: 1.61 ± 0.039
0.801AsnLys: 0.801 ± 0.03
4.52AsnLeu: 4.52 ± 0.079
0.465AsnMet: 0.465 ± 0.018
1.052AsnAsn: 1.052 ± 0.034
2.962AsnPro: 2.962 ± 0.053
1.896AsnGln: 1.896 ± 0.042
2.33AsnArg: 2.33 ± 0.046
2.064AsnSer: 2.064 ± 0.045
1.567AsnThr: 1.567 ± 0.041
1.816AsnVal: 1.816 ± 0.037
0.57AsnTrp: 0.57 ± 0.02
0.982AsnTyr: 0.982 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
3.81ProAla: 3.81 ± 0.08
0.365ProCys: 0.365 ± 0.017
3.767ProAsp: 3.767 ± 0.065
4.688ProGlu: 4.688 ± 0.066
1.784ProPhe: 1.784 ± 0.042
3.743ProGly: 3.743 ± 0.058
1.154ProHis: 1.154 ± 0.034
2.725ProIle: 2.725 ± 0.047
1.763ProLys: 1.763 ± 0.041
5.589ProLeu: 5.589 ± 0.081
0.923ProMet: 0.923 ± 0.03
1.952ProAsn: 1.952 ± 0.045
3.095ProPro: 3.095 ± 0.071
3.282ProGln: 3.282 ± 0.056
2.697ProArg: 2.697 ± 0.047
3.323ProSer: 3.323 ± 0.057
2.713ProThr: 2.713 ± 0.056
3.505ProVal: 3.505 ± 0.059
0.802ProTrp: 0.802 ± 0.029
1.313ProTyr: 1.313 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
5.253GlnAla: 5.253 ± 0.078
0.34GlnCys: 0.34 ± 0.017
2.73GlnAsp: 2.73 ± 0.054
3.48GlnGlu: 3.48 ± 0.07
1.835GlnPhe: 1.835 ± 0.039
3.984GlnGly: 3.984 ± 0.063
1.06GlnHis: 1.06 ± 0.036
2.741GlnIle: 2.741 ± 0.052
1.569GlnLys: 1.569 ± 0.042
6.449GlnLeu: 6.449 ± 0.092
0.984GlnMet: 0.984 ± 0.027
1.511GlnAsn: 1.511 ± 0.034
2.717GlnPro: 2.717 ± 0.062
3.908GlnGln: 3.908 ± 0.089
3.993GlnArg: 3.993 ± 0.073
2.758GlnSer: 2.758 ± 0.058
3.049GlnThr: 3.049 ± 0.055
4.083GlnVal: 4.083 ± 0.058
0.746GlnTrp: 0.746 ± 0.027
1.101GlnTyr: 1.101 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
4.595ArgAla: 4.595 ± 0.085
0.649ArgCys: 0.649 ± 0.025
4.066ArgAsp: 4.066 ± 0.059
4.237ArgGlu: 4.237 ± 0.056
2.606ArgPhe: 2.606 ± 0.047
4.118ArgGly: 4.118 ± 0.063
1.591ArgHis: 1.591 ± 0.036
3.288ArgIle: 3.288 ± 0.055
1.806ArgLys: 1.806 ± 0.047
8.46ArgLeu: 8.46 ± 0.106
1.152ArgMet: 1.152 ± 0.035
1.898ArgAsn: 1.898 ± 0.042
3.234ArgPro: 3.234 ± 0.054
4.512ArgGln: 4.512 ± 0.075
4.918ArgArg: 4.918 ± 0.073
4.096ArgSer: 4.096 ± 0.061
2.713ArgThr: 2.713 ± 0.05
4.328ArgVal: 4.328 ± 0.069
1.122ArgTrp: 1.122 ± 0.034
2.128ArgTyr: 2.128 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.41SerAla: 4.41 ± 0.066
0.604SerCys: 0.604 ± 0.019
3.582SerAsp: 3.582 ± 0.066
3.69SerGlu: 3.69 ± 0.069
2.305SerPhe: 2.305 ± 0.045
5.015SerGly: 5.015 ± 0.064
1.48SerHis: 1.48 ± 0.042
2.909SerIle: 2.909 ± 0.049
1.649SerLys: 1.649 ± 0.041
7.744SerLeu: 7.744 ± 0.095
1.242SerMet: 1.242 ± 0.034
1.807SerAsn: 1.807 ± 0.037
4.099SerPro: 4.099 ± 0.068
4.011SerGln: 4.011 ± 0.06
4.025SerArg: 4.025 ± 0.06
4.001SerSer: 4.001 ± 0.075
2.819SerThr: 2.819 ± 0.057
3.646SerVal: 3.646 ± 0.06
0.908SerTrp: 0.908 ± 0.028
1.545SerTyr: 1.545 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
5.031ThrAla: 5.031 ± 0.082
0.554ThrCys: 0.554 ± 0.018
2.505ThrAsp: 2.505 ± 0.05
2.949ThrGlu: 2.949 ± 0.059
1.717ThrPhe: 1.717 ± 0.038
4.112ThrGly: 4.112 ± 0.057
1.11ThrHis: 1.11 ± 0.033
2.973ThrIle: 2.973 ± 0.052
1.161ThrLys: 1.161 ± 0.04
6.67ThrLeu: 6.67 ± 0.079
0.777ThrMet: 0.777 ± 0.023
1.421ThrAsn: 1.421 ± 0.03
3.922ThrPro: 3.922 ± 0.068
2.568ThrGln: 2.568 ± 0.051
2.884ThrArg: 2.884 ± 0.054
3.086ThrSer: 3.086 ± 0.048
2.77ThrThr: 2.77 ± 0.052
4.136ThrVal: 4.136 ± 0.055
0.877ThrTrp: 0.877 ± 0.029
1.474ThrTyr: 1.474 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
6.419ValAla: 6.419 ± 0.087
0.744ValCys: 0.744 ± 0.023
3.619ValAsp: 3.619 ± 0.064
4.609ValGlu: 4.609 ± 0.061
2.544ValPhe: 2.544 ± 0.051
4.844ValGly: 4.844 ± 0.068
1.122ValHis: 1.122 ± 0.027
3.564ValIle: 3.564 ± 0.063
2.211ValLys: 2.211 ± 0.051
7.272ValLeu: 7.272 ± 0.091
1.574ValMet: 1.574 ± 0.034
2.328ValAsn: 2.328 ± 0.046
3.118ValPro: 3.118 ± 0.054
2.94ValGln: 2.94 ± 0.05
4.113ValArg: 4.113 ± 0.068
4.313ValSer: 4.313 ± 0.067
3.79ValThr: 3.79 ± 0.059
5.123ValVal: 5.123 ± 0.083
0.971ValTrp: 0.971 ± 0.037
1.741ValTyr: 1.741 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.985TrpAla: 0.985 ± 0.03
0.162TrpCys: 0.162 ± 0.012
0.788TrpAsp: 0.788 ± 0.03
0.899TrpGlu: 0.899 ± 0.031
0.636TrpPhe: 0.636 ± 0.026
1.252TrpGly: 1.252 ± 0.034
0.319TrpHis: 0.319 ± 0.017
0.791TrpIle: 0.791 ± 0.026
0.426TrpLys: 0.426 ± 0.018
2.199TrpLeu: 2.199 ± 0.051
0.348TrpMet: 0.348 ± 0.019
0.527TrpAsn: 0.527 ± 0.021
0.337TrpPro: 0.337 ± 0.018
1.223TrpGln: 1.223 ± 0.034
1.106TrpArg: 1.106 ± 0.032
0.907TrpSer: 0.907 ± 0.031
0.852TrpThr: 0.852 ± 0.03
1.035TrpVal: 1.035 ± 0.034
0.268TrpTrp: 0.268 ± 0.016
0.385TrpTyr: 0.385 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.908TyrAla: 1.908 ± 0.039
0.356TyrCys: 0.356 ± 0.015
1.651TyrAsp: 1.651 ± 0.033
1.735TyrGlu: 1.735 ± 0.045
1.116TyrPhe: 1.116 ± 0.035
2.179TyrGly: 2.179 ± 0.046
0.756TyrHis: 0.756 ± 0.03
1.204TyrIle: 1.204 ± 0.03
0.683TyrLys: 0.683 ± 0.028
3.272TyrLeu: 3.272 ± 0.057
0.363TyrMet: 0.363 ± 0.02
0.898TyrAsn: 0.898 ± 0.028
1.605TyrPro: 1.605 ± 0.04
1.737TyrGln: 1.737 ± 0.048
2.31TyrArg: 2.31 ± 0.047
1.585TyrSer: 1.585 ± 0.042
1.17TyrThr: 1.17 ± 0.033
1.508TyrVal: 1.508 ± 0.034
0.5TyrTrp: 0.5 ± 0.021
0.921TyrTyr: 0.921 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3770 proteins (1257126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski