Amino acid dipepetide frequency for Clostridium sp. CAG:914

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.352AlaAla: 1.352 ± 0.077
0.417AlaCys: 0.417 ± 0.034
1.796AlaAsp: 1.796 ± 0.067
1.699AlaGlu: 1.699 ± 0.074
1.659AlaPhe: 1.659 ± 0.064
2.025AlaGly: 2.025 ± 0.089
0.544AlaHis: 0.544 ± 0.042
4.537AlaIle: 4.537 ± 0.132
3.659AlaLys: 3.659 ± 0.11
3.584AlaLeu: 3.584 ± 0.116
1.088AlaMet: 1.088 ± 0.062
2.781AlaAsn: 2.781 ± 0.095
0.762AlaPro: 0.762 ± 0.046
0.805AlaGln: 0.805 ± 0.05
1.624AlaArg: 1.624 ± 0.072
2.738AlaSer: 2.738 ± 0.098
2.211AlaThr: 2.211 ± 0.102
2.124AlaVal: 2.124 ± 0.078
0.218AlaTrp: 0.218 ± 0.024
1.936AlaTyr: 1.936 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
0.401CysAla: 0.401 ± 0.035
0.183CysCys: 0.183 ± 0.023
0.689CysAsp: 0.689 ± 0.045
0.714CysGlu: 0.714 ± 0.044
0.544CysPhe: 0.544 ± 0.037
0.851CysGly: 0.851 ± 0.054
0.207CysHis: 0.207 ± 0.022
1.012CysIle: 1.012 ± 0.052
0.929CysLys: 0.929 ± 0.051
0.91CysLeu: 0.91 ± 0.05
0.218CysMet: 0.218 ± 0.024
0.875CysAsn: 0.875 ± 0.054
0.407CysPro: 0.407 ± 0.034
0.288CysGln: 0.288 ± 0.028
0.323CysArg: 0.323 ± 0.025
0.738CysSer: 0.738 ± 0.047
0.479CysThr: 0.479 ± 0.039
0.579CysVal: 0.579 ± 0.04
0.054CysTrp: 0.054 ± 0.012
0.644CysTyr: 0.644 ± 0.042
0.0CysXaa: 0.0 ± 0.0
Asp
2.224AspAla: 2.224 ± 0.083
0.53AspCys: 0.53 ± 0.044
3.794AspAsp: 3.794 ± 0.111
4.198AspGlu: 4.198 ± 0.115
2.614AspPhe: 2.614 ± 0.084
3.293AspGly: 3.293 ± 0.108
0.471AspHis: 0.471 ± 0.04
7.588AspIle: 7.588 ± 0.17
6.982AspLys: 6.982 ± 0.155
4.911AspLeu: 4.911 ± 0.13
1.594AspMet: 1.594 ± 0.07
5.668AspAsn: 5.668 ± 0.15
1.134AspPro: 1.134 ± 0.054
0.549AspGln: 0.549 ± 0.042
1.799AspArg: 1.799 ± 0.073
3.441AspSer: 3.441 ± 0.097
3.228AspThr: 3.228 ± 0.086
3.508AspVal: 3.508 ± 0.103
0.369AspTrp: 0.369 ± 0.038
4.12AspTyr: 4.12 ± 0.118
0.0AspXaa: 0.0 ± 0.0
Glu
2.709GluAla: 2.709 ± 0.097
0.711GluCys: 0.711 ± 0.042
3.937GluAsp: 3.937 ± 0.115
6.737GluGlu: 6.737 ± 0.222
2.687GluPhe: 2.687 ± 0.078
2.878GluGly: 2.878 ± 0.093
0.856GluHis: 0.856 ± 0.045
7.065GluIle: 7.065 ± 0.171
7.192GluLys: 7.192 ± 0.177
7.259GluLeu: 7.259 ± 0.178
1.852GluMet: 1.852 ± 0.071
5.318GluAsn: 5.318 ± 0.143
1.282GluPro: 1.282 ± 0.06
1.513GluGln: 1.513 ± 0.078
2.31GluArg: 2.31 ± 0.081
3.158GluSer: 3.158 ± 0.088
2.986GluThr: 2.986 ± 0.097
4.467GluVal: 4.467 ± 0.125
0.417GluTrp: 0.417 ± 0.031
4.332GluTyr: 4.332 ± 0.13
0.0GluXaa: 0.0 ± 0.0
Phe
1.726PheAla: 1.726 ± 0.079
0.46PheCys: 0.46 ± 0.036
2.886PheAsp: 2.886 ± 0.1
2.361PheGlu: 2.361 ± 0.084
1.572PhePhe: 1.572 ± 0.08
2.289PheGly: 2.289 ± 0.087
0.447PheHis: 0.447 ± 0.03
4.631PheIle: 4.631 ± 0.145
3.621PheLys: 3.621 ± 0.105
3.985PheLeu: 3.985 ± 0.119
0.945PheMet: 0.945 ± 0.047
3.358PheAsn: 3.358 ± 0.108
0.983PhePro: 0.983 ± 0.053
0.722PheGln: 0.722 ± 0.042
1.158PheArg: 1.158 ± 0.058
2.841PheSer: 2.841 ± 0.072
2.321PheThr: 2.321 ± 0.092
2.45PheVal: 2.45 ± 0.082
0.229PheTrp: 0.229 ± 0.025
1.995PheTyr: 1.995 ± 0.085
0.0PheXaa: 0.0 ± 0.0
Gly
2.186GlyAla: 2.186 ± 0.098
0.635GlyCys: 0.635 ± 0.046
2.609GlyAsp: 2.609 ± 0.086
3.002GlyGlu: 3.002 ± 0.091
2.324GlyPhe: 2.324 ± 0.098
3.271GlyGly: 3.271 ± 0.243
0.94GlyHis: 0.94 ± 0.058
5.741GlyIle: 5.741 ± 0.149
4.941GlyLys: 4.941 ± 0.133
4.227GlyLeu: 4.227 ± 0.121
1.298GlyMet: 1.298 ± 0.056
3.7GlyAsn: 3.7 ± 0.179
0.832GlyPro: 0.832 ± 0.051
1.023GlyGln: 1.023 ± 0.056
1.696GlyArg: 1.696 ± 0.081
3.32GlySer: 3.32 ± 0.138
3.212GlyThr: 3.212 ± 0.128
3.379GlyVal: 3.379 ± 0.111
0.272GlyTrp: 0.272 ± 0.029
3.376GlyTyr: 3.376 ± 0.123
0.0GlyXaa: 0.0 ± 0.0
His
0.506HisAla: 0.506 ± 0.034
0.137HisCys: 0.137 ± 0.021
0.73HisAsp: 0.73 ± 0.045
0.77HisGlu: 0.77 ± 0.042
0.53HisPhe: 0.53 ± 0.035
0.74HisGly: 0.74 ± 0.045
0.197HisHis: 0.197 ± 0.025
1.22HisIle: 1.22 ± 0.058
1.015HisLys: 1.015 ± 0.056
1.061HisLeu: 1.061 ± 0.057
0.291HisMet: 0.291 ± 0.027
0.994HisAsn: 0.994 ± 0.054
0.52HisPro: 0.52 ± 0.038
0.328HisGln: 0.328 ± 0.034
0.452HisArg: 0.452 ± 0.041
0.792HisSer: 0.792 ± 0.041
0.711HisThr: 0.711 ± 0.048
0.571HisVal: 0.571 ± 0.039
0.089HisTrp: 0.089 ± 0.017
0.646HisTyr: 0.646 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
4.017IleAla: 4.017 ± 0.122
1.282IleCys: 1.282 ± 0.06
7.682IleAsp: 7.682 ± 0.186
7.084IleGlu: 7.084 ± 0.184
4.351IlePhe: 4.351 ± 0.156
5.032IleGly: 5.032 ± 0.151
1.206IleHis: 1.206 ± 0.068
12.477IleIle: 12.477 ± 0.293
10.331IleLys: 10.331 ± 0.18
9.876IleLeu: 9.876 ± 0.185
2.361IleMet: 2.361 ± 0.077
8.786IleAsn: 8.786 ± 0.201
3.247IlePro: 3.247 ± 0.097
1.793IleGln: 1.793 ± 0.067
3.04IleArg: 3.04 ± 0.107
7.884IleSer: 7.884 ± 0.15
6.236IleThr: 6.236 ± 0.144
6.497IleVal: 6.497 ± 0.168
0.466IleTrp: 0.466 ± 0.04
5.331IleTyr: 5.331 ± 0.13
0.0IleXaa: 0.0 ± 0.0
Lys
2.975LysAla: 2.975 ± 0.092
1.037LysCys: 1.037 ± 0.061
6.602LysAsp: 6.602 ± 0.146
9.952LysGlu: 9.952 ± 0.226
2.911LysPhe: 2.911 ± 0.104
4.085LysGly: 4.085 ± 0.11
0.994LysHis: 0.994 ± 0.052
10.076LysIle: 10.076 ± 0.175
10.617LysLys: 10.617 ± 0.234
8.0LysLeu: 8.0 ± 0.145
2.849LysMet: 2.849 ± 0.094
7.962LysAsn: 7.962 ± 0.17
1.78LysPro: 1.78 ± 0.075
2.138LysGln: 2.138 ± 0.074
3.296LysArg: 3.296 ± 0.085
4.911LysSer: 4.911 ± 0.119
4.548LysThr: 4.548 ± 0.111
5.668LysVal: 5.668 ± 0.127
0.533LysTrp: 0.533 ± 0.034
6.643LysTyr: 6.643 ± 0.141
0.0LysXaa: 0.0 ± 0.0
Leu
3.562LeuAla: 3.562 ± 0.112
0.996LeuCys: 0.996 ± 0.052
5.514LeuAsp: 5.514 ± 0.141
6.691LeuGlu: 6.691 ± 0.166
4.128LeuPhe: 4.128 ± 0.135
4.895LeuGly: 4.895 ± 0.137
1.069LeuHis: 1.069 ± 0.055
9.114LeuIle: 9.114 ± 0.188
8.156LeuLys: 8.156 ± 0.168
8.29LeuLeu: 8.29 ± 0.196
1.885LeuMet: 1.885 ± 0.069
6.885LeuAsn: 6.885 ± 0.147
2.501LeuPro: 2.501 ± 0.096
1.626LeuGln: 1.626 ± 0.067
2.526LeuArg: 2.526 ± 0.093
6.774LeuSer: 6.774 ± 0.142
4.922LeuThr: 4.922 ± 0.122
5.474LeuVal: 5.474 ± 0.124
0.504LeuTrp: 0.504 ± 0.045
4.2LeuTyr: 4.2 ± 0.116
0.0LeuXaa: 0.0 ± 0.0
Met
1.252MetAla: 1.252 ± 0.07
0.269MetCys: 0.269 ± 0.028
1.473MetAsp: 1.473 ± 0.063
1.597MetGlu: 1.597 ± 0.07
1.061MetPhe: 1.061 ± 0.051
1.327MetGly: 1.327 ± 0.059
0.307MetHis: 0.307 ± 0.03
2.375MetIle: 2.375 ± 0.092
2.593MetLys: 2.593 ± 0.073
2.235MetLeu: 2.235 ± 0.078
0.574MetMet: 0.574 ± 0.048
1.777MetAsn: 1.777 ± 0.084
0.722MetPro: 0.722 ± 0.044
0.635MetGln: 0.635 ± 0.046
0.681MetArg: 0.681 ± 0.043
1.511MetSer: 1.511 ± 0.054
1.131MetThr: 1.131 ± 0.056
1.325MetVal: 1.325 ± 0.057
0.159MetTrp: 0.159 ± 0.024
1.325MetTyr: 1.325 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
2.612AsnAla: 2.612 ± 0.083
0.746AsnCys: 0.746 ± 0.043
4.892AsnAsp: 4.892 ± 0.131
5.32AsnGlu: 5.32 ± 0.127
2.803AsnPhe: 2.803 ± 0.101
4.066AsnGly: 4.066 ± 0.112
0.889AsnHis: 0.889 ± 0.055
9.693AsnIle: 9.693 ± 0.217
8.84AsnLys: 8.84 ± 0.189
6.163AsnLeu: 6.163 ± 0.156
1.922AsnMet: 1.922 ± 0.076
8.387AsnAsn: 8.387 ± 0.255
2.038AsnPro: 2.038 ± 0.081
1.737AsnGln: 1.737 ± 0.087
2.246AsnArg: 2.246 ± 0.091
4.857AsnSer: 4.857 ± 0.132
4.087AsnThr: 4.087 ± 0.151
4.491AsnVal: 4.491 ± 0.124
0.342AsnTrp: 0.342 ± 0.034
5.189AsnTyr: 5.189 ± 0.142
0.0AsnXaa: 0.0 ± 0.0
Pro
0.864ProAla: 0.864 ± 0.048
0.275ProCys: 0.275 ± 0.024
1.327ProAsp: 1.327 ± 0.062
1.572ProGlu: 1.572 ± 0.074
1.174ProPhe: 1.174 ± 0.054
1.158ProGly: 1.158 ± 0.053
0.331ProHis: 0.331 ± 0.031
2.526ProIle: 2.526 ± 0.089
2.111ProLys: 2.111 ± 0.081
2.041ProLeu: 2.041 ± 0.079
0.517ProMet: 0.517 ± 0.039
1.995ProAsn: 1.995 ± 0.091
0.345ProPro: 0.345 ± 0.034
0.495ProGln: 0.495 ± 0.04
0.665ProArg: 0.665 ± 0.045
1.758ProSer: 1.758 ± 0.069
1.494ProThr: 1.494 ± 0.072
1.54ProVal: 1.54 ± 0.074
0.167ProTrp: 0.167 ± 0.022
1.381ProTyr: 1.381 ± 0.067
0.0ProXaa: 0.0 ± 0.0
Gln
0.889GlnAla: 0.889 ± 0.049
0.17GlnCys: 0.17 ± 0.022
1.179GlnAsp: 1.179 ± 0.055
1.747GlnGlu: 1.747 ± 0.076
0.679GlnPhe: 0.679 ± 0.048
0.996GlnGly: 0.996 ± 0.047
0.197GlnHis: 0.197 ± 0.024
2.046GlnIle: 2.046 ± 0.067
1.992GlnLys: 1.992 ± 0.084
1.602GlnLeu: 1.602 ± 0.064
0.565GlnMet: 0.565 ± 0.043
1.583GlnAsn: 1.583 ± 0.077
0.377GlnPro: 0.377 ± 0.04
0.479GlnGln: 0.479 ± 0.05
0.848GlnArg: 0.848 ± 0.055
1.047GlnSer: 1.047 ± 0.066
1.101GlnThr: 1.101 ± 0.057
1.23GlnVal: 1.23 ± 0.067
0.092GlnTrp: 0.092 ± 0.015
0.999GlnTyr: 0.999 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
1.142ArgAla: 1.142 ± 0.058
0.382ArgCys: 0.382 ± 0.035
1.966ArgAsp: 1.966 ± 0.077
2.561ArgGlu: 2.561 ± 0.092
1.257ArgPhe: 1.257 ± 0.069
1.57ArgGly: 1.57 ± 0.072
0.46ArgHis: 0.46 ± 0.036
3.242ArgIle: 3.242 ± 0.096
3.228ArgLys: 3.228 ± 0.086
2.728ArgLeu: 2.728 ± 0.094
0.905ArgMet: 0.905 ± 0.053
2.283ArgAsn: 2.283 ± 0.078
0.792ArgPro: 0.792 ± 0.047
0.805ArgGln: 0.805 ± 0.055
1.19ArgArg: 1.19 ± 0.057
1.551ArgSer: 1.551 ± 0.072
1.435ArgThr: 1.435 ± 0.067
1.858ArgVal: 1.858 ± 0.078
0.17ArgTrp: 0.17 ± 0.022
1.597ArgTyr: 1.597 ± 0.077
0.0ArgXaa: 0.0 ± 0.0
Ser
2.299SerAla: 2.299 ± 0.086
0.708SerCys: 0.708 ± 0.043
3.969SerAsp: 3.969 ± 0.108
3.627SerGlu: 3.627 ± 0.094
3.096SerPhe: 3.096 ± 0.094
3.81SerGly: 3.81 ± 0.111
0.843SerHis: 0.843 ± 0.045
7.065SerIle: 7.065 ± 0.157
5.959SerLys: 5.959 ± 0.135
6.187SerLeu: 6.187 ± 0.138
1.605SerMet: 1.605 ± 0.066
4.981SerAsn: 4.981 ± 0.128
1.271SerPro: 1.271 ± 0.055
1.424SerGln: 1.424 ± 0.062
2.003SerArg: 2.003 ± 0.073
4.922SerSer: 4.922 ± 0.182
3.166SerThr: 3.166 ± 0.126
3.492SerVal: 3.492 ± 0.127
0.412SerTrp: 0.412 ± 0.042
3.42SerTyr: 3.42 ± 0.094
0.0SerXaa: 0.0 ± 0.0
Thr
1.992ThrAla: 1.992 ± 0.091
0.646ThrCys: 0.646 ± 0.044
3.016ThrAsp: 3.016 ± 0.095
2.892ThrGlu: 2.892 ± 0.083
2.388ThrPhe: 2.388 ± 0.08
3.15ThrGly: 3.15 ± 0.121
0.794ThrHis: 0.794 ± 0.045
5.951ThrIle: 5.951 ± 0.133
4.637ThrLys: 4.637 ± 0.119
5.127ThrLeu: 5.127 ± 0.123
1.142ThrMet: 1.142 ± 0.051
4.05ThrAsn: 4.05 ± 0.149
1.707ThrPro: 1.707 ± 0.071
0.999ThrGln: 0.999 ± 0.057
1.556ThrArg: 1.556 ± 0.068
3.667ThrSer: 3.667 ± 0.157
2.959ThrThr: 2.959 ± 0.144
2.749ThrVal: 2.749 ± 0.115
0.31ThrTrp: 0.31 ± 0.033
2.989ThrTyr: 2.989 ± 0.127
0.0ThrXaa: 0.0 ± 0.0
Val
2.434ValAla: 2.434 ± 0.086
0.827ValCys: 0.827 ± 0.059
3.724ValAsp: 3.724 ± 0.103
3.406ValGlu: 3.406 ± 0.105
2.493ValPhe: 2.493 ± 0.093
3.315ValGly: 3.315 ± 0.1
0.649ValHis: 0.649 ± 0.043
6.249ValIle: 6.249 ± 0.159
5.024ValLys: 5.024 ± 0.14
5.614ValLeu: 5.614 ± 0.135
1.481ValMet: 1.481 ± 0.07
4.432ValAsn: 4.432 ± 0.12
1.5ValPro: 1.5 ± 0.074
0.88ValGln: 0.88 ± 0.051
1.893ValArg: 1.893 ± 0.073
4.357ValSer: 4.357 ± 0.122
3.277ValThr: 3.277 ± 0.131
3.861ValVal: 3.861 ± 0.138
0.347ValTrp: 0.347 ± 0.035
2.903ValTyr: 2.903 ± 0.092
0.0ValXaa: 0.0 ± 0.0
Trp
0.248TrpAla: 0.248 ± 0.023
0.11TrpCys: 0.11 ± 0.015
0.302TrpAsp: 0.302 ± 0.031
0.272TrpGlu: 0.272 ± 0.031
0.334TrpPhe: 0.334 ± 0.032
0.25TrpGly: 0.25 ± 0.028
0.097TrpHis: 0.097 ± 0.016
0.552TrpIle: 0.552 ± 0.041
0.369TrpLys: 0.369 ± 0.035
0.549TrpLeu: 0.549 ± 0.042
0.102TrpMet: 0.102 ± 0.02
0.417TrpAsn: 0.417 ± 0.04
0.124TrpPro: 0.124 ± 0.017
0.145TrpGln: 0.145 ± 0.019
0.14TrpArg: 0.14 ± 0.02
0.372TrpSer: 0.372 ± 0.037
0.291TrpThr: 0.291 ± 0.033
0.326TrpVal: 0.326 ± 0.033
0.048TrpTrp: 0.048 ± 0.01
0.407TrpTyr: 0.407 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.168TyrAla: 2.168 ± 0.076
0.522TyrCys: 0.522 ± 0.042
3.928TyrAsp: 3.928 ± 0.105
3.465TyrGlu: 3.465 ± 0.107
2.375TyrPhe: 2.375 ± 0.095
2.983TyrGly: 2.983 ± 0.145
0.802TyrHis: 0.802 ± 0.045
5.821TyrIle: 5.821 ± 0.135
5.377TyrLys: 5.377 ± 0.136
5.364TyrLeu: 5.364 ± 0.111
1.131TyrMet: 1.131 ± 0.069
5.089TyrAsn: 5.089 ± 0.134
1.416TyrPro: 1.416 ± 0.071
1.432TyrGln: 1.432 ± 0.054
1.675TyrArg: 1.675 ± 0.074
3.621TyrSer: 3.621 ± 0.11
2.927TyrThr: 2.927 ± 0.112
3.075TyrVal: 3.075 ± 0.097
0.258TyrTrp: 0.258 ± 0.024
3.323TyrTyr: 3.323 ± 0.148
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1262 proteins (371395 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski