Amino acid dipepetide frequency for Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.306AlaAla: 8.306 ± 0.131	0.822AlaCys: 0.822 ± 0.029	5.189AlaAsp: 5.189 ± 0.081	6.781AlaGlu: 6.781 ± 0.098	3.378AlaPhe: 3.378 ± 0.073	6.303AlaGly: 6.303 ± 0.098	1.597AlaHis: 1.597 ± 0.042	5.521AlaIle: 5.521 ± 0.09	4.375AlaLys: 4.375 ± 0.072	9.664AlaLeu: 9.664 ± 0.11	2.526AlaMet: 2.526 ± 0.05	3.192AlaAsn: 3.192 ± 0.065	2.855AlaPro: 2.855 ± 0.057	3.781AlaGln: 3.781 ± 0.068	4.323AlaArg: 4.323 ± 0.07	5.115AlaSer: 5.115 ± 0.085	4.192AlaThr: 4.192 ± 0.072	6.469AlaVal: 6.469 ± 0.09	0.956AlaTrp: 0.956 ± 0.038	2.401AlaTyr: 2.401 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.652CysAla: 0.652 ± 0.026	0.122CysCys: 0.122 ± 0.012	0.501CysAsp: 0.501 ± 0.031	0.552CysGlu: 0.552 ± 0.024	0.347CysPhe: 0.347 ± 0.023	0.753CysGly: 0.753 ± 0.03	0.298CysHis: 0.298 ± 0.019	0.423CysIle: 0.423 ± 0.02	0.324CysLys: 0.324 ± 0.018	0.82CysLeu: 0.82 ± 0.03	0.156CysMet: 0.156 ± 0.013	0.286CysAsn: 0.286 ± 0.018	0.404CysPro: 0.404 ± 0.024	0.417CysGln: 0.417 ± 0.025	0.477CysArg: 0.477 ± 0.026	0.597CysSer: 0.597 ± 0.027	0.365CysThr: 0.365 ± 0.023	0.557CysVal: 0.557 ± 0.026	0.134CysTrp: 0.134 ± 0.013	0.261CysTyr: 0.261 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.826AspAla: 4.826 ± 0.079	0.452AspCys: 0.452 ± 0.023	3.772AspAsp: 3.772 ± 0.083	4.565AspGlu: 4.565 ± 0.095	2.656AspPhe: 2.656 ± 0.058	3.991AspGly: 3.991 ± 0.083	1.028AspHis: 1.028 ± 0.04	4.056AspIle: 4.056 ± 0.071	3.24AspLys: 3.24 ± 0.072	4.97AspLeu: 4.97 ± 0.072	1.461AspMet: 1.461 ± 0.045	2.646AspAsn: 2.646 ± 0.058	2.135AspPro: 2.135 ± 0.05	1.752AspGln: 1.752 ± 0.048	2.429AspArg: 2.429 ± 0.059	3.597AspSer: 3.597 ± 0.069	2.864AspThr: 2.864 ± 0.059	4.069AspVal: 4.069 ± 0.08	1.05AspTrp: 1.05 ± 0.039	2.238AspTyr: 2.238 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.727GluAla: 5.727 ± 0.095	0.457GluCys: 0.457 ± 0.024	3.328GluAsp: 3.328 ± 0.069	4.611GluGlu: 4.611 ± 0.092	2.621GluPhe: 2.621 ± 0.057	4.009GluGly: 4.009 ± 0.08	1.812GluHis: 1.812 ± 0.047	3.561GluIle: 3.561 ± 0.071	4.07GluLys: 4.07 ± 0.081	7.885GluLeu: 7.885 ± 0.108	1.632GluMet: 1.632 ± 0.042	3.029GluAsn: 3.029 ± 0.059	2.594GluPro: 2.594 ± 0.062	5.136GluGln: 5.136 ± 0.101	4.41GluArg: 4.41 ± 0.076	4.196GluSer: 4.196 ± 0.079	3.331GluThr: 3.331 ± 0.058	4.572GluVal: 4.572 ± 0.079	0.873GluTrp: 0.873 ± 0.031	1.903GluTyr: 1.903 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.53PheAla: 3.53 ± 0.061	0.401PheCys: 0.401 ± 0.02	2.645PheAsp: 2.645 ± 0.056	2.566PheGlu: 2.566 ± 0.059	1.685PhePhe: 1.685 ± 0.046	3.042PheGly: 3.042 ± 0.075	0.874PheHis: 0.874 ± 0.034	2.536PheIle: 2.536 ± 0.056	1.753PheLys: 1.753 ± 0.055	3.252PheLeu: 3.252 ± 0.069	0.906PheMet: 0.906 ± 0.036	1.902PheAsn: 1.902 ± 0.049	1.408PhePro: 1.408 ± 0.042	1.312PheGln: 1.312 ± 0.036	1.789PheArg: 1.789 ± 0.046	3.229PheSer: 3.229 ± 0.062	2.138PheThr: 2.138 ± 0.052	2.705PheVal: 2.705 ± 0.063	0.605PheTrp: 0.605 ± 0.031	1.385PheTyr: 1.385 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.411GlyAla: 5.411 ± 0.086	0.745GlyCys: 0.745 ± 0.03	3.959GlyAsp: 3.959 ± 0.081	4.836GlyGlu: 4.836 ± 0.085	3.19GlyPhe: 3.19 ± 0.064	4.967GlyGly: 4.967 ± 0.104	1.619GlyHis: 1.619 ± 0.045	4.426GlyIle: 4.426 ± 0.078	3.807GlyLys: 3.807 ± 0.071	6.876GlyLeu: 6.876 ± 0.105	1.946GlyMet: 1.946 ± 0.053	2.651GlyAsn: 2.651 ± 0.068	1.778GlyPro: 1.778 ± 0.044	2.784GlyGln: 2.784 ± 0.065	3.409GlyArg: 3.409 ± 0.061	4.48GlySer: 4.48 ± 0.077	3.289GlyThr: 3.289 ± 0.069	5.369GlyVal: 5.369 ± 0.079	1.036GlyTrp: 1.036 ± 0.033	2.534GlyTyr: 2.534 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.551HisAla: 1.551 ± 0.04	0.324HisCys: 0.324 ± 0.018	1.077HisAsp: 1.077 ± 0.039	1.305HisGlu: 1.305 ± 0.039	1.033HisPhe: 1.033 ± 0.032	1.637HisGly: 1.637 ± 0.047	0.599HisHis: 0.599 ± 0.031	1.22HisIle: 1.22 ± 0.039	1.052HisLys: 1.052 ± 0.034	2.108HisLeu: 2.108 ± 0.05	0.487HisMet: 0.487 ± 0.025	0.824HisAsn: 0.824 ± 0.032	1.196HisPro: 1.196 ± 0.042	1.109HisGln: 1.109 ± 0.034	1.217HisArg: 1.217 ± 0.032	1.405HisSer: 1.405 ± 0.038	0.911HisThr: 0.911 ± 0.033	1.186HisVal: 1.186 ± 0.036	0.431HisTrp: 0.431 ± 0.021	0.859HisTyr: 0.859 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.813IleAla: 5.813 ± 0.082	0.494IleCys: 0.494 ± 0.026	3.965IleAsp: 3.965 ± 0.079	4.574IleGlu: 4.574 ± 0.072	1.945IlePhe: 1.945 ± 0.055	4.379IleGly: 4.379 ± 0.09	1.125IleHis: 1.125 ± 0.036	3.336IleIle: 3.336 ± 0.079	2.865IleLys: 2.865 ± 0.056	4.611IleLeu: 4.611 ± 0.084	1.145IleMet: 1.145 ± 0.033	2.649IleAsn: 2.649 ± 0.058	2.444IlePro: 2.444 ± 0.046	2.151IleGln: 2.151 ± 0.048	2.906IleArg: 2.906 ± 0.061	3.847IleSer: 3.847 ± 0.074	3.271IleThr: 3.271 ± 0.07	3.766IleVal: 3.766 ± 0.076	0.583IleTrp: 0.583 ± 0.029	1.486IleTyr: 1.486 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.822LysAla: 4.822 ± 0.077	0.209LysCys: 0.209 ± 0.015	2.76LysAsp: 2.76 ± 0.064	3.502LysGlu: 3.502 ± 0.083	1.423LysPhe: 1.423 ± 0.044	3.164LysGly: 3.164 ± 0.068	1.165LysHis: 1.165 ± 0.037	2.351LysIle: 2.351 ± 0.053	2.769LysLys: 2.769 ± 0.062	5.121LysLeu: 5.121 ± 0.078	1.167LysMet: 1.167 ± 0.037	1.908LysAsn: 1.908 ± 0.051	2.443LysPro: 2.443 ± 0.059	2.911LysGln: 2.911 ± 0.061	3.042LysArg: 3.042 ± 0.065	3.006LysSer: 3.006 ± 0.058	2.774LysThr: 2.774 ± 0.055	3.652LysVal: 3.652 ± 0.075	0.559LysTrp: 0.559 ± 0.027	1.139LysTyr: 1.139 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.758LeuAla: 9.758 ± 0.126	0.859LeuCys: 0.859 ± 0.034	5.497LeuAsp: 5.497 ± 0.079	6.538LeuGlu: 6.538 ± 0.09	3.944LeuPhe: 3.944 ± 0.088	6.596LeuGly: 6.596 ± 0.1	2.085LeuHis: 2.085 ± 0.056	5.707LeuIle: 5.707 ± 0.103	5.531LeuLys: 5.531 ± 0.078	10.983LeuLeu: 10.983 ± 0.165	2.62LeuMet: 2.62 ± 0.059	4.376LeuAsn: 4.376 ± 0.081	4.881LeuPro: 4.881 ± 0.079	4.668LeuGln: 4.668 ± 0.075	5.16LeuArg: 5.16 ± 0.088	7.609LeuSer: 7.609 ± 0.105	5.965LeuThr: 5.965 ± 0.083	6.747LeuVal: 6.747 ± 0.099	1.269LeuTrp: 1.269 ± 0.041	2.617LeuTyr: 2.617 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.507MetAla: 2.507 ± 0.054	0.137MetCys: 0.137 ± 0.014	1.233MetAsp: 1.233 ± 0.037	1.311MetGlu: 1.311 ± 0.042	0.751MetPhe: 0.751 ± 0.029	1.65MetGly: 1.65 ± 0.038	0.46MetHis: 0.46 ± 0.025	1.186MetIle: 1.186 ± 0.039	1.435MetLys: 1.435 ± 0.04	2.566MetLeu: 2.566 ± 0.054	0.698MetMet: 0.698 ± 0.027	1.034MetAsn: 1.034 ± 0.032	1.21MetPro: 1.21 ± 0.038	1.189MetGln: 1.189 ± 0.041	1.279MetArg: 1.279 ± 0.033	1.952MetSer: 1.952 ± 0.046	1.669MetThr: 1.669 ± 0.044	1.69MetVal: 1.69 ± 0.044	0.195MetTrp: 0.195 ± 0.016	0.471MetTyr: 0.471 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.543AsnAla: 3.543 ± 0.07	0.375AsnCys: 0.375 ± 0.021	2.512AsnAsp: 2.512 ± 0.054	2.755AsnGlu: 2.755 ± 0.064	1.533AsnPhe: 1.533 ± 0.042	2.952AsnGly: 2.952 ± 0.067	0.778AsnHis: 0.778 ± 0.031	2.256AsnIle: 2.256 ± 0.051	1.919AsnLys: 1.919 ± 0.052	3.683AsnLeu: 3.683 ± 0.077	0.871AsnMet: 0.871 ± 0.032	1.825AsnAsn: 1.825 ± 0.053	1.97AsnPro: 1.97 ± 0.056	1.858AsnGln: 1.858 ± 0.052	2.073AsnArg: 2.073 ± 0.043	2.625AsnSer: 2.625 ± 0.066	2.072AsnThr: 2.072 ± 0.052	2.515AsnVal: 2.515 ± 0.052	0.698AsnTrp: 0.698 ± 0.027	1.427AsnTyr: 1.427 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	3.3ProAla: 3.3 ± 0.059	0.269ProCys: 0.269 ± 0.016	2.727ProAsp: 2.727 ± 0.058	3.813ProGlu: 3.813 ± 0.071	1.633ProPhe: 1.633 ± 0.042	2.938ProGly: 2.938 ± 0.07	0.785ProHis: 0.785 ± 0.028	2.151ProIle: 2.151 ± 0.054	1.918ProLys: 1.918 ± 0.048	4.178ProLeu: 4.178 ± 0.078	0.995ProMet: 0.995 ± 0.035	1.512ProAsn: 1.512 ± 0.043	1.24ProPro: 1.24 ± 0.047	1.786ProGln: 1.786 ± 0.049	1.485ProArg: 1.485 ± 0.045	2.183ProSer: 2.183 ± 0.048	1.993ProThr: 1.993 ± 0.053	3.43ProVal: 3.43 ± 0.065	0.515ProTrp: 0.515 ± 0.028	1.203ProTyr: 1.203 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.289GlnAla: 4.289 ± 0.083	0.322GlnCys: 0.322 ± 0.017	1.948GlnAsp: 1.948 ± 0.054	2.719GlnGlu: 2.719 ± 0.066	1.737GlnPhe: 1.737 ± 0.043	2.873GlnGly: 2.873 ± 0.061	1.247GlnHis: 1.247 ± 0.038	2.166GlnIle: 2.166 ± 0.059	2.233GlnLys: 2.233 ± 0.049	6.126GlnLeu: 6.126 ± 0.12	1.126GlnMet: 1.126 ± 0.035	1.599GlnAsn: 1.599 ± 0.044	2.122GlnPro: 2.122 ± 0.051	4.171GlnGln: 4.171 ± 0.11	3.123GlnArg: 3.123 ± 0.064	2.917GlnSer: 2.917 ± 0.067	2.168GlnThr: 2.168 ± 0.057	3.304GlnVal: 3.304 ± 0.057	0.819GlnTrp: 0.819 ± 0.032	1.326GlnTyr: 1.326 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.8ArgAla: 3.8 ± 0.062	0.415ArgCys: 0.415 ± 0.022	2.931ArgAsp: 2.931 ± 0.061	3.735ArgGlu: 3.735 ± 0.085	2.408ArgPhe: 2.408 ± 0.054	2.995ArgGly: 2.995 ± 0.062	1.25ArgHis: 1.25 ± 0.043	3.179ArgIle: 3.179 ± 0.067	2.612ArgLys: 2.612 ± 0.058	5.758ArgLeu: 5.758 ± 0.086	1.329ArgMet: 1.329 ± 0.039	1.985ArgAsn: 1.985 ± 0.043	1.845ArgPro: 1.845 ± 0.051	2.785ArgGln: 2.785 ± 0.063	2.959ArgArg: 2.959 ± 0.072	3.044ArgSer: 3.044 ± 0.07	2.219ArgThr: 2.219 ± 0.05	3.788ArgVal: 3.788 ± 0.068	0.876ArgTrp: 0.876 ± 0.032	2.02ArgTyr: 2.02 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.702SerAla: 5.702 ± 0.097	0.541SerCys: 0.541 ± 0.025	4.055SerAsp: 4.055 ± 0.075	4.607SerGlu: 4.607 ± 0.089	2.607SerPhe: 2.607 ± 0.064	5.266SerGly: 5.266 ± 0.088	1.334SerHis: 1.334 ± 0.042	3.646SerIle: 3.646 ± 0.07	2.796SerLys: 2.796 ± 0.059	6.784SerLeu: 6.784 ± 0.098	1.69SerMet: 1.69 ± 0.041	2.446SerAsn: 2.446 ± 0.058	2.429SerPro: 2.429 ± 0.05	2.842SerGln: 2.842 ± 0.06	3.16SerArg: 3.16 ± 0.069	4.299SerSer: 4.299 ± 0.089	2.922SerThr: 2.922 ± 0.062	4.939SerVal: 4.939 ± 0.082	0.895SerTrp: 0.895 ± 0.031	1.971SerTyr: 1.971 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.644ThrAla: 4.644 ± 0.084	0.384ThrCys: 0.384 ± 0.022	3.09ThrAsp: 3.09 ± 0.059	3.717ThrGlu: 3.717 ± 0.066	1.932ThrPhe: 1.932 ± 0.054	4.051ThrGly: 4.051 ± 0.074	1.084ThrHis: 1.084 ± 0.039	2.916ThrIle: 2.916 ± 0.061	1.969ThrLys: 1.969 ± 0.052	5.796ThrLeu: 5.796 ± 0.08	1.012ThrMet: 1.012 ± 0.033	1.749ThrAsn: 1.749 ± 0.052	2.49ThrPro: 2.49 ± 0.055	2.257ThrGln: 2.257 ± 0.054	2.481ThrArg: 2.481 ± 0.054	2.955ThrSer: 2.955 ± 0.05	2.589ThrThr: 2.589 ± 0.061	3.885ThrVal: 3.885 ± 0.079	0.555ThrTrp: 0.555 ± 0.023	1.365ThrTyr: 1.365 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	6.505ValAla: 6.505 ± 0.085	0.632ValCys: 0.632 ± 0.026	4.199ValAsp: 4.199 ± 0.087	4.824ValGlu: 4.824 ± 0.093	2.81ValPhe: 2.81 ± 0.063	4.68ValGly: 4.68 ± 0.081	1.254ValHis: 1.254 ± 0.039	4.626ValIle: 4.626 ± 0.076	3.457ValLys: 3.457 ± 0.072	6.938ValLeu: 6.938 ± 0.096	1.881ValMet: 1.881 ± 0.044	3.091ValAsn: 3.091 ± 0.066	2.72ValPro: 2.72 ± 0.056	2.386ValGln: 2.386 ± 0.053	3.469ValArg: 3.469 ± 0.073	5.046ValSer: 5.046 ± 0.09	4.258ValThr: 4.258 ± 0.071	5.364ValVal: 5.364 ± 0.083	0.811ValTrp: 0.811 ± 0.031	1.852ValTyr: 1.852 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.798TrpAla: 0.798 ± 0.033	0.134TrpCys: 0.134 ± 0.013	0.615TrpAsp: 0.615 ± 0.029	0.613TrpGlu: 0.613 ± 0.028	0.681TrpPhe: 0.681 ± 0.029	0.768TrpGly: 0.768 ± 0.035	0.388TrpHis: 0.388 ± 0.021	0.65TrpIle: 0.65 ± 0.026	0.502TrpLys: 0.502 ± 0.02	2.085TrpLeu: 2.085 ± 0.055	0.373TrpMet: 0.373 ± 0.019	0.438TrpAsn: 0.438 ± 0.022	0.562TrpPro: 0.562 ± 0.028	1.17TrpGln: 1.17 ± 0.037	0.856TrpArg: 0.856 ± 0.031	0.807TrpSer: 0.807 ± 0.03	0.499TrpThr: 0.499 ± 0.027	1.045TrpVal: 1.045 ± 0.032	0.233TrpTrp: 0.233 ± 0.017	0.402TrpTyr: 0.402 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.263TyrAla: 2.263 ± 0.058	0.356TyrCys: 0.356 ± 0.022	1.795TyrAsp: 1.795 ± 0.049	1.834TyrGlu: 1.834 ± 0.048	1.347TyrPhe: 1.347 ± 0.039	2.099TyrGly: 2.099 ± 0.051	0.749TyrHis: 0.749 ± 0.03	1.443TyrIle: 1.443 ± 0.041	1.259TyrLys: 1.259 ± 0.037	3.207TyrLeu: 3.207 ± 0.064	0.596TyrMet: 0.596 ± 0.025	1.097TyrAsn: 1.097 ± 0.043	1.327TyrPro: 1.327 ± 0.039	1.87TyrGln: 1.87 ± 0.05	1.885TyrArg: 1.885 ± 0.043	2.021TyrSer: 2.021 ± 0.051	1.43TyrThr: 1.43 ± 0.05	1.75TyrVal: 1.75 ± 0.043	0.531TyrTrp: 0.531 ± 0.025	0.989TyrTyr: 0.989 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2608 proteins (862909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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