Amino acid dipepetide frequency for Dictyobacter alpinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.87AlaAla: 8.87 ± 0.078	0.983AlaCys: 0.983 ± 0.023	4.3AlaAsp: 4.3 ± 0.044	5.065AlaGlu: 5.065 ± 0.06	3.417AlaPhe: 3.417 ± 0.038	6.546AlaGly: 6.546 ± 0.061	2.381AlaHis: 2.381 ± 0.037	5.941AlaIle: 5.941 ± 0.054	2.596AlaLys: 2.596 ± 0.041	11.179AlaLeu: 11.179 ± 0.091	2.223AlaMet: 2.223 ± 0.03	3.122AlaAsn: 3.122 ± 0.042	3.962AlaPro: 3.962 ± 0.047	4.794AlaGln: 4.794 ± 0.053	5.723AlaArg: 5.723 ± 0.055	5.931AlaSer: 5.931 ± 0.055	5.669AlaThr: 5.669 ± 0.05	5.815AlaVal: 5.815 ± 0.048	1.301AlaTrp: 1.301 ± 0.027	2.898AlaTyr: 2.898 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.778CysAla: 0.778 ± 0.019	0.146CysCys: 0.146 ± 0.008	0.454CysAsp: 0.454 ± 0.015	0.472CysGlu: 0.472 ± 0.015	0.383CysPhe: 0.383 ± 0.013	0.848CysGly: 0.848 ± 0.023	0.261CysHis: 0.261 ± 0.01	0.608CysIle: 0.608 ± 0.017	0.26CysLys: 0.26 ± 0.012	1.015CysLeu: 1.015 ± 0.022	0.204CysMet: 0.204 ± 0.011	0.313CysAsn: 0.313 ± 0.013	0.49CysPro: 0.49 ± 0.016	0.473CysGln: 0.473 ± 0.015	0.513CysArg: 0.513 ± 0.017	0.633CysSer: 0.633 ± 0.017	0.552CysThr: 0.552 ± 0.016	0.617CysVal: 0.617 ± 0.014	0.16CysTrp: 0.16 ± 0.008	0.338CysTyr: 0.338 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.425AspAla: 4.425 ± 0.046	0.398AspCys: 0.398 ± 0.012	2.331AspAsp: 2.331 ± 0.036	3.277AspGlu: 3.277 ± 0.038	1.837AspPhe: 1.837 ± 0.043	3.603AspGly: 3.603 ± 0.048	1.202AspHis: 1.202 ± 0.023	3.167AspIle: 3.167 ± 0.041	1.59AspLys: 1.59 ± 0.031	5.13AspLeu: 5.13 ± 0.053	1.134AspMet: 1.134 ± 0.022	1.658AspAsn: 1.658 ± 0.029	2.958AspPro: 2.958 ± 0.047	2.363AspGln: 2.363 ± 0.037	2.5AspArg: 2.5 ± 0.031	2.254AspSer: 2.254 ± 0.032	2.844AspThr: 2.844 ± 0.037	3.485AspVal: 3.485 ± 0.039	0.854AspTrp: 0.854 ± 0.018	1.655AspTyr: 1.655 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.596GluAla: 5.596 ± 0.064	0.44GluCys: 0.44 ± 0.013	2.69GluAsp: 2.69 ± 0.039	4.147GluGlu: 4.147 ± 0.053	1.48GluPhe: 1.48 ± 0.025	3.211GluGly: 3.211 ± 0.037	1.864GluHis: 1.864 ± 0.029	3.386GluIle: 3.386 ± 0.038	2.49GluLys: 2.49 ± 0.042	5.9GluLeu: 5.9 ± 0.056	1.444GluMet: 1.444 ± 0.024	1.832GluAsn: 1.832 ± 0.03	2.378GluPro: 2.378 ± 0.036	4.407GluGln: 4.407 ± 0.057	4.423GluArg: 4.423 ± 0.051	2.58GluSer: 2.58 ± 0.038	3.057GluThr: 3.057 ± 0.036	3.767GluVal: 3.767 ± 0.044	0.675GluTrp: 0.675 ± 0.015	1.573GluTyr: 1.573 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.295PheAla: 3.295 ± 0.038	0.458PheCys: 0.458 ± 0.014	1.926PheAsp: 1.926 ± 0.033	1.935PheGlu: 1.935 ± 0.031	1.768PhePhe: 1.768 ± 0.033	2.785PheGly: 2.785 ± 0.039	0.915PheHis: 0.915 ± 0.022	2.146PheIle: 2.146 ± 0.033	1.108PheLys: 1.108 ± 0.021	4.056PheLeu: 4.056 ± 0.054	0.832PheMet: 0.832 ± 0.019	1.215PheAsn: 1.215 ± 0.026	1.668PhePro: 1.668 ± 0.026	1.586PheGln: 1.586 ± 0.028	1.652PheArg: 1.652 ± 0.027	2.719PheSer: 2.719 ± 0.038	2.278PheThr: 2.278 ± 0.035	2.556PheVal: 2.556 ± 0.035	0.61PheTrp: 0.61 ± 0.016	1.237PheTyr: 1.237 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.58GlyAla: 5.58 ± 0.055	0.735GlyCys: 0.735 ± 0.019	3.047GlyAsp: 3.047 ± 0.037	3.625GlyGlu: 3.625 ± 0.044	2.571GlyPhe: 2.571 ± 0.037	5.223GlyGly: 5.223 ± 0.082	1.769GlyHis: 1.769 ± 0.027	4.722GlyIle: 4.722 ± 0.051	3.186GlyLys: 3.186 ± 0.037	7.112GlyLeu: 7.112 ± 0.067	1.891GlyMet: 1.891 ± 0.026	2.63GlyAsn: 2.63 ± 0.044	2.692GlyPro: 2.692 ± 0.031	3.378GlyGln: 3.378 ± 0.039	3.787GlyArg: 3.787 ± 0.04	4.677GlySer: 4.677 ± 0.053	4.301GlyThr: 4.301 ± 0.049	4.748GlyVal: 4.748 ± 0.048	1.217GlyTrp: 1.217 ± 0.024	2.617GlyTyr: 2.617 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.231HisAla: 2.231 ± 0.03	0.286HisCys: 0.286 ± 0.01	1.271HisAsp: 1.271 ± 0.023	1.429HisGlu: 1.429 ± 0.026	1.085HisPhe: 1.085 ± 0.022	1.832HisGly: 1.832 ± 0.027	0.788HisHis: 0.788 ± 0.022	1.713HisIle: 1.713 ± 0.028	0.812HisLys: 0.812 ± 0.019	2.954HisLeu: 2.954 ± 0.041	0.651HisMet: 0.651 ± 0.014	0.874HisAsn: 0.874 ± 0.019	1.653HisPro: 1.653 ± 0.025	1.175HisGln: 1.175 ± 0.021	1.266HisArg: 1.266 ± 0.024	1.476HisSer: 1.476 ± 0.025	1.585HisThr: 1.585 ± 0.028	1.756HisVal: 1.756 ± 0.028	0.477HisTrp: 0.477 ± 0.014	0.935HisTyr: 0.935 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.198IleAla: 6.198 ± 0.062	0.691IleCys: 0.691 ± 0.016	3.198IleAsp: 3.198 ± 0.039	3.701IleGlu: 3.701 ± 0.047	2.375IlePhe: 2.375 ± 0.039	4.503IleGly: 4.503 ± 0.053	1.503IleHis: 1.503 ± 0.026	3.73IleIle: 3.73 ± 0.044	2.008IleLys: 2.008 ± 0.03	6.153IleLeu: 6.153 ± 0.068	1.199IleMet: 1.199 ± 0.021	2.117IleAsn: 2.117 ± 0.029	3.122IlePro: 3.122 ± 0.035	2.799IleGln: 2.799 ± 0.035	2.961IleArg: 2.961 ± 0.035	3.923IleSer: 3.923 ± 0.044	3.646IleThr: 3.646 ± 0.037	4.329IleVal: 4.329 ± 0.044	0.885IleTrp: 0.885 ± 0.018	1.847IleTyr: 1.847 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.072LysAla: 3.072 ± 0.04	0.196LysCys: 0.196 ± 0.008	1.889LysAsp: 1.889 ± 0.031	2.133LysGlu: 2.133 ± 0.034	0.832LysPhe: 0.832 ± 0.02	2.165LysGly: 2.165 ± 0.035	0.907LysHis: 0.907 ± 0.02	1.97LysIle: 1.97 ± 0.032	1.719LysLys: 1.719 ± 0.031	3.286LysLeu: 3.286 ± 0.04	0.931LysMet: 0.931 ± 0.019	1.391LysAsn: 1.391 ± 0.025	1.739LysPro: 1.739 ± 0.026	2.105LysGln: 2.105 ± 0.035	2.373LysArg: 2.373 ± 0.036	1.92LysSer: 1.92 ± 0.034	2.101LysThr: 2.101 ± 0.033	2.299LysVal: 2.299 ± 0.035	0.365LysTrp: 0.365 ± 0.012	0.96LysTyr: 0.96 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	11.224LeuAla: 11.224 ± 0.074	1.18LeuCys: 1.18 ± 0.022	5.35LeuAsp: 5.35 ± 0.046	5.811LeuGlu: 5.811 ± 0.06	4.177LeuPhe: 4.177 ± 0.058	7.028LeuGly: 7.028 ± 0.075	2.947LeuHis: 2.947 ± 0.036	6.244LeuIle: 6.244 ± 0.058	3.662LeuLys: 3.662 ± 0.037	13.414LeuLeu: 13.414 ± 0.124	2.129LeuMet: 2.129 ± 0.033	3.429LeuAsn: 3.429 ± 0.04	6.005LeuPro: 6.005 ± 0.064	5.497LeuGln: 5.497 ± 0.061	6.328LeuArg: 6.328 ± 0.063	7.183LeuSer: 7.183 ± 0.065	6.276LeuThr: 6.276 ± 0.053	7.289LeuVal: 7.289 ± 0.065	1.475LeuTrp: 1.475 ± 0.025	3.111LeuTyr: 3.111 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.267MetAla: 2.267 ± 0.035	0.176MetCys: 0.176 ± 0.009	1.125MetAsp: 1.125 ± 0.024	1.129MetGlu: 1.129 ± 0.024	0.679MetPhe: 0.679 ± 0.02	1.575MetGly: 1.575 ± 0.028	0.612MetHis: 0.612 ± 0.017	1.276MetIle: 1.276 ± 0.026	0.875MetLys: 0.875 ± 0.02	2.664MetLeu: 2.664 ± 0.029	0.506MetMet: 0.506 ± 0.016	0.84MetAsn: 0.84 ± 0.017	1.23MetPro: 1.23 ± 0.023	1.334MetGln: 1.334 ± 0.021	1.498MetArg: 1.498 ± 0.027	1.543MetSer: 1.543 ± 0.024	1.396MetThr: 1.396 ± 0.026	1.594MetVal: 1.594 ± 0.026	0.199MetTrp: 0.199 ± 0.008	0.562MetTyr: 0.562 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.198AsnAla: 3.198 ± 0.044	0.298AsnCys: 0.298 ± 0.012	1.701AsnAsp: 1.701 ± 0.025	1.787AsnGlu: 1.787 ± 0.026	1.257AsnPhe: 1.257 ± 0.023	2.736AsnGly: 2.736 ± 0.048	0.773AsnHis: 0.773 ± 0.018	2.224AsnIle: 2.224 ± 0.035	1.204AsnLys: 1.204 ± 0.026	3.245AsnLeu: 3.245 ± 0.04	0.802AsnMet: 0.802 ± 0.02	1.605AsnAsn: 1.605 ± 0.049	2.045AsnPro: 2.045 ± 0.032	1.631AsnGln: 1.631 ± 0.028	1.696AsnArg: 1.696 ± 0.027	1.994AsnSer: 1.994 ± 0.033	2.322AsnThr: 2.322 ± 0.032	2.286AsnVal: 2.286 ± 0.035	0.627AsnTrp: 0.627 ± 0.017	1.149AsnTyr: 1.149 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.064ProAla: 5.064 ± 0.059	0.317ProCys: 0.317 ± 0.012	3.159ProAsp: 3.159 ± 0.043	3.601ProGlu: 3.601 ± 0.047	1.998ProPhe: 1.998 ± 0.029	3.682ProGly: 3.682 ± 0.043	1.27ProHis: 1.27 ± 0.024	2.691ProIle: 2.691 ± 0.037	1.409ProLys: 1.409 ± 0.024	5.419ProLeu: 5.419 ± 0.064	1.008ProMet: 1.008 ± 0.021	1.592ProAsn: 1.592 ± 0.03	2.394ProPro: 2.394 ± 0.041	2.482ProGln: 2.482 ± 0.037	2.354ProArg: 2.354 ± 0.03	2.856ProSer: 2.856 ± 0.036	3.381ProThr: 3.381 ± 0.053	3.558ProVal: 3.558 ± 0.043	0.71ProTrp: 0.71 ± 0.017	1.544ProTyr: 1.544 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.543GlnAla: 5.543 ± 0.06	0.384GlnCys: 0.384 ± 0.013	2.296GlnAsp: 2.296 ± 0.031	3.345GlnGlu: 3.345 ± 0.044	1.483GlnPhe: 1.483 ± 0.027	3.385GlnGly: 3.385 ± 0.044	1.596GlnHis: 1.596 ± 0.029	2.789GlnIle: 2.789 ± 0.035	2.011GlnLys: 2.011 ± 0.031	5.445GlnLeu: 5.445 ± 0.066	1.213GlnMet: 1.213 ± 0.02	1.582GlnAsn: 1.582 ± 0.033	2.898GlnPro: 2.898 ± 0.046	4.123GlnGln: 4.123 ± 0.073	3.735GlnArg: 3.735 ± 0.051	2.926GlnSer: 2.926 ± 0.035	2.911GlnThr: 2.911 ± 0.037	3.379GlnVal: 3.379 ± 0.04	0.733GlnTrp: 0.733 ± 0.021	1.319GlnTyr: 1.319 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	4.771ArgAla: 4.771 ± 0.054	0.52ArgCys: 0.52 ± 0.016	2.682ArgAsp: 2.682 ± 0.037	3.711ArgGlu: 3.711 ± 0.045	2.271ArgPhe: 2.271 ± 0.033	3.38ArgGly: 3.38 ± 0.041	1.503ArgHis: 1.503 ± 0.025	3.583ArgIle: 3.583 ± 0.04	2.176ArgLys: 2.176 ± 0.027	6.477ArgLeu: 6.477 ± 0.06	1.481ArgMet: 1.481 ± 0.024	1.838ArgAsn: 1.838 ± 0.026	2.636ArgPro: 2.636 ± 0.037	3.361ArgGln: 3.361 ± 0.041	4.01ArgArg: 4.01 ± 0.048	3.406ArgSer: 3.406 ± 0.037	3.179ArgThr: 3.179 ± 0.037	3.753ArgVal: 3.753 ± 0.041	1.02ArgTrp: 1.02 ± 0.025	2.131ArgTyr: 2.131 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.24SerAla: 5.24 ± 0.047	0.56SerCys: 0.56 ± 0.015	2.953SerAsp: 2.953 ± 0.034	3.084SerGlu: 3.084 ± 0.038	2.506SerPhe: 2.506 ± 0.036	4.788SerGly: 4.788 ± 0.049	1.502SerHis: 1.502 ± 0.021	3.912SerIle: 3.912 ± 0.044	1.898SerLys: 1.898 ± 0.028	6.683SerLeu: 6.683 ± 0.059	1.609SerMet: 1.609 ± 0.029	2.302SerAsn: 2.302 ± 0.032	3.163SerPro: 3.163 ± 0.038	2.924SerGln: 2.924 ± 0.031	3.138SerArg: 3.138 ± 0.037	4.477SerSer: 4.477 ± 0.058	3.983SerThr: 3.983 ± 0.043	3.803SerVal: 3.803 ± 0.042	1.083SerTrp: 1.083 ± 0.025	2.089SerTyr: 2.089 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.102ThrAla: 5.102 ± 0.054	0.537ThrCys: 0.537 ± 0.015	2.733ThrAsp: 2.733 ± 0.038	2.805ThrGlu: 2.805 ± 0.037	2.508ThrPhe: 2.508 ± 0.032	4.464ThrGly: 4.464 ± 0.053	1.541ThrHis: 1.541 ± 0.024	4.134ThrIle: 4.134 ± 0.042	1.667ThrLys: 1.667 ± 0.033	6.844ThrLeu: 6.844 ± 0.062	1.262ThrMet: 1.262 ± 0.023	2.203ThrAsn: 2.203 ± 0.034	3.82ThrPro: 3.82 ± 0.057	2.736ThrGln: 2.736 ± 0.038	3.182ThrArg: 3.182 ± 0.04	3.924ThrSer: 3.924 ± 0.053	4.038ThrThr: 4.038 ± 0.048	3.926ThrVal: 3.926 ± 0.044	0.833ThrTrp: 0.833 ± 0.019	1.963ThrTyr: 1.963 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	6.409ValAla: 6.409 ± 0.051	0.699ValCys: 0.699 ± 0.016	3.31ValAsp: 3.31 ± 0.041	3.832ValGlu: 3.832 ± 0.046	2.365ValPhe: 2.365 ± 0.036	4.562ValGly: 4.562 ± 0.043	1.525ValHis: 1.525 ± 0.028	4.056ValIle: 4.056 ± 0.047	2.234ValLys: 2.234 ± 0.033	7.476ValLeu: 7.476 ± 0.062	1.542ValMet: 1.542 ± 0.023	2.242ValAsn: 2.242 ± 0.038	3.432ValPro: 3.432 ± 0.04	3.1ValGln: 3.1 ± 0.04	3.799ValArg: 3.799 ± 0.045	4.32ValSer: 4.32 ± 0.049	3.985ValThr: 3.985 ± 0.043	5.028ValVal: 5.028 ± 0.053	0.885ValTrp: 0.885 ± 0.021	1.974ValTyr: 1.974 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.97TrpAla: 0.97 ± 0.024	0.153TrpCys: 0.153 ± 0.008	0.701TrpAsp: 0.701 ± 0.02	0.764TrpGlu: 0.764 ± 0.02	0.593TrpPhe: 0.593 ± 0.016	0.935TrpGly: 0.935 ± 0.023	0.479TrpHis: 0.479 ± 0.015	0.882TrpIle: 0.882 ± 0.02	0.533TrpLys: 0.533 ± 0.014	1.911TrpLeu: 1.911 ± 0.031	0.363TrpMet: 0.363 ± 0.012	0.647TrpAsn: 0.647 ± 0.018	0.616TrpPro: 0.616 ± 0.016	1.028TrpGln: 1.028 ± 0.024	0.929TrpArg: 0.929 ± 0.018	1.158TrpSer: 1.158 ± 0.028	0.789TrpThr: 0.789 ± 0.018	0.747TrpVal: 0.747 ± 0.019	0.284TrpTrp: 0.284 ± 0.011	0.468TrpTyr: 0.468 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.879TyrAla: 2.879 ± 0.036	0.361TyrCys: 0.361 ± 0.014	1.554TyrAsp: 1.554 ± 0.03	1.689TyrGlu: 1.689 ± 0.029	1.161TyrPhe: 1.161 ± 0.023	2.257TyrGly: 2.257 ± 0.031	0.912TyrHis: 0.912 ± 0.021	1.715TyrIle: 1.715 ± 0.025	0.913TyrLys: 0.913 ± 0.021	3.397TyrLeu: 3.397 ± 0.037	0.655TyrMet: 0.655 ± 0.017	1.147TyrAsn: 1.147 ± 0.027	1.588TyrPro: 1.588 ± 0.028	1.799TyrGln: 1.799 ± 0.031	2.022TyrArg: 2.022 ± 0.029	1.797TyrSer: 1.797 ± 0.026	1.929TyrThr: 1.929 ± 0.031	2.041TyrVal: 2.041 ± 0.066	0.556TyrTrp: 0.556 ± 0.016	1.109TyrTyr: 1.109 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7631 proteins (2422746 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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