Amino acid dipepetide frequency for Aequorivita viscosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.537AlaAla: 4.537 ± 0.084	0.534AlaCys: 0.534 ± 0.025	3.354AlaAsp: 3.354 ± 0.061	4.354AlaGlu: 4.354 ± 0.084	3.324AlaPhe: 3.324 ± 0.064	4.306AlaGly: 4.306 ± 0.088	1.124AlaHis: 1.124 ± 0.033	5.424AlaIle: 5.424 ± 0.076	4.423AlaLys: 4.423 ± 0.076	6.256AlaLeu: 6.256 ± 0.083	1.66AlaMet: 1.66 ± 0.046	3.465AlaAsn: 3.465 ± 0.068	1.954AlaPro: 1.954 ± 0.044	2.374AlaGln: 2.374 ± 0.049	2.176AlaArg: 2.176 ± 0.052	4.38AlaSer: 4.38 ± 0.066	4.003AlaThr: 4.003 ± 0.103	4.26AlaVal: 4.26 ± 0.073	0.54AlaTrp: 0.54 ± 0.027	2.421AlaTyr: 2.421 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.446CysAla: 0.446 ± 0.023	0.092CysCys: 0.092 ± 0.01	0.421CysAsp: 0.421 ± 0.024	0.496CysGlu: 0.496 ± 0.024	0.377CysPhe: 0.377 ± 0.022	0.649CysGly: 0.649 ± 0.028	0.144CysHis: 0.144 ± 0.012	0.538CysIle: 0.538 ± 0.027	0.392CysLys: 0.392 ± 0.02	0.602CysLeu: 0.602 ± 0.024	0.126CysMet: 0.126 ± 0.013	0.391CysAsn: 0.391 ± 0.019	0.327CysPro: 0.327 ± 0.023	0.187CysGln: 0.187 ± 0.016	0.226CysArg: 0.226 ± 0.015	0.523CysSer: 0.523 ± 0.027	0.446CysThr: 0.446 ± 0.024	0.398CysVal: 0.398 ± 0.02	0.067CysTrp: 0.067 ± 0.011	0.289CysTyr: 0.289 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.639AspAla: 3.639 ± 0.07	0.409AspCys: 0.409 ± 0.025	2.983AspAsp: 2.983 ± 0.063	3.746AspGlu: 3.746 ± 0.066	3.724AspPhe: 3.724 ± 0.055	3.824AspGly: 3.824 ± 0.093	0.833AspHis: 0.833 ± 0.028	4.234AspIle: 4.234 ± 0.077	3.857AspLys: 3.857 ± 0.086	4.926AspLeu: 4.926 ± 0.07	1.096AspMet: 1.096 ± 0.035	3.049AspAsn: 3.049 ± 0.064	1.814AspPro: 1.814 ± 0.05	1.381AspGln: 1.381 ± 0.035	2.021AspArg: 2.021 ± 0.043	3.512AspSer: 3.512 ± 0.062	2.737AspThr: 2.737 ± 0.05	3.659AspVal: 3.659 ± 0.062	0.693AspTrp: 0.693 ± 0.027	2.699AspTyr: 2.699 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.684GluAla: 4.684 ± 0.073	0.331GluCys: 0.331 ± 0.018	3.609GluAsp: 3.609 ± 0.06	5.04GluGlu: 5.04 ± 0.093	3.09GluPhe: 3.09 ± 0.055	3.895GluGly: 3.895 ± 0.082	1.1GluHis: 1.1 ± 0.031	5.853GluIle: 5.853 ± 0.088	6.105GluLys: 6.105 ± 0.105	6.163GluLeu: 6.163 ± 0.096	1.898GluMet: 1.898 ± 0.04	5.085GluAsn: 5.085 ± 0.075	1.588GluPro: 1.588 ± 0.043	2.145GluGln: 2.145 ± 0.045	2.731GluArg: 2.731 ± 0.057	3.482GluSer: 3.482 ± 0.065	4.044GluThr: 4.044 ± 0.066	4.519GluVal: 4.519 ± 0.071	0.639GluTrp: 0.639 ± 0.027	2.585GluTyr: 2.585 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.107PheAla: 3.107 ± 0.06	0.374PheCys: 0.374 ± 0.02	3.21PheAsp: 3.21 ± 0.059	3.665PheGlu: 3.665 ± 0.064	2.793PhePhe: 2.793 ± 0.07	3.707PheGly: 3.707 ± 0.066	0.864PheHis: 0.864 ± 0.033	3.828PheIle: 3.828 ± 0.069	3.611PheLys: 3.611 ± 0.074	4.883PheLeu: 4.883 ± 0.093	1.035PheMet: 1.035 ± 0.029	3.201PheAsn: 3.201 ± 0.072	1.853PhePro: 1.853 ± 0.043	1.668PheGln: 1.668 ± 0.045	1.769PheArg: 1.769 ± 0.053	4.102PheSer: 4.102 ± 0.07	3.118PheThr: 3.118 ± 0.062	3.151PheVal: 3.151 ± 0.056	0.541PheTrp: 0.541 ± 0.026	2.209PheTyr: 2.209 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.24GlyAla: 4.24 ± 0.058	0.542GlyCys: 0.542 ± 0.03	3.588GlyAsp: 3.588 ± 0.08	3.896GlyGlu: 3.896 ± 0.074	3.667GlyPhe: 3.667 ± 0.066	4.685GlyGly: 4.685 ± 0.108	1.047GlyHis: 1.047 ± 0.029	5.46GlyIle: 5.46 ± 0.088	4.858GlyLys: 4.858 ± 0.074	5.515GlyLeu: 5.515 ± 0.069	1.713GlyMet: 1.713 ± 0.048	3.9GlyAsn: 3.9 ± 0.084	1.372GlyPro: 1.372 ± 0.039	1.867GlyGln: 1.867 ± 0.049	2.177GlyArg: 2.177 ± 0.043	4.175GlySer: 4.175 ± 0.072	4.135GlyThr: 4.135 ± 0.129	4.424GlyVal: 4.424 ± 0.069	0.758GlyTrp: 0.758 ± 0.026	2.785GlyTyr: 2.785 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.863HisAla: 0.863 ± 0.029	0.165HisCys: 0.165 ± 0.013	0.8HisAsp: 0.8 ± 0.028	0.864HisGlu: 0.864 ± 0.028	1.142HisPhe: 1.142 ± 0.033	0.982HisGly: 0.982 ± 0.028	0.444HisHis: 0.444 ± 0.023	1.376HisIle: 1.376 ± 0.036	1.175HisLys: 1.175 ± 0.037	1.777HisLeu: 1.777 ± 0.042	0.23HisMet: 0.23 ± 0.018	0.957HisAsn: 0.957 ± 0.04	0.898HisPro: 0.898 ± 0.031	0.658HisGln: 0.658 ± 0.026	0.684HisArg: 0.684 ± 0.028	1.086HisSer: 1.086 ± 0.033	0.956HisThr: 0.956 ± 0.03	0.813HisVal: 0.813 ± 0.026	0.219HisTrp: 0.219 ± 0.014	0.851HisTyr: 0.851 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.741IleAla: 5.741 ± 0.082	0.626IleCys: 0.626 ± 0.028	4.77IleAsp: 4.77 ± 0.092	5.493IleGlu: 5.493 ± 0.081	3.662IlePhe: 3.662 ± 0.071	4.958IleGly: 4.958 ± 0.083	1.255IleHis: 1.255 ± 0.039	5.806IleIle: 5.806 ± 0.095	5.344IleLys: 5.344 ± 0.084	6.973IleLeu: 6.973 ± 0.107	1.328IleMet: 1.328 ± 0.041	4.266IleAsn: 4.266 ± 0.072	3.342IlePro: 3.342 ± 0.06	2.429IleGln: 2.429 ± 0.046	2.781IleArg: 2.781 ± 0.052	5.92IleSer: 5.92 ± 0.091	4.689IleThr: 4.689 ± 0.073	4.84IleVal: 4.84 ± 0.086	0.672IleTrp: 0.672 ± 0.024	2.831IleTyr: 2.831 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.651LysAla: 4.651 ± 0.094	0.315LysCys: 0.315 ± 0.02	4.014LysAsp: 4.014 ± 0.081	6.019LysGlu: 6.019 ± 0.104	3.02LysPhe: 3.02 ± 0.052	4.293LysGly: 4.293 ± 0.068	1.323LysHis: 1.323 ± 0.039	5.79LysIle: 5.79 ± 0.085	6.589LysLys: 6.589 ± 0.105	6.448LysLeu: 6.448 ± 0.098	2.133LysMet: 2.133 ± 0.05	5.093LysAsn: 5.093 ± 0.082	2.455LysPro: 2.455 ± 0.059	2.673LysGln: 2.673 ± 0.061	2.917LysArg: 2.917 ± 0.058	4.404LysSer: 4.404 ± 0.073	4.579LysThr: 4.579 ± 0.071	4.51LysVal: 4.51 ± 0.065	0.738LysTrp: 0.738 ± 0.028	3.008LysTyr: 3.008 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.948LeuAla: 5.948 ± 0.091	0.623LeuCys: 0.623 ± 0.025	5.048LeuAsp: 5.048 ± 0.075	6.307LeuGlu: 6.307 ± 0.09	4.848LeuPhe: 4.848 ± 0.087	5.763LeuGly: 5.763 ± 0.091	1.632LeuHis: 1.632 ± 0.047	6.756LeuIle: 6.756 ± 0.1	7.671LeuLys: 7.671 ± 0.106	8.907LeuLeu: 8.907 ± 0.143	2.113LeuMet: 2.113 ± 0.053	5.554LeuAsn: 5.554 ± 0.086	3.572LeuPro: 3.572 ± 0.063	3.359LeuGln: 3.359 ± 0.058	3.511LeuArg: 3.511 ± 0.065	6.612LeuSer: 6.612 ± 0.093	5.032LeuThr: 5.032 ± 0.072	5.316LeuVal: 5.316 ± 0.084	0.739LeuTrp: 0.739 ± 0.025	3.214LeuTyr: 3.214 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.765MetAla: 1.765 ± 0.04	0.134MetCys: 0.134 ± 0.011	1.304MetAsp: 1.304 ± 0.041	1.601MetGlu: 1.601 ± 0.041	0.93MetPhe: 0.93 ± 0.042	1.535MetGly: 1.535 ± 0.044	0.377MetHis: 0.377 ± 0.018	1.487MetIle: 1.487 ± 0.044	2.239MetLys: 2.239 ± 0.046	2.074MetLeu: 2.074 ± 0.049	0.568MetMet: 0.568 ± 0.025	1.268MetAsn: 1.268 ± 0.036	0.851MetPro: 0.851 ± 0.034	0.78MetGln: 0.78 ± 0.031	0.888MetArg: 0.888 ± 0.033	1.321MetSer: 1.321 ± 0.04	1.123MetThr: 1.123 ± 0.034	1.437MetVal: 1.437 ± 0.039	0.166MetTrp: 0.166 ± 0.011	0.705MetTyr: 0.705 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.761AsnAla: 3.761 ± 0.069	0.461AsnCys: 0.461 ± 0.024	3.095AsnAsp: 3.095 ± 0.056	3.809AsnGlu: 3.809 ± 0.065	3.018AsnPhe: 3.018 ± 0.054	4.031AsnGly: 4.031 ± 0.08	1.021AsnHis: 1.021 ± 0.03	4.708AsnIle: 4.708 ± 0.078	4.032AsnLys: 4.032 ± 0.073	5.685AsnLeu: 5.685 ± 0.073	1.196AsnMet: 1.196 ± 0.035	3.743AsnAsn: 3.743 ± 0.079	3.009AsnPro: 3.009 ± 0.06	2.121AsnGln: 2.121 ± 0.055	2.255AsnArg: 2.255 ± 0.054	3.986AsnSer: 3.986 ± 0.085	3.669AsnThr: 3.669 ± 0.084	3.528AsnVal: 3.528 ± 0.084	0.758AsnTrp: 0.758 ± 0.033	2.74AsnTyr: 2.74 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	1.977ProAla: 1.977 ± 0.05	0.227ProCys: 0.227 ± 0.02	1.999ProAsp: 1.999 ± 0.044	2.869ProGlu: 2.869 ± 0.054	1.985ProPhe: 1.985 ± 0.045	2.075ProGly: 2.075 ± 0.054	0.624ProHis: 0.624 ± 0.023	2.676ProIle: 2.676 ± 0.056	2.624ProLys: 2.624 ± 0.06	3.074ProLeu: 3.074 ± 0.055	0.814ProMet: 0.814 ± 0.027	2.307ProAsn: 2.307 ± 0.055	0.929ProPro: 0.929 ± 0.041	1.217ProGln: 1.217 ± 0.037	1.028ProArg: 1.028 ± 0.033	2.328ProSer: 2.328 ± 0.054	2.052ProThr: 2.052 ± 0.042	2.341ProVal: 2.341 ± 0.05	0.318ProTrp: 0.318 ± 0.018	1.386ProTyr: 1.386 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.053GlnAla: 2.053 ± 0.047	0.177GlnCys: 0.177 ± 0.016	1.621GlnAsp: 1.621 ± 0.044	2.27GlnGlu: 2.27 ± 0.059	1.686GlnPhe: 1.686 ± 0.041	1.891GlnGly: 1.891 ± 0.043	0.575GlnHis: 0.575 ± 0.024	2.568GlnIle: 2.568 ± 0.052	2.761GlnLys: 2.761 ± 0.061	3.367GlnLeu: 3.367 ± 0.068	0.872GlnMet: 0.872 ± 0.028	2.184GlnAsn: 2.184 ± 0.042	1.078GlnPro: 1.078 ± 0.031	1.413GlnGln: 1.413 ± 0.049	1.344GlnArg: 1.344 ± 0.038	1.892GlnSer: 1.892 ± 0.04	1.832GlnThr: 1.832 ± 0.043	1.918GlnVal: 1.918 ± 0.042	0.346GlnTrp: 0.346 ± 0.022	1.33GlnTyr: 1.33 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	2.176ArgAla: 2.176 ± 0.047	0.23ArgCys: 0.23 ± 0.028	1.956ArgAsp: 1.956 ± 0.049	2.461ArgGlu: 2.461 ± 0.053	1.994ArgPhe: 1.994 ± 0.047	2.122ArgGly: 2.122 ± 0.05	0.598ArgHis: 0.598 ± 0.023	3.008ArgIle: 3.008 ± 0.062	3.006ArgLys: 3.006 ± 0.06	3.441ArgLeu: 3.441 ± 0.055	0.96ArgMet: 0.96 ± 0.029	2.403ArgAsn: 2.403 ± 0.044	1.12ArgPro: 1.12 ± 0.031	1.171ArgGln: 1.171 ± 0.037	1.499ArgArg: 1.499 ± 0.043	2.026ArgSer: 2.026 ± 0.051	1.914ArgThr: 1.914 ± 0.041	2.239ArgVal: 2.239 ± 0.045	0.396ArgTrp: 0.396 ± 0.02	1.583ArgTyr: 1.583 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.888SerAla: 3.888 ± 0.074	0.63SerCys: 0.63 ± 0.026	3.402SerAsp: 3.402 ± 0.056	4.853SerGlu: 4.853 ± 0.073	3.885SerPhe: 3.885 ± 0.065	4.71SerGly: 4.71 ± 0.092	1.045SerHis: 1.045 ± 0.033	5.154SerIle: 5.154 ± 0.079	4.829SerLys: 4.829 ± 0.069	6.151SerLeu: 6.151 ± 0.105	1.299SerMet: 1.299 ± 0.036	3.761SerAsn: 3.761 ± 0.079	2.266SerPro: 2.266 ± 0.051	2.281SerGln: 2.281 ± 0.046	2.258SerArg: 2.258 ± 0.053	4.373SerSer: 4.373 ± 0.082	3.559SerThr: 3.559 ± 0.068	4.271SerVal: 4.271 ± 0.078	0.718SerTrp: 0.718 ± 0.035	2.746SerTyr: 2.746 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.951ThrAla: 3.951 ± 0.076	0.352ThrCys: 0.352 ± 0.02	3.277ThrAsp: 3.277 ± 0.061	3.633ThrGlu: 3.633 ± 0.065	2.933ThrPhe: 2.933 ± 0.055	4.129ThrGly: 4.129 ± 0.093	1.013ThrHis: 1.013 ± 0.036	4.78ThrIle: 4.78 ± 0.07	3.518ThrLys: 3.518 ± 0.061	5.488ThrLeu: 5.488 ± 0.084	1.05ThrMet: 1.05 ± 0.034	3.287ThrAsn: 3.287 ± 0.08	2.494ThrPro: 2.494 ± 0.075	1.786ThrGln: 1.786 ± 0.04	1.713ThrArg: 1.713 ± 0.043	4.007ThrSer: 4.007 ± 0.093	3.688ThrThr: 3.688 ± 0.117	3.989ThrVal: 3.989 ± 0.085	0.569ThrTrp: 0.569 ± 0.025	2.308ThrTyr: 2.308 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.424ValAla: 4.424 ± 0.069	0.496ValCys: 0.496 ± 0.021	3.533ValAsp: 3.533 ± 0.063	4.085ValGlu: 4.085 ± 0.066	3.517ValPhe: 3.517 ± 0.065	3.952ValGly: 3.952 ± 0.068	0.992ValHis: 0.992 ± 0.031	4.729ValIle: 4.729 ± 0.073	4.318ValLys: 4.318 ± 0.069	6.023ValLeu: 6.023 ± 0.095	1.402ValMet: 1.402 ± 0.043	3.451ValAsn: 3.451 ± 0.069	2.258ValPro: 2.258 ± 0.053	1.882ValGln: 1.882 ± 0.046	2.187ValArg: 2.187 ± 0.051	4.609ValSer: 4.609 ± 0.078	3.555ValThr: 3.555 ± 0.085	4.349ValVal: 4.349 ± 0.079	0.57ValTrp: 0.57 ± 0.024	2.496ValTyr: 2.496 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.618TrpAla: 0.618 ± 0.028	0.065TrpCys: 0.065 ± 0.008	0.572TrpAsp: 0.572 ± 0.027	0.711TrpGlu: 0.711 ± 0.035	0.565TrpPhe: 0.565 ± 0.03	0.62TrpGly: 0.62 ± 0.027	0.213TrpHis: 0.213 ± 0.016	0.777TrpIle: 0.777 ± 0.03	0.742TrpLys: 0.742 ± 0.032	0.922TrpLeu: 0.922 ± 0.03	0.326TrpMet: 0.326 ± 0.02	0.72TrpAsn: 0.72 ± 0.033	0.214TrpPro: 0.214 ± 0.015	0.382TrpGln: 0.382 ± 0.021	0.412TrpArg: 0.412 ± 0.023	0.558TrpSer: 0.558 ± 0.026	0.535TrpThr: 0.535 ± 0.026	0.569TrpVal: 0.569 ± 0.024	0.115TrpTrp: 0.115 ± 0.012	0.396TrpTyr: 0.396 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.4TyrAla: 2.4 ± 0.044	0.354TyrCys: 0.354 ± 0.021	2.284TyrAsp: 2.284 ± 0.05	2.412TyrGlu: 2.412 ± 0.062	2.523TyrPhe: 2.523 ± 0.057	2.674TyrGly: 2.674 ± 0.052	0.715TyrHis: 0.715 ± 0.026	2.774TyrIle: 2.774 ± 0.054	2.879TyrLys: 2.879 ± 0.053	3.853TyrLeu: 3.853 ± 0.071	0.733TyrMet: 0.733 ± 0.028	2.543TyrAsn: 2.543 ± 0.058	1.456TyrPro: 1.456 ± 0.041	1.406TyrGln: 1.406 ± 0.044	1.728TyrArg: 1.728 ± 0.043	2.783TyrSer: 2.783 ± 0.058	2.3TyrThr: 2.3 ± 0.059	2.296TyrVal: 2.296 ± 0.058	0.471TyrTrp: 0.471 ± 0.022	1.923TyrTyr: 1.923 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3078 proteins (1009815 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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