Amino acid dipepetide frequency for Haloarcula hispanica virus PH1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.037AlaAla: 14.037 ± 1.826
0.453AlaCys: 0.453 ± 0.241
13.131AlaAsp: 13.131 ± 1.341
8.49AlaGlu: 8.49 ± 1.265
4.415AlaPhe: 4.415 ± 1.005
8.603AlaGly: 8.603 ± 1.526
1.698AlaHis: 1.698 ± 0.435
2.49AlaIle: 2.49 ± 0.51
1.585AlaLys: 1.585 ± 0.34
7.584AlaLeu: 7.584 ± 1.22
3.17AlaMet: 3.17 ± 0.728
2.151AlaAsn: 2.151 ± 0.469
3.509AlaPro: 3.509 ± 0.609
3.056AlaGln: 3.056 ± 0.498
7.018AlaArg: 7.018 ± 1.047
4.754AlaSer: 4.754 ± 0.925
5.773AlaThr: 5.773 ± 0.716
10.188AlaVal: 10.188 ± 1.165
2.377AlaTrp: 2.377 ± 0.568
2.038AlaTyr: 2.038 ± 0.403
0.0AlaXaa: 0.0 ± 0.0
Cys
0.679CysAla: 0.679 ± 0.305
0.0CysCys: 0.0 ± 0.0
0.906CysAsp: 0.906 ± 0.394
0.453CysGlu: 0.453 ± 0.188
0.0CysPhe: 0.0 ± 0.0
1.019CysGly: 1.019 ± 0.435
0.113CysHis: 0.113 ± 0.114
0.34CysIle: 0.34 ± 0.263
0.113CysLys: 0.113 ± 0.143
0.566CysLeu: 0.566 ± 0.269
0.34CysMet: 0.34 ± 0.275
0.113CysAsn: 0.113 ± 0.125
0.906CysPro: 0.906 ± 0.311
0.453CysGln: 0.453 ± 0.297
1.019CysArg: 1.019 ± 0.412
0.906CysSer: 0.906 ± 0.406
0.34CysThr: 0.34 ± 0.196
0.0CysVal: 0.0 ± 0.0
0.453CysTrp: 0.453 ± 0.315
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
12.225AspAla: 12.225 ± 1.597
0.792AspCys: 0.792 ± 0.346
15.621AspAsp: 15.621 ± 1.994
9.509AspGlu: 9.509 ± 1.265
3.622AspPhe: 3.622 ± 0.753
12.225AspGly: 12.225 ± 1.399
2.038AspHis: 2.038 ± 0.601
3.509AspIle: 3.509 ± 0.612
1.698AspLys: 1.698 ± 0.519
7.245AspLeu: 7.245 ± 0.802
1.019AspMet: 1.019 ± 0.35
1.358AspAsn: 1.358 ± 0.545
7.471AspPro: 7.471 ± 1.205
2.943AspGln: 2.943 ± 0.468
4.981AspArg: 4.981 ± 0.808
5.434AspSer: 5.434 ± 0.735
4.188AspThr: 4.188 ± 0.6
6.113AspVal: 6.113 ± 1.023
1.698AspTrp: 1.698 ± 0.538
3.396AspTyr: 3.396 ± 0.608
0.0AspXaa: 0.0 ± 0.0
Glu
10.414GluAla: 10.414 ± 1.591
0.906GluCys: 0.906 ± 0.375
7.811GluAsp: 7.811 ± 1.264
9.509GluGlu: 9.509 ± 1.74
2.038GluPhe: 2.038 ± 0.38
7.018GluGly: 7.018 ± 0.871
1.924GluHis: 1.924 ± 0.589
1.811GluIle: 1.811 ± 0.579
2.943GluLys: 2.943 ± 0.516
3.17GluLeu: 3.17 ± 0.87
2.377GluMet: 2.377 ± 0.555
3.396GluAsn: 3.396 ± 0.59
3.17GluPro: 3.17 ± 0.591
2.717GluGln: 2.717 ± 0.458
5.886GluArg: 5.886 ± 1.137
4.641GluSer: 4.641 ± 0.805
4.415GluThr: 4.415 ± 0.616
6.339GluVal: 6.339 ± 0.842
1.811GluTrp: 1.811 ± 0.431
2.604GluTyr: 2.604 ± 0.554
0.0GluXaa: 0.0 ± 0.0
Phe
2.83PheAla: 2.83 ± 0.607
0.113PheCys: 0.113 ± 0.118
3.396PheAsp: 3.396 ± 0.73
2.943PheGlu: 2.943 ± 0.633
1.132PhePhe: 1.132 ± 0.35
3.056PheGly: 3.056 ± 0.497
0.679PheHis: 0.679 ± 0.262
0.792PheIle: 0.792 ± 0.282
0.566PheLys: 0.566 ± 0.209
1.245PheLeu: 1.245 ± 0.375
0.566PheMet: 0.566 ± 0.23
1.245PheAsn: 1.245 ± 0.537
1.132PhePro: 1.132 ± 0.366
0.792PheGln: 0.792 ± 0.24
0.906PheArg: 0.906 ± 0.39
1.924PheSer: 1.924 ± 0.488
2.377PheThr: 2.377 ± 0.608
1.698PheVal: 1.698 ± 0.519
0.566PheTrp: 0.566 ± 0.22
0.679PheTyr: 0.679 ± 0.22
0.0PheXaa: 0.0 ± 0.0
Gly
10.075GlyAla: 10.075 ± 2.487
0.679GlyCys: 0.679 ± 0.224
11.094GlyAsp: 11.094 ± 1.266
5.886GlyGlu: 5.886 ± 0.901
1.585GlyPhe: 1.585 ± 0.321
14.037GlyGly: 14.037 ± 2.133
1.811GlyHis: 1.811 ± 0.536
3.056GlyIle: 3.056 ± 0.802
3.056GlyLys: 3.056 ± 0.62
6.792GlyLeu: 6.792 ± 0.914
1.245GlyMet: 1.245 ± 0.38
2.604GlyAsn: 2.604 ± 0.732
5.547GlyPro: 5.547 ± 1.091
3.283GlyGln: 3.283 ± 0.655
6.226GlyArg: 6.226 ± 0.837
4.415GlySer: 4.415 ± 0.834
6.226GlyThr: 6.226 ± 0.754
6.792GlyVal: 6.792 ± 1.061
1.698GlyTrp: 1.698 ± 0.329
3.283GlyTyr: 3.283 ± 0.691
0.0GlyXaa: 0.0 ± 0.0
His
0.906HisAla: 0.906 ± 0.319
0.34HisCys: 0.34 ± 0.273
1.811HisAsp: 1.811 ± 0.557
1.698HisGlu: 1.698 ± 0.407
0.566HisPhe: 0.566 ± 0.276
2.038HisGly: 2.038 ± 0.406
0.226HisHis: 0.226 ± 0.177
1.019HisIle: 1.019 ± 0.32
0.226HisLys: 0.226 ± 0.15
1.019HisLeu: 1.019 ± 0.322
0.113HisMet: 0.113 ± 0.098
0.453HisAsn: 0.453 ± 0.241
1.358HisPro: 1.358 ± 0.479
0.566HisGln: 0.566 ± 0.26
1.245HisArg: 1.245 ± 0.296
0.34HisSer: 0.34 ± 0.225
1.245HisThr: 1.245 ± 0.313
1.358HisVal: 1.358 ± 0.416
0.34HisTrp: 0.34 ± 0.177
0.792HisTyr: 0.792 ± 0.269
0.0HisXaa: 0.0 ± 0.0
Ile
2.604IleAla: 2.604 ± 0.51
0.0IleCys: 0.0 ± 0.0
1.924IleAsp: 1.924 ± 0.381
2.604IleGlu: 2.604 ± 0.49
0.679IlePhe: 0.679 ± 0.235
2.943IleGly: 2.943 ± 0.462
0.226IleHis: 0.226 ± 0.25
0.906IleIle: 0.906 ± 0.353
0.453IleLys: 0.453 ± 0.198
1.019IleLeu: 1.019 ± 0.328
0.792IleMet: 0.792 ± 0.238
1.132IleAsn: 1.132 ± 0.324
1.132IlePro: 1.132 ± 0.324
1.132IleGln: 1.132 ± 0.396
1.924IleArg: 1.924 ± 0.5
2.151IleSer: 2.151 ± 0.752
1.585IleThr: 1.585 ± 0.45
2.49IleVal: 2.49 ± 0.583
0.0IleTrp: 0.0 ± 0.0
1.019IleTyr: 1.019 ± 0.327
0.0IleXaa: 0.0 ± 0.0
Lys
2.943LysAla: 2.943 ± 0.585
0.226LysCys: 0.226 ± 0.13
2.151LysAsp: 2.151 ± 0.567
1.472LysGlu: 1.472 ± 0.63
0.566LysPhe: 0.566 ± 0.232
1.472LysGly: 1.472 ± 0.5
0.566LysHis: 0.566 ± 0.251
0.34LysIle: 0.34 ± 0.255
0.679LysLys: 0.679 ± 0.285
2.038LysLeu: 2.038 ± 0.598
0.113LysMet: 0.113 ± 0.104
1.698LysAsn: 1.698 ± 0.351
1.472LysPro: 1.472 ± 0.397
1.472LysGln: 1.472 ± 0.322
2.151LysArg: 2.151 ± 0.528
0.792LysSer: 0.792 ± 0.349
1.585LysThr: 1.585 ± 0.433
1.924LysVal: 1.924 ± 0.439
0.226LysTrp: 0.226 ± 0.177
0.453LysTyr: 0.453 ± 0.223
0.0LysXaa: 0.0 ± 0.0
Leu
7.018LeuAla: 7.018 ± 0.79
0.566LeuCys: 0.566 ± 0.316
6.113LeuAsp: 6.113 ± 0.725
4.868LeuGlu: 4.868 ± 0.886
1.132LeuPhe: 1.132 ± 0.381
6.792LeuGly: 6.792 ± 0.879
1.698LeuHis: 1.698 ± 0.523
1.245LeuIle: 1.245 ± 0.447
1.698LeuLys: 1.698 ± 0.476
5.773LeuLeu: 5.773 ± 0.966
1.472LeuMet: 1.472 ± 0.513
0.566LeuAsn: 0.566 ± 0.205
3.962LeuPro: 3.962 ± 0.831
1.811LeuGln: 1.811 ± 0.374
5.547LeuArg: 5.547 ± 0.967
2.83LeuSer: 2.83 ± 0.674
4.754LeuThr: 4.754 ± 0.798
4.188LeuVal: 4.188 ± 0.466
0.226LeuTrp: 0.226 ± 0.164
2.038LeuTyr: 2.038 ± 0.539
0.0LeuXaa: 0.0 ± 0.0
Met
2.377MetAla: 2.377 ± 0.703
0.453MetCys: 0.453 ± 0.221
2.604MetAsp: 2.604 ± 0.618
0.453MetGlu: 0.453 ± 0.201
0.453MetPhe: 0.453 ± 0.243
2.151MetGly: 2.151 ± 0.416
0.0MetHis: 0.0 ± 0.0
0.453MetIle: 0.453 ± 0.203
0.566MetLys: 0.566 ± 0.217
0.453MetLeu: 0.453 ± 0.223
0.566MetMet: 0.566 ± 0.349
1.472MetAsn: 1.472 ± 0.409
0.679MetPro: 0.679 ± 0.361
0.226MetGln: 0.226 ± 0.161
1.698MetArg: 1.698 ± 0.519
1.019MetSer: 1.019 ± 0.422
1.811MetThr: 1.811 ± 0.495
1.585MetVal: 1.585 ± 0.373
0.226MetTrp: 0.226 ± 0.177
0.113MetTyr: 0.113 ± 0.113
0.0MetXaa: 0.0 ± 0.0
Asn
3.17AsnAla: 3.17 ± 0.548
0.113AsnCys: 0.113 ± 0.098
2.49AsnAsp: 2.49 ± 0.83
2.038AsnGlu: 2.038 ± 0.453
0.226AsnPhe: 0.226 ± 0.164
3.396AsnGly: 3.396 ± 0.749
0.453AsnHis: 0.453 ± 0.237
1.245AsnIle: 1.245 ± 0.371
0.906AsnLys: 0.906 ± 0.284
2.038AsnLeu: 2.038 ± 0.529
0.566AsnMet: 0.566 ± 0.292
1.245AsnAsn: 1.245 ± 0.591
2.038AsnPro: 2.038 ± 0.37
1.019AsnGln: 1.019 ± 0.39
1.585AsnArg: 1.585 ± 0.397
1.472AsnSer: 1.472 ± 0.628
2.377AsnThr: 2.377 ± 0.407
1.358AsnVal: 1.358 ± 0.497
0.906AsnTrp: 0.906 ± 0.331
0.566AsnTyr: 0.566 ± 0.203
0.0AsnXaa: 0.0 ± 0.0
Pro
4.754ProAla: 4.754 ± 0.624
0.453ProCys: 0.453 ± 0.268
7.811ProAsp: 7.811 ± 1.083
4.188ProGlu: 4.188 ± 0.71
2.151ProPhe: 2.151 ± 0.399
5.434ProGly: 5.434 ± 1.098
0.792ProHis: 0.792 ± 0.346
1.245ProIle: 1.245 ± 0.37
0.679ProLys: 0.679 ± 0.294
2.151ProLeu: 2.151 ± 0.621
0.566ProMet: 0.566 ± 0.261
2.264ProAsn: 2.264 ± 0.486
3.17ProPro: 3.17 ± 0.569
1.924ProGln: 1.924 ± 0.478
2.717ProArg: 2.717 ± 0.631
2.49ProSer: 2.49 ± 0.724
3.509ProThr: 3.509 ± 0.681
3.736ProVal: 3.736 ± 0.596
0.566ProTrp: 0.566 ± 0.221
1.019ProTyr: 1.019 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
4.868GlnAla: 4.868 ± 0.89
0.0GlnCys: 0.0 ± 0.0
2.604GlnAsp: 2.604 ± 0.504
2.038GlnGlu: 2.038 ± 0.551
1.245GlnPhe: 1.245 ± 0.418
2.49GlnGly: 2.49 ± 0.855
0.679GlnHis: 0.679 ± 0.258
1.585GlnIle: 1.585 ± 0.334
1.358GlnLys: 1.358 ± 0.346
2.038GlnLeu: 2.038 ± 0.514
0.566GlnMet: 0.566 ± 0.281
1.358GlnAsn: 1.358 ± 0.276
1.811GlnPro: 1.811 ± 0.44
2.038GlnGln: 2.038 ± 0.679
1.924GlnArg: 1.924 ± 0.532
1.358GlnSer: 1.358 ± 0.42
2.943GlnThr: 2.943 ± 0.611
2.604GlnVal: 2.604 ± 0.486
0.679GlnTrp: 0.679 ± 0.22
1.245GlnTyr: 1.245 ± 0.382
0.0GlnXaa: 0.0 ± 0.0
Arg
4.528ArgAla: 4.528 ± 0.716
1.132ArgCys: 1.132 ± 0.472
5.66ArgAsp: 5.66 ± 1.014
6.792ArgGlu: 6.792 ± 0.805
2.49ArgPhe: 2.49 ± 0.673
4.641ArgGly: 4.641 ± 1.023
0.113ArgHis: 0.113 ± 0.118
1.019ArgIle: 1.019 ± 0.287
2.151ArgLys: 2.151 ± 0.473
5.094ArgLeu: 5.094 ± 0.679
2.038ArgMet: 2.038 ± 0.508
1.245ArgAsn: 1.245 ± 0.356
2.377ArgPro: 2.377 ± 0.719
3.396ArgGln: 3.396 ± 0.559
5.773ArgArg: 5.773 ± 1.127
2.49ArgSer: 2.49 ± 0.678
5.434ArgThr: 5.434 ± 0.829
4.188ArgVal: 4.188 ± 0.802
1.472ArgTrp: 1.472 ± 0.47
1.698ArgTyr: 1.698 ± 0.411
0.0ArgXaa: 0.0 ± 0.0
Ser
4.302SerAla: 4.302 ± 0.765
0.679SerCys: 0.679 ± 0.289
4.754SerAsp: 4.754 ± 0.776
4.188SerGlu: 4.188 ± 0.569
1.472SerPhe: 1.472 ± 0.378
6.792SerGly: 6.792 ± 1.443
0.453SerHis: 0.453 ± 0.281
1.358SerIle: 1.358 ± 0.37
0.792SerLys: 0.792 ± 0.393
2.717SerLeu: 2.717 ± 0.467
1.019SerMet: 1.019 ± 0.358
2.151SerAsn: 2.151 ± 0.38
2.943SerPro: 2.943 ± 0.642
1.811SerGln: 1.811 ± 0.505
3.17SerArg: 3.17 ± 0.735
3.056SerSer: 3.056 ± 0.627
2.83SerThr: 2.83 ± 0.604
3.962SerVal: 3.962 ± 0.766
0.679SerTrp: 0.679 ± 0.37
1.358SerTyr: 1.358 ± 0.522
0.0SerXaa: 0.0 ± 0.0
Thr
6.339ThrAla: 6.339 ± 1.175
0.679ThrCys: 0.679 ± 0.283
7.018ThrAsp: 7.018 ± 0.966
5.547ThrGlu: 5.547 ± 0.806
2.038ThrPhe: 2.038 ± 0.37
6.905ThrGly: 6.905 ± 0.783
0.792ThrHis: 0.792 ± 0.248
1.698ThrIle: 1.698 ± 0.399
0.906ThrLys: 0.906 ± 0.296
4.302ThrLeu: 4.302 ± 0.957
0.679ThrMet: 0.679 ± 0.263
1.811ThrAsn: 1.811 ± 0.514
2.943ThrPro: 2.943 ± 0.537
1.358ThrGln: 1.358 ± 0.327
2.83ThrArg: 2.83 ± 0.639
3.622ThrSer: 3.622 ± 0.743
5.094ThrThr: 5.094 ± 0.99
5.434ThrVal: 5.434 ± 0.554
1.472ThrTrp: 1.472 ± 0.427
2.151ThrTyr: 2.151 ± 0.587
0.0ThrXaa: 0.0 ± 0.0
Val
8.603ValAla: 8.603 ± 0.835
0.113ValCys: 0.113 ± 0.143
6.113ValAsp: 6.113 ± 0.683
8.83ValGlu: 8.83 ± 1.089
1.585ValPhe: 1.585 ± 0.466
5.207ValGly: 5.207 ± 1.043
2.264ValHis: 2.264 ± 0.509
1.358ValIle: 1.358 ± 0.444
2.151ValLys: 2.151 ± 0.482
4.754ValLeu: 4.754 ± 0.922
1.132ValMet: 1.132 ± 0.347
1.585ValAsn: 1.585 ± 0.507
4.188ValPro: 4.188 ± 0.869
3.056ValGln: 3.056 ± 0.637
3.849ValArg: 3.849 ± 0.649
4.302ValSer: 4.302 ± 0.871
3.849ValThr: 3.849 ± 0.626
4.868ValVal: 4.868 ± 0.94
1.019ValTrp: 1.019 ± 0.434
3.17ValTyr: 3.17 ± 0.586
0.0ValXaa: 0.0 ± 0.0
Trp
1.811TrpAla: 1.811 ± 0.483
0.566TrpCys: 0.566 ± 0.28
1.245TrpAsp: 1.245 ± 0.359
1.811TrpGlu: 1.811 ± 0.42
0.34TrpPhe: 0.34 ± 0.159
0.679TrpGly: 0.679 ± 0.28
0.679TrpHis: 0.679 ± 0.28
0.34TrpIle: 0.34 ± 0.176
1.019TrpLys: 1.019 ± 0.323
1.698TrpLeu: 1.698 ± 0.436
0.679TrpMet: 0.679 ± 0.312
0.226TrpAsn: 0.226 ± 0.226
0.34TrpPro: 0.34 ± 0.217
0.34TrpGln: 0.34 ± 0.157
0.792TrpArg: 0.792 ± 0.285
1.245TrpSer: 1.245 ± 0.395
1.358TrpThr: 1.358 ± 0.433
1.019TrpVal: 1.019 ± 0.347
0.226TrpTrp: 0.226 ± 0.168
0.453TrpTyr: 0.453 ± 0.257
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.151TyrAla: 2.151 ± 0.488
0.453TyrCys: 0.453 ± 0.297
2.83TyrAsp: 2.83 ± 0.552
1.585TyrGlu: 1.585 ± 0.38
0.906TyrPhe: 0.906 ± 0.391
2.49TyrGly: 2.49 ± 0.554
0.453TyrHis: 0.453 ± 0.194
0.906TyrIle: 0.906 ± 0.327
0.792TyrLys: 0.792 ± 0.467
2.604TyrLeu: 2.604 ± 0.627
0.226TyrMet: 0.226 ± 0.15
1.132TyrAsn: 1.132 ± 0.424
1.472TyrPro: 1.472 ± 0.44
2.038TyrGln: 2.038 ± 0.699
2.49TyrArg: 2.49 ± 0.641
1.245TyrSer: 1.245 ± 0.338
1.924TyrThr: 1.924 ± 0.491
2.151TyrVal: 2.151 ± 0.473
0.226TyrTrp: 0.226 ± 0.144
1.358TyrTyr: 1.358 ± 0.465
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (8835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski