Amino acid dipepetide frequency for Roseburia sp. CAG:45

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.49AlaAla: 7.49 ± 0.133
0.983AlaCys: 0.983 ± 0.039
4.726AlaAsp: 4.726 ± 0.097
5.985AlaGlu: 5.985 ± 0.11
3.058AlaPhe: 3.058 ± 0.074
6.299AlaGly: 6.299 ± 0.119
1.141AlaHis: 1.141 ± 0.039
5.388AlaIle: 5.388 ± 0.095
5.127AlaLys: 5.127 ± 0.1
6.91AlaLeu: 6.91 ± 0.115
2.503AlaMet: 2.503 ± 0.063
2.615AlaAsn: 2.615 ± 0.06
1.964AlaPro: 1.964 ± 0.057
2.246AlaGln: 2.246 ± 0.062
2.709AlaArg: 2.709 ± 0.066
4.013AlaSer: 4.013 ± 0.081
3.447AlaThr: 3.447 ± 0.072
6.165AlaVal: 6.165 ± 0.114
0.542AlaTrp: 0.542 ± 0.026
2.909AlaTyr: 2.909 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.96CysAla: 0.96 ± 0.037
0.278CysCys: 0.278 ± 0.021
0.776CysAsp: 0.776 ± 0.035
0.832CysGlu: 0.832 ± 0.034
0.632CysPhe: 0.632 ± 0.029
1.441CysGly: 1.441 ± 0.047
0.27CysHis: 0.27 ± 0.022
1.241CysIle: 1.241 ± 0.042
0.809CysLys: 0.809 ± 0.036
1.03CysLeu: 1.03 ± 0.042
0.47CysMet: 0.47 ± 0.025
0.594CysAsn: 0.594 ± 0.029
0.539CysPro: 0.539 ± 0.032
0.399CysGln: 0.399 ± 0.023
0.642CysArg: 0.642 ± 0.032
0.839CysSer: 0.839 ± 0.029
0.659CysThr: 0.659 ± 0.029
0.956CysVal: 0.956 ± 0.031
0.09CysTrp: 0.09 ± 0.01
0.586CysTyr: 0.586 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
4.783AspAla: 4.783 ± 0.095
0.783AspCys: 0.783 ± 0.038
2.95AspAsp: 2.95 ± 0.069
5.042AspGlu: 5.042 ± 0.102
2.558AspPhe: 2.558 ± 0.07
4.462AspGly: 4.462 ± 0.1
0.776AspHis: 0.776 ± 0.036
4.537AspIle: 4.537 ± 0.084
3.771AspLys: 3.771 ± 0.079
4.3AspLeu: 4.3 ± 0.078
1.96AspMet: 1.96 ± 0.055
2.39AspAsn: 2.39 ± 0.056
1.363AspPro: 1.363 ± 0.044
0.997AspGln: 0.997 ± 0.039
1.997AspArg: 1.997 ± 0.053
3.059AspSer: 3.059 ± 0.074
3.451AspThr: 3.451 ± 0.068
3.947AspVal: 3.947 ± 0.089
0.522AspTrp: 0.522 ± 0.028
3.172AspTyr: 3.172 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
5.941GluAla: 5.941 ± 0.116
0.832GluCys: 0.832 ± 0.034
4.66GluAsp: 4.66 ± 0.098
8.398GluGlu: 8.398 ± 0.149
2.505GluPhe: 2.505 ± 0.065
4.327GluGly: 4.327 ± 0.078
1.671GluHis: 1.671 ± 0.045
5.925GluIle: 5.925 ± 0.112
7.35GluLys: 7.35 ± 0.113
7.025GluLeu: 7.025 ± 0.097
2.665GluMet: 2.665 ± 0.062
4.499GluAsn: 4.499 ± 0.089
1.91GluPro: 1.91 ± 0.057
3.37GluGln: 3.37 ± 0.073
3.263GluArg: 3.263 ± 0.078
3.411GluSer: 3.411 ± 0.074
4.06GluThr: 4.06 ± 0.08
4.947GluVal: 4.947 ± 0.088
0.58GluTrp: 0.58 ± 0.03
3.134GluTyr: 3.134 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.04PheAla: 3.04 ± 0.07
0.697PheCys: 0.697 ± 0.036
2.484PheAsp: 2.484 ± 0.058
2.584PheGlu: 2.584 ± 0.066
1.865PhePhe: 1.865 ± 0.065
2.904PheGly: 2.904 ± 0.074
0.865PheHis: 0.865 ± 0.038
2.727PheIle: 2.727 ± 0.072
1.854PheLys: 1.854 ± 0.055
3.789PheLeu: 3.789 ± 0.097
1.182PheMet: 1.182 ± 0.042
1.457PheAsn: 1.457 ± 0.04
1.314PhePro: 1.314 ± 0.045
1.233PheGln: 1.233 ± 0.046
1.611PheArg: 1.611 ± 0.048
2.642PheSer: 2.642 ± 0.073
2.296PheThr: 2.296 ± 0.065
2.976PheVal: 2.976 ± 0.059
0.365PheTrp: 0.365 ± 0.024
1.831PheTyr: 1.831 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.813GlyAla: 4.813 ± 0.101
1.207GlyCys: 1.207 ± 0.052
3.411GlyAsp: 3.411 ± 0.079
4.728GlyGlu: 4.728 ± 0.096
2.998GlyPhe: 2.998 ± 0.068
4.425GlyGly: 4.425 ± 0.101
1.2GlyHis: 1.2 ± 0.043
6.472GlyIle: 6.472 ± 0.104
5.503GlyLys: 5.503 ± 0.096
5.556GlyLeu: 5.556 ± 0.095
2.608GlyMet: 2.608 ± 0.059
3.374GlyAsn: 3.374 ± 0.064
1.205GlyPro: 1.205 ± 0.047
2.031GlyGln: 2.031 ± 0.057
2.915GlyArg: 2.915 ± 0.067
3.995GlySer: 3.995 ± 0.089
4.436GlyThr: 4.436 ± 0.101
4.935GlyVal: 4.935 ± 0.098
0.617GlyTrp: 0.617 ± 0.036
3.243GlyTyr: 3.243 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.219HisAla: 1.219 ± 0.04
0.297HisCys: 0.297 ± 0.018
0.884HisAsp: 0.884 ± 0.039
1.057HisGlu: 1.057 ± 0.04
0.884HisPhe: 0.884 ± 0.037
1.316HisGly: 1.316 ± 0.042
0.421HisHis: 0.421 ± 0.035
1.431HisIle: 1.431 ± 0.049
1.113HisLys: 1.113 ± 0.041
1.565HisLeu: 1.565 ± 0.053
0.526HisMet: 0.526 ± 0.029
0.802HisAsn: 0.802 ± 0.032
0.851HisPro: 0.851 ± 0.037
0.588HisGln: 0.588 ± 0.029
0.718HisArg: 0.718 ± 0.032
0.911HisSer: 0.911 ± 0.03
1.0HisThr: 1.0 ± 0.036
1.106HisVal: 1.106 ± 0.039
0.151HisTrp: 0.151 ± 0.015
0.839HisTyr: 0.839 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.244IleAla: 6.244 ± 0.095
1.323IleCys: 1.323 ± 0.046
4.117IleAsp: 4.117 ± 0.098
5.283IleGlu: 5.283 ± 0.102
2.975IlePhe: 2.975 ± 0.081
5.396IleGly: 5.396 ± 0.105
1.467IleHis: 1.467 ± 0.048
5.499IleIle: 5.499 ± 0.11
4.124IleLys: 4.124 ± 0.074
7.155IleLeu: 7.155 ± 0.125
2.032IleMet: 2.032 ± 0.052
2.871IleAsn: 2.871 ± 0.071
3.063IlePro: 3.063 ± 0.066
2.19IleGln: 2.19 ± 0.059
3.613IleArg: 3.613 ± 0.075
4.985IleSer: 4.985 ± 0.098
4.405IleThr: 4.405 ± 0.091
4.975IleVal: 4.975 ± 0.096
0.621IleTrp: 0.621 ± 0.03
3.066IleTyr: 3.066 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
5.24LysAla: 5.24 ± 0.101
0.708LysCys: 0.708 ± 0.034
4.213LysAsp: 4.213 ± 0.087
7.795LysGlu: 7.795 ± 0.125
1.884LysPhe: 1.884 ± 0.058
4.013LysGly: 4.013 ± 0.07
1.06LysHis: 1.06 ± 0.039
5.016LysIle: 5.016 ± 0.082
6.64LysLys: 6.64 ± 0.125
5.473LysLeu: 5.473 ± 0.096
2.437LysMet: 2.437 ± 0.058
3.712LysAsn: 3.712 ± 0.072
1.88LysPro: 1.88 ± 0.053
2.409LysGln: 2.409 ± 0.064
2.92LysArg: 2.92 ± 0.065
3.411LysSer: 3.411 ± 0.087
3.613LysThr: 3.613 ± 0.071
4.54LysVal: 4.54 ± 0.082
0.505LysTrp: 0.505 ± 0.028
2.873LysTyr: 2.873 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
6.772LeuAla: 6.772 ± 0.106
1.34LeuCys: 1.34 ± 0.047
4.895LeuAsp: 4.895 ± 0.095
6.449LeuGlu: 6.449 ± 0.125
3.701LeuPhe: 3.701 ± 0.105
5.658LeuGly: 5.658 ± 0.104
1.594LeuHis: 1.594 ± 0.048
6.122LeuIle: 6.122 ± 0.11
6.374LeuLys: 6.374 ± 0.094
8.509LeuLeu: 8.509 ± 0.16
2.727LeuMet: 2.727 ± 0.075
3.925LeuAsn: 3.925 ± 0.086
3.21LeuPro: 3.21 ± 0.08
2.86LeuGln: 2.86 ± 0.068
3.412LeuArg: 3.412 ± 0.065
6.061LeuSer: 6.061 ± 0.099
5.037LeuThr: 5.037 ± 0.09
5.636LeuVal: 5.636 ± 0.093
0.628LeuTrp: 0.628 ± 0.031
3.327LeuTyr: 3.327 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.467MetAla: 2.467 ± 0.062
0.36MetCys: 0.36 ± 0.022
2.048MetAsp: 2.048 ± 0.049
2.749MetGlu: 2.749 ± 0.065
1.013MetPhe: 1.013 ± 0.037
2.104MetGly: 2.104 ± 0.047
0.567MetHis: 0.567 ± 0.031
2.223MetIle: 2.223 ± 0.061
2.709MetLys: 2.709 ± 0.061
2.772MetLeu: 2.772 ± 0.066
0.888MetMet: 0.888 ± 0.036
1.636MetAsn: 1.636 ± 0.045
1.162MetPro: 1.162 ± 0.041
1.26MetGln: 1.26 ± 0.041
1.23MetArg: 1.23 ± 0.042
1.801MetSer: 1.801 ± 0.047
1.761MetThr: 1.761 ± 0.047
2.111MetVal: 2.111 ± 0.058
0.207MetTrp: 0.207 ± 0.018
0.948MetTyr: 0.948 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.307AsnAla: 3.307 ± 0.078
0.654AsnCys: 0.654 ± 0.032
2.253AsnAsp: 2.253 ± 0.055
3.032AsnGlu: 3.032 ± 0.076
1.632AsnPhe: 1.632 ± 0.048
3.671AsnGly: 3.671 ± 0.096
0.857AsnHis: 0.857 ± 0.033
3.552AsnIle: 3.552 ± 0.078
2.578AsnLys: 2.578 ± 0.062
3.846AsnLeu: 3.846 ± 0.07
1.442AsnMet: 1.442 ± 0.044
1.931AsnAsn: 1.931 ± 0.06
1.991AsnPro: 1.991 ± 0.055
1.652AsnGln: 1.652 ± 0.048
2.114AsnArg: 2.114 ± 0.059
2.363AsnSer: 2.363 ± 0.06
2.472AsnThr: 2.472 ± 0.057
2.964AsnVal: 2.964 ± 0.069
0.38AsnTrp: 0.38 ± 0.025
2.119AsnTyr: 2.119 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
2.351ProAla: 2.351 ± 0.064
0.409ProCys: 0.409 ± 0.023
2.25ProAsp: 2.25 ± 0.063
3.244ProGlu: 3.244 ± 0.069
1.382ProPhe: 1.382 ± 0.045
2.121ProGly: 2.121 ± 0.051
0.492ProHis: 0.492 ± 0.027
1.927ProIle: 1.927 ± 0.05
1.897ProLys: 1.897 ± 0.048
2.607ProLeu: 2.607 ± 0.065
0.928ProMet: 0.928 ± 0.037
1.165ProAsn: 1.165 ± 0.044
0.61ProPro: 0.61 ± 0.034
1.023ProGln: 1.023 ± 0.038
0.798ProArg: 0.798 ± 0.035
1.535ProSer: 1.535 ± 0.055
1.395ProThr: 1.395 ± 0.045
2.81ProVal: 2.81 ± 0.073
0.311ProTrp: 0.311 ± 0.022
1.369ProTyr: 1.369 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.352GlnAla: 2.352 ± 0.068
0.347GlnCys: 0.347 ± 0.022
1.54GlnAsp: 1.54 ± 0.055
2.78GlnGlu: 2.78 ± 0.067
1.218GlnPhe: 1.218 ± 0.039
1.861GlnGly: 1.861 ± 0.058
0.49GlnHis: 0.49 ± 0.028
2.528GlnIle: 2.528 ± 0.062
2.788GlnLys: 2.788 ± 0.077
2.896GlnLeu: 2.896 ± 0.059
1.256GlnMet: 1.256 ± 0.041
1.718GlnAsn: 1.718 ± 0.052
1.009GlnPro: 1.009 ± 0.039
1.513GlnGln: 1.513 ± 0.057
1.273GlnArg: 1.273 ± 0.041
1.666GlnSer: 1.666 ± 0.05
1.614GlnThr: 1.614 ± 0.047
2.057GlnVal: 2.057 ± 0.05
0.266GlnTrp: 0.266 ± 0.019
1.396GlnTyr: 1.396 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
2.434ArgAla: 2.434 ± 0.056
0.488ArgCys: 0.488 ± 0.026
2.054ArgAsp: 2.054 ± 0.06
3.526ArgGlu: 3.526 ± 0.077
1.735ArgPhe: 1.735 ± 0.05
2.273ArgGly: 2.273 ± 0.057
0.764ArgHis: 0.764 ± 0.032
3.348ArgIle: 3.348 ± 0.063
3.702ArgLys: 3.702 ± 0.085
3.495ArgLeu: 3.495 ± 0.078
1.583ArgMet: 1.583 ± 0.052
2.023ArgAsn: 2.023 ± 0.055
1.195ArgPro: 1.195 ± 0.046
1.57ArgGln: 1.57 ± 0.05
2.013ArgArg: 2.013 ± 0.057
1.952ArgSer: 1.952 ± 0.052
2.051ArgThr: 2.051 ± 0.057
2.45ArgVal: 2.45 ± 0.069
0.276ArgTrp: 0.276 ± 0.021
1.677ArgTyr: 1.677 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.969SerAla: 3.969 ± 0.09
0.82SerCys: 0.82 ± 0.034
3.434SerAsp: 3.434 ± 0.077
3.943SerGlu: 3.943 ± 0.079
2.535SerPhe: 2.535 ± 0.066
4.858SerGly: 4.858 ± 0.097
0.966SerHis: 0.966 ± 0.041
4.146SerIle: 4.146 ± 0.088
3.265SerLys: 3.265 ± 0.077
5.038SerLeu: 5.038 ± 0.088
1.889SerMet: 1.889 ± 0.054
2.404SerAsn: 2.404 ± 0.058
1.468SerPro: 1.468 ± 0.047
1.703SerGln: 1.703 ± 0.048
2.422SerArg: 2.422 ± 0.056
3.393SerSer: 3.393 ± 0.079
2.961SerThr: 2.961 ± 0.076
3.921SerVal: 3.921 ± 0.084
0.474SerTrp: 0.474 ± 0.028
2.623SerTyr: 2.623 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
4.278ThrAla: 4.278 ± 0.085
0.644ThrCys: 0.644 ± 0.029
3.236ThrAsp: 3.236 ± 0.078
4.378ThrGlu: 4.378 ± 0.101
2.151ThrPhe: 2.151 ± 0.056
4.788ThrGly: 4.788 ± 0.094
0.84ThrHis: 0.84 ± 0.034
4.299ThrIle: 4.299 ± 0.078
3.175ThrLys: 3.175 ± 0.063
4.929ThrLeu: 4.929 ± 0.09
1.427ThrMet: 1.427 ± 0.049
2.16ThrAsn: 2.16 ± 0.062
2.035ThrPro: 2.035 ± 0.056
1.467ThrGln: 1.467 ± 0.044
1.876ThrArg: 1.876 ± 0.05
2.983ThrSer: 2.983 ± 0.067
3.056ThrThr: 3.056 ± 0.089
4.371ThrVal: 4.371 ± 0.098
0.399ThrTrp: 0.399 ± 0.023
2.311ThrTyr: 2.311 ± 0.066
0.0ThrXaa: 0.0 ± 0.0
Val
5.207ValAla: 5.207 ± 0.101
1.129ValCys: 1.129 ± 0.044
3.865ValAsp: 3.865 ± 0.077
4.879ValGlu: 4.879 ± 0.083
2.847ValPhe: 2.847 ± 0.071
4.237ValGly: 4.237 ± 0.092
1.14ValHis: 1.14 ± 0.043
5.428ValIle: 5.428 ± 0.086
4.552ValLys: 4.552 ± 0.088
6.666ValLeu: 6.666 ± 0.123
2.012ValMet: 2.012 ± 0.05
3.033ValAsn: 3.033 ± 0.074
2.322ValPro: 2.322 ± 0.051
1.85ValGln: 1.85 ± 0.052
2.657ValArg: 2.657 ± 0.066
4.452ValSer: 4.452 ± 0.086
4.413ValThr: 4.413 ± 0.091
5.252ValVal: 5.252 ± 0.117
0.53ValTrp: 0.53 ± 0.027
2.717ValTyr: 2.717 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.447TrpAla: 0.447 ± 0.026
0.125TrpCys: 0.125 ± 0.015
0.455TrpAsp: 0.455 ± 0.024
0.571TrpGlu: 0.571 ± 0.029
0.336TrpPhe: 0.336 ± 0.025
0.527TrpGly: 0.527 ± 0.029
0.155TrpHis: 0.155 ± 0.013
0.59TrpIle: 0.59 ± 0.03
0.651TrpLys: 0.651 ± 0.033
0.761TrpLeu: 0.761 ± 0.039
0.29TrpMet: 0.29 ± 0.022
0.516TrpAsn: 0.516 ± 0.029
0.17TrpPro: 0.17 ± 0.016
0.334TrpGln: 0.334 ± 0.022
0.289TrpArg: 0.289 ± 0.021
0.436TrpSer: 0.436 ± 0.026
0.334TrpThr: 0.334 ± 0.02
0.429TrpVal: 0.429 ± 0.024
0.091TrpTrp: 0.091 ± 0.013
0.379TrpTyr: 0.379 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.907TyrAla: 2.907 ± 0.058
0.618TyrCys: 0.618 ± 0.029
2.57TyrAsp: 2.57 ± 0.074
3.218TyrGlu: 3.218 ± 0.072
1.81TyrPhe: 1.81 ± 0.049
2.99TyrGly: 2.99 ± 0.069
0.944TyrHis: 0.944 ± 0.038
3.006TyrIle: 3.006 ± 0.077
2.358TyrLys: 2.358 ± 0.07
3.917TyrLeu: 3.917 ± 0.087
1.188TyrMet: 1.188 ± 0.035
1.986TyrAsn: 1.986 ± 0.065
1.359TyrPro: 1.359 ± 0.044
1.873TyrGln: 1.873 ± 0.053
2.137TyrArg: 2.137 ± 0.059
2.325TyrSer: 2.325 ± 0.061
2.34TyrThr: 2.34 ± 0.06
2.642TyrVal: 2.642 ± 0.064
0.331TyrTrp: 0.331 ± 0.023
2.141TyrTyr: 2.141 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2315 proteins (734199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski