Amino acid dipepetide frequency for Blautia sp. CAG:52

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.848AlaAla: 6.848 ± 0.129
1.151AlaCys: 1.151 ± 0.043
4.443AlaAsp: 4.443 ± 0.08
4.943AlaGlu: 4.943 ± 0.085
2.87AlaPhe: 2.87 ± 0.062
6.203AlaGly: 6.203 ± 0.114
1.116AlaHis: 1.116 ± 0.047
4.902AlaIle: 4.902 ± 0.082
4.808AlaLys: 4.808 ± 0.085
6.549AlaLeu: 6.549 ± 0.101
2.626AlaMet: 2.626 ± 0.059
2.356AlaAsn: 2.356 ± 0.055
1.979AlaPro: 1.979 ± 0.056
2.497AlaGln: 2.497 ± 0.066
2.844AlaArg: 2.844 ± 0.061
3.833AlaSer: 3.833 ± 0.077
3.527AlaThr: 3.527 ± 0.08
6.105AlaVal: 6.105 ± 0.094
0.713AlaTrp: 0.713 ± 0.029
2.869AlaTyr: 2.869 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.009CysAla: 1.009 ± 0.033
0.295CysCys: 0.295 ± 0.023
0.785CysAsp: 0.785 ± 0.031
0.961CysGlu: 0.961 ± 0.041
0.659CysPhe: 0.659 ± 0.029
1.611CysGly: 1.611 ± 0.059
0.333CysHis: 0.333 ± 0.022
1.072CysIle: 1.072 ± 0.041
0.906CysLys: 0.906 ± 0.039
1.217CysLeu: 1.217 ± 0.041
0.549CysMet: 0.549 ± 0.025
0.601CysAsn: 0.601 ± 0.03
0.675CysPro: 0.675 ± 0.033
0.543CysGln: 0.543 ± 0.026
0.753CysArg: 0.753 ± 0.028
0.949CysSer: 0.949 ± 0.036
0.736CysThr: 0.736 ± 0.028
1.1CysVal: 1.1 ± 0.04
0.159CysTrp: 0.159 ± 0.015
0.643CysTyr: 0.643 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
4.176AspAla: 4.176 ± 0.074
0.776AspCys: 0.776 ± 0.03
2.872AspAsp: 2.872 ± 0.069
4.349AspGlu: 4.349 ± 0.08
2.342AspPhe: 2.342 ± 0.058
4.656AspGly: 4.656 ± 0.092
0.962AspHis: 0.962 ± 0.033
3.819AspIle: 3.819 ± 0.075
3.024AspLys: 3.024 ± 0.067
4.726AspLeu: 4.726 ± 0.085
1.796AspMet: 1.796 ± 0.047
2.036AspAsn: 2.036 ± 0.057
2.099AspPro: 2.099 ± 0.055
1.865AspGln: 1.865 ± 0.047
2.354AspArg: 2.354 ± 0.057
2.935AspSer: 2.935 ± 0.071
3.285AspThr: 3.285 ± 0.066
3.691AspVal: 3.691 ± 0.073
0.636AspTrp: 0.636 ± 0.029
2.584AspTyr: 2.584 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
5.623GluAla: 5.623 ± 0.1
0.806GluCys: 0.806 ± 0.036
4.532GluAsp: 4.532 ± 0.083
8.189GluGlu: 8.189 ± 0.152
2.489GluPhe: 2.489 ± 0.059
4.74GluGly: 4.74 ± 0.089
1.475GluHis: 1.475 ± 0.049
5.526GluIle: 5.526 ± 0.095
7.482GluLys: 7.482 ± 0.1
6.713GluLeu: 6.713 ± 0.113
2.389GluMet: 2.389 ± 0.052
4.012GluAsn: 4.012 ± 0.076
1.96GluPro: 1.96 ± 0.056
3.41GluGln: 3.41 ± 0.067
3.45GluArg: 3.45 ± 0.08
3.383GluSer: 3.383 ± 0.071
4.048GluThr: 4.048 ± 0.079
4.784GluVal: 4.784 ± 0.076
0.737GluTrp: 0.737 ± 0.031
3.151GluTyr: 3.151 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
2.864PheAla: 2.864 ± 0.069
0.82PheCys: 0.82 ± 0.035
2.32PheAsp: 2.32 ± 0.063
2.391PheGlu: 2.391 ± 0.06
1.845PhePhe: 1.845 ± 0.062
3.08PheGly: 3.08 ± 0.063
0.914PheHis: 0.914 ± 0.037
2.396PheIle: 2.396 ± 0.057
1.59PheLys: 1.59 ± 0.049
3.943PheLeu: 3.943 ± 0.085
1.126PheMet: 1.126 ± 0.04
1.19PheAsn: 1.19 ± 0.039
1.41PhePro: 1.41 ± 0.043
1.503PheGln: 1.503 ± 0.045
1.865PheArg: 1.865 ± 0.048
2.684PheSer: 2.684 ± 0.063
2.286PheThr: 2.286 ± 0.057
2.763PheVal: 2.763 ± 0.07
0.442PheTrp: 0.442 ± 0.026
1.677PheTyr: 1.677 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
5.236GlyAla: 5.236 ± 0.11
1.406GlyCys: 1.406 ± 0.042
3.677GlyAsp: 3.677 ± 0.076
5.09GlyGlu: 5.09 ± 0.09
3.052GlyPhe: 3.052 ± 0.062
4.869GlyGly: 4.869 ± 0.1
1.363GlyHis: 1.363 ± 0.042
6.347GlyIle: 6.347 ± 0.099
5.866GlyLys: 5.866 ± 0.103
5.736GlyLeu: 5.736 ± 0.079
2.727GlyMet: 2.727 ± 0.069
3.192GlyAsn: 3.192 ± 0.068
1.347GlyPro: 1.347 ± 0.046
2.3GlyGln: 2.3 ± 0.056
2.937GlyArg: 2.937 ± 0.061
4.308GlySer: 4.308 ± 0.066
4.559GlyThr: 4.559 ± 0.092
5.237GlyVal: 5.237 ± 0.103
0.962GlyTrp: 0.962 ± 0.06
3.34GlyTyr: 3.34 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.103HisAla: 1.103 ± 0.037
0.347HisCys: 0.347 ± 0.02
0.887HisAsp: 0.887 ± 0.04
1.112HisGlu: 1.112 ± 0.039
0.834HisPhe: 0.834 ± 0.031
1.427HisGly: 1.427 ± 0.043
0.477HisHis: 0.477 ± 0.034
1.256HisIle: 1.256 ± 0.042
0.946HisLys: 0.946 ± 0.038
1.792HisLeu: 1.792 ± 0.05
0.658HisMet: 0.658 ± 0.029
0.696HisAsn: 0.696 ± 0.028
1.04HisPro: 1.04 ± 0.039
0.649HisGln: 0.649 ± 0.03
0.92HisArg: 0.92 ± 0.035
0.93HisSer: 0.93 ± 0.034
1.068HisThr: 1.068 ± 0.041
1.152HisVal: 1.152 ± 0.038
0.209HisTrp: 0.209 ± 0.017
0.783HisTyr: 0.783 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.389IleAla: 5.389 ± 0.082
1.431IleCys: 1.431 ± 0.046
3.607IleAsp: 3.607 ± 0.074
4.239IleGlu: 4.239 ± 0.09
2.932IlePhe: 2.932 ± 0.076
5.212IleGly: 5.212 ± 0.095
1.483IleHis: 1.483 ± 0.049
4.378IleIle: 4.378 ± 0.087
3.444IleLys: 3.444 ± 0.071
7.177IleLeu: 7.177 ± 0.124
1.851IleMet: 1.851 ± 0.048
2.483IleAsn: 2.483 ± 0.056
3.276IlePro: 3.276 ± 0.071
2.598IleGln: 2.598 ± 0.055
4.186IleArg: 4.186 ± 0.085
4.429IleSer: 4.429 ± 0.083
4.178IleThr: 4.178 ± 0.078
4.742IleVal: 4.742 ± 0.09
0.711IleTrp: 0.711 ± 0.032
2.694IleTyr: 2.694 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.794LysAla: 4.794 ± 0.082
0.687LysCys: 0.687 ± 0.032
3.768LysAsp: 3.768 ± 0.075
7.397LysGlu: 7.397 ± 0.117
1.733LysPhe: 1.733 ± 0.052
4.028LysGly: 4.028 ± 0.078
1.007LysHis: 1.007 ± 0.041
4.923LysIle: 4.923 ± 0.076
6.575LysLys: 6.575 ± 0.114
5.203LysLeu: 5.203 ± 0.092
2.311LysMet: 2.311 ± 0.048
3.351LysAsn: 3.351 ± 0.066
2.011LysPro: 2.011 ± 0.055
2.459LysGln: 2.459 ± 0.051
2.909LysArg: 2.909 ± 0.06
2.89LysSer: 2.89 ± 0.06
3.859LysThr: 3.859 ± 0.08
4.438LysVal: 4.438 ± 0.069
0.579LysTrp: 0.579 ± 0.028
2.687LysTyr: 2.687 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
6.631LeuAla: 6.631 ± 0.093
1.484LeuCys: 1.484 ± 0.05
4.984LeuAsp: 4.984 ± 0.081
6.796LeuGlu: 6.796 ± 0.1
3.533LeuPhe: 3.533 ± 0.083
6.255LeuGly: 6.255 ± 0.09
1.779LeuHis: 1.779 ± 0.055
5.862LeuIle: 5.862 ± 0.122
5.816LeuLys: 5.816 ± 0.085
8.504LeuLeu: 8.504 ± 0.141
2.594LeuMet: 2.594 ± 0.062
3.449LeuAsn: 3.449 ± 0.069
3.486LeuPro: 3.486 ± 0.073
3.224LeuGln: 3.224 ± 0.073
3.704LeuArg: 3.704 ± 0.075
5.502LeuSer: 5.502 ± 0.087
5.104LeuThr: 5.104 ± 0.082
5.904LeuVal: 5.904 ± 0.1
0.818LeuTrp: 0.818 ± 0.03
3.365LeuTyr: 3.365 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.45MetAla: 2.45 ± 0.058
0.372MetCys: 0.372 ± 0.022
2.002MetAsp: 2.002 ± 0.043
3.047MetGlu: 3.047 ± 0.069
0.995MetPhe: 0.995 ± 0.04
2.295MetGly: 2.295 ± 0.051
0.535MetHis: 0.535 ± 0.026
2.339MetIle: 2.339 ± 0.061
2.684MetLys: 2.684 ± 0.064
2.547MetLeu: 2.547 ± 0.067
1.039MetMet: 1.039 ± 0.037
1.555MetAsn: 1.555 ± 0.043
1.102MetPro: 1.102 ± 0.034
1.151MetGln: 1.151 ± 0.04
1.298MetArg: 1.298 ± 0.038
1.656MetSer: 1.656 ± 0.045
1.815MetThr: 1.815 ± 0.048
2.11MetVal: 2.11 ± 0.056
0.248MetTrp: 0.248 ± 0.019
1.028MetTyr: 1.028 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.647AsnAla: 2.647 ± 0.056
0.647AsnCys: 0.647 ± 0.03
1.871AsnAsp: 1.871 ± 0.047
2.486AsnGlu: 2.486 ± 0.064
1.466AsnPhe: 1.466 ± 0.043
3.477AsnGly: 3.477 ± 0.089
0.788AsnHis: 0.788 ± 0.033
2.945AsnIle: 2.945 ± 0.065
2.22AsnLys: 2.22 ± 0.055
3.639AsnLeu: 3.639 ± 0.074
1.348AsnMet: 1.348 ± 0.042
1.553AsnAsn: 1.553 ± 0.049
2.08AsnPro: 2.08 ± 0.051
1.567AsnGln: 1.567 ± 0.049
2.12AsnArg: 2.12 ± 0.051
2.019AsnSer: 2.019 ± 0.052
2.301AsnThr: 2.301 ± 0.061
2.601AsnVal: 2.601 ± 0.058
0.47AsnTrp: 0.47 ± 0.026
1.745AsnTyr: 1.745 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
2.525ProAla: 2.525 ± 0.054
0.47ProCys: 0.47 ± 0.026
2.309ProAsp: 2.309 ± 0.055
3.66ProGlu: 3.66 ± 0.077
1.509ProPhe: 1.509 ± 0.045
2.676ProGly: 2.676 ± 0.056
0.541ProHis: 0.541 ± 0.028
1.989ProIle: 1.989 ± 0.057
1.921ProLys: 1.921 ± 0.055
2.774ProLeu: 2.774 ± 0.06
0.997ProMet: 0.997 ± 0.038
1.168ProAsn: 1.168 ± 0.037
0.613ProPro: 0.613 ± 0.029
1.129ProGln: 1.129 ± 0.043
1.093ProArg: 1.093 ± 0.036
1.844ProSer: 1.844 ± 0.053
1.657ProThr: 1.657 ± 0.057
3.294ProVal: 3.294 ± 0.063
0.405ProTrp: 0.405 ± 0.024
1.488ProTyr: 1.488 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.716GlnAla: 2.716 ± 0.057
0.437GlnCys: 0.437 ± 0.027
1.638GlnAsp: 1.638 ± 0.053
3.452GlnGlu: 3.452 ± 0.083
1.255GlnPhe: 1.255 ± 0.04
2.29GlnGly: 2.29 ± 0.065
0.472GlnHis: 0.472 ± 0.029
3.056GlnIle: 3.056 ± 0.069
2.951GlnLys: 2.951 ± 0.063
3.123GlnLeu: 3.123 ± 0.075
1.497GlnMet: 1.497 ± 0.041
1.6GlnAsn: 1.6 ± 0.046
1.07GlnPro: 1.07 ± 0.04
1.471GlnGln: 1.471 ± 0.054
1.437GlnArg: 1.437 ± 0.044
1.68GlnSer: 1.68 ± 0.05
1.904GlnThr: 1.904 ± 0.051
2.548GlnVal: 2.548 ± 0.068
0.395GlnTrp: 0.395 ± 0.026
1.431GlnTyr: 1.431 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.591ArgAla: 2.591 ± 0.057
0.653ArgCys: 0.653 ± 0.029
2.103ArgAsp: 2.103 ± 0.05
4.096ArgGlu: 4.096 ± 0.092
1.834ArgPhe: 1.834 ± 0.05
2.53ArgGly: 2.53 ± 0.054
0.816ArgHis: 0.816 ± 0.031
3.579ArgIle: 3.579 ± 0.073
3.888ArgLys: 3.888 ± 0.077
3.583ArgLeu: 3.583 ± 0.061
1.744ArgMet: 1.744 ± 0.049
1.941ArgAsn: 1.941 ± 0.053
1.339ArgPro: 1.339 ± 0.045
1.908ArgGln: 1.908 ± 0.051
2.192ArgArg: 2.192 ± 0.067
2.03ArgSer: 2.03 ± 0.048
2.223ArgThr: 2.223 ± 0.051
2.801ArgVal: 2.801 ± 0.064
0.461ArgTrp: 0.461 ± 0.024
1.941ArgTyr: 1.941 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.824SerAla: 3.824 ± 0.077
0.938SerCys: 0.938 ± 0.039
2.928SerAsp: 2.928 ± 0.059
3.58SerGlu: 3.58 ± 0.07
2.39SerPhe: 2.39 ± 0.058
4.816SerGly: 4.816 ± 0.08
1.044SerHis: 1.044 ± 0.04
3.67SerIle: 3.67 ± 0.064
2.878SerLys: 2.878 ± 0.059
4.768SerLeu: 4.768 ± 0.091
1.829SerMet: 1.829 ± 0.047
1.918SerAsn: 1.918 ± 0.045
1.689SerPro: 1.689 ± 0.049
1.893SerGln: 1.893 ± 0.052
2.693SerArg: 2.693 ± 0.057
3.244SerSer: 3.244 ± 0.083
2.781SerThr: 2.781 ± 0.06
4.218SerVal: 4.218 ± 0.067
0.663SerTrp: 0.663 ± 0.034
2.449SerTyr: 2.449 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.423ThrAla: 4.423 ± 0.079
0.755ThrCys: 0.755 ± 0.031
3.317ThrAsp: 3.317 ± 0.067
4.069ThrGlu: 4.069 ± 0.077
2.239ThrPhe: 2.239 ± 0.063
4.989ThrGly: 4.989 ± 0.087
0.887ThrHis: 0.887 ± 0.039
3.901ThrIle: 3.901 ± 0.073
2.935ThrLys: 2.935 ± 0.066
4.857ThrLeu: 4.857 ± 0.079
1.502ThrMet: 1.502 ± 0.045
1.968ThrAsn: 1.968 ± 0.047
2.396ThrPro: 2.396 ± 0.073
1.695ThrGln: 1.695 ± 0.048
2.092ThrArg: 2.092 ± 0.049
2.977ThrSer: 2.977 ± 0.067
3.183ThrThr: 3.183 ± 0.087
4.633ThrVal: 4.633 ± 0.094
0.664ThrTrp: 0.664 ± 0.045
2.287ThrTyr: 2.287 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.008ValAla: 5.008 ± 0.095
1.268ValCys: 1.268 ± 0.041
3.943ValAsp: 3.943 ± 0.075
5.114ValGlu: 5.114 ± 0.079
2.92ValPhe: 2.92 ± 0.072
4.6ValGly: 4.6 ± 0.083
1.223ValHis: 1.223 ± 0.041
5.128ValIle: 5.128 ± 0.079
4.554ValLys: 4.554 ± 0.091
6.931ValLeu: 6.931 ± 0.133
2.115ValMet: 2.115 ± 0.053
2.69ValAsn: 2.69 ± 0.056
2.606ValPro: 2.606 ± 0.062
2.276ValGln: 2.276 ± 0.054
2.9ValArg: 2.9 ± 0.073
4.309ValSer: 4.309 ± 0.08
4.376ValThr: 4.376 ± 0.086
5.022ValVal: 5.022 ± 0.094
0.76ValTrp: 0.76 ± 0.034
2.755ValTyr: 2.755 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.571TrpAla: 0.571 ± 0.03
0.171TrpCys: 0.171 ± 0.013
0.563TrpAsp: 0.563 ± 0.028
0.843TrpGlu: 0.843 ± 0.034
0.448TrpPhe: 0.448 ± 0.021
0.696TrpGly: 0.696 ± 0.033
0.173TrpHis: 0.173 ± 0.016
0.832TrpIle: 0.832 ± 0.034
0.947TrpLys: 0.947 ± 0.036
0.99TrpLeu: 0.99 ± 0.038
0.419TrpMet: 0.419 ± 0.024
0.574TrpAsn: 0.574 ± 0.029
0.241TrpPro: 0.241 ± 0.019
0.4TrpGln: 0.4 ± 0.024
0.384TrpArg: 0.384 ± 0.022
0.521TrpSer: 0.521 ± 0.027
0.465TrpThr: 0.465 ± 0.028
0.61TrpVal: 0.61 ± 0.031
0.171TrpTrp: 0.171 ± 0.018
0.556TrpTyr: 0.556 ± 0.061
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.754TyrAla: 2.754 ± 0.062
0.645TyrCys: 0.645 ± 0.033
2.433TyrAsp: 2.433 ± 0.058
3.086TyrGlu: 3.086 ± 0.065
1.763TyrPhe: 1.763 ± 0.049
3.102TyrGly: 3.102 ± 0.07
0.899TyrHis: 0.899 ± 0.039
2.517TyrIle: 2.517 ± 0.065
2.176TyrLys: 2.176 ± 0.056
4.024TyrLeu: 4.024 ± 0.084
1.152TyrMet: 1.152 ± 0.042
1.655TyrAsn: 1.655 ± 0.043
1.644TyrPro: 1.644 ± 0.045
1.886TyrGln: 1.886 ± 0.047
2.117TyrArg: 2.117 ± 0.054
2.089TyrSer: 2.089 ± 0.061
2.414TyrThr: 2.414 ± 0.073
2.745TyrVal: 2.745 ± 0.057
0.37TyrTrp: 0.37 ± 0.024
2.085TyrTyr: 2.085 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2465 proteins (785732 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski