Amino acid dipepetide frequency for Thermohalobacter berrensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.877AlaAla: 3.877 ± 0.095
0.577AlaCys: 0.577 ± 0.03
2.561AlaAsp: 2.561 ± 0.072
3.426AlaGlu: 3.426 ± 0.073
2.308AlaPhe: 2.308 ± 0.072
3.913AlaGly: 3.913 ± 0.094
0.834AlaHis: 0.834 ± 0.032
5.853AlaIle: 5.853 ± 0.098
5.168AlaLys: 5.168 ± 0.092
5.583AlaLeu: 5.583 ± 0.106
1.461AlaMet: 1.461 ± 0.045
2.514AlaAsn: 2.514 ± 0.067
1.448AlaPro: 1.448 ± 0.045
1.375AlaGln: 1.375 ± 0.045
2.021AlaArg: 2.021 ± 0.061
2.929AlaSer: 2.929 ± 0.066
2.644AlaThr: 2.644 ± 0.06
4.149AlaVal: 4.149 ± 0.086
0.336AlaTrp: 0.336 ± 0.02
1.933AlaTyr: 1.933 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.444CysAla: 0.444 ± 0.026
0.124CysCys: 0.124 ± 0.015
0.536CysAsp: 0.536 ± 0.028
0.567CysGlu: 0.567 ± 0.03
0.308CysPhe: 0.308 ± 0.019
0.815CysGly: 0.815 ± 0.034
0.175CysHis: 0.175 ± 0.017
0.796CysIle: 0.796 ± 0.036
0.805CysLys: 0.805 ± 0.033
0.668CysLeu: 0.668 ± 0.034
0.2CysMet: 0.2 ± 0.016
0.568CysAsn: 0.568 ± 0.029
0.453CysPro: 0.453 ± 0.029
0.203CysGln: 0.203 ± 0.016
0.306CysArg: 0.306 ± 0.017
0.514CysSer: 0.514 ± 0.029
0.417CysThr: 0.417 ± 0.022
0.54CysVal: 0.54 ± 0.033
0.051CysTrp: 0.051 ± 0.009
0.315CysTyr: 0.315 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
2.368AspAla: 2.368 ± 0.054
0.491AspCys: 0.491 ± 0.027
2.631AspAsp: 2.631 ± 0.07
4.645AspGlu: 4.645 ± 0.104
2.538AspPhe: 2.538 ± 0.051
3.166AspGly: 3.166 ± 0.077
0.597AspHis: 0.597 ± 0.025
7.013AspIle: 7.013 ± 0.106
6.093AspLys: 6.093 ± 0.11
4.752AspLeu: 4.752 ± 0.084
1.426AspMet: 1.426 ± 0.044
3.266AspAsn: 3.266 ± 0.069
1.504AspPro: 1.504 ± 0.047
0.753AspGln: 0.753 ± 0.032
1.989AspArg: 1.989 ± 0.057
2.608AspSer: 2.608 ± 0.067
2.535AspThr: 2.535 ± 0.071
3.616AspVal: 3.616 ± 0.069
0.375AspTrp: 0.375 ± 0.025
2.629AspTyr: 2.629 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
4.115GluAla: 4.115 ± 0.086
0.5GluCys: 0.5 ± 0.028
4.491GluAsp: 4.491 ± 0.088
7.467GluGlu: 7.467 ± 0.142
2.665GluPhe: 2.665 ± 0.055
4.507GluGly: 4.507 ± 0.09
0.988GluHis: 0.988 ± 0.037
8.219GluIle: 8.219 ± 0.122
8.904GluLys: 8.904 ± 0.135
6.685GluLeu: 6.685 ± 0.111
2.066GluMet: 2.066 ± 0.053
5.265GluAsn: 5.265 ± 0.091
1.599GluPro: 1.599 ± 0.054
1.559GluGln: 1.559 ± 0.045
3.014GluArg: 3.014 ± 0.077
3.109GluSer: 3.109 ± 0.069
2.94GluThr: 2.94 ± 0.067
5.375GluVal: 5.375 ± 0.099
0.472GluTrp: 0.472 ± 0.022
2.97GluTyr: 2.97 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.156PheAla: 2.156 ± 0.062
0.374PheCys: 0.374 ± 0.021
2.36PheAsp: 2.36 ± 0.056
2.379PheGlu: 2.379 ± 0.05
1.838PhePhe: 1.838 ± 0.061
2.897PheGly: 2.897 ± 0.07
0.572PheHis: 0.572 ± 0.026
4.554PheIle: 4.554 ± 0.099
3.622PheLys: 3.622 ± 0.066
3.728PheLeu: 3.728 ± 0.092
1.014PheMet: 1.014 ± 0.04
2.651PheAsn: 2.651 ± 0.07
1.245PhePro: 1.245 ± 0.046
0.865PheGln: 0.865 ± 0.034
1.357PheArg: 1.357 ± 0.044
2.689PheSer: 2.689 ± 0.068
2.37PheThr: 2.37 ± 0.054
2.52PheVal: 2.52 ± 0.059
0.299PheTrp: 0.299 ± 0.021
1.636PheTyr: 1.636 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.028GlyAla: 4.028 ± 0.097
0.823GlyCys: 0.823 ± 0.038
3.193GlyAsp: 3.193 ± 0.077
4.312GlyGlu: 4.312 ± 0.086
3.033GlyPhe: 3.033 ± 0.067
4.509GlyGly: 4.509 ± 0.105
1.071GlyHis: 1.071 ± 0.044
7.455GlyIle: 7.455 ± 0.116
6.364GlyLys: 6.364 ± 0.097
6.158GlyLeu: 6.158 ± 0.114
1.735GlyMet: 1.735 ± 0.057
3.245GlyAsn: 3.245 ± 0.063
1.598GlyPro: 1.598 ± 0.047
1.536GlyGln: 1.536 ± 0.043
2.471GlyArg: 2.471 ± 0.063
3.258GlySer: 3.258 ± 0.077
3.44GlyThr: 3.44 ± 0.066
4.719GlyVal: 4.719 ± 0.081
0.489GlyTrp: 0.489 ± 0.023
3.089GlyTyr: 3.089 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
0.677HisAla: 0.677 ± 0.03
0.148HisCys: 0.148 ± 0.015
0.64HisAsp: 0.64 ± 0.031
0.838HisGlu: 0.838 ± 0.036
0.64HisPhe: 0.64 ± 0.032
1.064HisGly: 1.064 ± 0.038
0.288HisHis: 0.288 ± 0.019
1.479HisIle: 1.479 ± 0.043
1.105HisLys: 1.105 ± 0.044
1.259HisLeu: 1.259 ± 0.042
0.343HisMet: 0.343 ± 0.022
0.774HisAsn: 0.774 ± 0.031
0.729HisPro: 0.729 ± 0.032
0.308HisGln: 0.308 ± 0.023
0.606HisArg: 0.606 ± 0.03
0.806HisSer: 0.806 ± 0.033
0.698HisThr: 0.698 ± 0.033
0.793HisVal: 0.793 ± 0.035
0.119HisTrp: 0.119 ± 0.012
0.556HisTyr: 0.556 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.133IleAla: 6.133 ± 0.108
0.939IleCys: 0.939 ± 0.041
6.459IleAsp: 6.459 ± 0.107
8.112IleGlu: 8.112 ± 0.128
4.106IlePhe: 4.106 ± 0.101
6.84IleGly: 6.84 ± 0.114
1.385IleHis: 1.385 ± 0.045
10.184IleIle: 10.184 ± 0.163
10.12IleLys: 10.12 ± 0.122
9.78IleLeu: 9.78 ± 0.158
2.14IleMet: 2.14 ± 0.05
6.166IleAsn: 6.166 ± 0.088
3.77IlePro: 3.77 ± 0.069
2.101IleGln: 2.101 ± 0.046
3.49IleArg: 3.49 ± 0.07
6.38IleSer: 6.38 ± 0.119
5.102IleThr: 5.102 ± 0.088
6.832IleVal: 6.832 ± 0.1
0.55IleTrp: 0.55 ± 0.028
3.59IleTyr: 3.59 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
5.214LysAla: 5.214 ± 0.078
0.716LysCys: 0.716 ± 0.034
6.372LysAsp: 6.372 ± 0.105
10.239LysGlu: 10.239 ± 0.153
3.139LysPhe: 3.139 ± 0.068
6.332LysGly: 6.332 ± 0.093
1.257LysHis: 1.257 ± 0.044
9.53LysIle: 9.53 ± 0.109
10.142LysLys: 10.142 ± 0.155
8.834LysLeu: 8.834 ± 0.131
2.382LysMet: 2.382 ± 0.049
6.143LysAsn: 6.143 ± 0.097
2.525LysPro: 2.525 ± 0.051
1.974LysGln: 1.974 ± 0.054
4.127LysArg: 4.127 ± 0.083
4.557LysSer: 4.557 ± 0.085
4.055LysThr: 4.055 ± 0.061
6.916LysVal: 6.916 ± 0.1
0.626LysTrp: 0.626 ± 0.03
4.234LysTyr: 4.234 ± 0.089
0.0LysXaa: 0.0 ± 0.0
Leu
5.514LeuAla: 5.514 ± 0.119
0.706LeuCys: 0.706 ± 0.037
5.294LeuAsp: 5.294 ± 0.092
6.784LeuGlu: 6.784 ± 0.12
3.599LeuPhe: 3.599 ± 0.076
6.493LeuGly: 6.493 ± 0.11
1.122LeuHis: 1.122 ± 0.044
8.897LeuIle: 8.897 ± 0.151
9.475LeuLys: 9.475 ± 0.137
8.25LeuLeu: 8.25 ± 0.157
2.12LeuMet: 2.12 ± 0.055
5.768LeuAsn: 5.768 ± 0.095
3.042LeuPro: 3.042 ± 0.069
1.996LeuGln: 1.996 ± 0.043
3.263LeuArg: 3.263 ± 0.064
5.776LeuSer: 5.776 ± 0.095
4.477LeuThr: 4.477 ± 0.085
5.772LeuVal: 5.772 ± 0.104
0.531LeuTrp: 0.531 ± 0.029
3.116LeuTyr: 3.116 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
1.781MetAla: 1.781 ± 0.053
0.174MetCys: 0.174 ± 0.018
1.467MetAsp: 1.467 ± 0.044
1.942MetGlu: 1.942 ± 0.045
0.872MetPhe: 0.872 ± 0.033
1.802MetGly: 1.802 ± 0.051
0.29MetHis: 0.29 ± 0.021
2.131MetIle: 2.131 ± 0.059
2.41MetLys: 2.41 ± 0.057
2.12MetLeu: 2.12 ± 0.054
0.595MetMet: 0.595 ± 0.03
1.247MetAsn: 1.247 ± 0.036
0.834MetPro: 0.834 ± 0.033
0.482MetGln: 0.482 ± 0.025
0.876MetArg: 0.876 ± 0.039
1.311MetSer: 1.311 ± 0.044
1.16MetThr: 1.16 ± 0.042
1.625MetVal: 1.625 ± 0.052
0.134MetTrp: 0.134 ± 0.013
0.751MetTyr: 0.751 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.433AsnAla: 2.433 ± 0.062
0.493AsnCys: 0.493 ± 0.029
2.654AsnAsp: 2.654 ± 0.057
4.094AsnGlu: 4.094 ± 0.075
2.413AsnPhe: 2.413 ± 0.055
3.341AsnGly: 3.341 ± 0.075
0.71AsnHis: 0.71 ± 0.032
7.18AsnIle: 7.18 ± 0.102
6.595AsnLys: 6.595 ± 0.106
5.416AsnLeu: 5.416 ± 0.094
1.499AsnMet: 1.499 ± 0.046
4.165AsnAsn: 4.165 ± 0.089
2.349AsnPro: 2.349 ± 0.059
1.342AsnGln: 1.342 ± 0.046
2.416AsnArg: 2.416 ± 0.056
3.226AsnSer: 3.226 ± 0.073
2.702AsnThr: 2.702 ± 0.055
3.426AsnVal: 3.426 ± 0.062
0.436AsnTrp: 0.436 ± 0.024
2.463AsnTyr: 2.463 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
1.476ProAla: 1.476 ± 0.049
0.313ProCys: 0.313 ± 0.021
1.721ProAsp: 1.721 ± 0.048
2.493ProGlu: 2.493 ± 0.06
1.524ProPhe: 1.524 ± 0.046
2.038ProGly: 2.038 ± 0.057
0.577ProHis: 0.577 ± 0.03
3.107ProIle: 3.107 ± 0.066
2.747ProLys: 2.747 ± 0.059
2.813ProLeu: 2.813 ± 0.069
0.7ProMet: 0.7 ± 0.028
1.746ProAsn: 1.746 ± 0.04
0.847ProPro: 0.847 ± 0.035
0.834ProGln: 0.834 ± 0.035
1.052ProArg: 1.052 ± 0.036
1.669ProSer: 1.669 ± 0.046
1.599ProThr: 1.599 ± 0.048
2.35ProVal: 2.35 ± 0.055
0.232ProTrp: 0.232 ± 0.02
1.428ProTyr: 1.428 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
1.238GlnAla: 1.238 ± 0.044
0.164GlnCys: 0.164 ± 0.015
1.0GlnAsp: 1.0 ± 0.038
1.643GlnGlu: 1.643 ± 0.043
0.938GlnPhe: 0.938 ± 0.032
1.379GlnGly: 1.379 ± 0.04
0.285GlnHis: 0.285 ± 0.02
2.13GlnIle: 2.13 ± 0.051
2.132GlnLys: 2.132 ± 0.044
2.127GlnLeu: 2.127 ± 0.058
0.603GlnMet: 0.603 ± 0.027
1.364GlnAsn: 1.364 ± 0.039
0.647GlnPro: 0.647 ± 0.031
0.67GlnGln: 0.67 ± 0.031
0.933GlnArg: 0.933 ± 0.032
1.023GlnSer: 1.023 ± 0.032
0.985GlnThr: 0.985 ± 0.039
1.469GlnVal: 1.469 ± 0.047
0.148GlnTrp: 0.148 ± 0.015
0.825GlnTyr: 0.825 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.007ArgAla: 2.007 ± 0.054
0.331ArgCys: 0.331 ± 0.024
1.937ArgAsp: 1.937 ± 0.054
3.315ArgGlu: 3.315 ± 0.071
1.545ArgPhe: 1.545 ± 0.045
2.349ArgGly: 2.349 ± 0.057
0.533ArgHis: 0.533 ± 0.029
3.629ArgIle: 3.629 ± 0.065
3.774ArgLys: 3.774 ± 0.073
3.586ArgLeu: 3.586 ± 0.072
0.945ArgMet: 0.945 ± 0.036
2.089ArgAsn: 2.089 ± 0.051
1.137ArgPro: 1.137 ± 0.041
0.984ArgGln: 0.984 ± 0.036
1.76ArgArg: 1.76 ± 0.061
1.411ArgSer: 1.411 ± 0.041
1.599ArgThr: 1.599 ± 0.048
2.649ArgVal: 2.649 ± 0.054
0.242ArgTrp: 0.242 ± 0.016
1.512ArgTyr: 1.512 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
2.656SerAla: 2.656 ± 0.064
0.441SerCys: 0.441 ± 0.027
2.487SerAsp: 2.487 ± 0.053
3.27SerGlu: 3.27 ± 0.071
2.661SerPhe: 2.661 ± 0.068
3.613SerGly: 3.613 ± 0.062
0.81SerHis: 0.81 ± 0.03
5.878SerIle: 5.878 ± 0.108
5.308SerLys: 5.308 ± 0.087
5.438SerLeu: 5.438 ± 0.098
1.281SerMet: 1.281 ± 0.044
3.133SerAsn: 3.133 ± 0.065
1.753SerPro: 1.753 ± 0.045
1.389SerGln: 1.389 ± 0.043
2.054SerArg: 2.054 ± 0.054
3.129SerSer: 3.129 ± 0.069
2.721SerThr: 2.721 ± 0.07
3.254SerVal: 3.254 ± 0.063
0.343SerTrp: 0.343 ± 0.02
2.132SerTyr: 2.132 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
2.807ThrAla: 2.807 ± 0.078
0.377ThrCys: 0.377 ± 0.025
2.415ThrAsp: 2.415 ± 0.057
3.146ThrGlu: 3.146 ± 0.068
1.998ThrPhe: 1.998 ± 0.06
3.807ThrGly: 3.807 ± 0.075
0.778ThrHis: 0.778 ± 0.035
4.939ThrIle: 4.939 ± 0.082
3.935ThrLys: 3.935 ± 0.074
4.532ThrLeu: 4.532 ± 0.084
0.942ThrMet: 0.942 ± 0.037
2.529ThrAsn: 2.529 ± 0.056
1.825ThrPro: 1.825 ± 0.05
1.058ThrGln: 1.058 ± 0.033
1.588ThrArg: 1.588 ± 0.043
2.717ThrSer: 2.717 ± 0.069
2.521ThrThr: 2.521 ± 0.061
3.348ThrVal: 3.348 ± 0.076
0.279ThrTrp: 0.279 ± 0.021
1.782ThrTyr: 1.782 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
3.894ValAla: 3.894 ± 0.087
0.626ValCys: 0.626 ± 0.035
4.155ValAsp: 4.155 ± 0.084
5.085ValGlu: 5.085 ± 0.089
2.853ValPhe: 2.853 ± 0.061
4.486ValGly: 4.486 ± 0.092
0.885ValHis: 0.885 ± 0.035
6.508ValIle: 6.508 ± 0.089
6.401ValLys: 6.401 ± 0.102
6.175ValLeu: 6.175 ± 0.087
1.478ValMet: 1.478 ± 0.045
3.739ValAsn: 3.739 ± 0.081
2.321ValPro: 2.321 ± 0.054
1.237ValGln: 1.237 ± 0.044
2.203ValArg: 2.203 ± 0.056
3.911ValSer: 3.911 ± 0.07
3.24ValThr: 3.24 ± 0.059
4.843ValVal: 4.843 ± 0.097
0.394ValTrp: 0.394 ± 0.021
2.413ValTyr: 2.413 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.394TrpAla: 0.394 ± 0.024
0.064TrpCys: 0.064 ± 0.009
0.376TrpAsp: 0.376 ± 0.022
0.468TrpGlu: 0.468 ± 0.022
0.303TrpPhe: 0.303 ± 0.021
0.486TrpGly: 0.486 ± 0.027
0.1TrpHis: 0.1 ± 0.011
0.62TrpIle: 0.62 ± 0.03
0.522TrpLys: 0.522 ± 0.029
0.537TrpLeu: 0.537 ± 0.03
0.168TrpMet: 0.168 ± 0.012
0.381TrpAsn: 0.381 ± 0.025
0.202TrpPro: 0.202 ± 0.014
0.179TrpGln: 0.179 ± 0.016
0.233TrpArg: 0.233 ± 0.019
0.308TrpSer: 0.308 ± 0.025
0.304TrpThr: 0.304 ± 0.018
0.422TrpVal: 0.422 ± 0.023
0.075TrpTrp: 0.075 ± 0.009
0.256TrpTyr: 0.256 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.699TyrAla: 1.699 ± 0.041
0.422TyrCys: 0.422 ± 0.024
2.249TyrAsp: 2.249 ± 0.061
2.688TyrGlu: 2.688 ± 0.068
1.846TyrPhe: 1.846 ± 0.052
2.689TyrGly: 2.689 ± 0.081
0.613TyrHis: 0.613 ± 0.028
4.074TyrIle: 4.074 ± 0.082
3.694TyrLys: 3.694 ± 0.088
3.554TyrLeu: 3.554 ± 0.069
0.91TyrMet: 0.91 ± 0.034
2.599TyrAsn: 2.599 ± 0.065
1.437TyrPro: 1.437 ± 0.044
0.857TyrGln: 0.857 ± 0.029
1.575TyrArg: 1.575 ± 0.046
2.418TyrSer: 2.418 ± 0.064
1.811TyrThr: 1.811 ± 0.053
2.227TyrVal: 2.227 ± 0.053
0.269TyrTrp: 0.269 ± 0.019
1.753TyrTyr: 1.753 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2592 proteins (781713 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski