Amino acid dipepetide frequency for Spiroplasma clarkii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.422AlaAla: 4.422 ± 0.133
0.705AlaCys: 0.705 ± 0.038
3.097AlaAsp: 3.097 ± 0.08
3.651AlaGlu: 3.651 ± 0.095
2.86AlaPhe: 2.86 ± 0.082
3.313AlaGly: 3.313 ± 0.107
0.813AlaHis: 0.813 ± 0.042
5.9AlaIle: 5.9 ± 0.137
5.767AlaLys: 5.767 ± 0.129
5.743AlaLeu: 5.743 ± 0.134
1.511AlaMet: 1.511 ± 0.063
3.611AlaAsn: 3.611 ± 0.086
1.568AlaPro: 1.568 ± 0.071
2.118AlaGln: 2.118 ± 0.071
1.937AlaArg: 1.937 ± 0.078
3.764AlaSer: 3.764 ± 0.105
3.598AlaThr: 3.598 ± 0.092
3.971AlaVal: 3.971 ± 0.123
0.663AlaTrp: 0.663 ± 0.04
2.107AlaTyr: 2.107 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.417CysAla: 0.417 ± 0.033
0.141CysCys: 0.141 ± 0.018
0.426CysAsp: 0.426 ± 0.036
0.543CysGlu: 0.543 ± 0.041
0.561CysPhe: 0.561 ± 0.041
0.647CysGly: 0.647 ± 0.04
0.157CysHis: 0.157 ± 0.019
0.535CysIle: 0.535 ± 0.036
0.528CysLys: 0.528 ± 0.036
0.839CysLeu: 0.839 ± 0.048
0.126CysMet: 0.126 ± 0.016
0.424CysAsn: 0.424 ± 0.03
0.192CysPro: 0.192 ± 0.023
0.393CysGln: 0.393 ± 0.032
0.172CysArg: 0.172 ± 0.018
0.526CysSer: 0.526 ± 0.035
0.338CysThr: 0.338 ± 0.031
0.466CysVal: 0.466 ± 0.035
0.115CysTrp: 0.115 ± 0.018
0.325CysTyr: 0.325 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.035AspAla: 3.035 ± 0.083
0.411AspCys: 0.411 ± 0.029
2.805AspAsp: 2.805 ± 0.106
4.234AspGlu: 4.234 ± 0.112
3.947AspPhe: 3.947 ± 0.102
2.823AspGly: 2.823 ± 0.085
0.685AspHis: 0.685 ± 0.034
4.292AspIle: 4.292 ± 0.103
4.672AspLys: 4.672 ± 0.111
5.783AspLeu: 5.783 ± 0.111
1.005AspMet: 1.005 ± 0.051
3.053AspAsn: 3.053 ± 0.095
1.646AspPro: 1.646 ± 0.071
1.997AspGln: 1.997 ± 0.072
1.38AspArg: 1.38 ± 0.055
3.167AspSer: 3.167 ± 0.117
2.235AspThr: 2.235 ± 0.079
3.368AspVal: 3.368 ± 0.105
0.751AspTrp: 0.751 ± 0.043
2.807AspTyr: 2.807 ± 0.098
0.0AspXaa: 0.0 ± 0.0
Glu
3.881GluAla: 3.881 ± 0.112
0.367GluCys: 0.367 ± 0.031
2.871GluAsp: 2.871 ± 0.091
4.289GluGlu: 4.289 ± 0.132
3.733GluPhe: 3.733 ± 0.105
2.452GluGly: 2.452 ± 0.086
0.859GluHis: 0.859 ± 0.04
7.152GluIle: 7.152 ± 0.15
6.712GluLys: 6.712 ± 0.131
6.564GluLeu: 6.564 ± 0.135
1.608GluMet: 1.608 ± 0.059
4.625GluAsn: 4.625 ± 0.107
1.564GluPro: 1.564 ± 0.067
2.507GluGln: 2.507 ± 0.088
1.897GluArg: 1.897 ± 0.073
3.09GluSer: 3.09 ± 0.073
3.53GluThr: 3.53 ± 0.107
4.362GluVal: 4.362 ± 0.12
0.711GluTrp: 0.711 ± 0.033
2.575GluTyr: 2.575 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
3.7PheAla: 3.7 ± 0.116
0.539PheCys: 0.539 ± 0.036
3.406PheAsp: 3.406 ± 0.079
3.876PheGlu: 3.876 ± 0.1
2.631PhePhe: 2.631 ± 0.088
3.167PheGly: 3.167 ± 0.12
0.599PheHis: 0.599 ± 0.04
4.683PheIle: 4.683 ± 0.127
5.016PheLys: 5.016 ± 0.117
5.056PheLeu: 5.056 ± 0.149
1.153PheMet: 1.153 ± 0.049
3.68PheAsn: 3.68 ± 0.111
1.062PhePro: 1.062 ± 0.048
1.608PheGln: 1.608 ± 0.058
1.354PheArg: 1.354 ± 0.06
3.775PheSer: 3.775 ± 0.102
3.066PheThr: 3.066 ± 0.084
3.549PheVal: 3.549 ± 0.091
0.691PheTrp: 0.691 ± 0.043
2.215PheTyr: 2.215 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
3.503GlyAla: 3.503 ± 0.13
0.406GlyCys: 0.406 ± 0.029
2.761GlyAsp: 2.761 ± 0.091
3.181GlyGlu: 3.181 ± 0.095
3.147GlyPhe: 3.147 ± 0.084
3.304GlyGly: 3.304 ± 0.124
0.835GlyHis: 0.835 ± 0.043
4.901GlyIle: 4.901 ± 0.129
4.097GlyLys: 4.097 ± 0.112
5.151GlyLeu: 5.151 ± 0.115
1.354GlyMet: 1.354 ± 0.059
2.496GlyAsn: 2.496 ± 0.069
1.142GlyPro: 1.142 ± 0.059
1.639GlyGln: 1.639 ± 0.06
1.526GlyArg: 1.526 ± 0.059
3.161GlySer: 3.161 ± 0.086
3.044GlyThr: 3.044 ± 0.08
4.018GlyVal: 4.018 ± 0.117
0.716GlyTrp: 0.716 ± 0.044
2.319GlyTyr: 2.319 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
0.68HisAla: 0.68 ± 0.042
0.163HisCys: 0.163 ± 0.02
0.736HisAsp: 0.736 ± 0.038
0.848HisGlu: 0.848 ± 0.045
0.811HisPhe: 0.811 ± 0.048
0.751HisGly: 0.751 ± 0.046
0.309HisHis: 0.309 ± 0.03
1.091HisIle: 1.091 ± 0.057
1.164HisLys: 1.164 ± 0.044
1.297HisLeu: 1.297 ± 0.054
0.247HisMet: 0.247 ± 0.021
0.842HisAsn: 0.842 ± 0.043
0.424HisPro: 0.424 ± 0.033
0.667HisGln: 0.667 ± 0.039
0.393HisArg: 0.393 ± 0.027
0.835HisSer: 0.835 ± 0.043
0.574HisThr: 0.574 ± 0.032
0.678HisVal: 0.678 ± 0.037
0.199HisTrp: 0.199 ± 0.022
0.66HisTyr: 0.66 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.981IleAla: 5.981 ± 0.145
0.992IleCys: 0.992 ± 0.051
5.491IleAsp: 5.491 ± 0.123
5.59IleGlu: 5.59 ± 0.116
5.087IlePhe: 5.087 ± 0.145
4.868IleGly: 4.868 ± 0.133
1.087IleHis: 1.087 ± 0.051
7.945IleIle: 7.945 ± 0.166
8.084IleLys: 8.084 ± 0.121
8.201IleLeu: 8.201 ± 0.169
1.842IleMet: 1.842 ± 0.065
6.465IleAsn: 6.465 ± 0.127
2.474IlePro: 2.474 ± 0.078
2.516IleGln: 2.516 ± 0.077
2.328IleArg: 2.328 ± 0.087
6.136IleSer: 6.136 ± 0.133
5.115IleThr: 5.115 ± 0.115
5.738IleVal: 5.738 ± 0.133
0.899IleTrp: 0.899 ± 0.05
3.607IleTyr: 3.607 ± 0.102
0.0IleXaa: 0.0 ± 0.0
Lys
4.937LysAla: 4.937 ± 0.124
0.47LysCys: 0.47 ± 0.035
4.647LysAsp: 4.647 ± 0.101
6.098LysGlu: 6.098 ± 0.154
4.365LysPhe: 4.365 ± 0.089
3.278LysGly: 3.278 ± 0.087
1.246LysHis: 1.246 ± 0.067
9.164LysIle: 9.164 ± 0.172
8.985LysLys: 8.985 ± 0.163
8.197LysLeu: 8.197 ± 0.128
2.315LysMet: 2.315 ± 0.07
7.351LysAsn: 7.351 ± 0.152
2.644LysPro: 2.644 ± 0.087
3.379LysGln: 3.379 ± 0.091
2.531LysArg: 2.531 ± 0.094
4.965LysSer: 4.965 ± 0.117
5.769LysThr: 5.769 ± 0.107
5.343LysVal: 5.343 ± 0.109
0.89LysTrp: 0.89 ± 0.044
4.044LysTyr: 4.044 ± 0.114
0.0LysXaa: 0.0 ± 0.0
Leu
6.266LeuAla: 6.266 ± 0.141
0.74LeuCys: 0.74 ± 0.041
5.434LeuAsp: 5.434 ± 0.112
6.045LeuGlu: 6.045 ± 0.146
4.74LeuPhe: 4.74 ± 0.134
5.279LeuGly: 5.279 ± 0.134
1.164LeuHis: 1.164 ± 0.045
8.493LeuIle: 8.493 ± 0.194
8.917LeuLys: 8.917 ± 0.146
8.718LeuLeu: 8.718 ± 0.168
2.218LeuMet: 2.218 ± 0.073
6.779LeuAsn: 6.779 ± 0.138
2.571LeuPro: 2.571 ± 0.069
3.39LeuGln: 3.39 ± 0.093
2.549LeuArg: 2.549 ± 0.076
5.831LeuSer: 5.831 ± 0.137
5.966LeuThr: 5.966 ± 0.124
6.474LeuVal: 6.474 ± 0.137
0.945LeuTrp: 0.945 ± 0.049
2.86LeuTyr: 2.86 ± 0.093
0.0LeuXaa: 0.0 ± 0.0
Met
1.319MetAla: 1.319 ± 0.058
0.124MetCys: 0.124 ± 0.016
0.967MetAsp: 0.967 ± 0.042
1.056MetGlu: 1.056 ± 0.043
1.252MetPhe: 1.252 ± 0.055
1.303MetGly: 1.303 ± 0.055
0.329MetHis: 0.329 ± 0.031
1.9MetIle: 1.9 ± 0.068
2.251MetLys: 2.251 ± 0.066
2.116MetLeu: 2.116 ± 0.069
0.543MetMet: 0.543 ± 0.039
1.292MetAsn: 1.292 ± 0.05
0.731MetPro: 0.731 ± 0.046
0.89MetGln: 0.89 ± 0.046
0.667MetArg: 0.667 ± 0.04
1.442MetSer: 1.442 ± 0.064
1.235MetThr: 1.235 ± 0.052
1.299MetVal: 1.299 ± 0.057
0.212MetTrp: 0.212 ± 0.023
0.811MetTyr: 0.811 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.337AsnAla: 3.337 ± 0.073
0.464AsnCys: 0.464 ± 0.035
3.602AsnAsp: 3.602 ± 0.108
4.303AsnGlu: 4.303 ± 0.098
3.956AsnPhe: 3.956 ± 0.112
3.267AsnGly: 3.267 ± 0.105
1.067AsnHis: 1.067 ± 0.049
5.535AsnIle: 5.535 ± 0.116
5.908AsnLys: 5.908 ± 0.139
7.439AsnLeu: 7.439 ± 0.157
1.177AsnMet: 1.177 ± 0.049
4.643AsnAsn: 4.643 ± 0.14
2.326AsnPro: 2.326 ± 0.072
3.276AsnGln: 3.276 ± 0.099
1.694AsnArg: 1.694 ± 0.063
4.393AsnSer: 4.393 ± 0.127
2.86AsnThr: 2.86 ± 0.084
3.565AsnVal: 3.565 ± 0.089
0.833AsnTrp: 0.833 ± 0.045
3.47AsnTyr: 3.47 ± 0.099
0.0AsnXaa: 0.0 ± 0.0
Pro
1.438ProAla: 1.438 ± 0.068
0.17ProCys: 0.17 ± 0.021
1.422ProAsp: 1.422 ± 0.061
2.112ProGlu: 2.112 ± 0.074
1.352ProPhe: 1.352 ± 0.05
1.699ProGly: 1.699 ± 0.069
0.409ProHis: 0.409 ± 0.028
2.527ProIle: 2.527 ± 0.084
2.178ProLys: 2.178 ± 0.079
2.268ProLeu: 2.268 ± 0.067
0.557ProMet: 0.557 ± 0.033
1.824ProAsn: 1.824 ± 0.063
0.552ProPro: 0.552 ± 0.037
1.186ProGln: 1.186 ± 0.058
0.716ProArg: 0.716 ± 0.041
1.71ProSer: 1.71 ± 0.059
1.849ProThr: 1.849 ± 0.066
1.849ProVal: 1.849 ± 0.066
0.336ProTrp: 0.336 ± 0.033
0.97ProTyr: 0.97 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.361GlnAla: 2.361 ± 0.071
0.15GlnCys: 0.15 ± 0.016
1.738GlnAsp: 1.738 ± 0.057
2.458GlnGlu: 2.458 ± 0.086
1.601GlnPhe: 1.601 ± 0.057
1.665GlnGly: 1.665 ± 0.068
0.442GlnHis: 0.442 ± 0.032
3.496GlnIle: 3.496 ± 0.089
3.618GlnLys: 3.618 ± 0.092
3.203GlnLeu: 3.203 ± 0.102
0.806GlnMet: 0.806 ± 0.039
2.77GlnAsn: 2.77 ± 0.091
1.014GlnPro: 1.014 ± 0.062
1.509GlnGln: 1.509 ± 0.078
1.157GlnArg: 1.157 ± 0.049
1.922GlnSer: 1.922 ± 0.073
2.251GlnThr: 2.251 ± 0.076
2.496GlnVal: 2.496 ± 0.079
0.382GlnTrp: 0.382 ± 0.031
1.259GlnTyr: 1.259 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
1.551ArgAla: 1.551 ± 0.069
0.172ArgCys: 0.172 ± 0.018
1.577ArgAsp: 1.577 ± 0.072
2.025ArgGlu: 2.025 ± 0.081
1.436ArgPhe: 1.436 ± 0.058
1.383ArgGly: 1.383 ± 0.056
0.444ArgHis: 0.444 ± 0.032
2.536ArgIle: 2.536 ± 0.084
2.39ArgLys: 2.39 ± 0.084
2.483ArgLeu: 2.483 ± 0.09
0.691ArgMet: 0.691 ± 0.04
1.937ArgAsn: 1.937 ± 0.072
0.729ArgPro: 0.729 ± 0.042
1.009ArgGln: 1.009 ± 0.046
1.049ArgArg: 1.049 ± 0.057
1.54ArgSer: 1.54 ± 0.06
1.654ArgThr: 1.654 ± 0.069
1.685ArgVal: 1.685 ± 0.066
0.3ArgTrp: 0.3 ± 0.025
1.202ArgTyr: 1.202 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.452SerAla: 3.452 ± 0.103
0.404SerCys: 0.404 ± 0.03
3.156SerAsp: 3.156 ± 0.094
4.038SerGlu: 4.038 ± 0.109
3.671SerPhe: 3.671 ± 0.112
3.786SerGly: 3.786 ± 0.099
0.793SerHis: 0.793 ± 0.042
5.301SerIle: 5.301 ± 0.098
5.844SerLys: 5.844 ± 0.137
5.88SerLeu: 5.88 ± 0.121
1.25SerMet: 1.25 ± 0.055
3.757SerAsn: 3.757 ± 0.131
1.475SerPro: 1.475 ± 0.059
2.326SerGln: 2.326 ± 0.077
1.833SerArg: 1.833 ± 0.068
4.455SerSer: 4.455 ± 0.117
3.684SerThr: 3.684 ± 0.097
3.649SerVal: 3.649 ± 0.089
0.791SerTrp: 0.791 ± 0.039
2.593SerTyr: 2.593 ± 0.083
0.0SerXaa: 0.0 ± 0.0
Thr
3.364ThrAla: 3.364 ± 0.1
0.411ThrCys: 0.411 ± 0.034
3.024ThrAsp: 3.024 ± 0.084
3.276ThrGlu: 3.276 ± 0.096
2.818ThrPhe: 2.818 ± 0.082
3.368ThrGly: 3.368 ± 0.1
0.705ThrHis: 0.705 ± 0.042
5.462ThrIle: 5.462 ± 0.145
4.78ThrLys: 4.78 ± 0.094
4.998ThrLeu: 4.998 ± 0.108
1.065ThrMet: 1.065 ± 0.04
4.024ThrAsn: 4.024 ± 0.094
2.045ThrPro: 2.045 ± 0.073
1.752ThrGln: 1.752 ± 0.063
1.526ThrArg: 1.526 ± 0.067
4.194ThrSer: 4.194 ± 0.108
3.53ThrThr: 3.53 ± 0.092
3.428ThrVal: 3.428 ± 0.098
0.523ThrTrp: 0.523 ± 0.039
2.158ThrTyr: 2.158 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
4.603ValAla: 4.603 ± 0.125
0.568ValCys: 0.568 ± 0.037
3.795ValAsp: 3.795 ± 0.094
4.351ValGlu: 4.351 ± 0.125
3.384ValPhe: 3.384 ± 0.096
3.591ValGly: 3.591 ± 0.102
0.713ValHis: 0.713 ± 0.039
5.482ValIle: 5.482 ± 0.114
5.405ValLys: 5.405 ± 0.121
6.021ValLeu: 6.021 ± 0.135
1.268ValMet: 1.268 ± 0.046
3.954ValAsn: 3.954 ± 0.103
1.767ValPro: 1.767 ± 0.066
1.729ValGln: 1.729 ± 0.069
1.705ValArg: 1.705 ± 0.075
4.011ValSer: 4.011 ± 0.098
3.563ValThr: 3.563 ± 0.101
4.678ValVal: 4.678 ± 0.13
0.643ValTrp: 0.643 ± 0.044
2.379ValTyr: 2.379 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.616TrpAla: 0.616 ± 0.043
0.077TrpCys: 0.077 ± 0.013
0.625TrpAsp: 0.625 ± 0.044
0.665TrpGlu: 0.665 ± 0.039
0.853TrpPhe: 0.853 ± 0.045
0.561TrpGly: 0.561 ± 0.038
0.137TrpHis: 0.137 ± 0.015
1.151TrpIle: 1.151 ± 0.058
0.901TrpLys: 0.901 ± 0.036
1.018TrpLeu: 1.018 ± 0.044
0.318TrpMet: 0.318 ± 0.025
0.819TrpAsn: 0.819 ± 0.045
0.208TrpPro: 0.208 ± 0.022
0.311TrpGln: 0.311 ± 0.024
0.331TrpArg: 0.331 ± 0.028
0.696TrpSer: 0.696 ± 0.048
0.652TrpThr: 0.652 ± 0.041
0.769TrpVal: 0.769 ± 0.041
0.234TrpTrp: 0.234 ± 0.026
0.442TrpTyr: 0.442 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.255TyrAla: 2.255 ± 0.077
0.398TyrCys: 0.398 ± 0.034
2.514TyrAsp: 2.514 ± 0.08
2.71TyrGlu: 2.71 ± 0.08
2.622TyrPhe: 2.622 ± 0.081
2.196TyrGly: 2.196 ± 0.071
0.579TyrHis: 0.579 ± 0.036
2.902TyrIle: 2.902 ± 0.071
3.404TyrLys: 3.404 ± 0.103
4.404TyrLeu: 4.404 ± 0.127
0.683TyrMet: 0.683 ± 0.04
2.77TyrAsn: 2.77 ± 0.095
0.987TyrPro: 0.987 ± 0.045
2.096TyrGln: 2.096 ± 0.08
1.045TyrArg: 1.045 ± 0.048
2.527TyrSer: 2.527 ± 0.079
1.939TyrThr: 1.939 ± 0.073
2.224TyrVal: 2.224 ± 0.08
0.55TyrTrp: 0.55 ± 0.035
1.767TyrTyr: 1.767 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1324 proteins (452743 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski