Amino acid dipepetide frequency for Streptomyces fagopyri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.568AlaAla: 20.568 ± 0.146	1.058AlaCys: 1.058 ± 0.021	8.129AlaAsp: 8.129 ± 0.066	8.339AlaGlu: 8.339 ± 0.092	3.465AlaPhe: 3.465 ± 0.039	13.352AlaGly: 13.352 ± 0.083	2.964AlaHis: 2.964 ± 0.039	3.336AlaIle: 3.336 ± 0.041	2.833AlaLys: 2.833 ± 0.054	14.134AlaLeu: 14.134 ± 0.104	2.451AlaMet: 2.451 ± 0.034	1.947AlaAsn: 1.947 ± 0.033	7.014AlaPro: 7.014 ± 0.076	3.679AlaGln: 3.679 ± 0.045	10.377AlaArg: 10.377 ± 0.093	6.246AlaSer: 6.246 ± 0.057	7.013AlaThr: 7.013 ± 0.06	12.333AlaVal: 12.333 ± 0.083	1.82AlaTrp: 1.82 ± 0.032	2.766AlaTyr: 2.766 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.072CysAla: 1.072 ± 0.025	0.09CysCys: 0.09 ± 0.007	0.448CysAsp: 0.448 ± 0.012	0.382CysGlu: 0.382 ± 0.012	0.229CysPhe: 0.229 ± 0.009	0.938CysGly: 0.938 ± 0.022	0.189CysHis: 0.189 ± 0.009	0.151CysIle: 0.151 ± 0.009	0.104CysLys: 0.104 ± 0.007	0.728CysLeu: 0.728 ± 0.019	0.108CysMet: 0.108 ± 0.007	0.135CysAsn: 0.135 ± 0.008	0.465CysPro: 0.465 ± 0.013	0.158CysGln: 0.158 ± 0.008	0.587CysArg: 0.587 ± 0.017	0.421CysSer: 0.421 ± 0.014	0.513CysThr: 0.513 ± 0.016	0.68CysVal: 0.68 ± 0.017	0.127CysTrp: 0.127 ± 0.008	0.152CysTyr: 0.152 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.606AspAla: 7.606 ± 0.059	0.396AspCys: 0.396 ± 0.015	3.601AspAsp: 3.601 ± 0.044	3.8AspGlu: 3.8 ± 0.047	1.688AspPhe: 1.688 ± 0.028	6.468AspGly: 6.468 ± 0.063	1.465AspHis: 1.465 ± 0.025	1.944AspIle: 1.944 ± 0.029	1.207AspLys: 1.207 ± 0.029	6.186AspLeu: 6.186 ± 0.052	0.84AspMet: 0.84 ± 0.016	1.021AspAsn: 1.021 ± 0.021	4.474AspPro: 4.474 ± 0.044	1.525AspGln: 1.525 ± 0.026	4.974AspArg: 4.974 ± 0.047	2.681AspSer: 2.681 ± 0.035	3.359AspThr: 3.359 ± 0.046	4.697AspVal: 4.697 ± 0.045	1.024AspTrp: 1.024 ± 0.024	1.074AspTyr: 1.074 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.964GluAla: 6.964 ± 0.073	0.352GluCys: 0.352 ± 0.014	2.719GluAsp: 2.719 ± 0.038	3.377GluGlu: 3.377 ± 0.049	1.439GluPhe: 1.439 ± 0.024	4.287GluGly: 4.287 ± 0.05	1.48GluHis: 1.48 ± 0.027	2.196GluIle: 2.196 ± 0.032	1.387GluLys: 1.387 ± 0.028	6.558GluLeu: 6.558 ± 0.065	0.861GluMet: 0.861 ± 0.022	1.06GluAsn: 1.06 ± 0.024	3.253GluPro: 3.253 ± 0.046	2.038GluGln: 2.038 ± 0.033	5.503GluArg: 5.503 ± 0.058	2.658GluSer: 2.658 ± 0.035	2.914GluThr: 2.914 ± 0.036	4.382GluVal: 4.382 ± 0.043	0.736GluTrp: 0.736 ± 0.018	1.081GluTyr: 1.081 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.66PheAla: 3.66 ± 0.04	0.266PheCys: 0.266 ± 0.012	1.919PheAsp: 1.919 ± 0.032	1.433PheGlu: 1.433 ± 0.026	0.855PhePhe: 0.855 ± 0.02	3.059PheGly: 3.059 ± 0.038	0.611PheHis: 0.611 ± 0.017	0.679PheIle: 0.679 ± 0.018	0.524PheLys: 0.524 ± 0.016	2.571PheLeu: 2.571 ± 0.038	0.401PheMet: 0.401 ± 0.015	0.569PheAsn: 0.569 ± 0.017	1.4PhePro: 1.4 ± 0.024	0.675PheGln: 0.675 ± 0.016	1.862PheArg: 1.862 ± 0.025	1.476PheSer: 1.476 ± 0.025	2.057PheThr: 2.057 ± 0.03	2.305PheVal: 2.305 ± 0.032	0.421PheTrp: 0.421 ± 0.014	0.602PheTyr: 0.602 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.407GlyAla: 11.407 ± 0.084	0.826GlyCys: 0.826 ± 0.021	5.354GlyAsp: 5.354 ± 0.055	5.005GlyGlu: 5.005 ± 0.059	2.937GlyPhe: 2.937 ± 0.036	9.201GlyGly: 9.201 ± 0.098	2.417GlyHis: 2.417 ± 0.036	3.476GlyIle: 3.476 ± 0.041	2.44GlyLys: 2.44 ± 0.044	9.487GlyLeu: 9.487 ± 0.08	1.95GlyMet: 1.95 ± 0.03	1.817GlyAsn: 1.817 ± 0.031	5.395GlyPro: 5.395 ± 0.058	2.678GlyGln: 2.678 ± 0.043	8.041GlyArg: 8.041 ± 0.065	5.692GlySer: 5.692 ± 0.056	6.705GlyThr: 6.705 ± 0.064	7.764GlyVal: 7.764 ± 0.062	1.75GlyTrp: 1.75 ± 0.027	2.259GlyTyr: 2.259 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.651HisAla: 2.651 ± 0.036	0.192HisCys: 0.192 ± 0.009	1.402HisAsp: 1.402 ± 0.028	1.28HisGlu: 1.28 ± 0.025	0.69HisPhe: 0.69 ± 0.019	2.55HisGly: 2.55 ± 0.034	0.732HisHis: 0.732 ± 0.018	0.668HisIle: 0.668 ± 0.018	0.346HisLys: 0.346 ± 0.013	2.397HisLeu: 2.397 ± 0.033	0.352HisMet: 0.352 ± 0.012	0.384HisAsn: 0.384 ± 0.012	1.86HisPro: 1.86 ± 0.03	0.636HisGln: 0.636 ± 0.018	2.165HisArg: 2.165 ± 0.032	1.05HisSer: 1.05 ± 0.021	1.394HisThr: 1.394 ± 0.024	1.723HisVal: 1.723 ± 0.027	0.371HisTrp: 0.371 ± 0.014	0.481HisTyr: 0.481 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.625IleAla: 4.625 ± 0.051	0.291IleCys: 0.291 ± 0.012	2.171IleAsp: 2.171 ± 0.031	1.866IleGlu: 1.866 ± 0.029	0.691IlePhe: 0.691 ± 0.019	3.531IleGly: 3.531 ± 0.04	0.611IleHis: 0.611 ± 0.016	0.843IleIle: 0.843 ± 0.024	0.728IleLys: 0.728 ± 0.02	2.391IleLeu: 2.391 ± 0.037	0.426IleMet: 0.426 ± 0.015	0.689IleAsn: 0.689 ± 0.018	1.748IlePro: 1.748 ± 0.029	0.703IleGln: 0.703 ± 0.018	2.211IleArg: 2.211 ± 0.03	1.691IleSer: 1.691 ± 0.026	2.246IleThr: 2.246 ± 0.033	2.714IleVal: 2.714 ± 0.037	0.37IleTrp: 0.37 ± 0.011	0.519IleTyr: 0.519 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.928LysAla: 2.928 ± 0.053	0.119LysCys: 0.119 ± 0.008	1.389LysAsp: 1.389 ± 0.028	1.131LysGlu: 1.131 ± 0.025	0.467LysPhe: 0.467 ± 0.016	1.9LysGly: 1.9 ± 0.031	0.422LysHis: 0.422 ± 0.014	0.852LysIle: 0.852 ± 0.021	0.879LysLys: 0.879 ± 0.027	1.993LysLeu: 1.993 ± 0.034	0.373LysMet: 0.373 ± 0.012	0.564LysAsn: 0.564 ± 0.017	1.296LysPro: 1.296 ± 0.029	0.691LysGln: 0.691 ± 0.02	1.405LysArg: 1.405 ± 0.029	1.222LysSer: 1.222 ± 0.025	1.307LysThr: 1.307 ± 0.029	1.932LysVal: 1.932 ± 0.036	0.272LysTrp: 0.272 ± 0.011	0.485LysTyr: 0.485 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.444LeuAla: 14.444 ± 0.092	0.83LeuCys: 0.83 ± 0.016	6.709LeuAsp: 6.709 ± 0.06	4.462LeuGlu: 4.462 ± 0.051	2.593LeuPhe: 2.593 ± 0.041	9.321LeuGly: 9.321 ± 0.07	2.256LeuHis: 2.256 ± 0.032	3.222LeuIle: 3.222 ± 0.045	2.024LeuLys: 2.024 ± 0.032	11.028LeuLeu: 11.028 ± 0.093	1.628LeuMet: 1.628 ± 0.027	1.706LeuAsn: 1.706 ± 0.028	6.342LeuPro: 6.342 ± 0.058	2.146LeuGln: 2.146 ± 0.032	8.715LeuArg: 8.715 ± 0.07	5.436LeuSer: 5.436 ± 0.045	6.809LeuThr: 6.809 ± 0.06	8.882LeuVal: 8.882 ± 0.066	1.288LeuTrp: 1.288 ± 0.027	1.872LeuTyr: 1.872 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.213MetAla: 2.213 ± 0.03	0.137MetCys: 0.137 ± 0.007	0.89MetAsp: 0.89 ± 0.019	0.733MetGlu: 0.733 ± 0.02	0.45MetPhe: 0.45 ± 0.014	1.305MetGly: 1.305 ± 0.025	0.364MetHis: 0.364 ± 0.013	0.65MetIle: 0.65 ± 0.019	0.415MetLys: 0.415 ± 0.014	1.612MetLeu: 1.612 ± 0.026	0.311MetMet: 0.311 ± 0.012	0.441MetAsn: 0.441 ± 0.014	1.111MetPro: 1.111 ± 0.023	0.405MetGln: 0.405 ± 0.013	1.445MetArg: 1.445 ± 0.027	1.332MetSer: 1.332 ± 0.024	1.583MetThr: 1.583 ± 0.023	1.278MetVal: 1.278 ± 0.026	0.221MetTrp: 0.221 ± 0.009	0.332MetTyr: 0.332 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.208AsnAla: 2.208 ± 0.03	0.154AsnCys: 0.154 ± 0.009	0.974AsnAsp: 0.974 ± 0.024	0.83AsnGlu: 0.83 ± 0.018	0.49AsnPhe: 0.49 ± 0.015	2.008AsnGly: 2.008 ± 0.039	0.406AsnHis: 0.406 ± 0.013	0.648AsnIle: 0.648 ± 0.016	0.426AsnLys: 0.426 ± 0.015	1.672AsnLeu: 1.672 ± 0.03	0.306AsnMet: 0.306 ± 0.012	0.443AsnAsn: 0.443 ± 0.017	1.349AsnPro: 1.349 ± 0.026	0.525AsnGln: 0.525 ± 0.015	1.261AsnArg: 1.261 ± 0.026	1.0AsnSer: 1.0 ± 0.023	1.161AsnThr: 1.161 ± 0.025	1.391AsnVal: 1.391 ± 0.026	0.303AsnTrp: 0.303 ± 0.012	0.392AsnTyr: 0.392 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.594ProAla: 8.594 ± 0.083	0.315ProCys: 0.315 ± 0.013	4.444ProAsp: 4.444 ± 0.045	4.039ProGlu: 4.039 ± 0.044	1.548ProPhe: 1.548 ± 0.026	6.834ProGly: 6.834 ± 0.078	1.468ProHis: 1.468 ± 0.026	1.209ProIle: 1.209 ± 0.025	1.185ProLys: 1.185 ± 0.026	5.288ProLeu: 5.288 ± 0.053	0.98ProMet: 0.98 ± 0.021	0.881ProAsn: 0.881 ± 0.02	3.567ProPro: 3.567 ± 0.07	1.652ProGln: 1.652 ± 0.034	4.249ProArg: 4.249 ± 0.046	3.316ProSer: 3.316 ± 0.047	3.16ProThr: 3.16 ± 0.038	5.625ProVal: 5.625 ± 0.058	0.897ProTrp: 0.897 ± 0.02	1.441ProTyr: 1.441 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.439GlnAla: 3.439 ± 0.046	0.163GlnCys: 0.163 ± 0.009	1.449GlnAsp: 1.449 ± 0.026	1.392GlnGlu: 1.392 ± 0.026	0.679GlnPhe: 0.679 ± 0.017	2.365GlnGly: 2.365 ± 0.036	0.65GlnHis: 0.65 ± 0.016	1.068GlnIle: 1.068 ± 0.022	0.653GlnLys: 0.653 ± 0.02	2.862GlnLeu: 2.862 ± 0.035	0.495GlnMet: 0.495 ± 0.014	0.529GlnAsn: 0.529 ± 0.016	1.588GlnPro: 1.588 ± 0.03	1.204GlnGln: 1.204 ± 0.037	2.314GlnArg: 2.314 ± 0.039	1.325GlnSer: 1.325 ± 0.026	1.349GlnThr: 1.349 ± 0.026	2.295GlnVal: 2.295 ± 0.032	0.442GlnTrp: 0.442 ± 0.014	0.625GlnTyr: 0.625 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.172ArgAla: 10.172 ± 0.086	0.569ArgCys: 0.569 ± 0.016	4.382ArgAsp: 4.382 ± 0.043	4.763ArgGlu: 4.763 ± 0.049	2.345ArgPhe: 2.345 ± 0.031	6.117ArgGly: 6.117 ± 0.049	2.195ArgHis: 2.195 ± 0.032	3.134ArgIle: 3.134 ± 0.037	1.602ArgLys: 1.602 ± 0.033	8.757ArgLeu: 8.757 ± 0.072	1.73ArgMet: 1.73 ± 0.025	1.388ArgAsn: 1.388 ± 0.028	5.101ArgPro: 5.101 ± 0.058	2.249ArgGln: 2.249 ± 0.031	7.932ArgArg: 7.932 ± 0.082	4.206ArgSer: 4.206 ± 0.045	5.705ArgThr: 5.705 ± 0.057	6.118ArgVal: 6.118 ± 0.055	1.395ArgTrp: 1.395 ± 0.024	1.771ArgTyr: 1.771 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.1SerAla: 7.1 ± 0.061	0.413SerCys: 0.413 ± 0.013	2.862SerAsp: 2.862 ± 0.04	2.469SerGlu: 2.469 ± 0.039	1.556SerPhe: 1.556 ± 0.025	6.29SerGly: 6.29 ± 0.058	1.063SerHis: 1.063 ± 0.022	1.415SerIle: 1.415 ± 0.025	1.099SerLys: 1.099 ± 0.025	4.993SerLeu: 4.993 ± 0.049	1.116SerMet: 1.116 ± 0.023	0.898SerAsn: 0.898 ± 0.022	3.239SerPro: 3.239 ± 0.043	1.287SerGln: 1.287 ± 0.023	3.863SerArg: 3.863 ± 0.041	2.98SerSer: 2.98 ± 0.046	3.231SerThr: 3.231 ± 0.04	4.517SerVal: 4.517 ± 0.045	0.924SerTrp: 0.924 ± 0.021	1.3SerTyr: 1.3 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.078ThrAla: 9.078 ± 0.067	0.439ThrCys: 0.439 ± 0.017	3.741ThrAsp: 3.741 ± 0.045	3.206ThrGlu: 3.206 ± 0.036	1.631ThrPhe: 1.631 ± 0.027	6.973ThrGly: 6.973 ± 0.055	1.275ThrHis: 1.275 ± 0.021	1.657ThrIle: 1.657 ± 0.031	1.21ThrLys: 1.21 ± 0.025	5.776ThrLeu: 5.776 ± 0.053	0.921ThrMet: 0.921 ± 0.02	1.012ThrAsn: 1.012 ± 0.024	4.3ThrPro: 4.3 ± 0.043	1.322ThrGln: 1.322 ± 0.022	4.129ThrArg: 4.129 ± 0.045	3.36ThrSer: 3.36 ± 0.04	3.965ThrThr: 3.965 ± 0.05	6.334ThrVal: 6.334 ± 0.058	0.905ThrTrp: 0.905 ± 0.019	1.41ThrTyr: 1.41 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.687ValAla: 10.687 ± 0.073	0.742ValCys: 0.742 ± 0.02	5.028ValAsp: 5.028 ± 0.048	4.712ValGlu: 4.712 ± 0.049	2.444ValPhe: 2.444 ± 0.038	6.66ValGly: 6.66 ± 0.055	2.014ValHis: 2.014 ± 0.032	2.847ValIle: 2.847 ± 0.036	1.784ValLys: 1.784 ± 0.029	9.485ValLeu: 9.485 ± 0.071	1.449ValMet: 1.449 ± 0.026	1.657ValAsn: 1.657 ± 0.028	5.363ValPro: 5.363 ± 0.054	2.096ValGln: 2.096 ± 0.027	7.481ValArg: 7.481 ± 0.066	4.542ValSer: 4.542 ± 0.047	5.877ValThr: 5.877 ± 0.057	8.181ValVal: 8.181 ± 0.072	1.162ValTrp: 1.162 ± 0.021	1.591ValTyr: 1.591 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.632TrpAla: 1.632 ± 0.025	0.15TrpCys: 0.15 ± 0.008	0.85TrpAsp: 0.85 ± 0.018	0.73TrpGlu: 0.73 ± 0.017	0.507TrpPhe: 0.507 ± 0.015	1.092TrpGly: 1.092 ± 0.025	0.364TrpHis: 0.364 ± 0.014	0.568TrpIle: 0.568 ± 0.017	0.381TrpLys: 0.381 ± 0.014	1.744TrpLeu: 1.744 ± 0.027	0.285TrpMet: 0.285 ± 0.012	0.415TrpAsn: 0.415 ± 0.012	0.776TrpPro: 0.776 ± 0.022	0.593TrpGln: 0.593 ± 0.017	1.325TrpArg: 1.325 ± 0.024	0.97TrpSer: 0.97 ± 0.02	1.076TrpThr: 1.076 ± 0.022	0.941TrpVal: 0.941 ± 0.02	0.338TrpTrp: 0.338 ± 0.013	0.378TrpTyr: 0.378 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.778TyrAla: 2.778 ± 0.038	0.175TyrCys: 0.175 ± 0.009	1.568TyrAsp: 1.568 ± 0.028	1.294TyrGlu: 1.294 ± 0.027	0.64TyrPhe: 0.64 ± 0.017	2.352TyrGly: 2.352 ± 0.032	0.378TyrHis: 0.378 ± 0.012	0.501TyrIle: 0.501 ± 0.015	0.404TyrLys: 0.404 ± 0.014	2.052TyrLeu: 2.052 ± 0.034	0.244TyrMet: 0.244 ± 0.01	0.393TyrAsn: 0.393 ± 0.015	1.052TyrPro: 1.052 ± 0.023	0.622TyrGln: 0.622 ± 0.017	1.796TyrArg: 1.796 ± 0.031	1.009TyrSer: 1.009 ± 0.021	1.219TyrThr: 1.219 ± 0.024	1.707TyrVal: 1.707 ± 0.033	0.346TyrTrp: 0.346 ± 0.013	0.459TyrTyr: 0.459 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7303 proteins (2412140 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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