Amino acid dipepetide frequency for Streptomyces sp. QMT-12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.86AlaAla: 21.86 ± 0.16
1.001AlaCys: 1.001 ± 0.02
8.44AlaAsp: 8.44 ± 0.077
8.464AlaGlu: 8.464 ± 0.092
3.607AlaPhe: 3.607 ± 0.045
14.116AlaGly: 14.116 ± 0.094
2.839AlaHis: 2.839 ± 0.044
3.246AlaIle: 3.246 ± 0.049
2.798AlaLys: 2.798 ± 0.054
14.601AlaLeu: 14.601 ± 0.109
2.381AlaMet: 2.381 ± 0.032
1.876AlaAsn: 1.876 ± 0.036
7.817AlaPro: 7.817 ± 0.096
3.489AlaGln: 3.489 ± 0.042
10.536AlaArg: 10.536 ± 0.08
6.189AlaSer: 6.189 ± 0.056
7.205AlaThr: 7.205 ± 0.064
12.532AlaVal: 12.532 ± 0.093
1.881AlaTrp: 1.881 ± 0.03
2.812AlaTyr: 2.812 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
0.989CysAla: 0.989 ± 0.024
0.076CysCys: 0.076 ± 0.006
0.439CysAsp: 0.439 ± 0.016
0.336CysGlu: 0.336 ± 0.014
0.196CysPhe: 0.196 ± 0.009
0.874CysGly: 0.874 ± 0.022
0.168CysHis: 0.168 ± 0.009
0.136CysIle: 0.136 ± 0.008
0.094CysLys: 0.094 ± 0.007
0.671CysLeu: 0.671 ± 0.017
0.099CysMet: 0.099 ± 0.006
0.132CysAsn: 0.132 ± 0.007
0.413CysPro: 0.413 ± 0.015
0.135CysGln: 0.135 ± 0.008
0.526CysArg: 0.526 ± 0.015
0.38CysSer: 0.38 ± 0.014
0.433CysThr: 0.433 ± 0.016
0.648CysVal: 0.648 ± 0.017
0.108CysTrp: 0.108 ± 0.007
0.133CysTyr: 0.133 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.947AspAla: 7.947 ± 0.067
0.376AspCys: 0.376 ± 0.014
3.553AspAsp: 3.553 ± 0.047
3.728AspGlu: 3.728 ± 0.055
1.658AspPhe: 1.658 ± 0.031
6.529AspGly: 6.529 ± 0.061
1.511AspHis: 1.511 ± 0.028
1.857AspIle: 1.857 ± 0.036
1.149AspLys: 1.149 ± 0.029
6.445AspLeu: 6.445 ± 0.062
0.76AspMet: 0.76 ± 0.021
1.023AspAsn: 1.023 ± 0.025
4.72AspPro: 4.72 ± 0.051
1.505AspGln: 1.505 ± 0.027
5.02AspArg: 5.02 ± 0.058
2.581AspSer: 2.581 ± 0.036
3.389AspThr: 3.389 ± 0.044
4.777AspVal: 4.777 ± 0.05
0.974AspTrp: 0.974 ± 0.02
1.028AspTyr: 1.028 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
7.283GluAla: 7.283 ± 0.084
0.324GluCys: 0.324 ± 0.012
2.793GluAsp: 2.793 ± 0.042
3.361GluGlu: 3.361 ± 0.051
1.398GluPhe: 1.398 ± 0.023
4.307GluGly: 4.307 ± 0.049
1.336GluHis: 1.336 ± 0.025
2.239GluIle: 2.239 ± 0.037
1.332GluLys: 1.332 ± 0.034
6.398GluLeu: 6.398 ± 0.073
0.823GluMet: 0.823 ± 0.021
0.997GluAsn: 0.997 ± 0.022
3.246GluPro: 3.246 ± 0.047
1.966GluGln: 1.966 ± 0.034
5.447GluArg: 5.447 ± 0.051
2.606GluSer: 2.606 ± 0.041
2.827GluThr: 2.827 ± 0.038
4.21GluVal: 4.21 ± 0.054
0.729GluTrp: 0.729 ± 0.021
1.029GluTyr: 1.029 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.741PheAla: 3.741 ± 0.046
0.256PheCys: 0.256 ± 0.01
2.011PheAsp: 2.011 ± 0.036
1.368PheGlu: 1.368 ± 0.027
0.887PhePhe: 0.887 ± 0.023
3.054PheGly: 3.054 ± 0.04
0.603PheHis: 0.603 ± 0.017
0.659PheIle: 0.659 ± 0.02
0.513PheLys: 0.513 ± 0.016
2.643PheLeu: 2.643 ± 0.043
0.39PheMet: 0.39 ± 0.015
0.557PheAsn: 0.557 ± 0.018
1.416PhePro: 1.416 ± 0.024
0.676PheGln: 0.676 ± 0.019
1.881PheArg: 1.881 ± 0.032
1.526PheSer: 1.526 ± 0.03
2.061PheThr: 2.061 ± 0.032
2.3PheVal: 2.3 ± 0.037
0.424PheTrp: 0.424 ± 0.014
0.559PheTyr: 0.559 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
12.002GlyAla: 12.002 ± 0.093
0.743GlyCys: 0.743 ± 0.02
5.416GlyAsp: 5.416 ± 0.048
5.173GlyGlu: 5.173 ± 0.051
2.939GlyPhe: 2.939 ± 0.044
9.668GlyGly: 9.668 ± 0.102
2.319GlyHis: 2.319 ± 0.038
3.432GlyIle: 3.432 ± 0.047
2.421GlyLys: 2.421 ± 0.047
9.596GlyLeu: 9.596 ± 0.075
1.856GlyMet: 1.856 ± 0.026
1.804GlyAsn: 1.804 ± 0.035
5.648GlyPro: 5.648 ± 0.081
2.675GlyGln: 2.675 ± 0.043
8.041GlyArg: 8.041 ± 0.075
5.61GlySer: 5.61 ± 0.058
6.873GlyThr: 6.873 ± 0.063
7.756GlyVal: 7.756 ± 0.057
1.658GlyTrp: 1.658 ± 0.028
2.254GlyTyr: 2.254 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
2.637HisAla: 2.637 ± 0.034
0.172HisCys: 0.172 ± 0.009
1.368HisAsp: 1.368 ± 0.024
1.125HisGlu: 1.125 ± 0.024
0.66HisPhe: 0.66 ± 0.017
2.323HisGly: 2.323 ± 0.036
0.734HisHis: 0.734 ± 0.021
0.611HisIle: 0.611 ± 0.016
0.299HisLys: 0.299 ± 0.012
2.396HisLeu: 2.396 ± 0.037
0.301HisMet: 0.301 ± 0.012
0.365HisAsn: 0.365 ± 0.012
1.839HisPro: 1.839 ± 0.033
0.647HisGln: 0.647 ± 0.016
2.04HisArg: 2.04 ± 0.035
0.984HisSer: 0.984 ± 0.021
1.283HisThr: 1.283 ± 0.024
1.641HisVal: 1.641 ± 0.029
0.348HisTrp: 0.348 ± 0.011
0.465HisTyr: 0.465 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.463IleAla: 4.463 ± 0.052
0.272IleCys: 0.272 ± 0.011
2.13IleAsp: 2.13 ± 0.032
1.872IleGlu: 1.872 ± 0.033
0.722IlePhe: 0.722 ± 0.018
3.46IleGly: 3.46 ± 0.043
0.584IleHis: 0.584 ± 0.016
0.842IleIle: 0.842 ± 0.021
0.705IleLys: 0.705 ± 0.019
2.453IleLeu: 2.453 ± 0.04
0.426IleMet: 0.426 ± 0.016
0.702IleAsn: 0.702 ± 0.019
1.755IlePro: 1.755 ± 0.028
0.737IleGln: 0.737 ± 0.019
2.15IleArg: 2.15 ± 0.034
1.642IleSer: 1.642 ± 0.031
2.144IleThr: 2.144 ± 0.035
2.62IleVal: 2.62 ± 0.042
0.369IleTrp: 0.369 ± 0.013
0.52IleTyr: 0.52 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
2.844LysAla: 2.844 ± 0.049
0.107LysCys: 0.107 ± 0.008
1.362LysAsp: 1.362 ± 0.029
1.144LysGlu: 1.144 ± 0.026
0.456LysPhe: 0.456 ± 0.015
1.793LysGly: 1.793 ± 0.036
0.416LysHis: 0.416 ± 0.017
0.841LysIle: 0.841 ± 0.02
0.824LysLys: 0.824 ± 0.033
1.95LysLeu: 1.95 ± 0.035
0.359LysMet: 0.359 ± 0.015
0.563LysAsn: 0.563 ± 0.022
1.264LysPro: 1.264 ± 0.033
0.618LysGln: 0.618 ± 0.023
1.347LysArg: 1.347 ± 0.027
1.103LysSer: 1.103 ± 0.027
1.246LysThr: 1.246 ± 0.027
1.774LysVal: 1.774 ± 0.038
0.253LysTrp: 0.253 ± 0.012
0.422LysTyr: 0.422 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
15.264LeuAla: 15.264 ± 0.12
0.77LeuCys: 0.77 ± 0.017
6.86LeuAsp: 6.86 ± 0.064
4.449LeuGlu: 4.449 ± 0.056
2.678LeuPhe: 2.678 ± 0.043
9.478LeuGly: 9.478 ± 0.07
2.214LeuHis: 2.214 ± 0.032
3.162LeuIle: 3.162 ± 0.049
1.847LeuLys: 1.847 ± 0.039
11.274LeuLeu: 11.274 ± 0.096
1.58LeuMet: 1.58 ± 0.031
1.668LeuAsn: 1.668 ± 0.036
6.657LeuPro: 6.657 ± 0.07
2.005LeuGln: 2.005 ± 0.031
8.533LeuArg: 8.533 ± 0.074
5.358LeuSer: 5.358 ± 0.051
7.057LeuThr: 7.057 ± 0.066
9.028LeuVal: 9.028 ± 0.086
1.264LeuTrp: 1.264 ± 0.029
1.888LeuTyr: 1.888 ± 0.032
0.0LeuXaa: 0.0 ± 0.0
Met
2.108MetAla: 2.108 ± 0.033
0.113MetCys: 0.113 ± 0.006
0.844MetAsp: 0.844 ± 0.02
0.721MetGlu: 0.721 ± 0.018
0.428MetPhe: 0.428 ± 0.015
1.245MetGly: 1.245 ± 0.026
0.323MetHis: 0.323 ± 0.012
0.628MetIle: 0.628 ± 0.019
0.394MetLys: 0.394 ± 0.014
1.556MetLeu: 1.556 ± 0.027
0.267MetMet: 0.267 ± 0.012
0.423MetAsn: 0.423 ± 0.013
1.052MetPro: 1.052 ± 0.023
0.378MetGln: 0.378 ± 0.015
1.337MetArg: 1.337 ± 0.025
1.265MetSer: 1.265 ± 0.022
1.509MetThr: 1.509 ± 0.026
1.208MetVal: 1.208 ± 0.029
0.198MetTrp: 0.198 ± 0.01
0.326MetTyr: 0.326 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.216AsnAla: 2.216 ± 0.031
0.15AsnCys: 0.15 ± 0.008
0.985AsnAsp: 0.985 ± 0.023
0.779AsnGlu: 0.779 ± 0.019
0.488AsnPhe: 0.488 ± 0.015
1.972AsnGly: 1.972 ± 0.041
0.384AsnHis: 0.384 ± 0.016
0.641AsnIle: 0.641 ± 0.021
0.425AsnLys: 0.425 ± 0.016
1.647AsnLeu: 1.647 ± 0.033
0.285AsnMet: 0.285 ± 0.012
0.501AsnAsn: 0.501 ± 0.023
1.317AsnPro: 1.317 ± 0.029
0.517AsnGln: 0.517 ± 0.018
1.261AsnArg: 1.261 ± 0.026
0.964AsnSer: 0.964 ± 0.024
1.158AsnThr: 1.158 ± 0.026
1.385AsnVal: 1.385 ± 0.028
0.277AsnTrp: 0.277 ± 0.011
0.419AsnTyr: 0.419 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
9.468ProAla: 9.468 ± 0.104
0.287ProCys: 0.287 ± 0.013
4.715ProAsp: 4.715 ± 0.057
4.153ProGlu: 4.153 ± 0.05
1.591ProPhe: 1.591 ± 0.029
7.311ProGly: 7.311 ± 0.076
1.395ProHis: 1.395 ± 0.028
1.182ProIle: 1.182 ± 0.026
1.088ProLys: 1.088 ± 0.028
5.581ProLeu: 5.581 ± 0.059
0.946ProMet: 0.946 ± 0.025
0.885ProAsn: 0.885 ± 0.024
4.027ProPro: 4.027 ± 0.077
1.619ProGln: 1.619 ± 0.039
4.216ProArg: 4.216 ± 0.056
3.289ProSer: 3.289 ± 0.047
3.277ProThr: 3.277 ± 0.044
5.683ProVal: 5.683 ± 0.064
0.868ProTrp: 0.868 ± 0.02
1.498ProTyr: 1.498 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.45GlnAla: 3.45 ± 0.048
0.135GlnCys: 0.135 ± 0.008
1.422GlnAsp: 1.422 ± 0.027
1.381GlnGlu: 1.381 ± 0.03
0.677GlnPhe: 0.677 ± 0.017
2.322GlnGly: 2.322 ± 0.042
0.575GlnHis: 0.575 ± 0.014
1.033GlnIle: 1.033 ± 0.023
0.557GlnLys: 0.557 ± 0.019
2.905GlnLeu: 2.905 ± 0.039
0.434GlnMet: 0.434 ± 0.016
0.517GlnAsn: 0.517 ± 0.019
1.52GlnPro: 1.52 ± 0.033
1.128GlnGln: 1.128 ± 0.041
2.152GlnArg: 2.152 ± 0.034
1.149GlnSer: 1.149 ± 0.026
1.182GlnThr: 1.182 ± 0.026
2.313GlnVal: 2.313 ± 0.032
0.394GlnTrp: 0.394 ± 0.014
0.596GlnTyr: 0.596 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
10.081ArgAla: 10.081 ± 0.096
0.519ArgCys: 0.519 ± 0.014
4.419ArgAsp: 4.419 ± 0.052
4.623ArgGlu: 4.623 ± 0.052
2.329ArgPhe: 2.329 ± 0.033
6.021ArgGly: 6.021 ± 0.057
2.009ArgHis: 2.009 ± 0.032
3.173ArgIle: 3.173 ± 0.034
1.574ArgLys: 1.574 ± 0.028
8.64ArgLeu: 8.64 ± 0.081
1.623ArgMet: 1.623 ± 0.03
1.383ArgAsn: 1.383 ± 0.027
5.084ArgPro: 5.084 ± 0.065
2.119ArgGln: 2.119 ± 0.031
7.485ArgArg: 7.485 ± 0.078
4.048ArgSer: 4.048 ± 0.044
5.844ArgThr: 5.844 ± 0.057
6.044ArgVal: 6.044 ± 0.054
1.386ArgTrp: 1.386 ± 0.028
1.77ArgTyr: 1.77 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
7.025SerAla: 7.025 ± 0.064
0.355SerCys: 0.355 ± 0.014
2.762SerAsp: 2.762 ± 0.036
2.261SerGlu: 2.261 ± 0.034
1.614SerPhe: 1.614 ± 0.027
6.158SerGly: 6.158 ± 0.063
1.001SerHis: 1.001 ± 0.022
1.393SerIle: 1.393 ± 0.027
1.022SerLys: 1.022 ± 0.027
4.86SerLeu: 4.86 ± 0.047
1.02SerMet: 1.02 ± 0.02
0.869SerAsn: 0.869 ± 0.023
3.303SerPro: 3.303 ± 0.042
1.169SerGln: 1.169 ± 0.027
3.674SerArg: 3.674 ± 0.045
2.85SerSer: 2.85 ± 0.05
3.098SerThr: 3.098 ± 0.043
4.548SerVal: 4.548 ± 0.044
0.88SerTrp: 0.88 ± 0.02
1.233SerTyr: 1.233 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
9.062ThrAla: 9.062 ± 0.073
0.37ThrCys: 0.37 ± 0.013
3.816ThrAsp: 3.816 ± 0.049
3.187ThrGlu: 3.187 ± 0.045
1.656ThrPhe: 1.656 ± 0.031
7.044ThrGly: 7.044 ± 0.065
1.204ThrHis: 1.204 ± 0.026
1.685ThrIle: 1.685 ± 0.03
1.15ThrLys: 1.15 ± 0.03
6.05ThrLeu: 6.05 ± 0.055
0.874ThrMet: 0.874 ± 0.019
1.014ThrAsn: 1.014 ± 0.024
4.512ThrPro: 4.512 ± 0.054
1.299ThrGln: 1.299 ± 0.026
3.932ThrArg: 3.932 ± 0.045
3.277ThrSer: 3.277 ± 0.04
4.196ThrThr: 4.196 ± 0.054
6.169ThrVal: 6.169 ± 0.055
0.914ThrTrp: 0.914 ± 0.021
1.423ThrTyr: 1.423 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
10.9ValAla: 10.9 ± 0.08
0.675ValCys: 0.675 ± 0.019
4.931ValAsp: 4.931 ± 0.048
4.598ValGlu: 4.598 ± 0.05
2.405ValPhe: 2.405 ± 0.035
6.757ValGly: 6.757 ± 0.064
1.887ValHis: 1.887 ± 0.032
2.768ValIle: 2.768 ± 0.04
1.775ValLys: 1.775 ± 0.033
9.615ValLeu: 9.615 ± 0.079
1.41ValMet: 1.41 ± 0.028
1.648ValAsn: 1.648 ± 0.032
5.646ValPro: 5.646 ± 0.06
2.012ValGln: 2.012 ± 0.031
7.482ValArg: 7.482 ± 0.065
4.369ValSer: 4.369 ± 0.048
5.821ValThr: 5.821 ± 0.048
8.291ValVal: 8.291 ± 0.083
1.123ValTrp: 1.123 ± 0.023
1.551ValTyr: 1.551 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.595TrpAla: 1.595 ± 0.026
0.126TrpCys: 0.126 ± 0.007
0.785TrpAsp: 0.785 ± 0.02
0.69TrpGlu: 0.69 ± 0.02
0.497TrpPhe: 0.497 ± 0.013
1.059TrpGly: 1.059 ± 0.021
0.351TrpHis: 0.351 ± 0.011
0.554TrpIle: 0.554 ± 0.015
0.354TrpLys: 0.354 ± 0.013
1.689TrpLeu: 1.689 ± 0.03
0.254TrpMet: 0.254 ± 0.011
0.423TrpAsn: 0.423 ± 0.015
0.775TrpPro: 0.775 ± 0.019
0.554TrpGln: 0.554 ± 0.017
1.309TrpArg: 1.309 ± 0.027
0.957TrpSer: 0.957 ± 0.022
1.032TrpThr: 1.032 ± 0.021
1.001TrpVal: 1.001 ± 0.021
0.35TrpTrp: 0.35 ± 0.013
0.365TrpTyr: 0.365 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.756TyrAla: 2.756 ± 0.034
0.161TyrCys: 0.161 ± 0.008
1.477TyrAsp: 1.477 ± 0.028
1.238TyrGlu: 1.238 ± 0.028
0.642TyrPhe: 0.642 ± 0.018
2.392TyrGly: 2.392 ± 0.036
0.384TyrHis: 0.384 ± 0.013
0.486TyrIle: 0.486 ± 0.017
0.365TyrLys: 0.365 ± 0.015
2.068TyrLeu: 2.068 ± 0.032
0.235TyrMet: 0.235 ± 0.011
0.421TyrAsn: 0.421 ± 0.016
1.065TyrPro: 1.065 ± 0.023
0.593TyrGln: 0.593 ± 0.017
1.804TyrArg: 1.804 ± 0.03
0.948TyrSer: 0.948 ± 0.023
1.199TyrThr: 1.199 ± 0.027
1.738TyrVal: 1.738 ± 0.027
0.322TyrTrp: 0.322 ± 0.013
0.417TyrTyr: 0.417 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6444 proteins (2205703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski