Amino acid dipepetide frequency for Mycobacterium virus Ramsey

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.528AlaAla: 14.528 ± 1.636
0.958AlaCys: 0.958 ± 0.243
7.078AlaAsp: 7.078 ± 0.626
7.983AlaGlu: 7.983 ± 0.893
2.927AlaPhe: 2.927 ± 0.453
9.419AlaGly: 9.419 ± 1.345
1.916AlaHis: 1.916 ± 0.339
4.63AlaIle: 4.63 ± 0.635
4.098AlaLys: 4.098 ± 0.416
8.142AlaLeu: 8.142 ± 0.708
2.608AlaMet: 2.608 ± 0.378
3.193AlaAsn: 3.193 ± 0.537
4.843AlaPro: 4.843 ± 0.621
3.938AlaGln: 3.938 ± 0.472
6.386AlaArg: 6.386 ± 0.635
5.801AlaSer: 5.801 ± 0.658
6.333AlaThr: 6.333 ± 0.611
6.865AlaVal: 6.865 ± 0.54
2.288AlaTrp: 2.288 ± 0.391
2.342AlaTyr: 2.342 ± 0.31
0.0AlaXaa: 0.0 ± 0.0
Cys
0.905CysAla: 0.905 ± 0.253
0.16CysCys: 0.16 ± 0.091
0.745CysAsp: 0.745 ± 0.166
1.064CysGlu: 1.064 ± 0.303
0.16CysPhe: 0.16 ± 0.089
1.65CysGly: 1.65 ± 0.345
0.266CysHis: 0.266 ± 0.124
0.319CysIle: 0.319 ± 0.126
0.319CysLys: 0.319 ± 0.128
0.585CysLeu: 0.585 ± 0.202
0.319CysMet: 0.319 ± 0.134
0.532CysAsn: 0.532 ± 0.153
1.171CysPro: 1.171 ± 0.282
0.426CysGln: 0.426 ± 0.169
0.798CysArg: 0.798 ± 0.26
0.639CysSer: 0.639 ± 0.23
0.639CysThr: 0.639 ± 0.205
0.692CysVal: 0.692 ± 0.208
0.266CysTrp: 0.266 ± 0.112
0.16CysTyr: 0.16 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
7.238AspAla: 7.238 ± 0.536
0.851AspCys: 0.851 ± 0.212
4.417AspAsp: 4.417 ± 0.576
3.353AspGlu: 3.353 ± 0.459
1.49AspPhe: 1.49 ± 0.222
6.173AspGly: 6.173 ± 0.572
1.118AspHis: 1.118 ± 0.183
2.661AspIle: 2.661 ± 0.435
1.809AspLys: 1.809 ± 0.304
6.067AspLeu: 6.067 ± 0.621
1.171AspMet: 1.171 ± 0.28
1.809AspAsn: 1.809 ± 0.339
4.79AspPro: 4.79 ± 0.526
2.714AspGln: 2.714 ± 0.409
5.162AspArg: 5.162 ± 0.697
3.193AspSer: 3.193 ± 0.527
3.566AspThr: 3.566 ± 0.471
4.577AspVal: 4.577 ± 0.57
1.543AspTrp: 1.543 ± 0.285
2.022AspTyr: 2.022 ± 0.315
0.0AspXaa: 0.0 ± 0.0
Glu
5.801GluAla: 5.801 ± 0.73
0.692GluCys: 0.692 ± 0.234
2.82GluAsp: 2.82 ± 0.335
3.033GluGlu: 3.033 ± 0.478
2.235GluPhe: 2.235 ± 0.289
3.619GluGly: 3.619 ± 0.447
1.277GluHis: 1.277 ± 0.346
2.608GluIle: 2.608 ± 0.41
1.703GluLys: 1.703 ± 0.353
5.109GluLeu: 5.109 ± 0.675
1.703GluMet: 1.703 ± 0.348
2.022GluAsn: 2.022 ± 0.317
3.033GluPro: 3.033 ± 0.43
2.98GluGln: 2.98 ± 0.427
4.896GluArg: 4.896 ± 0.548
2.98GluSer: 2.98 ± 0.395
4.417GluThr: 4.417 ± 0.609
4.47GluVal: 4.47 ± 0.555
1.33GluTrp: 1.33 ± 0.272
1.543GluTyr: 1.543 ± 0.322
0.0GluXaa: 0.0 ± 0.0
Phe
3.246PheAla: 3.246 ± 0.36
0.266PheCys: 0.266 ± 0.12
2.235PheAsp: 2.235 ± 0.322
1.543PheGlu: 1.543 ± 0.274
0.798PhePhe: 0.798 ± 0.276
3.353PheGly: 3.353 ± 0.722
0.426PheHis: 0.426 ± 0.154
1.118PheIle: 1.118 ± 0.296
1.171PheLys: 1.171 ± 0.247
1.756PheLeu: 1.756 ± 0.266
0.585PheMet: 0.585 ± 0.178
1.118PheAsn: 1.118 ± 0.343
1.809PhePro: 1.809 ± 0.311
0.905PheGln: 0.905 ± 0.304
1.703PheArg: 1.703 ± 0.312
1.65PheSer: 1.65 ± 0.281
1.863PheThr: 1.863 ± 0.344
2.075PheVal: 2.075 ± 0.264
0.639PheTrp: 0.639 ± 0.162
0.905PheTyr: 0.905 ± 0.208
0.0PheXaa: 0.0 ± 0.0
Gly
9.473GlyAla: 9.473 ± 1.016
0.905GlyCys: 0.905 ± 0.252
6.705GlyAsp: 6.705 ± 0.561
3.512GlyGlu: 3.512 ± 0.476
2.82GlyPhe: 2.82 ± 0.386
10.058GlyGly: 10.058 ± 2.072
1.916GlyHis: 1.916 ± 0.305
4.364GlyIle: 4.364 ± 0.492
3.087GlyLys: 3.087 ± 0.374
5.96GlyLeu: 5.96 ± 0.56
2.608GlyMet: 2.608 ± 0.429
3.14GlyAsn: 3.14 ± 0.346
3.832GlyPro: 3.832 ± 0.539
2.927GlyGln: 2.927 ± 0.664
5.109GlyArg: 5.109 ± 0.618
5.588GlySer: 5.588 ± 0.85
6.439GlyThr: 6.439 ± 0.74
6.226GlyVal: 6.226 ± 0.703
2.661GlyTrp: 2.661 ± 0.368
2.288GlyTyr: 2.288 ± 0.392
0.0GlyXaa: 0.0 ± 0.0
His
1.756HisAla: 1.756 ± 0.362
0.373HisCys: 0.373 ± 0.183
1.597HisAsp: 1.597 ± 0.325
1.224HisGlu: 1.224 ± 0.26
0.532HisPhe: 0.532 ± 0.164
1.916HisGly: 1.916 ± 0.325
0.798HisHis: 0.798 ± 0.222
1.597HisIle: 1.597 ± 0.265
0.692HisLys: 0.692 ± 0.24
1.437HisLeu: 1.437 ± 0.242
0.373HisMet: 0.373 ± 0.141
0.851HisAsn: 0.851 ± 0.213
1.224HisPro: 1.224 ± 0.225
0.639HisGln: 0.639 ± 0.22
1.916HisArg: 1.916 ± 0.358
0.745HisSer: 0.745 ± 0.181
1.49HisThr: 1.49 ± 0.314
1.277HisVal: 1.277 ± 0.282
0.319HisTrp: 0.319 ± 0.122
0.745HisTyr: 0.745 ± 0.169
0.0HisXaa: 0.0 ± 0.0
Ile
5.268IleAla: 5.268 ± 0.528
0.639IleCys: 0.639 ± 0.247
3.512IleAsp: 3.512 ± 0.442
3.459IleGlu: 3.459 ± 0.376
0.798IlePhe: 0.798 ± 0.232
4.098IleGly: 4.098 ± 0.401
1.49IleHis: 1.49 ± 0.274
1.543IleIle: 1.543 ± 0.267
1.118IleLys: 1.118 ± 0.234
2.448IleLeu: 2.448 ± 0.469
0.266IleMet: 0.266 ± 0.12
1.809IleAsn: 1.809 ± 0.306
2.608IlePro: 2.608 ± 0.388
1.703IleGln: 1.703 ± 0.285
3.193IleArg: 3.193 ± 0.485
2.235IleSer: 2.235 ± 0.492
3.512IleThr: 3.512 ± 0.438
3.406IleVal: 3.406 ± 0.461
0.851IleTrp: 0.851 ± 0.193
0.692IleTyr: 0.692 ± 0.187
0.0IleXaa: 0.0 ± 0.0
Lys
4.044LysAla: 4.044 ± 0.542
0.479LysCys: 0.479 ± 0.184
1.597LysAsp: 1.597 ± 0.312
1.33LysGlu: 1.33 ± 0.247
1.384LysPhe: 1.384 ± 0.268
2.342LysGly: 2.342 ± 0.349
0.958LysHis: 0.958 ± 0.27
1.011LysIle: 1.011 ± 0.25
1.597LysLys: 1.597 ± 0.425
3.033LysLeu: 3.033 ± 0.49
0.905LysMet: 0.905 ± 0.173
1.064LysAsn: 1.064 ± 0.217
2.554LysPro: 2.554 ± 0.377
1.277LysGln: 1.277 ± 0.232
1.863LysArg: 1.863 ± 0.341
1.969LysSer: 1.969 ± 0.307
1.969LysThr: 1.969 ± 0.311
2.448LysVal: 2.448 ± 0.389
1.171LysTrp: 1.171 ± 0.322
0.745LysTyr: 0.745 ± 0.229
0.0LysXaa: 0.0 ± 0.0
Leu
7.397LeuAla: 7.397 ± 0.744
0.639LeuCys: 0.639 ± 0.188
5.481LeuAsp: 5.481 ± 0.508
3.512LeuGlu: 3.512 ± 0.455
2.129LeuPhe: 2.129 ± 0.283
5.801LeuGly: 5.801 ± 0.553
0.905LeuHis: 0.905 ± 0.259
3.033LeuIle: 3.033 ± 0.318
2.022LeuLys: 2.022 ± 0.343
4.896LeuLeu: 4.896 ± 0.54
1.384LeuMet: 1.384 ± 0.316
2.608LeuAsn: 2.608 ± 0.364
5.854LeuPro: 5.854 ± 0.695
2.608LeuGln: 2.608 ± 0.437
5.694LeuArg: 5.694 ± 0.606
5.162LeuSer: 5.162 ± 0.533
5.481LeuThr: 5.481 ± 0.522
5.268LeuVal: 5.268 ± 0.534
1.437LeuTrp: 1.437 ± 0.261
1.916LeuTyr: 1.916 ± 0.331
0.0LeuXaa: 0.0 ± 0.0
Met
1.916MetAla: 1.916 ± 0.355
0.319MetCys: 0.319 ± 0.15
0.851MetAsp: 0.851 ± 0.207
0.958MetGlu: 0.958 ± 0.173
0.798MetPhe: 0.798 ± 0.213
2.129MetGly: 2.129 ± 0.288
0.16MetHis: 0.16 ± 0.097
0.958MetIle: 0.958 ± 0.266
1.118MetLys: 1.118 ± 0.285
1.437MetLeu: 1.437 ± 0.247
0.532MetMet: 0.532 ± 0.213
1.064MetAsn: 1.064 ± 0.185
1.277MetPro: 1.277 ± 0.303
0.426MetGln: 0.426 ± 0.147
1.543MetArg: 1.543 ± 0.233
2.98MetSer: 2.98 ± 0.429
2.182MetThr: 2.182 ± 0.365
1.171MetVal: 1.171 ± 0.304
0.319MetTrp: 0.319 ± 0.142
0.426MetTyr: 0.426 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
3.566AsnAla: 3.566 ± 0.448
0.213AsnCys: 0.213 ± 0.095
1.756AsnAsp: 1.756 ± 0.296
1.916AsnGlu: 1.916 ± 0.355
1.011AsnPhe: 1.011 ± 0.28
4.843AsnGly: 4.843 ± 0.629
0.798AsnHis: 0.798 ± 0.167
1.65AsnIle: 1.65 ± 0.5
0.798AsnLys: 0.798 ± 0.216
2.661AsnLeu: 2.661 ± 0.329
0.692AsnMet: 0.692 ± 0.171
1.703AsnAsn: 1.703 ± 0.333
2.661AsnPro: 2.661 ± 0.338
1.171AsnGln: 1.171 ± 0.297
2.395AsnArg: 2.395 ± 0.432
1.756AsnSer: 1.756 ± 0.293
2.501AsnThr: 2.501 ± 0.315
1.437AsnVal: 1.437 ± 0.222
0.585AsnTrp: 0.585 ± 0.204
0.851AsnTyr: 0.851 ± 0.167
0.0AsnXaa: 0.0 ± 0.0
Pro
5.375ProAla: 5.375 ± 0.48
0.692ProCys: 0.692 ± 0.221
4.47ProAsp: 4.47 ± 0.532
4.683ProGlu: 4.683 ± 0.521
1.969ProPhe: 1.969 ± 0.34
6.492ProGly: 6.492 ± 0.677
1.384ProHis: 1.384 ± 0.278
2.129ProIle: 2.129 ± 0.354
2.022ProLys: 2.022 ± 0.388
4.098ProLeu: 4.098 ± 0.562
1.543ProMet: 1.543 ± 0.349
2.235ProAsn: 2.235 ± 0.339
3.832ProPro: 3.832 ± 0.521
2.608ProGln: 2.608 ± 0.425
3.299ProArg: 3.299 ± 0.453
3.459ProSer: 3.459 ± 0.53
2.927ProThr: 2.927 ± 0.453
4.098ProVal: 4.098 ± 0.429
0.905ProTrp: 0.905 ± 0.204
1.703ProTyr: 1.703 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
4.311GlnAla: 4.311 ± 0.649
0.373GlnCys: 0.373 ± 0.152
1.437GlnAsp: 1.437 ± 0.28
1.809GlnGlu: 1.809 ± 0.29
1.171GlnPhe: 1.171 ± 0.254
2.448GlnGly: 2.448 ± 0.433
0.851GlnHis: 0.851 ± 0.195
1.969GlnIle: 1.969 ± 0.3
1.171GlnLys: 1.171 ± 0.207
3.406GlnLeu: 3.406 ± 0.536
0.958GlnMet: 0.958 ± 0.215
1.011GlnAsn: 1.011 ± 0.274
2.342GlnPro: 2.342 ± 0.407
2.022GlnGln: 2.022 ± 0.387
2.395GlnArg: 2.395 ± 0.424
2.554GlnSer: 2.554 ± 0.357
1.863GlnThr: 1.863 ± 0.359
2.395GlnVal: 2.395 ± 0.296
0.798GlnTrp: 0.798 ± 0.197
0.798GlnTyr: 0.798 ± 0.238
0.0GlnXaa: 0.0 ± 0.0
Arg
6.971ArgAla: 6.971 ± 0.726
1.437ArgCys: 1.437 ± 0.352
4.311ArgAsp: 4.311 ± 0.612
5.268ArgGlu: 5.268 ± 0.599
1.65ArgPhe: 1.65 ± 0.328
4.311ArgGly: 4.311 ± 0.403
1.65ArgHis: 1.65 ± 0.331
3.087ArgIle: 3.087 ± 0.401
2.075ArgLys: 2.075 ± 0.322
5.056ArgLeu: 5.056 ± 0.529
2.448ArgMet: 2.448 ± 0.449
2.608ArgAsn: 2.608 ± 0.467
3.619ArgPro: 3.619 ± 0.424
2.235ArgGln: 2.235 ± 0.418
5.428ArgArg: 5.428 ± 0.771
3.512ArgSer: 3.512 ± 0.394
3.566ArgThr: 3.566 ± 0.485
5.322ArgVal: 5.322 ± 0.533
1.437ArgTrp: 1.437 ± 0.299
2.075ArgTyr: 2.075 ± 0.358
0.0ArgXaa: 0.0 ± 0.0
Ser
5.907SerAla: 5.907 ± 0.719
0.426SerCys: 0.426 ± 0.173
4.311SerAsp: 4.311 ± 0.54
3.193SerGlu: 3.193 ± 0.434
2.288SerPhe: 2.288 ± 0.426
6.014SerGly: 6.014 ± 0.887
1.064SerHis: 1.064 ± 0.223
2.98SerIle: 2.98 ± 0.404
2.342SerLys: 2.342 ± 0.41
3.672SerLeu: 3.672 ± 0.493
1.118SerMet: 1.118 ± 0.258
2.235SerAsn: 2.235 ± 0.515
3.459SerPro: 3.459 ± 0.396
1.437SerGln: 1.437 ± 0.25
3.566SerArg: 3.566 ± 0.406
4.257SerSer: 4.257 ± 0.638
3.353SerThr: 3.353 ± 0.486
4.683SerVal: 4.683 ± 0.529
1.437SerTrp: 1.437 ± 0.29
1.543SerTyr: 1.543 ± 0.264
0.0SerXaa: 0.0 ± 0.0
Thr
5.907ThrAla: 5.907 ± 0.663
0.639ThrCys: 0.639 ± 0.227
3.512ThrAsp: 3.512 ± 0.602
3.246ThrGlu: 3.246 ± 0.337
1.49ThrPhe: 1.49 ± 0.277
6.014ThrGly: 6.014 ± 0.58
1.65ThrHis: 1.65 ± 0.364
3.512ThrIle: 3.512 ± 0.473
2.767ThrLys: 2.767 ± 0.392
4.417ThrLeu: 4.417 ± 0.553
0.798ThrMet: 0.798 ± 0.215
1.969ThrAsn: 1.969 ± 0.306
4.896ThrPro: 4.896 ± 0.481
1.809ThrGln: 1.809 ± 0.304
4.523ThrArg: 4.523 ± 0.492
3.406ThrSer: 3.406 ± 0.456
4.843ThrThr: 4.843 ± 0.717
6.28ThrVal: 6.28 ± 0.61
1.277ThrTrp: 1.277 ± 0.259
2.075ThrTyr: 2.075 ± 0.308
0.0ThrXaa: 0.0 ± 0.0
Val
7.716ValAla: 7.716 ± 0.623
1.171ValCys: 1.171 ± 0.228
5.694ValAsp: 5.694 ± 0.549
4.364ValGlu: 4.364 ± 0.557
1.863ValPhe: 1.863 ± 0.297
6.067ValGly: 6.067 ± 0.63
1.969ValHis: 1.969 ± 0.344
2.874ValIle: 2.874 ± 0.368
2.342ValLys: 2.342 ± 0.388
5.375ValLeu: 5.375 ± 0.636
1.277ValMet: 1.277 ± 0.225
2.661ValAsn: 2.661 ± 0.422
3.832ValPro: 3.832 ± 0.415
2.608ValGln: 2.608 ± 0.319
4.417ValArg: 4.417 ± 0.587
5.002ValSer: 5.002 ± 0.498
5.002ValThr: 5.002 ± 0.489
5.801ValVal: 5.801 ± 0.547
1.543ValTrp: 1.543 ± 0.315
1.118ValTyr: 1.118 ± 0.299
0.0ValXaa: 0.0 ± 0.0
Trp
2.182TrpAla: 2.182 ± 0.327
0.319TrpCys: 0.319 ± 0.134
1.543TrpAsp: 1.543 ± 0.249
1.011TrpGlu: 1.011 ± 0.219
0.851TrpPhe: 0.851 ± 0.232
0.851TrpGly: 0.851 ± 0.246
0.479TrpHis: 0.479 ± 0.165
1.384TrpIle: 1.384 ± 0.249
0.745TrpLys: 0.745 ± 0.167
1.543TrpLeu: 1.543 ± 0.289
0.905TrpMet: 0.905 ± 0.228
0.479TrpAsn: 0.479 ± 0.204
1.064TrpPro: 1.064 ± 0.266
0.851TrpGln: 0.851 ± 0.227
1.863TrpArg: 1.863 ± 0.359
1.171TrpSer: 1.171 ± 0.281
1.65TrpThr: 1.65 ± 0.307
1.863TrpVal: 1.863 ± 0.408
1.011TrpTrp: 1.011 ± 0.198
0.532TrpTyr: 0.532 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.767TyrAla: 2.767 ± 0.346
0.266TyrCys: 0.266 ± 0.122
1.65TyrAsp: 1.65 ± 0.358
1.863TyrGlu: 1.863 ± 0.295
0.798TyrPhe: 0.798 ± 0.227
2.022TyrGly: 2.022 ± 0.392
0.426TyrHis: 0.426 ± 0.144
1.224TyrIle: 1.224 ± 0.269
0.745TyrLys: 0.745 ± 0.211
2.129TyrLeu: 2.129 ± 0.303
0.319TyrMet: 0.319 ± 0.12
0.851TyrAsn: 0.851 ± 0.213
1.224TyrPro: 1.224 ± 0.292
0.798TyrGln: 0.798 ± 0.21
1.916TyrArg: 1.916 ± 0.37
1.224TyrSer: 1.224 ± 0.242
1.437TyrThr: 1.437 ± 0.318
2.342TyrVal: 2.342 ± 0.293
0.479TyrTrp: 0.479 ± 0.139
0.639TyrTyr: 0.639 ± 0.162
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 108 proteins (18792 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski