Amino acid dipepetide frequency for Ruminococcus sp. CAG:254

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.235AlaAla: 10.235 ± 0.173
1.582AlaCys: 1.582 ± 0.056
5.336AlaAsp: 5.336 ± 0.097
6.683AlaGlu: 6.683 ± 0.119
3.509AlaPhe: 3.509 ± 0.087
5.921AlaGly: 5.921 ± 0.117
1.188AlaHis: 1.188 ± 0.047
5.681AlaIle: 5.681 ± 0.097
4.984AlaLys: 4.984 ± 0.1
7.552AlaLeu: 7.552 ± 0.121
2.754AlaMet: 2.754 ± 0.075
2.934AlaAsn: 2.934 ± 0.08
2.634AlaPro: 2.634 ± 0.078
2.806AlaGln: 2.806 ± 0.06
2.574AlaArg: 2.574 ± 0.068
4.039AlaSer: 4.039 ± 0.087
4.654AlaThr: 4.654 ± 0.111
6.978AlaVal: 6.978 ± 0.112
0.755AlaTrp: 0.755 ± 0.036
3.159AlaTyr: 3.159 ± 0.061
0.003AlaXaa: 0.003 ± 0.002
Cys
1.379CysAla: 1.379 ± 0.057
0.46CysCys: 0.46 ± 0.035
0.995CysAsp: 0.995 ± 0.037
0.976CysGlu: 0.976 ± 0.041
0.814CysPhe: 0.814 ± 0.034
1.843CysGly: 1.843 ± 0.059
0.337CysHis: 0.337 ± 0.027
1.264CysIle: 1.264 ± 0.049
1.042CysLys: 1.042 ± 0.043
1.394CysLeu: 1.394 ± 0.049
0.494CysMet: 0.494 ± 0.031
0.793CysAsn: 0.793 ± 0.036
0.846CysPro: 0.846 ± 0.044
0.637CysGln: 0.637 ± 0.034
0.84CysArg: 0.84 ± 0.044
1.376CysSer: 1.376 ± 0.055
1.174CysThr: 1.174 ± 0.05
1.125CysVal: 1.125 ± 0.041
0.183CysTrp: 0.183 ± 0.018
0.741CysTyr: 0.741 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
5.537AspAla: 5.537 ± 0.098
1.172AspCys: 1.172 ± 0.052
2.926AspAsp: 2.926 ± 0.088
3.276AspGlu: 3.276 ± 0.082
2.641AspPhe: 2.641 ± 0.07
4.989AspGly: 4.989 ± 0.136
0.958AspHis: 0.958 ± 0.041
3.474AspIle: 3.474 ± 0.083
2.336AspLys: 2.336 ± 0.057
4.886AspLeu: 4.886 ± 0.091
1.397AspMet: 1.397 ± 0.049
1.952AspAsn: 1.952 ± 0.068
1.862AspPro: 1.862 ± 0.056
1.506AspGln: 1.506 ± 0.051
2.114AspArg: 2.114 ± 0.065
3.148AspSer: 3.148 ± 0.09
3.519AspThr: 3.519 ± 0.088
4.031AspVal: 4.031 ± 0.088
0.78AspTrp: 0.78 ± 0.037
2.559AspTyr: 2.559 ± 0.074
0.002AspXaa: 0.002 ± 0.002
Glu
5.271GluAla: 5.271 ± 0.104
0.757GluCys: 0.757 ± 0.038
3.402GluAsp: 3.402 ± 0.078
5.373GluGlu: 5.373 ± 0.107
1.861GluPhe: 1.861 ± 0.057
3.158GluGly: 3.158 ± 0.093
1.496GluHis: 1.496 ± 0.048
4.359GluIle: 4.359 ± 0.094
4.68GluLys: 4.68 ± 0.098
5.633GluLeu: 5.633 ± 0.12
2.13GluMet: 2.13 ± 0.052
3.222GluAsn: 3.222 ± 0.067
2.342GluPro: 2.342 ± 0.089
4.71GluGln: 4.71 ± 0.127
3.3GluArg: 3.3 ± 0.076
3.647GluSer: 3.647 ± 0.08
5.184GluThr: 5.184 ± 0.1
3.629GluVal: 3.629 ± 0.084
0.601GluTrp: 0.601 ± 0.034
2.003GluTyr: 2.003 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
3.302PheAla: 3.302 ± 0.073
1.075PheCys: 1.075 ± 0.048
2.295PheAsp: 2.295 ± 0.063
1.953PheGlu: 1.953 ± 0.06
1.88PhePhe: 1.88 ± 0.066
2.936PheGly: 2.936 ± 0.076
0.948PheHis: 0.948 ± 0.043
2.052PheIle: 2.052 ± 0.063
1.3PheLys: 1.3 ± 0.05
4.192PheLeu: 4.192 ± 0.105
0.857PheMet: 0.857 ± 0.039
1.229PheAsn: 1.229 ± 0.054
1.642PhePro: 1.642 ± 0.055
1.9PheGln: 1.9 ± 0.061
1.798PheArg: 1.798 ± 0.057
3.247PheSer: 3.247 ± 0.079
2.305PheThr: 2.305 ± 0.064
2.606PheVal: 2.606 ± 0.079
0.415PheTrp: 0.415 ± 0.03
1.726PheTyr: 1.726 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
5.046GlyAla: 5.046 ± 0.106
1.571GlyCys: 1.571 ± 0.055
3.692GlyAsp: 3.692 ± 0.102
3.91GlyGlu: 3.91 ± 0.081
2.793GlyPhe: 2.793 ± 0.074
4.646GlyGly: 4.646 ± 0.147
1.187GlyHis: 1.187 ± 0.041
5.407GlyIle: 5.407 ± 0.108
5.077GlyLys: 5.077 ± 0.1
5.508GlyLeu: 5.508 ± 0.113
2.363GlyMet: 2.363 ± 0.073
3.015GlyAsn: 3.015 ± 0.084
0.815GlyPro: 0.815 ± 0.043
1.906GlyGln: 1.906 ± 0.06
2.405GlyArg: 2.405 ± 0.07
4.088GlySer: 4.088 ± 0.081
5.091GlyThr: 5.091 ± 0.124
5.116GlyVal: 5.116 ± 0.096
0.702GlyTrp: 0.702 ± 0.036
3.038GlyTyr: 3.038 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
1.686HisAla: 1.686 ± 0.055
0.519HisCys: 0.519 ± 0.031
0.89HisAsp: 0.89 ± 0.048
0.872HisGlu: 0.872 ± 0.043
0.945HisPhe: 0.945 ± 0.043
1.473HisGly: 1.473 ± 0.047
0.562HisHis: 0.562 ± 0.039
1.391HisIle: 1.391 ± 0.053
0.861HisLys: 0.861 ± 0.043
1.843HisLeu: 1.843 ± 0.056
0.532HisMet: 0.532 ± 0.036
0.799HisAsn: 0.799 ± 0.037
1.138HisPro: 1.138 ± 0.046
0.725HisGln: 0.725 ± 0.035
0.989HisArg: 0.989 ± 0.043
1.12HisSer: 1.12 ± 0.041
1.331HisThr: 1.331 ± 0.049
1.159HisVal: 1.159 ± 0.05
0.243HisTrp: 0.243 ± 0.022
0.78HisTyr: 0.78 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.254IleAla: 6.254 ± 0.112
1.473IleCys: 1.473 ± 0.053
3.42IleAsp: 3.42 ± 0.076
3.36IleGlu: 3.36 ± 0.08
2.465IlePhe: 2.465 ± 0.077
4.772IleGly: 4.772 ± 0.102
1.318IleHis: 1.318 ± 0.053
3.576IleIle: 3.576 ± 0.085
2.339IleLys: 2.339 ± 0.078
6.826IleLeu: 6.826 ± 0.129
1.363IleMet: 1.363 ± 0.052
1.999IleAsn: 1.999 ± 0.058
3.423IlePro: 3.423 ± 0.079
3.038IleGln: 3.038 ± 0.078
3.245IleArg: 3.245 ± 0.085
4.516IleSer: 4.516 ± 0.095
4.203IleThr: 4.203 ± 0.1
4.341IleVal: 4.341 ± 0.093
0.59IleTrp: 0.59 ± 0.037
2.256IleTyr: 2.256 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
4.38LysAla: 4.38 ± 0.085
0.661LysCys: 0.661 ± 0.037
3.03LysAsp: 3.03 ± 0.091
4.474LysGlu: 4.474 ± 0.104
1.535LysPhe: 1.535 ± 0.051
3.167LysGly: 3.167 ± 0.072
0.981LysHis: 0.981 ± 0.044
3.587LysIle: 3.587 ± 0.079
4.829LysLys: 4.829 ± 0.092
4.511LysLeu: 4.511 ± 0.083
1.88LysMet: 1.88 ± 0.054
2.866LysAsn: 2.866 ± 0.074
2.328LysPro: 2.328 ± 0.079
3.07LysGln: 3.07 ± 0.072
2.775LysArg: 2.775 ± 0.076
2.816LysSer: 2.816 ± 0.064
3.767LysThr: 3.767 ± 0.077
3.102LysVal: 3.102 ± 0.085
0.517LysTrp: 0.517 ± 0.034
1.961LysTyr: 1.961 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
7.119LeuAla: 7.119 ± 0.136
1.931LeuCys: 1.931 ± 0.067
4.701LeuAsp: 4.701 ± 0.092
6.1LeuGlu: 6.1 ± 0.107
3.911LeuPhe: 3.911 ± 0.118
5.263LeuGly: 5.263 ± 0.105
2.198LeuHis: 2.198 ± 0.065
5.283LeuIle: 5.283 ± 0.115
4.898LeuLys: 4.898 ± 0.09
9.69LeuLeu: 9.69 ± 0.222
2.415LeuMet: 2.415 ± 0.068
3.305LeuAsn: 3.305 ± 0.075
4.518LeuPro: 4.518 ± 0.099
5.552LeuGln: 5.552 ± 0.134
4.109LeuArg: 4.109 ± 0.095
6.151LeuSer: 6.151 ± 0.119
5.55LeuThr: 5.55 ± 0.105
5.244LeuVal: 5.244 ± 0.106
0.726LeuTrp: 0.726 ± 0.042
3.365LeuTyr: 3.365 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
2.247MetAla: 2.247 ± 0.065
0.35MetCys: 0.35 ± 0.023
1.519MetAsp: 1.519 ± 0.047
2.138MetGlu: 2.138 ± 0.064
0.78MetPhe: 0.78 ± 0.036
1.919MetGly: 1.919 ± 0.065
0.619MetHis: 0.619 ± 0.036
1.734MetIle: 1.734 ± 0.057
1.982MetLys: 1.982 ± 0.052
2.702MetLeu: 2.702 ± 0.072
0.945MetMet: 0.945 ± 0.039
1.182MetAsn: 1.182 ± 0.044
1.31MetPro: 1.31 ± 0.048
2.073MetGln: 2.073 ± 0.063
1.214MetArg: 1.214 ± 0.042
1.302MetSer: 1.302 ± 0.047
1.864MetThr: 1.864 ± 0.06
1.661MetVal: 1.661 ± 0.051
0.193MetTrp: 0.193 ± 0.018
0.708MetTyr: 0.708 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.504AsnAla: 3.504 ± 0.082
0.833AsnCys: 0.833 ± 0.042
2.102AsnAsp: 2.102 ± 0.068
2.127AsnGlu: 2.127 ± 0.064
1.388AsnPhe: 1.388 ± 0.052
3.808AsnGly: 3.808 ± 0.105
0.887AsnHis: 0.887 ± 0.044
2.532AsnIle: 2.532 ± 0.058
1.721AsnLys: 1.721 ± 0.055
3.764AsnLeu: 3.764 ± 0.075
0.995AsnMet: 0.995 ± 0.042
1.533AsnAsn: 1.533 ± 0.07
2.188AsnPro: 2.188 ± 0.072
1.674AsnGln: 1.674 ± 0.058
2.052AsnArg: 2.052 ± 0.06
2.062AsnSer: 2.062 ± 0.075
2.286AsnThr: 2.286 ± 0.073
2.477AsnVal: 2.477 ± 0.062
0.528AsnTrp: 0.528 ± 0.029
1.637AsnTyr: 1.637 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
3.047ProAla: 3.047 ± 0.074
0.635ProCys: 0.635 ± 0.033
2.595ProAsp: 2.595 ± 0.073
3.898ProGlu: 3.898 ± 0.095
1.746ProPhe: 1.746 ± 0.054
1.746ProGly: 1.746 ± 0.059
0.833ProHis: 0.833 ± 0.041
2.449ProIle: 2.449 ± 0.069
2.192ProLys: 2.192 ± 0.071
3.315ProLeu: 3.315 ± 0.088
1.078ProMet: 1.078 ± 0.043
1.747ProAsn: 1.747 ± 0.059
1.235ProPro: 1.235 ± 0.069
1.589ProGln: 1.589 ± 0.065
1.047ProArg: 1.047 ± 0.042
2.01ProSer: 2.01 ± 0.057
2.273ProThr: 2.273 ± 0.073
3.192ProVal: 3.192 ± 0.088
0.272ProTrp: 0.272 ± 0.024
1.613ProTyr: 1.613 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
3.855GlnAla: 3.855 ± 0.089
0.588GlnCys: 0.588 ± 0.033
1.987GlnAsp: 1.987 ± 0.061
3.201GlnGlu: 3.201 ± 0.086
1.738GlnPhe: 1.738 ± 0.057
2.196GlnGly: 2.196 ± 0.06
0.964GlnHis: 0.964 ± 0.039
3.151GlnIle: 3.151 ± 0.077
3.42GlnLys: 3.42 ± 0.084
4.151GlnLeu: 4.151 ± 0.103
1.392GlnMet: 1.392 ± 0.045
2.093GlnAsn: 2.093 ± 0.063
1.895GlnPro: 1.895 ± 0.075
2.947GlnGln: 2.947 ± 0.123
1.858GlnArg: 1.858 ± 0.064
2.05GlnSer: 2.05 ± 0.059
2.958GlnThr: 2.958 ± 0.071
2.593GlnVal: 2.593 ± 0.066
0.415GlnTrp: 0.415 ± 0.024
1.859GlnTyr: 1.859 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
2.889ArgAla: 2.889 ± 0.065
0.825ArgCys: 0.825 ± 0.039
1.807ArgAsp: 1.807 ± 0.059
2.845ArgGlu: 2.845 ± 0.081
1.843ArgPhe: 1.843 ± 0.056
2.081ArgGly: 2.081 ± 0.063
0.822ArgHis: 0.822 ± 0.043
3.132ArgIle: 3.132 ± 0.079
3.09ArgLys: 3.09 ± 0.074
3.728ArgLeu: 3.728 ± 0.099
1.499ArgMet: 1.499 ± 0.057
2.062ArgAsn: 2.062 ± 0.065
1.308ArgPro: 1.308 ± 0.045
1.785ArgGln: 1.785 ± 0.061
2.026ArgArg: 2.026 ± 0.059
2.302ArgSer: 2.302 ± 0.076
2.561ArgThr: 2.561 ± 0.061
2.427ArgVal: 2.427 ± 0.071
0.434ArgTrp: 0.434 ± 0.029
1.887ArgTyr: 1.887 ± 0.057
0.003ArgXaa: 0.003 ± 0.002
Ser
4.707SerAla: 4.707 ± 0.095
0.998SerCys: 0.998 ± 0.049
3.647SerAsp: 3.647 ± 0.095
3.856SerGlu: 3.856 ± 0.081
2.529SerPhe: 2.529 ± 0.064
5.009SerGly: 5.009 ± 0.1
1.105SerHis: 1.105 ± 0.042
3.975SerIle: 3.975 ± 0.082
2.772SerLys: 2.772 ± 0.075
4.996SerLeu: 4.996 ± 0.092
1.843SerMet: 1.843 ± 0.064
2.397SerAsn: 2.397 ± 0.078
1.773SerPro: 1.773 ± 0.053
1.853SerGln: 1.853 ± 0.061
2.112SerArg: 2.112 ± 0.057
3.642SerSer: 3.642 ± 0.11
3.26SerThr: 3.26 ± 0.091
4.477SerVal: 4.477 ± 0.094
0.58SerTrp: 0.58 ± 0.034
2.383SerTyr: 2.383 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
6.422ThrAla: 6.422 ± 0.103
0.966ThrCys: 0.966 ± 0.037
3.939ThrAsp: 3.939 ± 0.104
4.783ThrGlu: 4.783 ± 0.107
2.43ThrPhe: 2.43 ± 0.067
4.748ThrGly: 4.748 ± 0.114
1.002ThrHis: 1.002 ± 0.045
4.722ThrIle: 4.722 ± 0.105
3.083ThrLys: 3.083 ± 0.086
5.913ThrLeu: 5.913 ± 0.108
1.674ThrMet: 1.674 ± 0.051
2.213ThrAsn: 2.213 ± 0.086
2.78ThrPro: 2.78 ± 0.068
1.922ThrGln: 1.922 ± 0.052
1.822ThrArg: 1.822 ± 0.061
2.997ThrSer: 2.997 ± 0.077
6.429ThrThr: 6.429 ± 0.417
5.456ThrVal: 5.456 ± 0.11
0.587ThrTrp: 0.587 ± 0.033
2.326ThrTyr: 2.326 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
5.122ValAla: 5.122 ± 0.099
1.388ValCys: 1.388 ± 0.052
3.671ValAsp: 3.671 ± 0.091
3.947ValGlu: 3.947 ± 0.099
2.652ValPhe: 2.652 ± 0.076
4.098ValGly: 4.098 ± 0.097
1.224ValHis: 1.224 ± 0.045
4.231ValIle: 4.231 ± 0.082
3.55ValLys: 3.55 ± 0.082
6.79ValLeu: 6.79 ± 0.12
1.7ValMet: 1.7 ± 0.052
2.512ValAsn: 2.512 ± 0.068
2.861ValPro: 2.861 ± 0.079
2.974ValGln: 2.974 ± 0.079
2.783ValArg: 2.783 ± 0.071
4.889ValSer: 4.889 ± 0.093
4.819ValThr: 4.819 ± 0.106
4.706ValVal: 4.706 ± 0.112
0.674ValTrp: 0.674 ± 0.032
2.478ValTyr: 2.478 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.575TrpAla: 0.575 ± 0.032
0.16TrpCys: 0.16 ± 0.017
0.546TrpAsp: 0.546 ± 0.031
0.65TrpGlu: 0.65 ± 0.039
0.444TrpPhe: 0.444 ± 0.03
0.66TrpGly: 0.66 ± 0.038
0.243TrpHis: 0.243 ± 0.021
0.726TrpIle: 0.726 ± 0.036
0.671TrpLys: 0.671 ± 0.04
1.002TrpLeu: 1.002 ± 0.046
0.402TrpMet: 0.402 ± 0.028
0.674TrpAsn: 0.674 ± 0.031
0.126TrpPro: 0.126 ± 0.016
0.438TrpGln: 0.438 ± 0.027
0.326TrpArg: 0.326 ± 0.022
0.454TrpSer: 0.454 ± 0.03
0.501TrpThr: 0.501 ± 0.033
0.507TrpVal: 0.507 ± 0.029
0.125TrpTrp: 0.125 ± 0.016
0.48TrpTyr: 0.48 ± 0.03
0.002TrpXaa: 0.002 ± 0.002
Tyr
3.385TyrAla: 3.385 ± 0.076
0.768TyrCys: 0.768 ± 0.036
2.561TyrAsp: 2.561 ± 0.07
2.337TyrGlu: 2.337 ± 0.062
1.755TyrPhe: 1.755 ± 0.052
2.942TyrGly: 2.942 ± 0.077
0.984TyrHis: 0.984 ± 0.038
2.052TyrIle: 2.052 ± 0.063
1.412TyrLys: 1.412 ± 0.06
3.633TyrLeu: 3.633 ± 0.089
0.725TyrMet: 0.725 ± 0.033
1.572TyrAsn: 1.572 ± 0.068
1.485TyrPro: 1.485 ± 0.04
2.206TyrGln: 2.206 ± 0.059
1.966TyrArg: 1.966 ± 0.062
2.059TyrSer: 2.059 ± 0.066
2.487TyrThr: 2.487 ± 0.08
2.242TyrVal: 2.242 ± 0.055
0.391TyrTrp: 0.391 ± 0.029
1.948TyrTyr: 1.948 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.002XaaPro: 0.002 ± 0.002
0.003XaaGln: 0.003 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.016XaaXaa: 0.016 ± 0.007
Statistics based on 1961 proteins (616928 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski