Amino acid dipepetide frequency for Rarobacter incanus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.091AlaAla: 21.091 ± 0.28	0.871AlaCys: 0.871 ± 0.038	8.23AlaAsp: 8.23 ± 0.131	6.235AlaGlu: 6.235 ± 0.112	3.33AlaPhe: 3.33 ± 0.076	13.021AlaGly: 13.021 ± 0.182	2.536AlaHis: 2.536 ± 0.082	6.145AlaIle: 6.145 ± 0.094	4.048AlaLys: 4.048 ± 0.119	12.602AlaLeu: 12.602 ± 0.207	2.656AlaMet: 2.656 ± 0.074	3.17AlaAsn: 3.17 ± 0.078	6.392AlaPro: 6.392 ± 0.143	5.016AlaGln: 5.016 ± 0.105	9.256AlaArg: 9.256 ± 0.161	7.973AlaSer: 7.973 ± 0.14	8.962AlaThr: 8.962 ± 0.176	10.891AlaVal: 10.891 ± 0.153	1.806AlaTrp: 1.806 ± 0.056	2.547AlaTyr: 2.547 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.879CysAla: 0.879 ± 0.039	0.05CysCys: 0.05 ± 0.008	0.373CysAsp: 0.373 ± 0.025	0.338CysGlu: 0.338 ± 0.02	0.148CysPhe: 0.148 ± 0.014	0.75CysGly: 0.75 ± 0.037	0.137CysHis: 0.137 ± 0.013	0.218CysIle: 0.218 ± 0.017	0.13CysLys: 0.13 ± 0.013	0.517CysLeu: 0.517 ± 0.031	0.076CysMet: 0.076 ± 0.009	0.152CysAsn: 0.152 ± 0.014	0.36CysPro: 0.36 ± 0.029	0.157CysGln: 0.157 ± 0.013	0.347CysArg: 0.347 ± 0.025	0.33CysSer: 0.33 ± 0.023	0.362CysThr: 0.362 ± 0.023	0.506CysVal: 0.506 ± 0.03	0.061CysTrp: 0.061 ± 0.01	0.14CysTyr: 0.14 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.745AspAla: 7.745 ± 0.131	0.289AspCys: 0.289 ± 0.02	3.606AspAsp: 3.606 ± 0.078	3.879AspGlu: 3.879 ± 0.099	1.733AspPhe: 1.733 ± 0.052	5.57AspGly: 5.57 ± 0.112	1.124AspHis: 1.124 ± 0.041	2.572AspIle: 2.572 ± 0.062	1.46AspLys: 1.46 ± 0.049	5.951AspLeu: 5.951 ± 0.097	0.907AspMet: 0.907 ± 0.038	1.3AspAsn: 1.3 ± 0.057	4.092AspPro: 4.092 ± 0.096	2.041AspGln: 2.041 ± 0.059	3.961AspArg: 3.961 ± 0.098	3.363AspSer: 3.363 ± 0.083	3.005AspThr: 3.005 ± 0.071	5.069AspVal: 5.069 ± 0.088	0.802AspTrp: 0.802 ± 0.035	1.318AspTyr: 1.318 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.994GluAla: 5.994 ± 0.113	0.282GluCys: 0.282 ± 0.018	2.327GluAsp: 2.327 ± 0.059	2.216GluGlu: 2.216 ± 0.071	1.667GluPhe: 1.667 ± 0.045	3.296GluGly: 3.296 ± 0.07	1.2GluHis: 1.2 ± 0.047	2.636GluIle: 2.636 ± 0.068	1.395GluLys: 1.395 ± 0.049	5.591GluLeu: 5.591 ± 0.12	0.93GluMet: 0.93 ± 0.038	1.094GluAsn: 1.094 ± 0.04	2.663GluPro: 2.663 ± 0.07	2.152GluGln: 2.152 ± 0.052	4.069GluArg: 4.069 ± 0.101	3.162GluSer: 3.162 ± 0.07	2.598GluThr: 2.598 ± 0.062	4.195GluVal: 4.195 ± 0.089	0.62GluTrp: 0.62 ± 0.028	1.137GluTyr: 1.137 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	4.12PheAla: 4.12 ± 0.08	0.178PheCys: 0.178 ± 0.014	2.129PheAsp: 2.129 ± 0.055	1.5PheGlu: 1.5 ± 0.044	0.916PhePhe: 0.916 ± 0.043	3.025PheGly: 3.025 ± 0.066	0.516PheHis: 0.516 ± 0.026	1.08PheIle: 1.08 ± 0.042	0.721PheLys: 0.721 ± 0.034	2.246PheLeu: 2.246 ± 0.068	0.387PheMet: 0.387 ± 0.025	0.748PheAsn: 0.748 ± 0.034	1.293PhePro: 1.293 ± 0.042	0.687PheGln: 0.687 ± 0.032	1.449PheArg: 1.449 ± 0.049	1.668PheSer: 1.668 ± 0.048	1.985PheThr: 1.985 ± 0.065	2.478PheVal: 2.478 ± 0.06	0.347PheTrp: 0.347 ± 0.025	0.613PheTyr: 0.613 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.284GlyAla: 11.284 ± 0.169	0.604GlyCys: 0.604 ± 0.031	5.119GlyAsp: 5.119 ± 0.107	4.276GlyGlu: 4.276 ± 0.081	2.802GlyPhe: 2.802 ± 0.066	8.073GlyGly: 8.073 ± 0.187	1.774GlyHis: 1.774 ± 0.047	4.473GlyIle: 4.473 ± 0.091	3.546GlyLys: 3.546 ± 0.099	7.541GlyLeu: 7.541 ± 0.121	1.806GlyMet: 1.806 ± 0.056	2.336GlyAsn: 2.336 ± 0.095	3.79GlyPro: 3.79 ± 0.079	2.91GlyGln: 2.91 ± 0.067	5.794GlyArg: 5.794 ± 0.108	6.347GlySer: 6.347 ± 0.155	6.495GlyThr: 6.495 ± 0.154	7.049GlyVal: 7.049 ± 0.105	1.402GlyTrp: 1.402 ± 0.05	2.272GlyTyr: 2.272 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	2.311HisAla: 2.311 ± 0.062	0.166HisCys: 0.166 ± 0.014	1.164HisAsp: 1.164 ± 0.041	0.919HisGlu: 0.919 ± 0.04	0.498HisPhe: 0.498 ± 0.027	1.786HisGly: 1.786 ± 0.058	0.487HisHis: 0.487 ± 0.029	0.818HisIle: 0.818 ± 0.034	0.403HisLys: 0.403 ± 0.02	1.789HisLeu: 1.789 ± 0.046	0.332HisMet: 0.332 ± 0.022	0.437HisAsn: 0.437 ± 0.026	1.257HisPro: 1.257 ± 0.049	0.559HisGln: 0.559 ± 0.03	1.485HisArg: 1.485 ± 0.051	1.069HisSer: 1.069 ± 0.043	1.116HisThr: 1.116 ± 0.039	1.633HisVal: 1.633 ± 0.046	0.265HisTrp: 0.265 ± 0.02	0.471HisTyr: 0.471 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	7.353IleAla: 7.353 ± 0.127	0.261IleCys: 0.261 ± 0.019	3.708IleAsp: 3.708 ± 0.082	3.055IleGlu: 3.055 ± 0.077	1.072IlePhe: 1.072 ± 0.047	4.434IleGly: 4.434 ± 0.095	0.718IleHis: 0.718 ± 0.039	1.942IleIle: 1.942 ± 0.056	1.401IleLys: 1.401 ± 0.056	3.273IleLeu: 3.273 ± 0.08	0.676IleMet: 0.676 ± 0.035	1.159IleAsn: 1.159 ± 0.048	2.399IlePro: 2.399 ± 0.058	1.012IleGln: 1.012 ± 0.039	2.754IleArg: 2.754 ± 0.065	2.756IleSer: 2.756 ± 0.064	3.097IleThr: 3.097 ± 0.073	4.682IleVal: 4.682 ± 0.085	0.475IleTrp: 0.475 ± 0.024	0.822IleTyr: 0.822 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.6LysAla: 3.6 ± 0.097	0.13LysCys: 0.13 ± 0.015	1.527LysAsp: 1.527 ± 0.057	1.274LysGlu: 1.274 ± 0.05	0.75LysPhe: 0.75 ± 0.031	1.995LysGly: 1.995 ± 0.073	0.497LysHis: 0.497 ± 0.025	1.54LysIle: 1.54 ± 0.055	1.676LysLys: 1.676 ± 0.096	2.531LysLeu: 2.531 ± 0.076	0.603LysMet: 0.603 ± 0.027	0.809LysAsn: 0.809 ± 0.04	1.481LysPro: 1.481 ± 0.056	0.911LysGln: 0.911 ± 0.04	2.0LysArg: 2.0 ± 0.06	1.919LysSer: 1.919 ± 0.065	2.03LysThr: 2.03 ± 0.065	2.84LysVal: 2.84 ± 0.099	0.399LysTrp: 0.399 ± 0.026	0.696LysTyr: 0.696 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	13.378LeuAla: 13.378 ± 0.197	0.552LeuCys: 0.552 ± 0.03	5.768LeuAsp: 5.768 ± 0.109	4.35LeuGlu: 4.35 ± 0.101	2.203LeuPhe: 2.203 ± 0.067	8.008LeuGly: 8.008 ± 0.125	1.696LeuHis: 1.696 ± 0.054	4.123LeuIle: 4.123 ± 0.099	2.089LeuLys: 2.089 ± 0.059	7.885LeuLeu: 7.885 ± 0.17	1.441LeuMet: 1.441 ± 0.055	1.893LeuAsn: 1.893 ± 0.059	4.853LeuPro: 4.853 ± 0.083	2.355LeuGln: 2.355 ± 0.056	6.876LeuArg: 6.876 ± 0.127	5.557LeuSer: 5.557 ± 0.091	6.089LeuThr: 6.089 ± 0.094	8.125LeuVal: 8.125 ± 0.143	1.111LeuTrp: 1.111 ± 0.043	1.57LeuTyr: 1.57 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.26MetAla: 2.26 ± 0.063	0.118MetCys: 0.118 ± 0.013	0.858MetAsp: 0.858 ± 0.036	0.699MetGlu: 0.699 ± 0.03	0.472MetPhe: 0.472 ± 0.024	1.356MetGly: 1.356 ± 0.054	0.319MetHis: 0.319 ± 0.021	0.824MetIle: 0.824 ± 0.033	0.505MetLys: 0.505 ± 0.027	1.634MetLeu: 1.634 ± 0.057	0.349MetMet: 0.349 ± 0.024	0.54MetAsn: 0.54 ± 0.024	0.97MetPro: 0.97 ± 0.035	0.505MetGln: 0.505 ± 0.026	1.425MetArg: 1.425 ± 0.048	1.372MetSer: 1.372 ± 0.045	1.539MetThr: 1.539 ± 0.05	1.403MetVal: 1.403 ± 0.046	0.225MetTrp: 0.225 ± 0.017	0.304MetTyr: 0.304 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.949AsnAla: 2.949 ± 0.079	0.168AsnCys: 0.168 ± 0.013	1.493AsnAsp: 1.493 ± 0.057	1.186AsnGlu: 1.186 ± 0.043	0.684AsnPhe: 0.684 ± 0.032	2.295AsnGly: 2.295 ± 0.093	0.411AsnHis: 0.411 ± 0.025	1.021AsnIle: 1.021 ± 0.038	0.699AsnLys: 0.699 ± 0.034	2.117AsnLeu: 2.117 ± 0.06	0.408AsnMet: 0.408 ± 0.025	0.698AsnAsn: 0.698 ± 0.045	1.806AsnPro: 1.806 ± 0.051	0.788AsnGln: 0.788 ± 0.035	1.399AsnArg: 1.399 ± 0.047	1.39AsnSer: 1.39 ± 0.058	1.42AsnThr: 1.42 ± 0.063	2.113AsnVal: 2.113 ± 0.063	0.358AsnTrp: 0.358 ± 0.029	0.631AsnTyr: 0.631 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	7.731ProAla: 7.731 ± 0.143	0.246ProCys: 0.246 ± 0.019	3.203ProAsp: 3.203 ± 0.062	2.649ProGlu: 2.649 ± 0.069	1.407ProPhe: 1.407 ± 0.035	5.073ProGly: 5.073 ± 0.109	1.159ProHis: 1.159 ± 0.049	2.148ProIle: 2.148 ± 0.064	1.296ProLys: 1.296 ± 0.052	4.269ProLeu: 4.269 ± 0.092	0.738ProMet: 0.738 ± 0.034	1.255ProAsn: 1.255 ± 0.042	2.175ProPro: 2.175 ± 0.083	1.941ProGln: 1.941 ± 0.051	3.382ProArg: 3.382 ± 0.081	3.132ProSer: 3.132 ± 0.078	3.604ProThr: 3.604 ± 0.08	4.47ProVal: 4.47 ± 0.083	0.786ProTrp: 0.786 ± 0.031	1.014ProTyr: 1.014 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.381GlnAla: 4.381 ± 0.083	0.182GlnCys: 0.182 ± 0.016	1.573GlnAsp: 1.573 ± 0.046	1.365GlnGlu: 1.365 ± 0.045	0.973GlnPhe: 0.973 ± 0.035	2.583GlnGly: 2.583 ± 0.066	0.638GlnHis: 0.638 ± 0.027	1.785GlnIle: 1.785 ± 0.045	0.688GlnLys: 0.688 ± 0.033	3.129GlnLeu: 3.129 ± 0.068	0.585GlnMet: 0.585 ± 0.027	0.676GlnAsn: 0.676 ± 0.032	1.661GlnPro: 1.661 ± 0.056	1.243GlnGln: 1.243 ± 0.044	2.61GlnArg: 2.61 ± 0.068	1.9GlnSer: 1.9 ± 0.061	1.725GlnThr: 1.725 ± 0.053	3.067GlnVal: 3.067 ± 0.07	0.67GlnTrp: 0.67 ± 0.029	0.768GlnTyr: 0.768 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	9.01ArgAla: 9.01 ± 0.168	0.399ArgCys: 0.399 ± 0.029	3.997ArgAsp: 3.997 ± 0.08	3.767ArgGlu: 3.767 ± 0.098	1.979ArgPhe: 1.979 ± 0.054	5.481ArgGly: 5.481 ± 0.105	1.413ArgHis: 1.413 ± 0.054	3.653ArgIle: 3.653 ± 0.082	1.933ArgLys: 1.933 ± 0.058	6.146ArgLeu: 6.146 ± 0.132	1.509ArgMet: 1.509 ± 0.045	1.54ArgAsn: 1.54 ± 0.046	3.471ArgPro: 3.471 ± 0.088	2.105ArgGln: 2.105 ± 0.056	5.756ArgArg: 5.756 ± 0.129	4.089ArgSer: 4.089 ± 0.076	4.183ArgThr: 4.183 ± 0.071	5.758ArgVal: 5.758 ± 0.114	1.251ArgTrp: 1.251 ± 0.047	1.57ArgTyr: 1.57 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	8.458SerAla: 8.458 ± 0.147	0.338SerCys: 0.338 ± 0.022	3.66SerAsp: 3.66 ± 0.086	2.653SerGlu: 2.653 ± 0.067	1.908SerPhe: 1.908 ± 0.061	6.411SerGly: 6.411 ± 0.153	1.12SerHis: 1.12 ± 0.042	2.865SerIle: 2.865 ± 0.065	1.694SerLys: 1.694 ± 0.066	5.518SerLeu: 5.518 ± 0.099	1.186SerMet: 1.186 ± 0.041	1.65SerAsn: 1.65 ± 0.068	3.044SerPro: 3.044 ± 0.069	2.15SerGln: 2.15 ± 0.068	3.807SerArg: 3.807 ± 0.076	4.331SerSer: 4.331 ± 0.121	3.991SerThr: 3.991 ± 0.101	5.294SerVal: 5.294 ± 0.11	0.911SerTrp: 0.911 ± 0.035	1.401SerTyr: 1.401 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	8.32ThrAla: 8.32 ± 0.17	0.368ThrCys: 0.368 ± 0.025	3.731ThrAsp: 3.731 ± 0.092	2.796ThrGlu: 2.796 ± 0.067	1.922ThrPhe: 1.922 ± 0.069	6.358ThrGly: 6.358 ± 0.157	1.102ThrHis: 1.102 ± 0.043	3.375ThrIle: 3.375 ± 0.079	1.96ThrLys: 1.96 ± 0.064	5.72ThrLeu: 5.72 ± 0.095	1.04ThrMet: 1.04 ± 0.034	1.703ThrAsn: 1.703 ± 0.063	3.69ThrPro: 3.69 ± 0.086	2.017ThrGln: 2.017 ± 0.053	3.782ThrArg: 3.782 ± 0.083	4.097ThrSer: 4.097 ± 0.107	4.421ThrThr: 4.421 ± 0.128	6.408ThrVal: 6.408 ± 0.153	0.897ThrTrp: 0.897 ± 0.037	1.692ThrTyr: 1.692 ± 0.08	0.0ThrXaa: 0.0 ± 0.0
Val	11.937ValAla: 11.937 ± 0.165	0.574ValCys: 0.574 ± 0.032	5.149ValAsp: 5.149 ± 0.106	4.369ValGlu: 4.369 ± 0.093	2.443ValPhe: 2.443 ± 0.061	7.178ValGly: 7.178 ± 0.14	1.47ValHis: 1.47 ± 0.045	4.371ValIle: 4.371 ± 0.09	2.585ValLys: 2.585 ± 0.096	7.851ValLeu: 7.851 ± 0.141	1.445ValMet: 1.445 ± 0.043	1.908ValAsn: 1.908 ± 0.058	4.56ValPro: 4.56 ± 0.092	2.256ValGln: 2.256 ± 0.059	6.069ValArg: 6.069 ± 0.11	5.536ValSer: 5.536 ± 0.104	6.642ValThr: 6.642 ± 0.14	8.618ValVal: 8.618 ± 0.146	1.073ValTrp: 1.073 ± 0.043	1.437ValTyr: 1.437 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.485TrpAla: 1.485 ± 0.047	0.095TrpCys: 0.095 ± 0.011	0.825TrpAsp: 0.825 ± 0.034	0.608TrpGlu: 0.608 ± 0.028	0.497TrpPhe: 0.497 ± 0.03	1.034TrpGly: 1.034 ± 0.041	0.311TrpHis: 0.311 ± 0.022	0.666TrpIle: 0.666 ± 0.035	0.387TrpLys: 0.387 ± 0.028	1.489TrpLeu: 1.489 ± 0.058	0.305TrpMet: 0.305 ± 0.019	0.446TrpAsn: 0.446 ± 0.026	0.608TrpPro: 0.608 ± 0.031	0.636TrpGln: 0.636 ± 0.03	1.137TrpArg: 1.137 ± 0.047	0.962TrpSer: 0.962 ± 0.045	0.885TrpThr: 0.885 ± 0.034	1.082TrpVal: 1.082 ± 0.045	0.365TrpTrp: 0.365 ± 0.026	0.313TrpTyr: 0.313 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.492TyrAla: 2.492 ± 0.059	0.163TyrCys: 0.163 ± 0.014	1.346TyrAsp: 1.346 ± 0.051	1.092TyrGlu: 1.092 ± 0.041	0.683TyrPhe: 0.683 ± 0.034	1.966TyrGly: 1.966 ± 0.053	0.338TyrHis: 0.338 ± 0.026	0.793TyrIle: 0.793 ± 0.038	0.594TyrLys: 0.594 ± 0.039	2.123TyrLeu: 2.123 ± 0.056	0.296TyrMet: 0.296 ± 0.023	0.52TyrAsn: 0.52 ± 0.029	1.114TyrPro: 1.114 ± 0.046	0.761TyrGln: 0.761 ± 0.033	1.653TyrArg: 1.653 ± 0.05	1.434TyrSer: 1.434 ± 0.066	1.25TyrThr: 1.25 ± 0.059	1.789TyrVal: 1.789 ± 0.055	0.311TyrTrp: 0.311 ± 0.021	0.537TyrTyr: 0.537 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2018 proteins (736860 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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