Amino acid dipepetide frequency for Pseudomonas sp. LPB0260

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.298AlaAla: 14.298 ± 0.192	1.428AlaCys: 1.428 ± 0.041	5.892AlaAsp: 5.892 ± 0.089	8.586AlaGlu: 8.586 ± 0.137	4.013AlaPhe: 4.013 ± 0.076	9.661AlaGly: 9.661 ± 0.124	2.266AlaHis: 2.266 ± 0.048	5.132AlaIle: 5.132 ± 0.09	3.75AlaLys: 3.75 ± 0.091	15.155AlaLeu: 15.155 ± 0.191	2.948AlaMet: 2.948 ± 0.052	2.779AlaAsn: 2.779 ± 0.06	4.921AlaPro: 4.921 ± 0.083	5.51AlaGln: 5.51 ± 0.09	7.869AlaArg: 7.869 ± 0.107	6.168AlaSer: 6.168 ± 0.077	4.474AlaThr: 4.474 ± 0.066	7.447AlaVal: 7.447 ± 0.103	1.758AlaTrp: 1.758 ± 0.053	2.612AlaTyr: 2.612 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.271CysAla: 1.271 ± 0.04	0.159CysCys: 0.159 ± 0.014	0.572CysAsp: 0.572 ± 0.022	0.592CysGlu: 0.592 ± 0.027	0.385CysPhe: 0.385 ± 0.02	1.059CysGly: 1.059 ± 0.036	0.3CysHis: 0.3 ± 0.019	0.467CysIle: 0.467 ± 0.02	0.3CysLys: 0.3 ± 0.02	1.212CysLeu: 1.212 ± 0.038	0.21CysMet: 0.21 ± 0.014	0.299CysAsn: 0.299 ± 0.02	0.561CysPro: 0.561 ± 0.023	0.457CysGln: 0.457 ± 0.024	0.698CysArg: 0.698 ± 0.028	0.621CysSer: 0.621 ± 0.023	0.46CysThr: 0.46 ± 0.021	0.709CysVal: 0.709 ± 0.027	0.149CysTrp: 0.149 ± 0.012	0.264CysTyr: 0.264 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.791AspAla: 5.791 ± 0.084	0.628AspCys: 0.628 ± 0.026	2.648AspAsp: 2.648 ± 0.062	3.601AspGlu: 3.601 ± 0.07	2.072AspPhe: 2.072 ± 0.047	4.51AspGly: 4.51 ± 0.08	1.016AspHis: 1.016 ± 0.035	2.467AspIle: 2.467 ± 0.063	1.768AspLys: 1.768 ± 0.05	5.854AspLeu: 5.854 ± 0.082	1.062AspMet: 1.062 ± 0.037	1.466AspAsn: 1.466 ± 0.041	2.803AspPro: 2.803 ± 0.054	2.057AspGln: 2.057 ± 0.046	2.964AspArg: 2.964 ± 0.053	3.084AspSer: 3.084 ± 0.057	1.99AspThr: 1.99 ± 0.047	3.092AspVal: 3.092 ± 0.057	0.996AspTrp: 0.996 ± 0.031	1.762AspTyr: 1.762 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.368GluAla: 7.368 ± 0.118	0.491GluCys: 0.491 ± 0.024	2.629GluAsp: 2.629 ± 0.059	3.537GluGlu: 3.537 ± 0.082	1.871GluPhe: 1.871 ± 0.042	4.162GluGly: 4.162 ± 0.066	1.669GluHis: 1.669 ± 0.045	2.784GluIle: 2.784 ± 0.055	1.95GluLys: 1.95 ± 0.049	8.073GluLeu: 8.073 ± 0.095	1.318GluMet: 1.318 ± 0.043	1.325GluAsn: 1.325 ± 0.032	2.639GluPro: 2.639 ± 0.055	4.549GluGln: 4.549 ± 0.08	5.539GluArg: 5.539 ± 0.094	2.746GluSer: 2.746 ± 0.055	2.284GluThr: 2.284 ± 0.049	4.609GluVal: 4.609 ± 0.078	0.738GluTrp: 0.738 ± 0.028	1.199GluTyr: 1.199 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.399PheAla: 4.399 ± 0.079	0.452PheCys: 0.452 ± 0.023	2.371PheAsp: 2.371 ± 0.045	2.065PheGlu: 2.065 ± 0.047	1.368PhePhe: 1.368 ± 0.049	3.15PheGly: 3.15 ± 0.072	0.76PheHis: 0.76 ± 0.028	1.755PheIle: 1.755 ± 0.048	1.196PheLys: 1.196 ± 0.034	3.353PheLeu: 3.353 ± 0.063	0.761PheMet: 0.761 ± 0.031	1.246PheAsn: 1.246 ± 0.034	1.421PhePro: 1.421 ± 0.036	1.243PheGln: 1.243 ± 0.036	1.907PheArg: 1.907 ± 0.046	2.469PheSer: 2.469 ± 0.052	1.618PheThr: 1.618 ± 0.042	2.57PheVal: 2.57 ± 0.054	0.538PheTrp: 0.538 ± 0.026	0.997PheTyr: 0.997 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.071GlyAla: 8.071 ± 0.114	1.044GlyCys: 1.044 ± 0.03	3.966GlyAsp: 3.966 ± 0.073	5.379GlyGlu: 5.379 ± 0.074	3.261GlyPhe: 3.261 ± 0.059	6.332GlyGly: 6.332 ± 0.13	1.956GlyHis: 1.956 ± 0.05	4.085GlyIle: 4.085 ± 0.067	3.119GlyLys: 3.119 ± 0.067	10.124GlyLeu: 10.124 ± 0.115	2.149GlyMet: 2.149 ± 0.049	2.191GlyAsn: 2.191 ± 0.054	2.641GlyPro: 2.641 ± 0.057	3.847GlyGln: 3.847 ± 0.063	5.259GlyArg: 5.259 ± 0.086	4.434GlySer: 4.434 ± 0.073	3.41GlyThr: 3.41 ± 0.067	5.901GlyVal: 5.901 ± 0.102	1.359GlyTrp: 1.359 ± 0.04	2.542GlyTyr: 2.542 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.384HisAla: 2.384 ± 0.054	0.359HisCys: 0.359 ± 0.019	1.166HisAsp: 1.166 ± 0.035	1.23HisGlu: 1.23 ± 0.034	1.01HisPhe: 1.01 ± 0.039	2.07HisGly: 2.07 ± 0.046	0.577HisHis: 0.577 ± 0.028	0.958HisIle: 0.958 ± 0.031	0.677HisLys: 0.677 ± 0.023	2.707HisLeu: 2.707 ± 0.051	0.465HisMet: 0.465 ± 0.023	0.59HisAsn: 0.59 ± 0.023	1.466HisPro: 1.466 ± 0.038	0.968HisGln: 0.968 ± 0.033	1.404HisArg: 1.404 ± 0.041	1.302HisSer: 1.302 ± 0.036	0.826HisThr: 0.826 ± 0.034	1.299HisVal: 1.299 ± 0.041	0.462HisTrp: 0.462 ± 0.021	0.779HisTyr: 0.779 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.731IleAla: 5.731 ± 0.085	0.517IleCys: 0.517 ± 0.022	3.112IleAsp: 3.112 ± 0.051	3.423IleGlu: 3.423 ± 0.062	1.391IlePhe: 1.391 ± 0.043	4.422IleGly: 4.422 ± 0.076	0.959IleHis: 0.959 ± 0.034	1.969IleIle: 1.969 ± 0.056	1.583IleLys: 1.583 ± 0.044	4.101IleLeu: 4.101 ± 0.076	0.792IleMet: 0.792 ± 0.029	1.5IleAsn: 1.5 ± 0.04	2.122IlePro: 2.122 ± 0.051	1.6IleGln: 1.6 ± 0.042	3.024IleArg: 3.024 ± 0.06	2.848IleSer: 2.848 ± 0.064	2.148IleThr: 2.148 ± 0.053	2.896IleVal: 2.896 ± 0.068	0.476IleTrp: 0.476 ± 0.024	1.104IleTyr: 1.104 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.898LysAla: 3.898 ± 0.071	0.172LysCys: 0.172 ± 0.013	1.535LysAsp: 1.535 ± 0.048	1.606LysGlu: 1.606 ± 0.046	0.808LysPhe: 0.808 ± 0.033	2.397LysGly: 2.397 ± 0.062	0.773LysHis: 0.773 ± 0.025	1.475LysIle: 1.475 ± 0.045	1.155LysLys: 1.155 ± 0.05	3.746LysLeu: 3.746 ± 0.075	0.622LysMet: 0.622 ± 0.027	0.856LysAsn: 0.856 ± 0.034	1.88LysPro: 1.88 ± 0.045	1.573LysGln: 1.573 ± 0.044	2.312LysArg: 2.312 ± 0.05	1.65LysSer: 1.65 ± 0.045	1.597LysThr: 1.597 ± 0.048	2.541LysVal: 2.541 ± 0.062	0.331LysTrp: 0.331 ± 0.021	0.663LysTyr: 0.663 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	15.907LeuAla: 15.907 ± 0.185	1.372LeuCys: 1.372 ± 0.034	7.021LeuAsp: 7.021 ± 0.1	7.263LeuGlu: 7.263 ± 0.102	4.413LeuPhe: 4.413 ± 0.078	10.096LeuGly: 10.096 ± 0.13	2.67LeuHis: 2.67 ± 0.055	5.555LeuIle: 5.555 ± 0.086	4.128LeuLys: 4.128 ± 0.082	15.41LeuLeu: 15.41 ± 0.251	2.504LeuMet: 2.504 ± 0.053	3.377LeuAsn: 3.377 ± 0.064	6.576LeuPro: 6.576 ± 0.086	5.36LeuGln: 5.36 ± 0.095	8.296LeuArg: 8.296 ± 0.121	7.423LeuSer: 7.423 ± 0.1	5.198LeuThr: 5.198 ± 0.08	7.989LeuVal: 7.989 ± 0.1	1.515LeuTrp: 1.515 ± 0.048	2.719LeuTyr: 2.719 ± 0.061	0.001LeuXaa: 0.001 ± 0.001
Met	2.67MetAla: 2.67 ± 0.05	0.159MetCys: 0.159 ± 0.013	0.969MetAsp: 0.969 ± 0.032	0.91MetGlu: 0.91 ± 0.029	0.602MetPhe: 0.602 ± 0.026	1.594MetGly: 1.594 ± 0.052	0.531MetHis: 0.531 ± 0.023	1.011MetIle: 1.011 ± 0.031	0.774MetLys: 0.774 ± 0.025	2.612MetLeu: 2.612 ± 0.056	0.459MetMet: 0.459 ± 0.023	0.809MetAsn: 0.809 ± 0.027	1.316MetPro: 1.316 ± 0.039	1.026MetGln: 1.026 ± 0.033	1.461MetArg: 1.461 ± 0.038	1.656MetSer: 1.656 ± 0.041	1.217MetThr: 1.217 ± 0.041	1.474MetVal: 1.474 ± 0.043	0.174MetTrp: 0.174 ± 0.014	0.353MetTyr: 0.353 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.899AsnAla: 2.899 ± 0.054	0.295AsnCys: 0.295 ± 0.018	1.327AsnAsp: 1.327 ± 0.036	1.292AsnGlu: 1.292 ± 0.046	0.909AsnPhe: 0.909 ± 0.034	2.294AsnGly: 2.294 ± 0.058	0.536AsnHis: 0.536 ± 0.027	1.28AsnIle: 1.28 ± 0.039	0.84AsnLys: 0.84 ± 0.032	3.335AsnLeu: 3.335 ± 0.061	0.515AsnMet: 0.515 ± 0.026	0.79AsnAsn: 0.79 ± 0.03	1.897AsnPro: 1.897 ± 0.046	1.229AsnGln: 1.229 ± 0.042	1.783AsnArg: 1.783 ± 0.041	1.411AsnSer: 1.411 ± 0.043	1.165AsnThr: 1.165 ± 0.039	1.632AsnVal: 1.632 ± 0.042	0.427AsnTrp: 0.427 ± 0.023	0.714AsnTyr: 0.714 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.039ProAla: 6.039 ± 0.095	0.39ProCys: 0.39 ± 0.023	2.596ProAsp: 2.596 ± 0.053	3.37ProGlu: 3.37 ± 0.06	1.744ProPhe: 1.744 ± 0.039	4.082ProGly: 4.082 ± 0.07	1.089ProHis: 1.089 ± 0.035	1.933ProIle: 1.933 ± 0.05	1.385ProLys: 1.385 ± 0.041	6.057ProLeu: 6.057 ± 0.097	1.083ProMet: 1.083 ± 0.032	1.213ProAsn: 1.213 ± 0.04	2.031ProPro: 2.031 ± 0.051	2.465ProGln: 2.465 ± 0.056	2.818ProArg: 2.818 ± 0.06	2.652ProSer: 2.652 ± 0.049	1.968ProThr: 1.968 ± 0.052	3.545ProVal: 3.545 ± 0.068	0.734ProTrp: 0.734 ± 0.026	1.212ProTyr: 1.212 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	6.709GlnAla: 6.709 ± 0.1	0.395GlnCys: 0.395 ± 0.02	1.972GlnAsp: 1.972 ± 0.051	2.161GlnGlu: 2.161 ± 0.053	1.4GlnPhe: 1.4 ± 0.042	3.724GlnGly: 3.724 ± 0.06	1.204GlnHis: 1.204 ± 0.03	2.048GlnIle: 2.048 ± 0.056	1.095GlnLys: 1.095 ± 0.033	6.393GlnLeu: 6.393 ± 0.097	1.0GlnMet: 1.0 ± 0.034	0.936GlnAsn: 0.936 ± 0.034	2.645GlnPro: 2.645 ± 0.063	2.965GlnGln: 2.965 ± 0.078	4.201GlnArg: 4.201 ± 0.081	2.159GlnSer: 2.159 ± 0.055	1.685GlnThr: 1.685 ± 0.036	3.677GlnVal: 3.677 ± 0.074	0.679GlnTrp: 0.679 ± 0.024	0.963GlnTyr: 0.963 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.809ArgAla: 6.809 ± 0.094	0.652ArgCys: 0.652 ± 0.026	3.569ArgAsp: 3.569 ± 0.051	4.668ArgGlu: 4.668 ± 0.078	2.869ArgPhe: 2.869 ± 0.055	4.442ArgGly: 4.442 ± 0.074	1.848ArgHis: 1.848 ± 0.051	3.349ArgIle: 3.349 ± 0.055	1.993ArgLys: 1.993 ± 0.049	9.579ArgLeu: 9.579 ± 0.142	1.582ArgMet: 1.582 ± 0.038	1.823ArgAsn: 1.823 ± 0.049	2.883ArgPro: 2.883 ± 0.058	3.931ArgGln: 3.931 ± 0.079	4.967ArgArg: 4.967 ± 0.087	3.417ArgSer: 3.417 ± 0.067	2.474ArgThr: 2.474 ± 0.051	4.642ArgVal: 4.642 ± 0.067	1.081ArgTrp: 1.081 ± 0.038	2.114ArgTyr: 2.114 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.167SerAla: 6.167 ± 0.081	0.563SerCys: 0.563 ± 0.024	2.651SerAsp: 2.651 ± 0.053	3.169SerGlu: 3.169 ± 0.063	2.085SerPhe: 2.085 ± 0.053	5.415SerGly: 5.415 ± 0.084	1.271SerHis: 1.271 ± 0.041	2.624SerIle: 2.624 ± 0.052	1.655SerLys: 1.655 ± 0.046	7.192SerLeu: 7.192 ± 0.093	1.239SerMet: 1.239 ± 0.031	1.54SerAsn: 1.54 ± 0.05	2.655SerPro: 2.655 ± 0.054	2.433SerGln: 2.433 ± 0.058	3.645SerArg: 3.645 ± 0.066	3.258SerSer: 3.258 ± 0.063	2.521SerThr: 2.521 ± 0.058	3.587SerVal: 3.587 ± 0.062	0.841SerTrp: 0.841 ± 0.036	1.346SerTyr: 1.346 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.595ThrAla: 4.595 ± 0.073	0.425ThrCys: 0.425 ± 0.019	1.94ThrAsp: 1.94 ± 0.044	2.167ThrGlu: 2.167 ± 0.043	1.56ThrPhe: 1.56 ± 0.045	3.634ThrGly: 3.634 ± 0.077	0.88ThrHis: 0.88 ± 0.033	1.709ThrIle: 1.709 ± 0.045	0.924ThrLys: 0.924 ± 0.034	5.984ThrLeu: 5.984 ± 0.073	0.731ThrMet: 0.731 ± 0.027	0.928ThrAsn: 0.928 ± 0.037	2.797ThrPro: 2.797 ± 0.059	1.732ThrGln: 1.732 ± 0.047	2.808ThrArg: 2.808 ± 0.05	2.336ThrSer: 2.336 ± 0.048	1.883ThrThr: 1.883 ± 0.054	2.874ThrVal: 2.874 ± 0.061	0.588ThrTrp: 0.588 ± 0.025	1.067ThrTyr: 1.067 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.792ValAla: 7.792 ± 0.102	0.732ValCys: 0.732 ± 0.03	3.802ValAsp: 3.802 ± 0.056	4.71ValGlu: 4.71 ± 0.081	2.375ValPhe: 2.375 ± 0.053	5.085ValGly: 5.085 ± 0.08	1.383ValHis: 1.383 ± 0.038	3.574ValIle: 3.574 ± 0.059	2.148ValLys: 2.148 ± 0.06	8.219ValLeu: 8.219 ± 0.102	1.59ValMet: 1.59 ± 0.042	1.879ValAsn: 1.879 ± 0.047	3.114ValPro: 3.114 ± 0.064	2.649ValGln: 2.649 ± 0.06	4.441ValArg: 4.441 ± 0.068	3.929ValSer: 3.929 ± 0.068	3.1ValThr: 3.1 ± 0.06	4.953ValVal: 4.953 ± 0.077	0.768ValTrp: 0.768 ± 0.033	1.511ValTyr: 1.511 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.26TrpAla: 1.26 ± 0.042	0.174TrpCys: 0.174 ± 0.013	0.605TrpAsp: 0.605 ± 0.027	0.552TrpGlu: 0.552 ± 0.025	0.535TrpPhe: 0.535 ± 0.029	0.899TrpGly: 0.899 ± 0.036	0.381TrpHis: 0.381 ± 0.019	0.601TrpIle: 0.601 ± 0.027	0.414TrpLys: 0.414 ± 0.023	2.414TrpLeu: 2.414 ± 0.071	0.327TrpMet: 0.327 ± 0.016	0.395TrpAsn: 0.395 ± 0.019	0.692TrpPro: 0.692 ± 0.025	1.051TrpGln: 1.051 ± 0.036	1.147TrpArg: 1.147 ± 0.039	0.782TrpSer: 0.782 ± 0.03	0.549TrpThr: 0.549 ± 0.028	0.866TrpVal: 0.866 ± 0.029	0.233TrpTrp: 0.233 ± 0.018	0.391TrpTyr: 0.391 ± 0.035	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.612TyrAla: 2.612 ± 0.055	0.339TyrCys: 0.339 ± 0.017	1.287TyrAsp: 1.287 ± 0.038	1.2TyrGlu: 1.2 ± 0.034	0.967TyrPhe: 0.967 ± 0.031	2.041TyrGly: 2.041 ± 0.054	0.629TyrHis: 0.629 ± 0.024	0.941TyrIle: 0.941 ± 0.032	0.735TyrLys: 0.735 ± 0.029	3.274TyrLeu: 3.274 ± 0.057	0.419TyrMet: 0.419 ± 0.022	0.629TyrAsn: 0.629 ± 0.026	1.347TyrPro: 1.347 ± 0.039	1.367TyrGln: 1.367 ± 0.037	2.148TyrArg: 2.148 ± 0.059	1.513TyrSer: 1.513 ± 0.044	0.992TyrThr: 0.992 ± 0.035	1.452TyrVal: 1.452 ± 0.04	0.422TyrTrp: 0.422 ± 0.021	0.76TyrTyr: 0.76 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2912 proteins (970066 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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