Amino acid dipepetide frequency for Simplicispira metamorpha

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.486AlaAla: 18.486 ± 0.214	1.415AlaCys: 1.415 ± 0.035	6.362AlaAsp: 6.362 ± 0.08	5.982AlaGlu: 5.982 ± 0.081	3.873AlaPhe: 3.873 ± 0.069	9.992AlaGly: 9.992 ± 0.114	3.406AlaHis: 3.406 ± 0.066	5.012AlaIle: 5.012 ± 0.058	3.784AlaLys: 3.784 ± 0.075	16.698AlaLeu: 16.698 ± 0.167	3.529AlaMet: 3.529 ± 0.062	2.857AlaAsn: 2.857 ± 0.052	7.673AlaPro: 7.673 ± 0.127	8.239AlaGln: 8.239 ± 0.111	8.841AlaArg: 8.841 ± 0.119	7.171AlaSer: 7.171 ± 0.103	6.686AlaThr: 6.686 ± 0.085	9.194AlaVal: 9.194 ± 0.091	1.96AlaTrp: 1.96 ± 0.047	2.455AlaTyr: 2.455 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.327CysAla: 1.327 ± 0.037	0.143CysCys: 0.143 ± 0.011	0.574CysAsp: 0.574 ± 0.026	0.452CysGlu: 0.452 ± 0.02	0.307CysPhe: 0.307 ± 0.016	0.966CysGly: 0.966 ± 0.035	0.301CysHis: 0.301 ± 0.016	0.415CysIle: 0.415 ± 0.021	0.24CysLys: 0.24 ± 0.015	0.861CysLeu: 0.861 ± 0.027	0.248CysMet: 0.248 ± 0.015	0.264CysAsn: 0.264 ± 0.017	0.526CysPro: 0.526 ± 0.023	0.348CysGln: 0.348 ± 0.017	0.506CysArg: 0.506 ± 0.018	0.517CysSer: 0.517 ± 0.022	0.581CysThr: 0.581 ± 0.021	0.712CysVal: 0.712 ± 0.026	0.126CysTrp: 0.126 ± 0.01	0.208CysTyr: 0.208 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.192AspAla: 7.192 ± 0.091	0.458AspCys: 0.458 ± 0.021	2.391AspAsp: 2.391 ± 0.053	2.788AspGlu: 2.788 ± 0.052	2.007AspPhe: 2.007 ± 0.043	4.224AspGly: 4.224 ± 0.072	1.088AspHis: 1.088 ± 0.035	2.54AspIle: 2.54 ± 0.049	1.846AspLys: 1.846 ± 0.049	5.152AspLeu: 5.152 ± 0.062	1.291AspMet: 1.291 ± 0.04	1.23AspAsn: 1.23 ± 0.034	2.544AspPro: 2.544 ± 0.045	1.705AspGln: 1.705 ± 0.04	2.713AspArg: 2.713 ± 0.053	2.374AspSer: 2.374 ± 0.048	2.78AspThr: 2.78 ± 0.05	3.921AspVal: 3.921 ± 0.062	1.004AspTrp: 1.004 ± 0.029	1.337AspTyr: 1.337 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.321GluAla: 6.321 ± 0.088	0.409GluCys: 0.409 ± 0.02	2.053GluAsp: 2.053 ± 0.048	2.374GluGlu: 2.374 ± 0.059	1.781GluPhe: 1.781 ± 0.042	3.609GluGly: 3.609 ± 0.057	1.4GluHis: 1.4 ± 0.036	2.474GluIle: 2.474 ± 0.054	1.952GluLys: 1.952 ± 0.053	5.342GluLeu: 5.342 ± 0.076	1.209GluMet: 1.209 ± 0.037	1.299GluAsn: 1.299 ± 0.043	2.383GluPro: 2.383 ± 0.069	2.82GluGln: 2.82 ± 0.045	4.488GluArg: 4.488 ± 0.079	2.383GluSer: 2.383 ± 0.049	2.235GluThr: 2.235 ± 0.046	3.877GluVal: 3.877 ± 0.072	0.663GluTrp: 0.663 ± 0.022	1.005GluTyr: 1.005 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.143PheAla: 4.143 ± 0.067	0.394PheCys: 0.394 ± 0.022	2.363PheAsp: 2.363 ± 0.051	1.817PheGlu: 1.817 ± 0.046	1.291PhePhe: 1.291 ± 0.043	3.015PheGly: 3.015 ± 0.062	0.718PheHis: 0.718 ± 0.026	1.436PheIle: 1.436 ± 0.039	1.218PheLys: 1.218 ± 0.038	2.853PheLeu: 2.853 ± 0.052	0.807PheMet: 0.807 ± 0.029	1.02PheAsn: 1.02 ± 0.035	1.36PhePro: 1.36 ± 0.04	1.174PheGln: 1.174 ± 0.034	1.634PheArg: 1.634 ± 0.037	2.091PheSer: 2.091 ± 0.048	1.854PheThr: 1.854 ± 0.042	2.589PheVal: 2.589 ± 0.057	0.494PheTrp: 0.494 ± 0.026	0.835PheTyr: 0.835 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.871GlyAla: 9.871 ± 0.11	0.898GlyCys: 0.898 ± 0.033	3.771GlyAsp: 3.771 ± 0.061	3.903GlyGlu: 3.903 ± 0.067	2.987GlyPhe: 2.987 ± 0.052	6.557GlyGly: 6.557 ± 0.106	2.084GlyHis: 2.084 ± 0.044	3.608GlyIle: 3.608 ± 0.061	3.155GlyLys: 3.155 ± 0.067	8.634GlyLeu: 8.634 ± 0.108	2.267GlyMet: 2.267 ± 0.053	2.162GlyAsn: 2.162 ± 0.064	2.859GlyPro: 2.859 ± 0.051	4.105GlyGln: 4.105 ± 0.073	4.896GlyArg: 4.896 ± 0.068	4.47GlySer: 4.47 ± 0.081	4.531GlyThr: 4.531 ± 0.088	6.463GlyVal: 6.463 ± 0.08	1.45GlyTrp: 1.45 ± 0.038	2.255GlyTyr: 2.255 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	3.129HisAla: 3.129 ± 0.063	0.334HisCys: 0.334 ± 0.019	1.274HisAsp: 1.274 ± 0.037	1.166HisGlu: 1.166 ± 0.034	0.956HisPhe: 0.956 ± 0.026	2.289HisGly: 2.289 ± 0.05	0.782HisHis: 0.782 ± 0.031	1.196HisIle: 1.196 ± 0.034	0.602HisLys: 0.602 ± 0.022	2.526HisLeu: 2.526 ± 0.056	0.565HisMet: 0.565 ± 0.02	0.582HisAsn: 0.582 ± 0.024	1.648HisPro: 1.648 ± 0.047	1.056HisGln: 1.056 ± 0.032	1.498HisArg: 1.498 ± 0.041	1.295HisSer: 1.295 ± 0.032	1.463HisThr: 1.463 ± 0.036	1.449HisVal: 1.449 ± 0.038	0.501HisTrp: 0.501 ± 0.021	0.69HisTyr: 0.69 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.936IleAla: 5.936 ± 0.09	0.384IleCys: 0.384 ± 0.02	2.913IleAsp: 2.913 ± 0.046	2.952IleGlu: 2.952 ± 0.063	1.241IlePhe: 1.241 ± 0.036	3.561IleGly: 3.561 ± 0.064	0.955IleHis: 0.955 ± 0.032	1.465IleIle: 1.465 ± 0.039	1.451IleLys: 1.451 ± 0.04	3.097IleLeu: 3.097 ± 0.055	0.745IleMet: 0.745 ± 0.029	1.508IleAsn: 1.508 ± 0.042	1.874IlePro: 1.874 ± 0.042	1.364IleGln: 1.364 ± 0.037	2.291IleArg: 2.291 ± 0.052	2.3IleSer: 2.3 ± 0.052	2.702IleThr: 2.702 ± 0.054	3.156IleVal: 3.156 ± 0.055	0.412IleTrp: 0.412 ± 0.02	0.9IleTyr: 0.9 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.004LysAla: 4.004 ± 0.073	0.149LysCys: 0.149 ± 0.012	1.657LysAsp: 1.657 ± 0.051	1.602LysGlu: 1.602 ± 0.048	0.906LysPhe: 0.906 ± 0.029	2.308LysGly: 2.308 ± 0.054	0.67LysHis: 0.67 ± 0.025	1.545LysIle: 1.545 ± 0.043	1.51LysLys: 1.51 ± 0.044	3.207LysLeu: 3.207 ± 0.061	0.818LysMet: 0.818 ± 0.028	1.117LysAsn: 1.117 ± 0.038	1.882LysPro: 1.882 ± 0.053	1.177LysGln: 1.177 ± 0.033	1.937LysArg: 1.937 ± 0.044	1.738LysSer: 1.738 ± 0.045	2.037LysThr: 2.037 ± 0.047	2.431LysVal: 2.431 ± 0.058	0.287LysTrp: 0.287 ± 0.018	0.663LysTyr: 0.663 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.373LeuAla: 15.373 ± 0.158	1.094LeuCys: 1.094 ± 0.037	5.612LeuAsp: 5.612 ± 0.08	5.238LeuGlu: 5.238 ± 0.076	3.067LeuPhe: 3.067 ± 0.059	8.714LeuGly: 8.714 ± 0.101	2.959LeuHis: 2.959 ± 0.066	4.066LeuIle: 4.066 ± 0.075	3.32LeuLys: 3.32 ± 0.067	11.523LeuLeu: 11.523 ± 0.138	2.387LeuMet: 2.387 ± 0.046	2.741LeuAsn: 2.741 ± 0.052	6.29LeuPro: 6.29 ± 0.084	5.383LeuGln: 5.383 ± 0.088	7.834LeuArg: 7.834 ± 0.107	5.947LeuSer: 5.947 ± 0.075	5.223LeuThr: 5.223 ± 0.072	7.985LeuVal: 7.985 ± 0.097	1.423LeuTrp: 1.423 ± 0.043	2.072LeuTyr: 2.072 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.432MetAla: 3.432 ± 0.059	0.159MetCys: 0.159 ± 0.011	1.184MetAsp: 1.184 ± 0.033	1.108MetGlu: 1.108 ± 0.029	0.644MetPhe: 0.644 ± 0.025	2.024MetGly: 2.024 ± 0.048	0.574MetHis: 0.574 ± 0.023	0.73MetIle: 0.73 ± 0.026	0.867MetLys: 0.867 ± 0.028	2.514MetLeu: 2.514 ± 0.052	0.483MetMet: 0.483 ± 0.02	0.79MetAsn: 0.79 ± 0.026	1.414MetPro: 1.414 ± 0.036	1.224MetGln: 1.224 ± 0.035	1.493MetArg: 1.493 ± 0.036	1.365MetSer: 1.365 ± 0.038	1.462MetThr: 1.462 ± 0.035	1.854MetVal: 1.854 ± 0.049	0.211MetTrp: 0.211 ± 0.012	0.349MetTyr: 0.349 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.553AsnAla: 3.553 ± 0.063	0.224AsnCys: 0.224 ± 0.014	1.355AsnAsp: 1.355 ± 0.039	1.136AsnGlu: 1.136 ± 0.035	0.927AsnPhe: 0.927 ± 0.033	2.029AsnGly: 2.029 ± 0.05	0.598AsnHis: 0.598 ± 0.025	1.25AsnIle: 1.25 ± 0.04	0.8AsnLys: 0.8 ± 0.03	2.596AsnLeu: 2.596 ± 0.053	0.561AsnMet: 0.561 ± 0.021	0.728AsnAsn: 0.728 ± 0.031	1.828AsnPro: 1.828 ± 0.04	1.025AsnGln: 1.025 ± 0.03	1.555AsnArg: 1.555 ± 0.046	1.205AsnSer: 1.205 ± 0.038	1.568AsnThr: 1.568 ± 0.045	1.876AsnVal: 1.876 ± 0.046	0.37AsnTrp: 0.37 ± 0.019	0.653AsnTyr: 0.653 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.622ProAla: 7.622 ± 0.12	0.427ProCys: 0.427 ± 0.022	3.162ProAsp: 3.162 ± 0.059	3.501ProGlu: 3.501 ± 0.065	1.621ProPhe: 1.621 ± 0.038	4.795ProGly: 4.795 ± 0.071	1.339ProHis: 1.339 ± 0.034	1.738ProIle: 1.738 ± 0.038	1.385ProLys: 1.385 ± 0.041	5.512ProLeu: 5.512 ± 0.078	1.247ProMet: 1.247 ± 0.031	1.124ProAsn: 1.124 ± 0.034	3.031ProPro: 3.031 ± 0.068	2.639ProGln: 2.639 ± 0.056	2.83ProArg: 2.83 ± 0.052	2.716ProSer: 2.716 ± 0.051	2.825ProThr: 2.825 ± 0.048	4.322ProVal: 4.322 ± 0.06	0.875ProTrp: 0.875 ± 0.034	1.144ProTyr: 1.144 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	7.33GlnAla: 7.33 ± 0.104	0.41GlnCys: 0.41 ± 0.022	2.07GlnAsp: 2.07 ± 0.042	2.11GlnGlu: 2.11 ± 0.047	1.374GlnPhe: 1.374 ± 0.037	3.804GlnGly: 3.804 ± 0.065	1.363GlnHis: 1.363 ± 0.035	1.857GlnIle: 1.857 ± 0.04	1.346GlnLys: 1.346 ± 0.039	4.957GlnLeu: 4.957 ± 0.072	1.052GlnMet: 1.052 ± 0.032	1.056GlnAsn: 1.056 ± 0.033	2.744GlnPro: 2.744 ± 0.057	2.552GlnGln: 2.552 ± 0.06	4.236GlnArg: 4.236 ± 0.073	2.392GlnSer: 2.392 ± 0.046	2.358GlnThr: 2.358 ± 0.056	3.579GlnVal: 3.579 ± 0.07	0.907GlnTrp: 0.907 ± 0.03	0.883GlnTyr: 0.883 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.986ArgAla: 7.986 ± 0.087	0.611ArgCys: 0.611 ± 0.028	3.152ArgAsp: 3.152 ± 0.049	3.613ArgGlu: 3.613 ± 0.065	2.564ArgPhe: 2.564 ± 0.045	4.275ArgGly: 4.275 ± 0.066	1.776ArgHis: 1.776 ± 0.042	3.203ArgIle: 3.203 ± 0.063	2.033ArgLys: 2.033 ± 0.044	7.449ArgLeu: 7.449 ± 0.102	1.76ArgMet: 1.76 ± 0.043	1.73ArgAsn: 1.73 ± 0.042	2.961ArgPro: 2.961 ± 0.054	3.308ArgGln: 3.308 ± 0.067	4.39ArgArg: 4.39 ± 0.068	3.409ArgSer: 3.409 ± 0.066	3.454ArgThr: 3.454 ± 0.052	4.707ArgVal: 4.707 ± 0.07	1.22ArgTrp: 1.22 ± 0.042	1.701ArgTyr: 1.701 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.472SerAla: 7.472 ± 0.103	0.444SerCys: 0.444 ± 0.021	2.694SerAsp: 2.694 ± 0.053	2.416SerGlu: 2.416 ± 0.045	1.884SerPhe: 1.884 ± 0.045	5.137SerGly: 5.137 ± 0.081	1.272SerHis: 1.272 ± 0.03	2.221SerIle: 2.221 ± 0.051	1.502SerLys: 1.502 ± 0.041	5.282SerLeu: 5.282 ± 0.072	1.206SerMet: 1.206 ± 0.033	1.328SerAsn: 1.328 ± 0.044	2.88SerPro: 2.88 ± 0.06	1.985SerGln: 1.985 ± 0.046	3.0SerArg: 3.0 ± 0.053	3.014SerSer: 3.014 ± 0.067	3.106SerThr: 3.106 ± 0.059	4.128SerVal: 4.128 ± 0.067	0.652SerTrp: 0.652 ± 0.024	1.241SerTyr: 1.241 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.516ThrAla: 6.516 ± 0.086	0.443ThrCys: 0.443 ± 0.019	2.658ThrAsp: 2.658 ± 0.049	2.62ThrGlu: 2.62 ± 0.043	1.693ThrPhe: 1.693 ± 0.05	4.828ThrGly: 4.828 ± 0.073	1.306ThrHis: 1.306 ± 0.033	2.169ThrIle: 2.169 ± 0.051	1.297ThrLys: 1.297 ± 0.038	6.56ThrLeu: 6.56 ± 0.088	1.085ThrMet: 1.085 ± 0.032	1.231ThrAsn: 1.231 ± 0.035	3.896ThrPro: 3.896 ± 0.074	2.381ThrGln: 2.381 ± 0.053	3.092ThrArg: 3.092 ± 0.055	2.739ThrSer: 2.739 ± 0.058	3.057ThrThr: 3.057 ± 0.059	4.253ThrVal: 4.253 ± 0.071	0.717ThrTrp: 0.717 ± 0.029	0.999ThrTyr: 0.999 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.729ValAla: 9.729 ± 0.098	0.792ValCys: 0.792 ± 0.028	3.567ValAsp: 3.567 ± 0.06	3.693ValGlu: 3.693 ± 0.065	2.593ValPhe: 2.593 ± 0.054	5.772ValGly: 5.772 ± 0.081	1.51ValHis: 1.51 ± 0.039	2.96ValIle: 2.96 ± 0.058	2.242ValLys: 2.242 ± 0.056	8.901ValLeu: 8.901 ± 0.115	1.767ValMet: 1.767 ± 0.043	2.055ValAsn: 2.055 ± 0.051	4.161ValPro: 4.161 ± 0.07	3.921ValGln: 3.921 ± 0.068	5.267ValArg: 5.267 ± 0.073	3.76ValSer: 3.76 ± 0.064	3.756ValThr: 3.756 ± 0.069	6.521ValVal: 6.521 ± 0.087	1.072ValTrp: 1.072 ± 0.033	1.516ValTyr: 1.516 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.565TrpAla: 1.565 ± 0.039	0.199TrpCys: 0.199 ± 0.013	0.605TrpAsp: 0.605 ± 0.025	0.534TrpGlu: 0.534 ± 0.021	0.515TrpPhe: 0.515 ± 0.02	1.076TrpGly: 1.076 ± 0.035	0.411TrpHis: 0.411 ± 0.02	0.549TrpIle: 0.549 ± 0.022	0.459TrpLys: 0.459 ± 0.022	2.236TrpLeu: 2.236 ± 0.058	0.429TrpMet: 0.429 ± 0.018	0.411TrpAsn: 0.411 ± 0.02	0.786TrpPro: 0.786 ± 0.032	0.921TrpGln: 0.921 ± 0.035	1.197TrpArg: 1.197 ± 0.038	0.814TrpSer: 0.814 ± 0.03	0.655TrpThr: 0.655 ± 0.028	1.064TrpVal: 1.064 ± 0.039	0.326TrpTrp: 0.326 ± 0.019	0.268TrpTyr: 0.268 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.628TyrAla: 2.628 ± 0.047	0.24TyrCys: 0.24 ± 0.016	1.17TyrAsp: 1.17 ± 0.037	1.071TyrGlu: 1.071 ± 0.032	0.874TyrPhe: 0.874 ± 0.027	1.953TyrGly: 1.953 ± 0.04	0.489TyrHis: 0.489 ± 0.019	0.77TyrIle: 0.77 ± 0.026	0.637TyrLys: 0.637 ± 0.025	2.351TyrLeu: 2.351 ± 0.056	0.427TyrMet: 0.427 ± 0.02	0.605TyrAsn: 0.605 ± 0.027	1.114TyrPro: 1.114 ± 0.03	1.053TyrGln: 1.053 ± 0.031	1.605TyrArg: 1.605 ± 0.04	1.159TyrSer: 1.159 ± 0.032	1.205TyrThr: 1.205 ± 0.033	1.473TyrVal: 1.473 ± 0.038	0.35TyrTrp: 0.35 ± 0.018	0.551TyrTyr: 0.551 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3355 proteins (1122844 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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