Amino acid dipepetide frequency for Streptococcus phage Javan474

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.732AlaAla: 3.732 ± 1.432
0.609AlaCys: 0.609 ± 0.255
3.961AlaAsp: 3.961 ± 0.566
4.646AlaGlu: 4.646 ± 0.575
3.199AlaPhe: 3.199 ± 0.749
4.189AlaGly: 4.189 ± 1.329
0.381AlaHis: 0.381 ± 0.166
5.484AlaIle: 5.484 ± 1.268
6.855AlaLys: 6.855 ± 0.857
5.408AlaLeu: 5.408 ± 0.751
2.971AlaMet: 2.971 ± 0.612
4.57AlaAsn: 4.57 ± 0.568
0.838AlaPro: 0.838 ± 0.254
2.742AlaGln: 2.742 ± 0.613
2.133AlaArg: 2.133 ± 0.399
3.885AlaSer: 3.885 ± 0.974
3.885AlaThr: 3.885 ± 0.859
4.646AlaVal: 4.646 ± 1.252
0.99AlaTrp: 0.99 ± 0.265
2.361AlaTyr: 2.361 ± 0.373
0.0AlaXaa: 0.0 ± 0.0
Cys
0.152CysAla: 0.152 ± 0.111
0.0CysCys: 0.0 ± 0.0
0.457CysAsp: 0.457 ± 0.185
0.533CysGlu: 0.533 ± 0.213
0.0CysPhe: 0.0 ± 0.0
0.381CysGly: 0.381 ± 0.197
0.0CysHis: 0.0 ± 0.0
0.609CysIle: 0.609 ± 0.227
0.305CysLys: 0.305 ± 0.129
0.381CysLeu: 0.381 ± 0.163
0.0CysMet: 0.0 ± 0.0
0.305CysAsn: 0.305 ± 0.185
0.152CysPro: 0.152 ± 0.116
0.305CysGln: 0.305 ± 0.171
0.305CysArg: 0.305 ± 0.146
0.229CysSer: 0.229 ± 0.166
0.152CysThr: 0.152 ± 0.096
0.305CysVal: 0.305 ± 0.163
0.229CysTrp: 0.229 ± 0.14
0.229CysTyr: 0.229 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
2.818AspAla: 2.818 ± 0.521
0.457AspCys: 0.457 ± 0.174
3.656AspAsp: 3.656 ± 0.565
4.113AspGlu: 4.113 ± 0.64
3.199AspPhe: 3.199 ± 0.516
4.722AspGly: 4.722 ± 0.566
0.914AspHis: 0.914 ± 0.262
5.56AspIle: 5.56 ± 0.724
6.322AspLys: 6.322 ± 0.724
6.398AspLeu: 6.398 ± 0.799
1.98AspMet: 1.98 ± 0.397
2.894AspAsn: 2.894 ± 0.564
1.066AspPro: 1.066 ± 0.284
1.676AspGln: 1.676 ± 0.349
2.361AspArg: 2.361 ± 0.414
3.351AspSer: 3.351 ± 0.52
3.656AspThr: 3.656 ± 0.675
4.722AspVal: 4.722 ± 0.506
0.838AspTrp: 0.838 ± 0.245
3.428AspTyr: 3.428 ± 0.599
0.0AspXaa: 0.0 ± 0.0
Glu
5.103GluAla: 5.103 ± 0.644
0.229GluCys: 0.229 ± 0.13
3.504GluAsp: 3.504 ± 0.63
5.332GluGlu: 5.332 ± 1.078
3.504GluPhe: 3.504 ± 0.445
3.961GluGly: 3.961 ± 0.519
1.523GluHis: 1.523 ± 0.339
5.56GluIle: 5.56 ± 0.894
6.474GluLys: 6.474 ± 0.828
7.464GluLeu: 7.464 ± 0.973
2.742GluMet: 2.742 ± 0.465
3.047GluAsn: 3.047 ± 0.596
1.6GluPro: 1.6 ± 0.4
2.59GluGln: 2.59 ± 0.473
2.818GluArg: 2.818 ± 0.495
4.875GluSer: 4.875 ± 0.525
3.428GluThr: 3.428 ± 0.616
4.722GluVal: 4.722 ± 0.713
0.686GluTrp: 0.686 ± 0.245
3.275GluTyr: 3.275 ± 0.51
0.0GluXaa: 0.0 ± 0.0
Phe
2.514PheAla: 2.514 ± 0.602
0.229PheCys: 0.229 ± 0.14
3.504PheAsp: 3.504 ± 0.567
3.047PheGlu: 3.047 ± 0.437
1.6PhePhe: 1.6 ± 0.377
3.123PheGly: 3.123 ± 0.68
0.838PheHis: 0.838 ± 0.251
2.361PheIle: 2.361 ± 0.517
5.484PheLys: 5.484 ± 0.815
2.59PheLeu: 2.59 ± 0.4
1.066PheMet: 1.066 ± 0.283
2.818PheAsn: 2.818 ± 0.468
0.609PhePro: 0.609 ± 0.226
0.838PheGln: 0.838 ± 0.235
2.437PheArg: 2.437 ± 0.389
2.437PheSer: 2.437 ± 0.43
2.437PheThr: 2.437 ± 0.364
2.666PheVal: 2.666 ± 0.365
0.305PheTrp: 0.305 ± 0.156
1.066PheTyr: 1.066 ± 0.294
0.0PheXaa: 0.0 ± 0.0
Gly
3.885GlyAla: 3.885 ± 1.166
0.381GlyCys: 0.381 ± 0.214
4.189GlyAsp: 4.189 ± 0.545
3.275GlyGlu: 3.275 ± 0.482
3.732GlyPhe: 3.732 ± 0.516
4.037GlyGly: 4.037 ± 0.746
0.914GlyHis: 0.914 ± 0.27
4.189GlyIle: 4.189 ± 0.712
6.398GlyLys: 6.398 ± 0.857
5.789GlyLeu: 5.789 ± 1.272
1.828GlyMet: 1.828 ± 0.331
3.656GlyAsn: 3.656 ± 0.47
0.762GlyPro: 0.762 ± 0.386
2.209GlyGln: 2.209 ± 0.446
3.123GlyArg: 3.123 ± 0.467
3.199GlySer: 3.199 ± 0.722
4.494GlyThr: 4.494 ± 0.669
4.037GlyVal: 4.037 ± 0.659
0.533GlyTrp: 0.533 ± 0.194
3.58GlyTyr: 3.58 ± 0.666
0.0GlyXaa: 0.0 ± 0.0
His
0.99HisAla: 0.99 ± 0.313
0.0HisCys: 0.0 ± 0.0
0.762HisAsp: 0.762 ± 0.256
1.371HisGlu: 1.371 ± 0.328
0.609HisPhe: 0.609 ± 0.217
1.143HisGly: 1.143 ± 0.333
0.305HisHis: 0.305 ± 0.184
1.295HisIle: 1.295 ± 0.364
1.066HisLys: 1.066 ± 0.326
1.066HisLeu: 1.066 ± 0.304
0.229HisMet: 0.229 ± 0.124
0.609HisAsn: 0.609 ± 0.23
0.457HisPro: 0.457 ± 0.186
0.762HisGln: 0.762 ± 0.236
0.305HisArg: 0.305 ± 0.128
0.914HisSer: 0.914 ± 0.259
0.686HisThr: 0.686 ± 0.217
1.371HisVal: 1.371 ± 0.303
0.229HisTrp: 0.229 ± 0.127
0.686HisTyr: 0.686 ± 0.272
0.0HisXaa: 0.0 ± 0.0
Ile
4.646IleAla: 4.646 ± 0.773
0.305IleCys: 0.305 ± 0.126
6.703IleAsp: 6.703 ± 0.822
4.951IleGlu: 4.951 ± 0.641
2.285IlePhe: 2.285 ± 0.459
4.799IleGly: 4.799 ± 0.796
1.523IleHis: 1.523 ± 0.341
4.799IleIle: 4.799 ± 0.576
7.007IleLys: 7.007 ± 0.883
5.179IleLeu: 5.179 ± 0.694
0.99IleMet: 0.99 ± 0.269
5.027IleAsn: 5.027 ± 0.691
1.752IlePro: 1.752 ± 0.384
2.666IleGln: 2.666 ± 0.449
3.428IleArg: 3.428 ± 0.601
4.875IleSer: 4.875 ± 1.035
5.332IleThr: 5.332 ± 0.651
3.732IleVal: 3.732 ± 0.447
0.609IleTrp: 0.609 ± 0.218
2.894IleTyr: 2.894 ± 0.51
0.0IleXaa: 0.0 ± 0.0
Lys
6.931LysAla: 6.931 ± 0.678
0.0LysCys: 0.0 ± 0.0
4.951LysAsp: 4.951 ± 0.611
6.779LysGlu: 6.779 ± 0.83
3.123LysPhe: 3.123 ± 0.438
4.646LysGly: 4.646 ± 0.778
0.686LysHis: 0.686 ± 0.186
6.931LysIle: 6.931 ± 0.759
7.617LysLys: 7.617 ± 1.035
7.769LysLeu: 7.769 ± 0.919
2.361LysMet: 2.361 ± 0.391
6.017LysAsn: 6.017 ± 0.709
2.894LysPro: 2.894 ± 0.619
4.722LysGln: 4.722 ± 0.601
4.189LysArg: 4.189 ± 0.651
5.103LysSer: 5.103 ± 0.634
6.17LysThr: 6.17 ± 0.827
6.17LysVal: 6.17 ± 0.731
0.914LysTrp: 0.914 ± 0.222
3.808LysTyr: 3.808 ± 0.64
0.0LysXaa: 0.0 ± 0.0
Leu
5.865LeuAla: 5.865 ± 1.0
0.533LeuCys: 0.533 ± 0.253
6.017LeuAsp: 6.017 ± 0.527
7.464LeuGlu: 7.464 ± 0.721
3.656LeuPhe: 3.656 ± 0.454
4.799LeuGly: 4.799 ± 0.905
0.609LeuHis: 0.609 ± 0.197
6.093LeuIle: 6.093 ± 0.914
8.074LeuLys: 8.074 ± 0.904
6.017LeuLeu: 6.017 ± 0.787
1.904LeuMet: 1.904 ± 0.342
4.875LeuAsn: 4.875 ± 0.609
1.752LeuPro: 1.752 ± 0.306
3.504LeuGln: 3.504 ± 0.695
3.047LeuArg: 3.047 ± 0.564
5.789LeuSer: 5.789 ± 0.636
5.408LeuThr: 5.408 ± 0.49
3.885LeuVal: 3.885 ± 0.437
0.609LeuTrp: 0.609 ± 0.206
1.752LeuTyr: 1.752 ± 0.364
0.0LeuXaa: 0.0 ± 0.0
Met
2.742MetAla: 2.742 ± 0.606
0.0MetCys: 0.0 ± 0.0
1.447MetAsp: 1.447 ± 0.311
1.752MetGlu: 1.752 ± 0.424
0.99MetPhe: 0.99 ± 0.275
0.99MetGly: 0.99 ± 0.301
0.076MetHis: 0.076 ± 0.075
1.904MetIle: 1.904 ± 0.278
1.447MetLys: 1.447 ± 0.32
2.514MetLeu: 2.514 ± 0.507
0.152MetMet: 0.152 ± 0.102
1.371MetAsn: 1.371 ± 0.328
0.533MetPro: 0.533 ± 0.194
1.523MetGln: 1.523 ± 0.31
1.752MetArg: 1.752 ± 0.356
1.295MetSer: 1.295 ± 0.267
2.133MetThr: 2.133 ± 0.447
0.686MetVal: 0.686 ± 0.292
0.152MetTrp: 0.152 ± 0.111
0.838MetTyr: 0.838 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
4.57AsnAla: 4.57 ± 0.707
0.533AsnCys: 0.533 ± 0.18
2.514AsnAsp: 2.514 ± 0.478
3.808AsnGlu: 3.808 ± 0.68
2.209AsnPhe: 2.209 ± 0.36
5.484AsnGly: 5.484 ± 0.674
0.99AsnHis: 0.99 ± 0.238
4.418AsnIle: 4.418 ± 0.799
4.494AsnLys: 4.494 ± 0.558
4.722AsnLeu: 4.722 ± 0.496
0.914AsnMet: 0.914 ± 0.304
2.514AsnAsn: 2.514 ± 0.558
1.523AsnPro: 1.523 ± 0.341
2.742AsnGln: 2.742 ± 0.579
2.666AsnArg: 2.666 ± 0.575
3.58AsnSer: 3.58 ± 0.653
2.818AsnThr: 2.818 ± 0.483
2.818AsnVal: 2.818 ± 0.401
0.99AsnTrp: 0.99 ± 0.352
1.98AsnTyr: 1.98 ± 0.364
0.0AsnXaa: 0.0 ± 0.0
Pro
0.914ProAla: 0.914 ± 0.32
0.076ProCys: 0.076 ± 0.072
1.676ProAsp: 1.676 ± 0.346
1.523ProGlu: 1.523 ± 0.366
1.295ProPhe: 1.295 ± 0.326
0.99ProGly: 0.99 ± 0.213
0.381ProHis: 0.381 ± 0.164
1.676ProIle: 1.676 ± 0.343
2.742ProLys: 2.742 ± 0.462
1.066ProLeu: 1.066 ± 0.314
0.457ProMet: 0.457 ± 0.153
1.752ProAsn: 1.752 ± 0.421
1.066ProPro: 1.066 ± 0.306
0.914ProGln: 0.914 ± 0.318
1.066ProArg: 1.066 ± 0.304
1.676ProSer: 1.676 ± 0.366
1.752ProThr: 1.752 ± 0.298
1.523ProVal: 1.523 ± 0.36
0.305ProTrp: 0.305 ± 0.161
1.219ProTyr: 1.219 ± 0.368
0.0ProXaa: 0.0 ± 0.0
Gln
4.113GlnAla: 4.113 ± 1.055
0.152GlnCys: 0.152 ± 0.096
2.133GlnAsp: 2.133 ± 0.419
2.742GlnGlu: 2.742 ± 0.538
1.295GlnPhe: 1.295 ± 0.343
2.894GlnGly: 2.894 ± 0.494
0.457GlnHis: 0.457 ± 0.205
3.428GlnIle: 3.428 ± 0.453
3.58GlnLys: 3.58 ± 0.496
3.504GlnLeu: 3.504 ± 0.614
0.609GlnMet: 0.609 ± 0.257
2.361GlnAsn: 2.361 ± 0.419
1.371GlnPro: 1.371 ± 0.292
2.514GlnGln: 2.514 ± 0.642
1.523GlnArg: 1.523 ± 0.308
4.113GlnSer: 4.113 ± 0.792
1.98GlnThr: 1.98 ± 0.516
1.828GlnVal: 1.828 ± 0.332
0.229GlnTrp: 0.229 ± 0.14
1.371GlnTyr: 1.371 ± 0.374
0.0GlnXaa: 0.0 ± 0.0
Arg
2.133ArgAla: 2.133 ± 0.372
0.152ArgCys: 0.152 ± 0.103
2.285ArgAsp: 2.285 ± 0.44
3.428ArgGlu: 3.428 ± 0.539
1.447ArgPhe: 1.447 ± 0.381
2.742ArgGly: 2.742 ± 0.412
0.914ArgHis: 0.914 ± 0.266
3.351ArgIle: 3.351 ± 0.575
4.646ArgLys: 4.646 ± 0.608
3.808ArgLeu: 3.808 ± 0.521
1.066ArgMet: 1.066 ± 0.266
1.904ArgAsn: 1.904 ± 0.408
0.838ArgPro: 0.838 ± 0.239
1.904ArgGln: 1.904 ± 0.349
1.98ArgArg: 1.98 ± 0.487
2.057ArgSer: 2.057 ± 0.333
1.6ArgThr: 1.6 ± 0.375
2.666ArgVal: 2.666 ± 0.49
0.381ArgTrp: 0.381 ± 0.161
1.904ArgTyr: 1.904 ± 0.418
0.0ArgXaa: 0.0 ± 0.0
Ser
4.951SerAla: 4.951 ± 1.486
0.152SerCys: 0.152 ± 0.116
3.732SerAsp: 3.732 ± 0.556
4.265SerGlu: 4.265 ± 0.699
2.285SerPhe: 2.285 ± 0.362
3.885SerGly: 3.885 ± 0.768
1.143SerHis: 1.143 ± 0.323
5.027SerIle: 5.027 ± 0.535
5.027SerLys: 5.027 ± 0.649
3.961SerLeu: 3.961 ± 0.758
2.285SerMet: 2.285 ± 0.636
3.656SerAsn: 3.656 ± 0.606
1.447SerPro: 1.447 ± 0.286
3.351SerGln: 3.351 ± 0.858
2.361SerArg: 2.361 ± 0.415
4.342SerSer: 4.342 ± 1.17
3.885SerThr: 3.885 ± 0.712
4.646SerVal: 4.646 ± 0.609
0.686SerTrp: 0.686 ± 0.256
2.59SerTyr: 2.59 ± 0.455
0.0SerXaa: 0.0 ± 0.0
Thr
4.189ThrAla: 4.189 ± 0.843
0.381ThrCys: 0.381 ± 0.192
4.494ThrAsp: 4.494 ± 0.516
3.656ThrGlu: 3.656 ± 0.692
2.59ThrPhe: 2.59 ± 0.452
4.57ThrGly: 4.57 ± 0.874
1.066ThrHis: 1.066 ± 0.282
4.189ThrIle: 4.189 ± 0.52
4.57ThrLys: 4.57 ± 0.698
5.408ThrLeu: 5.408 ± 0.569
0.914ThrMet: 0.914 ± 0.284
3.428ThrAsn: 3.428 ± 0.527
2.057ThrPro: 2.057 ± 0.426
2.514ThrGln: 2.514 ± 0.389
1.523ThrArg: 1.523 ± 0.306
4.342ThrSer: 4.342 ± 0.43
5.027ThrThr: 5.027 ± 0.753
3.808ThrVal: 3.808 ± 0.544
0.381ThrTrp: 0.381 ± 0.194
2.133ThrTyr: 2.133 ± 0.463
0.0ThrXaa: 0.0 ± 0.0
Val
4.494ValAla: 4.494 ± 1.095
0.457ValCys: 0.457 ± 0.166
4.113ValAsp: 4.113 ± 0.587
5.789ValGlu: 5.789 ± 0.759
2.666ValPhe: 2.666 ± 0.405
4.113ValGly: 4.113 ± 0.776
0.99ValHis: 0.99 ± 0.285
3.656ValIle: 3.656 ± 0.395
5.789ValLys: 5.789 ± 0.765
4.113ValLeu: 4.113 ± 0.629
1.219ValMet: 1.219 ± 0.351
2.818ValAsn: 2.818 ± 0.416
2.057ValPro: 2.057 ± 0.347
2.057ValGln: 2.057 ± 0.375
1.904ValArg: 1.904 ± 0.471
3.808ValSer: 3.808 ± 0.75
3.732ValThr: 3.732 ± 0.498
4.494ValVal: 4.494 ± 0.528
0.686ValTrp: 0.686 ± 0.201
1.6ValTyr: 1.6 ± 0.432
0.0ValXaa: 0.0 ± 0.0
Trp
0.762TrpAla: 0.762 ± 0.285
0.076TrpCys: 0.076 ± 0.075
0.686TrpAsp: 0.686 ± 0.204
0.686TrpGlu: 0.686 ± 0.225
0.533TrpPhe: 0.533 ± 0.225
0.914TrpGly: 0.914 ± 0.261
0.076TrpHis: 0.076 ± 0.079
0.533TrpIle: 0.533 ± 0.221
0.99TrpLys: 0.99 ± 0.231
1.371TrpLeu: 1.371 ± 0.366
0.152TrpMet: 0.152 ± 0.108
0.381TrpAsn: 0.381 ± 0.198
0.229TrpPro: 0.229 ± 0.139
0.305TrpGln: 0.305 ± 0.138
1.066TrpArg: 1.066 ± 0.293
0.686TrpSer: 0.686 ± 0.23
0.076TrpThr: 0.076 ± 0.08
0.381TrpVal: 0.381 ± 0.181
0.305TrpTrp: 0.305 ± 0.132
0.229TrpTyr: 0.229 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.98TyrAla: 1.98 ± 0.305
0.305TyrCys: 0.305 ± 0.148
3.351TyrAsp: 3.351 ± 0.582
3.275TyrGlu: 3.275 ± 0.575
1.752TyrPhe: 1.752 ± 0.447
1.828TyrGly: 1.828 ± 0.44
1.066TyrHis: 1.066 ± 0.363
2.437TyrIle: 2.437 ± 0.378
2.971TyrLys: 2.971 ± 0.577
3.123TyrLeu: 3.123 ± 0.585
0.381TyrMet: 0.381 ± 0.176
2.285TyrAsn: 2.285 ± 0.43
1.066TyrPro: 1.066 ± 0.38
2.361TyrGln: 2.361 ± 0.488
1.219TyrArg: 1.219 ± 0.279
3.123TyrSer: 3.123 ± 0.662
2.59TyrThr: 2.59 ± 0.446
1.447TyrVal: 1.447 ± 0.311
0.381TyrTrp: 0.381 ± 0.189
2.057TyrTyr: 2.057 ± 0.436
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (13130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski