Amino acid dipepetide frequency for Klebsiella phage vB_KpnP_NahiliMali

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.363AlaAla: 10.363 ± 1.71
0.729AlaCys: 0.729 ± 0.251
5.505AlaAsp: 5.505 ± 0.791
5.262AlaGlu: 5.262 ± 0.67
3.157AlaPhe: 3.157 ± 0.489
6.801AlaGly: 6.801 ± 0.679
2.186AlaHis: 2.186 ± 0.421
4.858AlaIle: 4.858 ± 0.734
7.205AlaLys: 7.205 ± 0.71
7.529AlaLeu: 7.529 ± 0.834
3.319AlaMet: 3.319 ± 0.547
4.777AlaAsn: 4.777 ± 0.666
3.4AlaPro: 3.4 ± 0.415
4.21AlaGln: 4.21 ± 0.826
3.886AlaArg: 3.886 ± 0.562
4.858AlaSer: 4.858 ± 0.548
4.453AlaThr: 4.453 ± 0.72
5.586AlaVal: 5.586 ± 0.819
1.619AlaTrp: 1.619 ± 0.547
2.429AlaTyr: 2.429 ± 0.517
0.0AlaXaa: 0.0 ± 0.0
Cys
0.648CysAla: 0.648 ± 0.231
0.081CysCys: 0.081 ± 0.084
0.567CysAsp: 0.567 ± 0.358
0.486CysGlu: 0.486 ± 0.18
0.567CysPhe: 0.567 ± 0.207
0.405CysGly: 0.405 ± 0.207
0.243CysHis: 0.243 ± 0.176
0.243CysIle: 0.243 ± 0.125
0.486CysLys: 0.486 ± 0.221
0.567CysLeu: 0.567 ± 0.199
0.081CysMet: 0.081 ± 0.091
0.243CysAsn: 0.243 ± 0.124
0.324CysPro: 0.324 ± 0.154
0.405CysGln: 0.405 ± 0.173
0.486CysArg: 0.486 ± 0.221
0.486CysSer: 0.486 ± 0.232
0.243CysThr: 0.243 ± 0.145
0.891CysVal: 0.891 ± 0.364
0.243CysTrp: 0.243 ± 0.156
0.405CysTyr: 0.405 ± 0.194
0.0CysXaa: 0.0 ± 0.0
Asp
5.424AspAla: 5.424 ± 0.729
0.648AspCys: 0.648 ± 0.176
4.858AspAsp: 4.858 ± 0.772
4.696AspGlu: 4.696 ± 0.695
2.753AspPhe: 2.753 ± 0.438
6.72AspGly: 6.72 ± 0.567
0.81AspHis: 0.81 ± 0.256
2.834AspIle: 2.834 ± 0.402
3.4AspLys: 3.4 ± 0.572
4.21AspLeu: 4.21 ± 0.463
1.619AspMet: 1.619 ± 0.273
3.238AspAsn: 3.238 ± 0.4
3.076AspPro: 3.076 ± 0.543
2.186AspGln: 2.186 ± 0.502
2.753AspArg: 2.753 ± 0.447
4.21AspSer: 4.21 ± 0.514
3.643AspThr: 3.643 ± 0.474
3.967AspVal: 3.967 ± 0.489
0.81AspTrp: 0.81 ± 0.337
2.429AspTyr: 2.429 ± 0.405
0.0AspXaa: 0.0 ± 0.0
Glu
6.962GluAla: 6.962 ± 0.828
0.567GluCys: 0.567 ± 0.24
3.643GluAsp: 3.643 ± 0.544
2.915GluGlu: 2.915 ± 0.579
2.915GluPhe: 2.915 ± 0.513
5.1GluGly: 5.1 ± 0.686
1.619GluHis: 1.619 ± 0.437
2.267GluIle: 2.267 ± 0.527
2.591GluLys: 2.591 ± 0.543
5.991GluLeu: 5.991 ± 1.03
2.105GluMet: 2.105 ± 0.401
4.048GluAsn: 4.048 ± 0.608
1.538GluPro: 1.538 ± 0.315
3.076GluGln: 3.076 ± 0.428
3.481GluArg: 3.481 ± 0.474
3.4GluSer: 3.4 ± 0.722
4.615GluThr: 4.615 ± 0.641
4.615GluVal: 4.615 ± 0.665
1.052GluTrp: 1.052 ± 0.339
3.076GluTyr: 3.076 ± 0.527
0.0GluXaa: 0.0 ± 0.0
Phe
2.591PheAla: 2.591 ± 0.401
0.486PheCys: 0.486 ± 0.225
2.267PheAsp: 2.267 ± 0.514
1.619PheGlu: 1.619 ± 0.313
1.133PhePhe: 1.133 ± 0.313
3.076PheGly: 3.076 ± 0.47
0.729PheHis: 0.729 ± 0.233
1.7PheIle: 1.7 ± 0.416
2.429PheLys: 2.429 ± 0.601
3.562PheLeu: 3.562 ± 0.602
1.619PheMet: 1.619 ± 0.264
2.429PheAsn: 2.429 ± 0.492
1.133PhePro: 1.133 ± 0.316
1.457PheGln: 1.457 ± 0.329
1.538PheArg: 1.538 ± 0.341
2.591PheSer: 2.591 ± 0.534
3.076PheThr: 3.076 ± 0.363
2.591PheVal: 2.591 ± 0.446
0.243PheTrp: 0.243 ± 0.129
0.891PheTyr: 0.891 ± 0.202
0.0PheXaa: 0.0 ± 0.0
Gly
6.315GlyAla: 6.315 ± 0.689
0.648GlyCys: 0.648 ± 0.257
5.91GlyAsp: 5.91 ± 0.617
5.586GlyGlu: 5.586 ± 0.555
2.834GlyPhe: 2.834 ± 0.392
4.696GlyGly: 4.696 ± 0.476
1.376GlyHis: 1.376 ± 0.349
4.777GlyIle: 4.777 ± 0.718
4.858GlyLys: 4.858 ± 0.753
5.991GlyLeu: 5.991 ± 0.722
1.943GlyMet: 1.943 ± 0.377
3.238GlyAsn: 3.238 ± 0.57
1.133GlyPro: 1.133 ± 0.364
2.429GlyGln: 2.429 ± 0.392
4.291GlyArg: 4.291 ± 0.471
4.615GlySer: 4.615 ± 0.681
5.1GlyThr: 5.1 ± 0.615
4.372GlyVal: 4.372 ± 0.483
1.376GlyTrp: 1.376 ± 0.335
3.076GlyTyr: 3.076 ± 0.436
0.0GlyXaa: 0.0 ± 0.0
His
1.214HisAla: 1.214 ± 0.265
0.405HisCys: 0.405 ± 0.219
1.214HisAsp: 1.214 ± 0.283
1.214HisGlu: 1.214 ± 0.292
1.133HisPhe: 1.133 ± 0.332
1.457HisGly: 1.457 ± 0.257
0.162HisHis: 0.162 ± 0.116
1.376HisIle: 1.376 ± 0.355
0.81HisLys: 0.81 ± 0.249
1.295HisLeu: 1.295 ± 0.302
1.052HisMet: 1.052 ± 0.282
0.891HisAsn: 0.891 ± 0.305
0.324HisPro: 0.324 ± 0.168
0.648HisGln: 0.648 ± 0.214
0.972HisArg: 0.972 ± 0.256
1.376HisSer: 1.376 ± 0.362
1.457HisThr: 1.457 ± 0.357
1.133HisVal: 1.133 ± 0.267
0.324HisTrp: 0.324 ± 0.156
0.891HisTyr: 0.891 ± 0.32
0.0HisXaa: 0.0 ± 0.0
Ile
4.696IleAla: 4.696 ± 0.597
0.324IleCys: 0.324 ± 0.174
3.238IleAsp: 3.238 ± 0.436
3.157IleGlu: 3.157 ± 0.674
1.133IlePhe: 1.133 ± 0.271
4.21IleGly: 4.21 ± 0.51
1.133IleHis: 1.133 ± 0.348
2.915IleIle: 2.915 ± 0.476
3.238IleLys: 3.238 ± 0.474
4.048IleLeu: 4.048 ± 0.574
1.214IleMet: 1.214 ± 0.261
3.076IleAsn: 3.076 ± 0.552
2.348IlePro: 2.348 ± 0.477
2.267IleGln: 2.267 ± 0.441
3.643IleArg: 3.643 ± 0.468
2.672IleSer: 2.672 ± 0.482
2.915IleThr: 2.915 ± 0.431
3.4IleVal: 3.4 ± 0.646
0.486IleTrp: 0.486 ± 0.213
1.295IleTyr: 1.295 ± 0.336
0.0IleXaa: 0.0 ± 0.0
Lys
7.529LysAla: 7.529 ± 0.922
0.243LysCys: 0.243 ± 0.133
3.481LysAsp: 3.481 ± 0.403
5.586LysGlu: 5.586 ± 0.712
1.7LysPhe: 1.7 ± 0.317
4.291LysGly: 4.291 ± 0.696
1.538LysHis: 1.538 ± 0.51
2.267LysIle: 2.267 ± 0.44
3.724LysLys: 3.724 ± 0.823
5.181LysLeu: 5.181 ± 0.725
1.862LysMet: 1.862 ± 0.272
2.348LysAsn: 2.348 ± 0.33
3.4LysPro: 3.4 ± 0.702
2.672LysGln: 2.672 ± 0.536
4.048LysArg: 4.048 ± 0.784
3.724LysSer: 3.724 ± 0.495
4.129LysThr: 4.129 ± 0.713
4.938LysVal: 4.938 ± 0.595
0.324LysTrp: 0.324 ± 0.124
2.186LysTyr: 2.186 ± 0.354
0.0LysXaa: 0.0 ± 0.0
Leu
6.801LeuAla: 6.801 ± 0.927
0.324LeuCys: 0.324 ± 0.22
4.696LeuAsp: 4.696 ± 0.689
5.424LeuGlu: 5.424 ± 0.88
2.753LeuPhe: 2.753 ± 0.428
4.534LeuGly: 4.534 ± 0.767
1.295LeuHis: 1.295 ± 0.308
4.291LeuIle: 4.291 ± 0.584
7.853LeuLys: 7.853 ± 0.908
4.858LeuLeu: 4.858 ± 0.714
2.186LeuMet: 2.186 ± 0.455
4.453LeuAsn: 4.453 ± 0.632
2.672LeuPro: 2.672 ± 0.37
3.724LeuGln: 3.724 ± 0.567
4.938LeuArg: 4.938 ± 0.487
4.938LeuSer: 4.938 ± 0.637
4.777LeuThr: 4.777 ± 0.576
5.748LeuVal: 5.748 ± 0.545
1.457LeuTrp: 1.457 ± 0.329
2.591LeuTyr: 2.591 ± 0.377
0.0LeuXaa: 0.0 ± 0.0
Met
2.995MetAla: 2.995 ± 0.474
0.162MetCys: 0.162 ± 0.119
1.538MetAsp: 1.538 ± 0.381
1.781MetGlu: 1.781 ± 0.386
1.619MetPhe: 1.619 ± 0.413
2.024MetGly: 2.024 ± 0.395
0.162MetHis: 0.162 ± 0.123
1.214MetIle: 1.214 ± 0.288
1.862MetLys: 1.862 ± 0.387
2.995MetLeu: 2.995 ± 0.409
0.891MetMet: 0.891 ± 0.271
1.052MetAsn: 1.052 ± 0.256
1.214MetPro: 1.214 ± 0.28
2.024MetGln: 2.024 ± 0.52
1.862MetArg: 1.862 ± 0.369
1.862MetSer: 1.862 ± 0.302
1.457MetThr: 1.457 ± 0.348
1.943MetVal: 1.943 ± 0.43
0.243MetTrp: 0.243 ± 0.135
0.405MetTyr: 0.405 ± 0.205
0.0MetXaa: 0.0 ± 0.0
Asn
4.291AsnAla: 4.291 ± 0.613
0.486AsnCys: 0.486 ± 0.25
3.157AsnAsp: 3.157 ± 0.499
3.4AsnGlu: 3.4 ± 0.517
2.105AsnPhe: 2.105 ± 0.375
4.858AsnGly: 4.858 ± 0.664
0.729AsnHis: 0.729 ± 0.353
2.348AsnIle: 2.348 ± 0.279
2.348AsnLys: 2.348 ± 0.5
3.157AsnLeu: 3.157 ± 0.497
1.295AsnMet: 1.295 ± 0.398
1.943AsnAsn: 1.943 ± 0.416
2.348AsnPro: 2.348 ± 0.373
2.591AsnGln: 2.591 ± 0.503
1.943AsnArg: 1.943 ± 0.491
2.429AsnSer: 2.429 ± 0.64
2.51AsnThr: 2.51 ± 0.476
2.834AsnVal: 2.834 ± 0.464
0.648AsnTrp: 0.648 ± 0.201
1.943AsnTyr: 1.943 ± 0.473
0.0AsnXaa: 0.0 ± 0.0
Pro
3.481ProAla: 3.481 ± 0.508
0.162ProCys: 0.162 ± 0.115
2.672ProAsp: 2.672 ± 0.343
3.157ProGlu: 3.157 ± 0.513
1.781ProPhe: 1.781 ± 0.333
0.891ProGly: 0.891 ± 0.328
0.729ProHis: 0.729 ± 0.212
1.376ProIle: 1.376 ± 0.249
2.267ProLys: 2.267 ± 0.5
2.51ProLeu: 2.51 ± 0.368
1.295ProMet: 1.295 ± 0.304
1.781ProAsn: 1.781 ± 0.435
0.729ProPro: 0.729 ± 0.263
1.295ProGln: 1.295 ± 0.291
1.619ProArg: 1.619 ± 0.42
2.834ProSer: 2.834 ± 0.338
1.781ProThr: 1.781 ± 0.288
2.51ProVal: 2.51 ± 0.398
0.891ProTrp: 0.891 ± 0.271
1.214ProTyr: 1.214 ± 0.339
0.0ProXaa: 0.0 ± 0.0
Gln
4.858GlnAla: 4.858 ± 0.76
0.486GlnCys: 0.486 ± 0.215
2.995GlnAsp: 2.995 ± 0.629
2.51GlnGlu: 2.51 ± 0.445
1.781GlnPhe: 1.781 ± 0.341
2.915GlnGly: 2.915 ± 0.653
0.648GlnHis: 0.648 ± 0.189
1.862GlnIle: 1.862 ± 0.311
3.157GlnLys: 3.157 ± 0.509
3.805GlnLeu: 3.805 ± 0.877
1.619GlnMet: 1.619 ± 0.367
1.133GlnAsn: 1.133 ± 0.244
1.295GlnPro: 1.295 ± 0.293
2.834GlnGln: 2.834 ± 0.635
2.186GlnArg: 2.186 ± 0.5
1.862GlnSer: 1.862 ± 0.333
2.51GlnThr: 2.51 ± 0.557
3.238GlnVal: 3.238 ± 0.688
1.052GlnTrp: 1.052 ± 0.312
1.457GlnTyr: 1.457 ± 0.377
0.0GlnXaa: 0.0 ± 0.0
Arg
4.453ArgAla: 4.453 ± 0.566
0.567ArgCys: 0.567 ± 0.265
2.834ArgAsp: 2.834 ± 0.425
3.076ArgGlu: 3.076 ± 0.539
2.105ArgPhe: 2.105 ± 0.4
3.805ArgGly: 3.805 ± 0.554
1.133ArgHis: 1.133 ± 0.308
2.995ArgIle: 2.995 ± 0.502
3.967ArgLys: 3.967 ± 0.781
4.938ArgLeu: 4.938 ± 0.647
0.972ArgMet: 0.972 ± 0.217
2.51ArgAsn: 2.51 ± 0.502
1.376ArgPro: 1.376 ± 0.307
2.51ArgGln: 2.51 ± 0.734
2.267ArgArg: 2.267 ± 0.407
3.805ArgSer: 3.805 ± 0.501
2.915ArgThr: 2.915 ± 0.469
3.562ArgVal: 3.562 ± 0.503
0.648ArgTrp: 0.648 ± 0.269
1.619ArgTyr: 1.619 ± 0.33
0.0ArgXaa: 0.0 ± 0.0
Ser
4.858SerAla: 4.858 ± 0.871
0.567SerCys: 0.567 ± 0.29
5.343SerAsp: 5.343 ± 0.708
4.372SerGlu: 4.372 ± 0.7
2.51SerPhe: 2.51 ± 0.443
5.019SerGly: 5.019 ± 0.643
1.214SerHis: 1.214 ± 0.288
3.967SerIle: 3.967 ± 0.669
3.724SerLys: 3.724 ± 0.668
4.696SerLeu: 4.696 ± 0.762
1.214SerMet: 1.214 ± 0.31
2.753SerAsn: 2.753 ± 0.36
1.943SerPro: 1.943 ± 0.353
2.186SerGln: 2.186 ± 0.465
3.076SerArg: 3.076 ± 0.599
3.319SerSer: 3.319 ± 0.635
2.429SerThr: 2.429 ± 0.506
3.319SerVal: 3.319 ± 0.528
0.648SerTrp: 0.648 ± 0.186
3.157SerTyr: 3.157 ± 0.574
0.0SerXaa: 0.0 ± 0.0
Thr
4.291ThrAla: 4.291 ± 0.669
0.405ThrCys: 0.405 ± 0.164
4.048ThrAsp: 4.048 ± 0.644
3.967ThrGlu: 3.967 ± 0.587
1.862ThrPhe: 1.862 ± 0.416
5.019ThrGly: 5.019 ± 0.651
1.133ThrHis: 1.133 ± 0.286
3.562ThrIle: 3.562 ± 0.588
3.967ThrLys: 3.967 ± 0.447
5.343ThrLeu: 5.343 ± 0.688
1.7ThrMet: 1.7 ± 0.314
2.348ThrAsn: 2.348 ± 0.384
2.51ThrPro: 2.51 ± 0.406
2.267ThrGln: 2.267 ± 0.538
1.619ThrArg: 1.619 ± 0.314
4.21ThrSer: 4.21 ± 0.711
3.319ThrThr: 3.319 ± 0.565
4.048ThrVal: 4.048 ± 0.667
0.567ThrTrp: 0.567 ± 0.174
2.105ThrTyr: 2.105 ± 0.275
0.0ThrXaa: 0.0 ± 0.0
Val
6.801ValAla: 6.801 ± 0.682
0.324ValCys: 0.324 ± 0.158
3.157ValAsp: 3.157 ± 0.473
4.372ValGlu: 4.372 ± 0.602
2.348ValPhe: 2.348 ± 0.718
4.938ValGly: 4.938 ± 0.656
1.943ValHis: 1.943 ± 0.589
4.048ValIle: 4.048 ± 0.6
4.696ValLys: 4.696 ± 0.52
5.019ValLeu: 5.019 ± 0.586
1.781ValMet: 1.781 ± 0.318
3.238ValAsn: 3.238 ± 0.573
2.591ValPro: 2.591 ± 0.358
2.672ValGln: 2.672 ± 0.403
4.372ValArg: 4.372 ± 0.685
4.129ValSer: 4.129 ± 0.619
4.048ValThr: 4.048 ± 0.501
4.938ValVal: 4.938 ± 0.756
0.729ValTrp: 0.729 ± 0.219
1.538ValTyr: 1.538 ± 0.363
0.0ValXaa: 0.0 ± 0.0
Trp
0.891TrpAla: 0.891 ± 0.279
0.162TrpCys: 0.162 ± 0.125
0.486TrpAsp: 0.486 ± 0.158
0.81TrpGlu: 0.81 ± 0.302
0.324TrpPhe: 0.324 ± 0.174
1.133TrpGly: 1.133 ± 0.263
0.243TrpHis: 0.243 ± 0.194
0.648TrpIle: 0.648 ± 0.248
1.214TrpLys: 1.214 ± 0.367
1.214TrpLeu: 1.214 ± 0.345
0.486TrpMet: 0.486 ± 0.175
0.648TrpAsn: 0.648 ± 0.284
0.243TrpPro: 0.243 ± 0.151
0.891TrpGln: 0.891 ± 0.224
0.729TrpArg: 0.729 ± 0.221
1.052TrpSer: 1.052 ± 0.308
1.052TrpThr: 1.052 ± 0.243
1.376TrpVal: 1.376 ± 0.439
0.081TrpTrp: 0.081 ± 0.074
0.405TrpTyr: 0.405 ± 0.245
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.672TyrAla: 2.672 ± 0.463
0.324TyrCys: 0.324 ± 0.166
2.672TyrAsp: 2.672 ± 0.473
2.267TyrGlu: 2.267 ± 0.51
0.648TyrPhe: 0.648 ± 0.232
2.672TyrGly: 2.672 ± 0.405
0.324TyrHis: 0.324 ± 0.154
1.862TyrIle: 1.862 ± 0.384
1.376TyrLys: 1.376 ± 0.381
3.4TyrLeu: 3.4 ± 0.506
0.972TyrMet: 0.972 ± 0.242
1.214TyrAsn: 1.214 ± 0.329
1.376TyrPro: 1.376 ± 0.375
1.862TyrGln: 1.862 ± 0.391
2.348TyrArg: 2.348 ± 0.392
1.943TyrSer: 1.943 ± 0.297
1.862TyrThr: 1.862 ± 0.413
2.672TyrVal: 2.672 ± 0.346
0.648TyrTrp: 0.648 ± 0.21
0.567TyrTyr: 0.567 ± 0.275
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (12353 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski