Amino acid dipepetide frequency for Prevotella sp. CAG:1031

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.163AlaAla: 10.163 ± 0.216	0.968AlaCys: 0.968 ± 0.041	6.82AlaAsp: 6.82 ± 0.124	5.782AlaGlu: 5.782 ± 0.099	3.374AlaPhe: 3.374 ± 0.067	6.922AlaGly: 6.922 ± 0.13	1.312AlaHis: 1.312 ± 0.05	5.667AlaIle: 5.667 ± 0.105	3.959AlaLys: 3.959 ± 0.091	8.808AlaLeu: 8.808 ± 0.132	2.61AlaMet: 2.61 ± 0.078	3.264AlaAsn: 3.264 ± 0.064	3.63AlaPro: 3.63 ± 0.087	2.486AlaGln: 2.486 ± 0.066	5.394AlaArg: 5.394 ± 0.101	5.391AlaSer: 5.391 ± 0.095	5.3AlaThr: 5.3 ± 0.107	7.02AlaVal: 7.02 ± 0.105	0.905AlaTrp: 0.905 ± 0.04	2.716AlaTyr: 2.716 ± 0.061	0.001AlaXaa: 0.001 ± 0.001
Cys	0.9CysAla: 0.9 ± 0.036	0.156CysCys: 0.156 ± 0.015	0.7CysAsp: 0.7 ± 0.033	0.579CysGlu: 0.579 ± 0.031	0.478CysPhe: 0.478 ± 0.026	1.071CysGly: 1.071 ± 0.04	0.288CysHis: 0.288 ± 0.019	0.603CysIle: 0.603 ± 0.031	0.426CysLys: 0.426 ± 0.027	0.971CysLeu: 0.971 ± 0.038	0.226CysMet: 0.226 ± 0.015	0.479CysAsn: 0.479 ± 0.029	0.521CysPro: 0.521 ± 0.03	0.308CysGln: 0.308 ± 0.02	0.85CysArg: 0.85 ± 0.039	0.694CysSer: 0.694 ± 0.03	0.506CysThr: 0.506 ± 0.031	0.708CysVal: 0.708 ± 0.027	0.104CysTrp: 0.104 ± 0.012	0.481CysTyr: 0.481 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	5.443AspAla: 5.443 ± 0.087	0.657AspCys: 0.657 ± 0.03	3.722AspAsp: 3.722 ± 0.085	3.87AspGlu: 3.87 ± 0.088	3.019AspPhe: 3.019 ± 0.072	4.956AspGly: 4.956 ± 0.109	0.936AspHis: 0.936 ± 0.037	4.63AspIle: 4.63 ± 0.082	3.163AspLys: 3.163 ± 0.075	4.987AspLeu: 4.987 ± 0.085	1.692AspMet: 1.692 ± 0.05	3.107AspAsn: 3.107 ± 0.074	2.661AspPro: 2.661 ± 0.062	1.148AspGln: 1.148 ± 0.047	3.467AspArg: 3.467 ± 0.072	4.16AspSer: 4.16 ± 0.084	3.178AspThr: 3.178 ± 0.068	3.969AspVal: 3.969 ± 0.081	0.756AspTrp: 0.756 ± 0.032	2.745AspTyr: 2.745 ± 0.058	0.001AspXaa: 0.001 ± 0.001
Glu	5.845GluAla: 5.845 ± 0.108	0.506GluCys: 0.506 ± 0.023	2.574GluAsp: 2.574 ± 0.067	3.553GluGlu: 3.553 ± 0.093	2.422GluPhe: 2.422 ± 0.056	3.995GluGly: 3.995 ± 0.079	1.013GluHis: 1.013 ± 0.039	4.371GluIle: 4.371 ± 0.087	3.574GluLys: 3.574 ± 0.089	5.651GluLeu: 5.651 ± 0.085	1.852GluMet: 1.852 ± 0.056	2.816GluAsn: 2.816 ± 0.071	2.441GluPro: 2.441 ± 0.06	2.113GluGln: 2.113 ± 0.058	3.69GluArg: 3.69 ± 0.076	3.29GluSer: 3.29 ± 0.063	3.083GluThr: 3.083 ± 0.071	3.976GluVal: 3.976 ± 0.075	0.79GluTrp: 0.79 ± 0.036	2.148GluTyr: 2.148 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.621PheAla: 3.621 ± 0.072	0.573PheCys: 0.573 ± 0.032	3.123PheAsp: 3.123 ± 0.065	2.366PheGlu: 2.366 ± 0.059	1.908PhePhe: 1.908 ± 0.062	3.306PheGly: 3.306 ± 0.072	0.752PheHis: 0.752 ± 0.028	2.724PheIle: 2.724 ± 0.072	1.908PheLys: 1.908 ± 0.061	3.223PheLeu: 3.223 ± 0.076	1.17PheMet: 1.17 ± 0.044	2.192PheAsn: 2.192 ± 0.055	1.657PhePro: 1.657 ± 0.048	0.829PheGln: 0.829 ± 0.037	2.318PheArg: 2.318 ± 0.057	3.161PheSer: 3.161 ± 0.065	2.758PheThr: 2.758 ± 0.069	2.836PheVal: 2.836 ± 0.064	0.482PheTrp: 0.482 ± 0.028	1.501PheTyr: 1.501 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	6.167GlyAla: 6.167 ± 0.114	1.065GlyCys: 1.065 ± 0.042	4.402GlyAsp: 4.402 ± 0.069	4.227GlyGlu: 4.227 ± 0.077	3.282GlyPhe: 3.282 ± 0.069	5.165GlyGly: 5.165 ± 0.102	1.514GlyHis: 1.514 ± 0.055	4.894GlyIle: 4.894 ± 0.076	3.925GlyLys: 3.925 ± 0.082	6.188GlyLeu: 6.188 ± 0.098	1.983GlyMet: 1.983 ± 0.053	3.483GlyAsn: 3.483 ± 0.078	1.852GlyPro: 1.852 ± 0.049	2.123GlyGln: 2.123 ± 0.048	4.697GlyArg: 4.697 ± 0.092	4.753GlySer: 4.753 ± 0.086	4.116GlyThr: 4.116 ± 0.085	5.242GlyVal: 5.242 ± 0.095	0.976GlyTrp: 0.976 ± 0.039	3.099GlyTyr: 3.099 ± 0.081	0.001GlyXaa: 0.001 ± 0.001
His	1.348HisAla: 1.348 ± 0.046	0.246HisCys: 0.246 ± 0.02	1.073HisAsp: 1.073 ± 0.037	0.896HisGlu: 0.896 ± 0.034	0.804HisPhe: 0.804 ± 0.033	1.343HisGly: 1.343 ± 0.042	0.406HisHis: 0.406 ± 0.027	1.378HisIle: 1.378 ± 0.047	0.769HisLys: 0.769 ± 0.038	1.531HisLeu: 1.531 ± 0.05	0.302HisMet: 0.302 ± 0.021	0.857HisAsn: 0.857 ± 0.039	0.973HisPro: 0.973 ± 0.046	0.395HisGln: 0.395 ± 0.023	1.144HisArg: 1.144 ± 0.042	1.065HisSer: 1.065 ± 0.039	0.9HisThr: 0.9 ± 0.037	0.977HisVal: 0.977 ± 0.036	0.212HisTrp: 0.212 ± 0.02	0.737HisTyr: 0.737 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.513IleAla: 6.513 ± 0.12	0.77IleCys: 0.77 ± 0.034	4.769IleAsp: 4.769 ± 0.093	4.271IleGlu: 4.271 ± 0.102	2.595IlePhe: 2.595 ± 0.068	4.578IleGly: 4.578 ± 0.088	1.06IleHis: 1.06 ± 0.04	4.218IleIle: 4.218 ± 0.09	3.013IleLys: 3.013 ± 0.08	4.862IleLeu: 4.862 ± 0.1	1.322IleMet: 1.322 ± 0.044	2.893IleAsn: 2.893 ± 0.064	2.761IlePro: 2.761 ± 0.064	1.372IleGln: 1.372 ± 0.047	3.049IleArg: 3.049 ± 0.068	4.168IleSer: 4.168 ± 0.083	3.7IleThr: 3.7 ± 0.081	4.96IleVal: 4.96 ± 0.085	0.581IleTrp: 0.581 ± 0.032	2.243IleTyr: 2.243 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.609LysAla: 4.609 ± 0.098	0.397LysCys: 0.397 ± 0.023	2.463LysAsp: 2.463 ± 0.067	3.294LysGlu: 3.294 ± 0.08	1.829LysPhe: 1.829 ± 0.058	3.298LysGly: 3.298 ± 0.076	0.782LysHis: 0.782 ± 0.029	3.332LysIle: 3.332 ± 0.062	3.25LysLys: 3.25 ± 0.094	4.177LysLeu: 4.177 ± 0.086	1.656LysMet: 1.656 ± 0.044	2.208LysAsn: 2.208 ± 0.063	2.127LysPro: 2.127 ± 0.068	1.423LysGln: 1.423 ± 0.047	2.698LysArg: 2.698 ± 0.073	2.936LysSer: 2.936 ± 0.068	2.849LysThr: 2.849 ± 0.064	3.327LysVal: 3.327 ± 0.083	0.573LysTrp: 0.573 ± 0.029	1.885LysTyr: 1.885 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.886LeuAla: 7.886 ± 0.105	1.105LeuCys: 1.105 ± 0.038	5.406LeuAsp: 5.406 ± 0.096	4.829LeuGlu: 4.829 ± 0.094	3.605LeuPhe: 3.605 ± 0.092	6.18LeuGly: 6.18 ± 0.121	1.594LeuHis: 1.594 ± 0.051	5.036LeuIle: 5.036 ± 0.102	4.542LeuLys: 4.542 ± 0.091	7.814LeuLeu: 7.814 ± 0.123	2.342LeuMet: 2.342 ± 0.06	3.868LeuAsn: 3.868 ± 0.085	4.148LeuPro: 4.148 ± 0.084	2.411LeuGln: 2.411 ± 0.059	5.67LeuArg: 5.67 ± 0.107	6.424LeuSer: 6.424 ± 0.105	6.601LeuThr: 6.601 ± 0.115	5.206LeuVal: 5.206 ± 0.102	0.991LeuTrp: 0.991 ± 0.043	2.941LeuTyr: 2.941 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.789MetAla: 2.789 ± 0.06	0.214MetCys: 0.214 ± 0.017	1.075MetAsp: 1.075 ± 0.041	1.352MetGlu: 1.352 ± 0.042	0.976MetPhe: 0.976 ± 0.041	1.753MetGly: 1.753 ± 0.056	0.391MetHis: 0.391 ± 0.023	1.475MetIle: 1.475 ± 0.044	1.912MetLys: 1.912 ± 0.052	2.551MetLeu: 2.551 ± 0.057	0.796MetMet: 0.796 ± 0.035	1.218MetAsn: 1.218 ± 0.037	1.36MetPro: 1.36 ± 0.048	0.72MetGln: 0.72 ± 0.032	1.647MetArg: 1.647 ± 0.051	1.948MetSer: 1.948 ± 0.053	2.001MetThr: 2.001 ± 0.051	1.537MetVal: 1.537 ± 0.047	0.244MetTrp: 0.244 ± 0.017	0.603MetTyr: 0.603 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.793AsnAla: 3.793 ± 0.084	0.461AsnCys: 0.461 ± 0.028	2.607AsnAsp: 2.607 ± 0.065	2.26AsnGlu: 2.26 ± 0.06	1.924AsnPhe: 1.924 ± 0.056	3.659AsnGly: 3.659 ± 0.089	0.841AsnHis: 0.841 ± 0.032	3.194AsnIle: 3.194 ± 0.071	1.984AsnLys: 1.984 ± 0.06	3.724AsnLeu: 3.724 ± 0.073	1.068AsnMet: 1.068 ± 0.04	2.188AsnAsn: 2.188 ± 0.065	2.622AsnPro: 2.622 ± 0.052	1.044AsnGln: 1.044 ± 0.047	2.613AsnArg: 2.613 ± 0.065	2.629AsnSer: 2.629 ± 0.061	2.236AsnThr: 2.236 ± 0.062	3.005AsnVal: 3.005 ± 0.065	0.534AsnTrp: 0.534 ± 0.027	1.812AsnTyr: 1.812 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	4.392ProAla: 4.392 ± 0.082	0.348ProCys: 0.348 ± 0.023	3.396ProAsp: 3.396 ± 0.07	3.671ProGlu: 3.671 ± 0.072	1.742ProPhe: 1.742 ± 0.056	3.324ProGly: 3.324 ± 0.068	0.684ProHis: 0.684 ± 0.03	1.896ProIle: 1.896 ± 0.058	1.76ProLys: 1.76 ± 0.058	3.547ProLeu: 3.547 ± 0.078	1.103ProMet: 1.103 ± 0.038	1.343ProAsn: 1.343 ± 0.044	1.107ProPro: 1.107 ± 0.05	1.307ProGln: 1.307 ± 0.045	2.203ProArg: 2.203 ± 0.059	2.573ProSer: 2.573 ± 0.065	2.372ProThr: 2.372 ± 0.068	3.606ProVal: 3.606 ± 0.064	0.498ProTrp: 0.498 ± 0.024	1.531ProTyr: 1.531 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.466GlnAla: 2.466 ± 0.071	0.222GlnCys: 0.222 ± 0.016	1.048GlnAsp: 1.048 ± 0.04	1.372GlnGlu: 1.372 ± 0.053	1.101GlnPhe: 1.101 ± 0.047	1.721GlnGly: 1.721 ± 0.054	0.425GlnHis: 0.425 ± 0.027	1.832GlnIle: 1.832 ± 0.055	1.494GlnLys: 1.494 ± 0.051	2.756GlnLeu: 2.756 ± 0.069	0.864GlnMet: 0.864 ± 0.04	1.196GlnAsn: 1.196 ± 0.046	1.303GlnPro: 1.303 ± 0.045	1.137GlnGln: 1.137 ± 0.05	1.782GlnArg: 1.782 ± 0.057	1.642GlnSer: 1.642 ± 0.051	1.649GlnThr: 1.649 ± 0.052	1.455GlnVal: 1.455 ± 0.05	0.454GlnTrp: 0.454 ± 0.025	1.047GlnTyr: 1.047 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	4.546ArgAla: 4.546 ± 0.085	0.684ArgCys: 0.684 ± 0.032	3.195ArgAsp: 3.195 ± 0.085	3.643ArgGlu: 3.643 ± 0.076	2.79ArgPhe: 2.79 ± 0.068	3.637ArgGly: 3.637 ± 0.087	1.414ArgHis: 1.414 ± 0.049	3.834ArgIle: 3.834 ± 0.082	2.797ArgLys: 2.797 ± 0.073	6.515ArgLeu: 6.515 ± 0.121	1.662ArgMet: 1.662 ± 0.045	2.594ArgAsn: 2.594 ± 0.055	2.575ArgPro: 2.575 ± 0.074	2.299ArgGln: 2.299 ± 0.07	5.356ArgArg: 5.356 ± 0.134	3.263ArgSer: 3.263 ± 0.069	2.497ArgThr: 2.497 ± 0.06	3.566ArgVal: 3.566 ± 0.072	0.805ArgTrp: 0.805 ± 0.033	2.392ArgTyr: 2.392 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	5.57SerAla: 5.57 ± 0.099	0.736SerCys: 0.736 ± 0.034	3.979SerAsp: 3.979 ± 0.083	3.606SerGlu: 3.606 ± 0.067	3.041SerPhe: 3.041 ± 0.071	5.219SerGly: 5.219 ± 0.094	1.188SerHis: 1.188 ± 0.045	3.618SerIle: 3.618 ± 0.079	2.685SerLys: 2.685 ± 0.061	6.14SerLeu: 6.14 ± 0.109	1.597SerMet: 1.597 ± 0.041	2.483SerAsn: 2.483 ± 0.062	2.657SerPro: 2.657 ± 0.065	1.766SerGln: 1.766 ± 0.053	4.007SerArg: 4.007 ± 0.077	3.838SerSer: 3.838 ± 0.082	3.625SerThr: 3.625 ± 0.089	4.575SerVal: 4.575 ± 0.08	0.79SerTrp: 0.79 ± 0.038	2.379SerTyr: 2.379 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	5.744ThrAla: 5.744 ± 0.089	0.481ThrCys: 0.481 ± 0.026	3.865ThrAsp: 3.865 ± 0.074	3.029ThrGlu: 3.029 ± 0.07	2.657ThrPhe: 2.657 ± 0.073	4.602ThrGly: 4.602 ± 0.077	0.88ThrHis: 0.88 ± 0.037	3.678ThrIle: 3.678 ± 0.071	2.084ThrLys: 2.084 ± 0.069	5.602ThrLeu: 5.602 ± 0.086	1.318ThrMet: 1.318 ± 0.044	2.013ThrAsn: 2.013 ± 0.054	3.312ThrPro: 3.312 ± 0.068	1.262ThrGln: 1.262 ± 0.042	2.86ThrArg: 2.86 ± 0.066	3.571ThrSer: 3.571 ± 0.078	3.555ThrThr: 3.555 ± 0.091	5.099ThrVal: 5.099 ± 0.105	0.611ThrTrp: 0.611 ± 0.033	2.125ThrTyr: 2.125 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	6.97ValAla: 6.97 ± 0.114	0.837ValCys: 0.837 ± 0.036	4.965ValAsp: 4.965 ± 0.095	4.509ValGlu: 4.509 ± 0.099	2.63ValPhe: 2.63 ± 0.065	4.952ValGly: 4.952 ± 0.101	0.903ValHis: 0.903 ± 0.03	4.37ValIle: 4.37 ± 0.068	3.737ValLys: 3.737 ± 0.083	5.115ValLeu: 5.115 ± 0.092	1.764ValMet: 1.764 ± 0.049	3.248ValAsn: 3.248 ± 0.073	2.726ValPro: 2.726 ± 0.065	1.306ValGln: 1.306 ± 0.044	3.593ValArg: 3.593 ± 0.072	4.773ValSer: 4.773 ± 0.087	4.495ValThr: 4.495 ± 0.091	5.47ValVal: 5.47 ± 0.097	0.71ValTrp: 0.71 ± 0.029	2.431ValTyr: 2.431 ± 0.065	0.003ValXaa: 0.003 ± 0.002
Trp	0.872TrpAla: 0.872 ± 0.037	0.14TrpCys: 0.14 ± 0.014	0.662TrpAsp: 0.662 ± 0.035	0.644TrpGlu: 0.644 ± 0.031	0.557TrpPhe: 0.557 ± 0.03	0.812TrpGly: 0.812 ± 0.037	0.252TrpHis: 0.252 ± 0.021	0.75TrpIle: 0.75 ± 0.031	0.546TrpLys: 0.546 ± 0.027	1.284TrpLeu: 1.284 ± 0.052	0.368TrpMet: 0.368 ± 0.023	0.59TrpAsn: 0.59 ± 0.028	0.336TrpPro: 0.336 ± 0.022	0.465TrpGln: 0.465 ± 0.024	0.734TrpArg: 0.734 ± 0.034	0.621TrpSer: 0.621 ± 0.029	0.742TrpThr: 0.742 ± 0.035	0.696TrpVal: 0.696 ± 0.032	0.218TrpTrp: 0.218 ± 0.017	0.378TrpTyr: 0.378 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.856TyrAla: 2.856 ± 0.072	0.485TyrCys: 0.485 ± 0.027	2.422TyrAsp: 2.422 ± 0.063	1.947TyrGlu: 1.947 ± 0.05	1.672TyrPhe: 1.672 ± 0.048	2.659TyrGly: 2.659 ± 0.068	0.722TyrHis: 0.722 ± 0.032	2.198TyrIle: 2.198 ± 0.057	1.587TyrLys: 1.587 ± 0.048	3.152TyrLeu: 3.152 ± 0.07	0.87TyrMet: 0.87 ± 0.035	2.156TyrAsn: 2.156 ± 0.067	1.634TyrPro: 1.634 ± 0.054	1.051TyrGln: 1.051 ± 0.043	2.291TyrArg: 2.291 ± 0.056	2.598TyrSer: 2.598 ± 0.066	2.186TyrThr: 2.186 ± 0.061	2.276TyrVal: 2.276 ± 0.06	0.433TyrTrp: 0.433 ± 0.025	1.732TyrTyr: 1.732 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.012XaaXaa: 0.012 ± 0.006

Statistics based on 2199 proteins (749015 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---