Amino acid dipepetide frequency for Klebsiella pneumoniae IS43

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.412AlaAla: 10.412 ± 0.122	1.134AlaCys: 1.134 ± 0.03	5.186AlaAsp: 5.186 ± 0.056	5.871AlaGlu: 5.871 ± 0.077	3.74AlaPhe: 3.74 ± 0.066	7.907AlaGly: 7.907 ± 0.09	1.965AlaHis: 1.965 ± 0.041	6.022AlaIle: 6.022 ± 0.074	3.917AlaLys: 3.917 ± 0.067	11.585AlaLeu: 11.585 ± 0.119	3.2AlaMet: 3.2 ± 0.048	2.971AlaAsn: 2.971 ± 0.053	3.673AlaPro: 3.673 ± 0.055	4.32AlaGln: 4.32 ± 0.058	5.684AlaArg: 5.684 ± 0.071	5.539AlaSer: 5.539 ± 0.072	4.603AlaThr: 4.603 ± 0.067	7.015AlaVal: 7.015 ± 0.081	1.741AlaTrp: 1.741 ± 0.04	2.033AlaTyr: 2.033 ± 0.042	0.003AlaXaa: 0.003 ± 0.002
Cys	1.043CysAla: 1.043 ± 0.033	0.237CysCys: 0.237 ± 0.014	0.572CysAsp: 0.572 ± 0.024	0.55CysGlu: 0.55 ± 0.023	0.49CysPhe: 0.49 ± 0.02	1.09CysGly: 1.09 ± 0.034	0.33CysHis: 0.33 ± 0.016	0.549CysIle: 0.549 ± 0.021	0.341CysLys: 0.341 ± 0.017	1.063CysLeu: 1.063 ± 0.029	0.312CysMet: 0.312 ± 0.018	0.293CysAsn: 0.293 ± 0.015	0.57CysPro: 0.57 ± 0.023	0.457CysGln: 0.457 ± 0.02	0.841CysArg: 0.841 ± 0.029	0.715CysSer: 0.715 ± 0.023	0.516CysThr: 0.516 ± 0.022	0.752CysVal: 0.752 ± 0.026	0.255CysTrp: 0.255 ± 0.014	0.346CysTyr: 0.346 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.041AspAla: 5.041 ± 0.06	0.497AspCys: 0.497 ± 0.019	3.017AspAsp: 3.017 ± 0.058	3.473AspGlu: 3.473 ± 0.05	2.1AspPhe: 2.1 ± 0.037	3.773AspGly: 3.773 ± 0.057	1.048AspHis: 1.048 ± 0.03	3.321AspIle: 3.321 ± 0.052	2.569AspLys: 2.569 ± 0.046	4.675AspLeu: 4.675 ± 0.062	1.359AspMet: 1.359 ± 0.039	2.131AspAsn: 2.131 ± 0.046	2.345AspPro: 2.345 ± 0.048	1.624AspGln: 1.624 ± 0.041	2.973AspArg: 2.973 ± 0.054	2.714AspSer: 2.714 ± 0.051	2.388AspThr: 2.388 ± 0.049	3.612AspVal: 3.612 ± 0.062	0.798AspTrp: 0.798 ± 0.031	1.952AspTyr: 1.952 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.485GluAla: 5.485 ± 0.076	0.464GluCys: 0.464 ± 0.021	2.297GluAsp: 2.297 ± 0.045	3.433GluGlu: 3.433 ± 0.065	1.827GluPhe: 1.827 ± 0.034	3.649GluGly: 3.649 ± 0.065	1.359GluHis: 1.359 ± 0.034	3.254GluIle: 3.254 ± 0.052	3.251GluLys: 3.251 ± 0.052	5.641GluLeu: 5.641 ± 0.076	1.872GluMet: 1.872 ± 0.034	2.116GluAsn: 2.116 ± 0.043	2.046GluPro: 2.046 ± 0.041	3.228GluGln: 3.228 ± 0.057	3.621GluArg: 3.621 ± 0.057	2.853GluSer: 2.853 ± 0.05	2.767GluThr: 2.767 ± 0.044	3.715GluVal: 3.715 ± 0.055	0.764GluTrp: 0.764 ± 0.026	1.461GluTyr: 1.461 ± 0.036	0.002GluXaa: 0.002 ± 0.001
Phe	3.856PheAla: 3.856 ± 0.055	0.615PheCys: 0.615 ± 0.022	2.36PheAsp: 2.36 ± 0.042	1.703PheGlu: 1.703 ± 0.037	1.924PhePhe: 1.924 ± 0.053	3.151PheGly: 3.151 ± 0.057	0.857PheHis: 0.857 ± 0.028	2.624PheIle: 2.624 ± 0.046	1.259PheLys: 1.259 ± 0.04	3.466PheLeu: 3.466 ± 0.07	1.134PheMet: 1.134 ± 0.031	1.788PheAsn: 1.788 ± 0.039	1.606PhePro: 1.606 ± 0.039	1.18PheGln: 1.18 ± 0.035	2.06PheArg: 2.06 ± 0.045	3.199PheSer: 3.199 ± 0.056	2.519PheThr: 2.519 ± 0.049	2.637PheVal: 2.637 ± 0.053	0.68PheTrp: 0.68 ± 0.026	1.288PheTyr: 1.288 ± 0.035	0.001PheXaa: 0.001 ± 0.001
Gly	6.408GlyAla: 6.408 ± 0.088	1.031GlyCys: 1.031 ± 0.027	3.799GlyAsp: 3.799 ± 0.06	4.596GlyGlu: 4.596 ± 0.062	3.391GlyPhe: 3.391 ± 0.054	5.637GlyGly: 5.637 ± 0.082	1.692GlyHis: 1.692 ± 0.04	5.055GlyIle: 5.055 ± 0.075	4.068GlyLys: 4.068 ± 0.065	7.503GlyLeu: 7.503 ± 0.09	2.611GlyMet: 2.611 ± 0.043	2.617GlyAsn: 2.617 ± 0.054	2.109GlyPro: 2.109 ± 0.047	2.861GlyGln: 2.861 ± 0.05	4.096GlyArg: 4.096 ± 0.056	4.097GlySer: 4.097 ± 0.063	3.593GlyThr: 3.593 ± 0.052	5.647GlyVal: 5.647 ± 0.071	1.332GlyTrp: 1.332 ± 0.032	2.764GlyTyr: 2.764 ± 0.053	0.001GlyXaa: 0.001 ± 0.001
His	1.938HisAla: 1.938 ± 0.041	0.326HisCys: 0.326 ± 0.014	1.235HisAsp: 1.235 ± 0.033	1.081HisGlu: 1.081 ± 0.034	1.099HisPhe: 1.099 ± 0.032	1.842HisGly: 1.842 ± 0.047	0.865HisHis: 0.865 ± 0.033	1.356HisIle: 1.356 ± 0.033	0.781HisLys: 0.781 ± 0.024	2.337HisLeu: 2.337 ± 0.047	0.598HisMet: 0.598 ± 0.021	0.787HisAsn: 0.787 ± 0.025	1.392HisPro: 1.392 ± 0.036	1.253HisGln: 1.253 ± 0.035	1.446HisArg: 1.446 ± 0.039	1.304HisSer: 1.304 ± 0.034	1.078HisThr: 1.078 ± 0.028	1.291HisVal: 1.291 ± 0.033	0.39HisTrp: 0.39 ± 0.017	0.958HisTyr: 0.958 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.518IleAla: 6.518 ± 0.074	0.715IleCys: 0.715 ± 0.023	3.532IleAsp: 3.532 ± 0.052	3.19IleGlu: 3.19 ± 0.053	2.185IlePhe: 2.185 ± 0.053	4.568IleGly: 4.568 ± 0.066	1.216IleHis: 1.216 ± 0.033	3.527IleIle: 3.527 ± 0.063	2.342IleLys: 2.342 ± 0.053	4.998IleLeu: 4.998 ± 0.068	1.329IleMet: 1.329 ± 0.035	2.583IleAsn: 2.583 ± 0.049	2.785IlePro: 2.785 ± 0.047	1.782IleGln: 1.782 ± 0.037	3.081IleArg: 3.081 ± 0.051	3.67IleSer: 3.67 ± 0.056	3.387IleThr: 3.387 ± 0.063	4.039IleVal: 4.039 ± 0.056	0.687IleTrp: 0.687 ± 0.021	1.602IleTyr: 1.602 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.414LysAla: 4.414 ± 0.068	0.301LysCys: 0.301 ± 0.016	2.018LysAsp: 2.018 ± 0.04	2.388LysGlu: 2.388 ± 0.046	1.132LysPhe: 1.132 ± 0.031	3.033LysGly: 3.033 ± 0.047	0.862LysHis: 0.862 ± 0.026	2.304LysIle: 2.304 ± 0.042	2.431LysLys: 2.431 ± 0.056	4.117LysLeu: 4.117 ± 0.061	1.321LysMet: 1.321 ± 0.033	1.727LysAsn: 1.727 ± 0.038	2.094LysPro: 2.094 ± 0.036	1.938LysGln: 1.938 ± 0.04	2.753LysArg: 2.753 ± 0.05	2.343LysSer: 2.343 ± 0.048	2.588LysThr: 2.588 ± 0.046	3.003LysVal: 3.003 ± 0.053	0.461LysTrp: 0.461 ± 0.019	1.177LysTyr: 1.177 ± 0.032	0.001LysXaa: 0.001 ± 0.001
Leu	11.358LeuAla: 11.358 ± 0.116	1.263LeuCys: 1.263 ± 0.035	5.108LeuAsp: 5.108 ± 0.071	5.197LeuGlu: 5.197 ± 0.081	4.386LeuPhe: 4.386 ± 0.06	7.235LeuGly: 7.235 ± 0.083	2.276LeuHis: 2.276 ± 0.042	5.78LeuIle: 5.78 ± 0.068	4.465LeuLys: 4.465 ± 0.07	11.653LeuLeu: 11.653 ± 0.143	3.021LeuMet: 3.021 ± 0.06	4.029LeuAsn: 4.029 ± 0.054	5.517LeuPro: 5.517 ± 0.072	4.271LeuGln: 4.271 ± 0.052	6.314LeuArg: 6.314 ± 0.081	7.162LeuSer: 7.162 ± 0.081	6.163LeuThr: 6.163 ± 0.078	6.88LeuVal: 6.88 ± 0.08	1.435LeuTrp: 1.435 ± 0.033	2.619LeuTyr: 2.619 ± 0.051	0.001LeuXaa: 0.001 ± 0.001
Met	3.215MetAla: 3.215 ± 0.046	0.218MetCys: 0.218 ± 0.014	1.218MetAsp: 1.218 ± 0.032	1.308MetGlu: 1.308 ± 0.028	1.0MetPhe: 1.0 ± 0.03	1.973MetGly: 1.973 ± 0.043	0.595MetHis: 0.595 ± 0.019	1.597MetIle: 1.597 ± 0.038	1.535MetLys: 1.535 ± 0.035	3.349MetLeu: 3.349 ± 0.049	0.984MetMet: 0.984 ± 0.029	1.177MetAsn: 1.177 ± 0.033	1.51MetPro: 1.51 ± 0.036	1.236MetGln: 1.236 ± 0.03	1.646MetArg: 1.646 ± 0.033	1.909MetSer: 1.909 ± 0.034	1.906MetThr: 1.906 ± 0.041	2.131MetVal: 2.131 ± 0.05	0.291MetTrp: 0.291 ± 0.015	0.584MetTyr: 0.584 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.276AsnAla: 3.276 ± 0.048	0.338AsnCys: 0.338 ± 0.015	1.954AsnAsp: 1.954 ± 0.041	1.821AsnGlu: 1.821 ± 0.041	1.337AsnPhe: 1.337 ± 0.038	2.966AsnGly: 2.966 ± 0.055	0.898AsnHis: 0.898 ± 0.028	2.29AsnIle: 2.29 ± 0.047	1.568AsnLys: 1.568 ± 0.039	3.374AsnLeu: 3.374 ± 0.067	0.972AsnMet: 0.972 ± 0.027	1.517AsnAsn: 1.517 ± 0.035	2.071AsnPro: 2.071 ± 0.041	1.465AsnGln: 1.465 ± 0.037	1.953AsnArg: 1.953 ± 0.04	1.916AsnSer: 1.916 ± 0.045	1.845AsnThr: 1.845 ± 0.039	2.482AsnVal: 2.482 ± 0.046	0.575AsnTrp: 0.575 ± 0.021	1.181AsnTyr: 1.181 ± 0.037	0.001AsnXaa: 0.001 ± 0.001
Pro	4.806ProAla: 4.806 ± 0.073	0.436ProCys: 0.436 ± 0.02	2.763ProAsp: 2.763 ± 0.046	3.233ProGlu: 3.233 ± 0.047	1.937ProPhe: 1.937 ± 0.036	3.706ProGly: 3.706 ± 0.057	1.075ProHis: 1.075 ± 0.033	1.859ProIle: 1.859 ± 0.037	1.468ProLys: 1.468 ± 0.039	5.06ProLeu: 5.06 ± 0.064	1.187ProMet: 1.187 ± 0.03	1.234ProAsn: 1.234 ± 0.033	1.822ProPro: 1.822 ± 0.044	2.304ProGln: 2.304 ± 0.043	2.259ProArg: 2.259 ± 0.045	2.247ProSer: 2.247 ± 0.044	2.035ProThr: 2.035 ± 0.042	3.813ProVal: 3.813 ± 0.062	0.786ProTrp: 0.786 ± 0.025	1.229ProTyr: 1.229 ± 0.032	0.002ProXaa: 0.002 ± 0.001
Gln	4.634GlnAla: 4.634 ± 0.068	0.384GlnCys: 0.384 ± 0.017	1.698GlnAsp: 1.698 ± 0.035	2.127GlnGlu: 2.127 ± 0.041	1.495GlnPhe: 1.495 ± 0.037	3.045GlnGly: 3.045 ± 0.049	1.265GlnHis: 1.265 ± 0.034	2.173GlnIle: 2.173 ± 0.043	1.801GlnLys: 1.801 ± 0.039	4.789GlnLeu: 4.789 ± 0.067	1.247GlnMet: 1.247 ± 0.032	1.381GlnAsn: 1.381 ± 0.033	2.159GlnPro: 2.159 ± 0.037	3.233GlnGln: 3.233 ± 0.065	3.299GlnArg: 3.299 ± 0.056	2.192GlnSer: 2.192 ± 0.048	2.11GlnThr: 2.11 ± 0.043	2.91GlnVal: 2.91 ± 0.054	0.661GlnTrp: 0.661 ± 0.025	1.201GlnTyr: 1.201 ± 0.033	0.002GlnXaa: 0.002 ± 0.001
Arg	4.8ArgAla: 4.8 ± 0.065	0.756ArgCys: 0.756 ± 0.024	3.11ArgAsp: 3.11 ± 0.055	3.817ArgGlu: 3.817 ± 0.06	2.759ArgPhe: 2.759 ± 0.056	3.675ArgGly: 3.675 ± 0.057	1.881ArgHis: 1.881 ± 0.043	3.36ArgIle: 3.36 ± 0.056	2.515ArgLys: 2.515 ± 0.051	6.509ArgLeu: 6.509 ± 0.08	1.909ArgMet: 1.909 ± 0.041	2.009ArgAsn: 2.009 ± 0.04	2.566ArgPro: 2.566 ± 0.048	3.312ArgGln: 3.312 ± 0.061	4.456ArgArg: 4.456 ± 0.084	3.146ArgSer: 3.146 ± 0.054	2.494ArgThr: 2.494 ± 0.05	3.814ArgVal: 3.814 ± 0.05	1.115ArgTrp: 1.115 ± 0.033	2.319ArgTyr: 2.319 ± 0.041	0.001ArgXaa: 0.001 ± 0.001
Ser	5.808SerAla: 5.808 ± 0.087	0.664SerCys: 0.664 ± 0.024	3.115SerAsp: 3.115 ± 0.053	3.024SerGlu: 3.024 ± 0.051	2.37SerPhe: 2.37 ± 0.045	5.242SerGly: 5.242 ± 0.077	1.441SerHis: 1.441 ± 0.04	3.037SerIle: 3.037 ± 0.044	1.998SerLys: 1.998 ± 0.045	6.556SerLeu: 6.556 ± 0.078	1.616SerMet: 1.616 ± 0.038	1.77SerAsn: 1.77 ± 0.045	2.786SerPro: 2.786 ± 0.051	2.425SerGln: 2.425 ± 0.05	3.652SerArg: 3.652 ± 0.057	3.481SerSer: 3.481 ± 0.058	2.858SerThr: 2.858 ± 0.05	4.096SerVal: 4.096 ± 0.062	1.062SerTrp: 1.062 ± 0.031	1.634SerTyr: 1.634 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.945ThrAla: 4.945 ± 0.06	0.555ThrCys: 0.555 ± 0.021	2.45ThrAsp: 2.45 ± 0.045	2.501ThrGlu: 2.501 ± 0.052	2.084ThrPhe: 2.084 ± 0.046	4.358ThrGly: 4.358 ± 0.067	1.192ThrHis: 1.192 ± 0.03	2.917ThrIle: 2.917 ± 0.051	1.456ThrLys: 1.456 ± 0.039	7.035ThrLeu: 7.035 ± 0.074	1.244ThrMet: 1.244 ± 0.034	1.464ThrAsn: 1.464 ± 0.04	3.091ThrPro: 3.091 ± 0.049	1.845ThrGln: 1.845 ± 0.038	3.086ThrArg: 3.086 ± 0.046	2.901ThrSer: 2.901 ± 0.054	2.825ThrThr: 2.825 ± 0.05	3.771ThrVal: 3.771 ± 0.057	0.857ThrTrp: 0.857 ± 0.024	1.177ThrTyr: 1.177 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.905ValAla: 6.905 ± 0.08	0.788ValCys: 0.788 ± 0.026	3.741ValAsp: 3.741 ± 0.057	3.973ValGlu: 3.973 ± 0.058	2.658ValPhe: 2.658 ± 0.048	4.873ValGly: 4.873 ± 0.071	1.296ValHis: 1.296 ± 0.034	4.592ValIle: 4.592 ± 0.07	3.164ValLys: 3.164 ± 0.059	6.953ValLeu: 6.953 ± 0.08	2.304ValMet: 2.304 ± 0.048	2.735ValAsn: 2.735 ± 0.052	2.985ValPro: 2.985 ± 0.047	2.325ValGln: 2.325 ± 0.043	3.753ValArg: 3.753 ± 0.051	4.573ValSer: 4.573 ± 0.066	3.98ValThr: 3.98 ± 0.046	5.562ValVal: 5.562 ± 0.072	0.963ValTrp: 0.963 ± 0.029	1.788ValTyr: 1.788 ± 0.042	0.001ValXaa: 0.001 ± 0.001
Trp	1.049TrpAla: 1.049 ± 0.03	0.197TrpCys: 0.197 ± 0.013	0.662TrpAsp: 0.662 ± 0.024	0.594TrpGlu: 0.594 ± 0.025	0.735TrpPhe: 0.735 ± 0.027	0.949TrpGly: 0.949 ± 0.028	0.441TrpHis: 0.441 ± 0.022	0.734TrpIle: 0.734 ± 0.024	0.546TrpLys: 0.546 ± 0.02	2.355TrpLeu: 2.355 ± 0.055	0.504TrpMet: 0.504 ± 0.022	0.495TrpAsn: 0.495 ± 0.021	0.712TrpPro: 0.712 ± 0.024	1.15TrpGln: 1.15 ± 0.035	1.261TrpArg: 1.261 ± 0.032	0.879TrpSer: 0.879 ± 0.027	0.611TrpThr: 0.611 ± 0.021	0.982TrpVal: 0.982 ± 0.032	0.258TrpTrp: 0.258 ± 0.016	0.438TrpTyr: 0.438 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.609TyrAla: 2.609 ± 0.049	0.402TyrCys: 0.402 ± 0.018	1.571TyrAsp: 1.571 ± 0.04	1.223TyrGlu: 1.223 ± 0.028	1.256TyrPhe: 1.256 ± 0.033	2.237TyrGly: 2.237 ± 0.046	0.802TyrHis: 0.802 ± 0.026	1.384TyrIle: 1.384 ± 0.034	0.929TyrLys: 0.929 ± 0.032	3.115TyrLeu: 3.115 ± 0.044	0.659TyrMet: 0.659 ± 0.025	0.978TyrAsn: 0.978 ± 0.03	1.418TyrPro: 1.418 ± 0.037	1.598TyrGln: 1.598 ± 0.039	2.088TyrArg: 2.088 ± 0.042	1.797TyrSer: 1.797 ± 0.044	1.488TyrThr: 1.488 ± 0.038	1.758TyrVal: 1.758 ± 0.041	0.44TyrTrp: 0.44 ± 0.02	1.007TyrTyr: 1.007 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 5959 proteins (1213322 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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