Amino acid dipepetide frequency for Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.873AlaAla: 19.873 ± 0.147	1.084AlaCys: 1.084 ± 0.021	8.017AlaAsp: 8.017 ± 0.067	8.643AlaGlu: 8.643 ± 0.077	3.425AlaPhe: 3.425 ± 0.042	12.717AlaGly: 12.717 ± 0.098	2.857AlaHis: 2.857 ± 0.035	3.321AlaIle: 3.321 ± 0.042	2.828AlaLys: 2.828 ± 0.051	14.052AlaLeu: 14.052 ± 0.101	2.462AlaMet: 2.462 ± 0.034	1.858AlaAsn: 1.858 ± 0.032	6.973AlaPro: 6.973 ± 0.063	3.715AlaGln: 3.715 ± 0.044	10.465AlaArg: 10.465 ± 0.079	5.872AlaSer: 5.872 ± 0.059	6.807AlaThr: 6.807 ± 0.055	12.013AlaVal: 12.013 ± 0.089	1.845AlaTrp: 1.845 ± 0.032	2.782AlaTyr: 2.782 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.022	0.115CysCys: 0.115 ± 0.008	0.475CysAsp: 0.475 ± 0.013	0.436CysGlu: 0.436 ± 0.013	0.229CysPhe: 0.229 ± 0.01	1.001CysGly: 1.001 ± 0.021	0.199CysHis: 0.199 ± 0.009	0.164CysIle: 0.164 ± 0.009	0.117CysLys: 0.117 ± 0.007	0.771CysLeu: 0.771 ± 0.016	0.12CysMet: 0.12 ± 0.007	0.133CysAsn: 0.133 ± 0.007	0.515CysPro: 0.515 ± 0.018	0.173CysGln: 0.173 ± 0.009	0.66CysArg: 0.66 ± 0.019	0.457CysSer: 0.457 ± 0.014	0.505CysThr: 0.505 ± 0.015	0.695CysVal: 0.695 ± 0.015	0.139CysTrp: 0.139 ± 0.008	0.151CysTyr: 0.151 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.365AspAla: 7.365 ± 0.054	0.434AspCys: 0.434 ± 0.013	3.62AspAsp: 3.62 ± 0.038	3.959AspGlu: 3.959 ± 0.049	1.692AspPhe: 1.692 ± 0.026	6.349AspGly: 6.349 ± 0.059	1.45AspHis: 1.45 ± 0.028	1.866AspIle: 1.866 ± 0.029	1.229AspLys: 1.229 ± 0.025	6.139AspLeu: 6.139 ± 0.053	0.835AspMet: 0.835 ± 0.018	0.985AspAsn: 0.985 ± 0.021	4.517AspPro: 4.517 ± 0.044	1.549AspGln: 1.549 ± 0.027	5.001AspArg: 5.001 ± 0.047	2.606AspSer: 2.606 ± 0.035	3.247AspThr: 3.247 ± 0.037	4.871AspVal: 4.871 ± 0.048	1.06AspTrp: 1.06 ± 0.019	1.112AspTyr: 1.112 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.446GluAla: 7.446 ± 0.071	0.376GluCys: 0.376 ± 0.015	2.926GluAsp: 2.926 ± 0.036	3.737GluGlu: 3.737 ± 0.043	1.49GluPhe: 1.49 ± 0.023	4.48GluGly: 4.48 ± 0.046	1.539GluHis: 1.539 ± 0.026	2.222GluIle: 2.222 ± 0.032	1.521GluLys: 1.521 ± 0.032	6.75GluLeu: 6.75 ± 0.063	0.9GluMet: 0.9 ± 0.021	1.074GluAsn: 1.074 ± 0.025	3.508GluPro: 3.508 ± 0.04	2.34GluGln: 2.34 ± 0.031	5.532GluArg: 5.532 ± 0.058	2.636GluSer: 2.636 ± 0.031	2.926GluThr: 2.926 ± 0.033	4.486GluVal: 4.486 ± 0.047	0.788GluTrp: 0.788 ± 0.018	1.153GluTyr: 1.153 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.545PheAla: 3.545 ± 0.042	0.268PheCys: 0.268 ± 0.01	1.915PheAsp: 1.915 ± 0.031	1.464PheGlu: 1.464 ± 0.025	0.873PhePhe: 0.873 ± 0.027	2.967PheGly: 2.967 ± 0.036	0.633PheHis: 0.633 ± 0.018	0.663PheIle: 0.663 ± 0.017	0.532PheLys: 0.532 ± 0.018	2.621PheLeu: 2.621 ± 0.037	0.417PheMet: 0.417 ± 0.013	0.569PheAsn: 0.569 ± 0.016	1.403PhePro: 1.403 ± 0.024	0.699PheGln: 0.699 ± 0.015	1.91PheArg: 1.91 ± 0.025	1.458PheSer: 1.458 ± 0.023	1.96PheThr: 1.96 ± 0.029	2.29PheVal: 2.29 ± 0.034	0.438PheTrp: 0.438 ± 0.012	0.597PheTyr: 0.597 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.834GlyAla: 10.834 ± 0.075	0.875GlyCys: 0.875 ± 0.019	5.196GlyAsp: 5.196 ± 0.054	5.271GlyGlu: 5.271 ± 0.048	2.833GlyPhe: 2.833 ± 0.041	8.926GlyGly: 8.926 ± 0.088	2.411GlyHis: 2.411 ± 0.039	3.397GlyIle: 3.397 ± 0.038	2.509GlyLys: 2.509 ± 0.043	9.361GlyLeu: 9.361 ± 0.066	2.027GlyMet: 2.027 ± 0.026	1.738GlyAsn: 1.738 ± 0.032	5.339GlyPro: 5.339 ± 0.057	2.704GlyGln: 2.704 ± 0.045	8.131GlyArg: 8.131 ± 0.061	5.391GlySer: 5.391 ± 0.05	6.343GlyThr: 6.343 ± 0.066	7.603GlyVal: 7.603 ± 0.058	1.718GlyTrp: 1.718 ± 0.028	2.252GlyTyr: 2.252 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.679HisAla: 2.679 ± 0.038	0.229HisCys: 0.229 ± 0.01	1.392HisAsp: 1.392 ± 0.026	1.255HisGlu: 1.255 ± 0.026	0.639HisPhe: 0.639 ± 0.017	2.493HisGly: 2.493 ± 0.036	0.72HisHis: 0.72 ± 0.018	0.671HisIle: 0.671 ± 0.015	0.354HisLys: 0.354 ± 0.013	2.445HisLeu: 2.445 ± 0.035	0.354HisMet: 0.354 ± 0.011	0.375HisAsn: 0.375 ± 0.012	1.872HisPro: 1.872 ± 0.028	0.652HisGln: 0.652 ± 0.015	2.215HisArg: 2.215 ± 0.035	1.015HisSer: 1.015 ± 0.02	1.356HisThr: 1.356 ± 0.024	1.724HisVal: 1.724 ± 0.026	0.382HisTrp: 0.382 ± 0.014	0.487HisTyr: 0.487 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.587IleAla: 4.587 ± 0.047	0.284IleCys: 0.284 ± 0.01	2.151IleAsp: 2.151 ± 0.031	1.912IleGlu: 1.912 ± 0.029	0.686IlePhe: 0.686 ± 0.018	3.438IleGly: 3.438 ± 0.042	0.601IleHis: 0.601 ± 0.016	0.868IleIle: 0.868 ± 0.023	0.735IleLys: 0.735 ± 0.02	2.364IleLeu: 2.364 ± 0.036	0.471IleMet: 0.471 ± 0.014	0.679IleAsn: 0.679 ± 0.017	1.717IlePro: 1.717 ± 0.029	0.723IleGln: 0.723 ± 0.019	2.234IleArg: 2.234 ± 0.031	1.627IleSer: 1.627 ± 0.028	2.166IleThr: 2.166 ± 0.031	2.671IleVal: 2.671 ± 0.038	0.367IleTrp: 0.367 ± 0.011	0.514IleTyr: 0.514 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.991LysAla: 2.991 ± 0.047	0.122LysCys: 0.122 ± 0.007	1.392LysAsp: 1.392 ± 0.033	1.263LysGlu: 1.263 ± 0.024	0.465LysPhe: 0.465 ± 0.014	1.961LysGly: 1.961 ± 0.037	0.44LysHis: 0.44 ± 0.012	0.879LysIle: 0.879 ± 0.023	0.922LysLys: 0.922 ± 0.026	2.049LysLeu: 2.049 ± 0.035	0.395LysMet: 0.395 ± 0.015	0.543LysAsn: 0.543 ± 0.019	1.393LysPro: 1.393 ± 0.027	0.747LysGln: 0.747 ± 0.019	1.511LysArg: 1.511 ± 0.025	1.193LysSer: 1.193 ± 0.024	1.322LysThr: 1.322 ± 0.027	1.982LysVal: 1.982 ± 0.037	0.272LysTrp: 0.272 ± 0.011	0.477LysTyr: 0.477 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.612LeuAla: 14.612 ± 0.097	0.856LeuCys: 0.856 ± 0.016	6.646LeuAsp: 6.646 ± 0.055	4.734LeuGlu: 4.734 ± 0.049	2.633LeuPhe: 2.633 ± 0.034	9.061LeuGly: 9.061 ± 0.071	2.272LeuHis: 2.272 ± 0.03	3.1LeuIle: 3.1 ± 0.038	2.176LeuLys: 2.176 ± 0.038	11.137LeuLeu: 11.137 ± 0.094	1.64LeuMet: 1.64 ± 0.025	1.688LeuAsn: 1.688 ± 0.028	6.504LeuPro: 6.504 ± 0.056	2.172LeuGln: 2.172 ± 0.028	8.754LeuArg: 8.754 ± 0.073	5.355LeuSer: 5.355 ± 0.054	6.813LeuThr: 6.813 ± 0.056	8.862LeuVal: 8.862 ± 0.074	1.308LeuTrp: 1.308 ± 0.025	1.893LeuTyr: 1.893 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.242MetAla: 2.242 ± 0.03	0.153MetCys: 0.153 ± 0.008	0.925MetAsp: 0.925 ± 0.017	0.776MetGlu: 0.776 ± 0.019	0.482MetPhe: 0.482 ± 0.015	1.362MetGly: 1.362 ± 0.026	0.367MetHis: 0.367 ± 0.013	0.671MetIle: 0.671 ± 0.016	0.426MetLys: 0.426 ± 0.015	1.658MetLeu: 1.658 ± 0.024	0.317MetMet: 0.317 ± 0.012	0.443MetAsn: 0.443 ± 0.014	1.12MetPro: 1.12 ± 0.021	0.428MetGln: 0.428 ± 0.013	1.481MetArg: 1.481 ± 0.023	1.348MetSer: 1.348 ± 0.022	1.563MetThr: 1.563 ± 0.028	1.301MetVal: 1.301 ± 0.024	0.23MetTrp: 0.23 ± 0.01	0.339MetTyr: 0.339 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.18AsnAla: 2.18 ± 0.031	0.155AsnCys: 0.155 ± 0.007	0.982AsnAsp: 0.982 ± 0.02	0.809AsnGlu: 0.809 ± 0.02	0.481AsnPhe: 0.481 ± 0.014	1.823AsnGly: 1.823 ± 0.034	0.405AsnHis: 0.405 ± 0.013	0.649AsnIle: 0.649 ± 0.018	0.431AsnLys: 0.431 ± 0.015	1.682AsnLeu: 1.682 ± 0.029	0.297AsnMet: 0.297 ± 0.011	0.469AsnAsn: 0.469 ± 0.02	1.374AsnPro: 1.374 ± 0.03	0.558AsnGln: 0.558 ± 0.017	1.278AsnArg: 1.278 ± 0.027	0.933AsnSer: 0.933 ± 0.021	1.146AsnThr: 1.146 ± 0.025	1.396AsnVal: 1.396 ± 0.023	0.314AsnTrp: 0.314 ± 0.011	0.403AsnTyr: 0.403 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.453ProAla: 8.453 ± 0.073	0.396ProCys: 0.396 ± 0.014	4.573ProAsp: 4.573 ± 0.046	4.525ProGlu: 4.525 ± 0.046	1.549ProPhe: 1.549 ± 0.026	6.903ProGly: 6.903 ± 0.062	1.452ProHis: 1.452 ± 0.024	1.244ProIle: 1.244 ± 0.022	1.233ProLys: 1.233 ± 0.026	5.392ProLeu: 5.392 ± 0.046	1.023ProMet: 1.023 ± 0.021	0.862ProAsn: 0.862 ± 0.02	3.789ProPro: 3.789 ± 0.048	1.783ProGln: 1.783 ± 0.031	4.327ProArg: 4.327 ± 0.05	3.259ProSer: 3.259 ± 0.036	3.153ProThr: 3.153 ± 0.036	5.528ProVal: 5.528 ± 0.051	0.935ProTrp: 0.935 ± 0.02	1.425ProTyr: 1.425 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.706GlnAla: 3.706 ± 0.044	0.179GlnCys: 0.179 ± 0.008	1.488GlnAsp: 1.488 ± 0.022	1.551GlnGlu: 1.551 ± 0.029	0.659GlnPhe: 0.659 ± 0.018	2.424GlnGly: 2.424 ± 0.033	0.663GlnHis: 0.663 ± 0.016	1.05GlnIle: 1.05 ± 0.021	0.646GlnLys: 0.646 ± 0.017	2.945GlnLeu: 2.945 ± 0.03	0.497GlnMet: 0.497 ± 0.016	0.516GlnAsn: 0.516 ± 0.016	1.705GlnPro: 1.705 ± 0.03	1.23GlnGln: 1.23 ± 0.029	2.423GlnArg: 2.423 ± 0.026	1.274GlnSer: 1.274 ± 0.021	1.36GlnThr: 1.36 ± 0.024	2.383GlnVal: 2.383 ± 0.035	0.474GlnTrp: 0.474 ± 0.015	0.628GlnTyr: 0.628 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.838ArgAla: 9.838 ± 0.081	0.644ArgCys: 0.644 ± 0.018	4.425ArgAsp: 4.425 ± 0.035	4.839ArgGlu: 4.839 ± 0.051	2.336ArgPhe: 2.336 ± 0.033	6.161ArgGly: 6.161 ± 0.055	2.296ArgHis: 2.296 ± 0.033	3.153ArgIle: 3.153 ± 0.041	1.714ArgLys: 1.714 ± 0.031	8.992ArgLeu: 8.992 ± 0.079	1.762ArgMet: 1.762 ± 0.027	1.398ArgAsn: 1.398 ± 0.027	5.435ArgPro: 5.435 ± 0.058	2.394ArgGln: 2.394 ± 0.034	8.365ArgArg: 8.365 ± 0.08	4.301ArgSer: 4.301 ± 0.046	5.502ArgThr: 5.502 ± 0.048	6.118ArgVal: 6.118 ± 0.052	1.386ArgTrp: 1.386 ± 0.026	1.848ArgTyr: 1.848 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.607SerAla: 6.607 ± 0.06	0.445SerCys: 0.445 ± 0.015	2.741SerAsp: 2.741 ± 0.038	2.545SerGlu: 2.545 ± 0.035	1.539SerPhe: 1.539 ± 0.024	6.122SerGly: 6.122 ± 0.055	1.06SerHis: 1.06 ± 0.022	1.386SerIle: 1.386 ± 0.025	1.089SerLys: 1.089 ± 0.022	4.776SerLeu: 4.776 ± 0.04	1.116SerMet: 1.116 ± 0.022	0.865SerAsn: 0.865 ± 0.02	3.298SerPro: 3.298 ± 0.041	1.262SerGln: 1.262 ± 0.026	3.864SerArg: 3.864 ± 0.042	2.943SerSer: 2.943 ± 0.047	3.088SerThr: 3.088 ± 0.041	4.337SerVal: 4.337 ± 0.043	0.907SerTrp: 0.907 ± 0.019	1.257SerTyr: 1.257 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.612ThrAla: 8.612 ± 0.062	0.439ThrCys: 0.439 ± 0.013	3.685ThrAsp: 3.685 ± 0.04	3.288ThrGlu: 3.288 ± 0.04	1.628ThrPhe: 1.628 ± 0.025	6.739ThrGly: 6.739 ± 0.058	1.198ThrHis: 1.198 ± 0.021	1.679ThrIle: 1.679 ± 0.03	1.232ThrLys: 1.232 ± 0.025	5.652ThrLeu: 5.652 ± 0.054	0.977ThrMet: 0.977 ± 0.022	1.033ThrAsn: 1.033 ± 0.023	4.156ThrPro: 4.156 ± 0.045	1.332ThrGln: 1.332 ± 0.025	4.025ThrArg: 4.025 ± 0.037	3.215ThrSer: 3.215 ± 0.04	3.85ThrThr: 3.85 ± 0.045	6.032ThrVal: 6.032 ± 0.054	0.898ThrTrp: 0.898 ± 0.019	1.393ThrTyr: 1.393 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.523ValAla: 10.523 ± 0.086	0.776ValCys: 0.776 ± 0.019	4.956ValAsp: 4.956 ± 0.05	4.757ValGlu: 4.757 ± 0.045	2.413ValPhe: 2.413 ± 0.03	6.489ValGly: 6.489 ± 0.056	1.987ValHis: 1.987 ± 0.03	2.775ValIle: 2.775 ± 0.041	1.803ValLys: 1.803 ± 0.031	9.538ValLeu: 9.538 ± 0.078	1.472ValMet: 1.472 ± 0.025	1.714ValAsn: 1.714 ± 0.027	5.337ValPro: 5.337 ± 0.05	2.089ValGln: 2.089 ± 0.03	7.495ValArg: 7.495 ± 0.062	4.43ValSer: 4.43 ± 0.041	5.707ValThr: 5.707 ± 0.052	8.026ValVal: 8.026 ± 0.076	1.193ValTrp: 1.193 ± 0.021	1.577ValTyr: 1.577 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.631TrpAla: 1.631 ± 0.028	0.157TrpCys: 0.157 ± 0.008	0.83TrpAsp: 0.83 ± 0.02	0.764TrpGlu: 0.764 ± 0.018	0.52TrpPhe: 0.52 ± 0.015	1.097TrpGly: 1.097 ± 0.019	0.365TrpHis: 0.365 ± 0.012	0.558TrpIle: 0.558 ± 0.015	0.393TrpLys: 0.393 ± 0.013	1.794TrpLeu: 1.794 ± 0.026	0.288TrpMet: 0.288 ± 0.012	0.411TrpAsn: 0.411 ± 0.016	0.8TrpPro: 0.8 ± 0.018	0.638TrpGln: 0.638 ± 0.018	1.378TrpArg: 1.378 ± 0.026	0.967TrpSer: 0.967 ± 0.021	1.047TrpThr: 1.047 ± 0.02	1.001TrpVal: 1.001 ± 0.02	0.351TrpTrp: 0.351 ± 0.014	0.384TrpTyr: 0.384 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.774TyrAla: 2.774 ± 0.035	0.18TyrCys: 0.18 ± 0.008	1.551TyrAsp: 1.551 ± 0.028	1.301TyrGlu: 1.301 ± 0.023	0.651TyrPhe: 0.651 ± 0.016	2.348TyrGly: 2.348 ± 0.032	0.393TyrHis: 0.393 ± 0.012	0.481TyrIle: 0.481 ± 0.014	0.431TyrLys: 0.431 ± 0.016	2.098TyrLeu: 2.098 ± 0.038	0.262TyrMet: 0.262 ± 0.009	0.41TyrAsn: 0.41 ± 0.014	1.05TyrPro: 1.05 ± 0.022	0.612TyrGln: 0.612 ± 0.015	1.857TyrArg: 1.857 ± 0.028	0.967TyrSer: 0.967 ± 0.018	1.201TyrThr: 1.201 ± 0.02	1.737TyrVal: 1.737 ± 0.029	0.368TyrTrp: 0.368 ± 0.012	0.464TyrTyr: 0.464 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7706 proteins (2496427 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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