Amino acid dipepetide frequency for Ectothiorhodospiraceae bacterium 2226

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.255AlaAla: 18.255 ± 0.223	1.142AlaCys: 1.142 ± 0.038	6.379AlaAsp: 6.379 ± 0.083	8.612AlaGlu: 8.612 ± 0.136	3.695AlaPhe: 3.695 ± 0.08	11.084AlaGly: 11.084 ± 0.128	3.184AlaHis: 3.184 ± 0.071	4.384AlaIle: 4.384 ± 0.08	2.479AlaLys: 2.479 ± 0.076	16.19AlaLeu: 16.19 ± 0.171	2.861AlaMet: 2.861 ± 0.067	2.173AlaAsn: 2.173 ± 0.057	6.65AlaPro: 6.65 ± 0.11	5.377AlaGln: 5.377 ± 0.083	11.589AlaArg: 11.589 ± 0.15	4.774AlaSer: 4.774 ± 0.084	4.919AlaThr: 4.919 ± 0.077	9.826AlaVal: 9.826 ± 0.105	1.946AlaTrp: 1.946 ± 0.06	2.965AlaTyr: 2.965 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.071CysAla: 1.071 ± 0.032	0.105CysCys: 0.105 ± 0.012	0.48CysAsp: 0.48 ± 0.024	0.486CysGlu: 0.486 ± 0.023	0.231CysPhe: 0.231 ± 0.017	0.911CysGly: 0.911 ± 0.036	0.291CysHis: 0.291 ± 0.018	0.344CysIle: 0.344 ± 0.022	0.183CysLys: 0.183 ± 0.014	0.757CysLeu: 0.757 ± 0.03	0.174CysMet: 0.174 ± 0.015	0.203CysAsn: 0.203 ± 0.015	0.543CysPro: 0.543 ± 0.031	0.227CysGln: 0.227 ± 0.015	0.677CysArg: 0.677 ± 0.029	0.39CysSer: 0.39 ± 0.022	0.418CysThr: 0.418 ± 0.022	0.662CysVal: 0.662 ± 0.031	0.098CysTrp: 0.098 ± 0.011	0.22CysTyr: 0.22 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.181AspAla: 7.181 ± 0.102	0.444AspCys: 0.444 ± 0.024	2.968AspAsp: 2.968 ± 0.092	3.99AspGlu: 3.99 ± 0.067	1.884AspPhe: 1.884 ± 0.051	4.773AspGly: 4.773 ± 0.112	1.219AspHis: 1.219 ± 0.039	2.376AspIle: 2.376 ± 0.056	1.308AspLys: 1.308 ± 0.049	5.808AspLeu: 5.808 ± 0.08	1.2AspMet: 1.2 ± 0.042	1.191AspAsn: 1.191 ± 0.041	3.507AspPro: 3.507 ± 0.07	1.671AspGln: 1.671 ± 0.047	3.629AspArg: 3.629 ± 0.069	1.955AspSer: 1.955 ± 0.048	2.556AspThr: 2.556 ± 0.053	4.313AspVal: 4.313 ± 0.081	0.885AspTrp: 0.885 ± 0.033	1.655AspTyr: 1.655 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	9.034GluAla: 9.034 ± 0.113	0.417GluCys: 0.417 ± 0.024	3.056GluAsp: 3.056 ± 0.066	3.881GluGlu: 3.881 ± 0.09	1.807GluPhe: 1.807 ± 0.046	5.204GluGly: 5.204 ± 0.089	1.825GluHis: 1.825 ± 0.055	2.625GluIle: 2.625 ± 0.057	1.342GluLys: 1.342 ± 0.05	6.991GluLeu: 6.991 ± 0.102	1.342GluMet: 1.342 ± 0.043	1.269GluAsn: 1.269 ± 0.04	3.324GluPro: 3.324 ± 0.076	3.19GluGln: 3.19 ± 0.074	7.09GluArg: 7.09 ± 0.091	2.327GluSer: 2.327 ± 0.051	2.802GluThr: 2.802 ± 0.056	5.258GluVal: 5.258 ± 0.089	0.78GluTrp: 0.78 ± 0.028	1.425GluTyr: 1.425 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.655PheAla: 3.655 ± 0.078	0.319PheCys: 0.319 ± 0.017	2.252PheAsp: 2.252 ± 0.054	2.228PheGlu: 2.228 ± 0.05	1.183PhePhe: 1.183 ± 0.043	2.932PheGly: 2.932 ± 0.063	0.811PheHis: 0.811 ± 0.037	1.412PheIle: 1.412 ± 0.04	0.713PheLys: 0.713 ± 0.028	3.158PheLeu: 3.158 ± 0.071	0.765PheMet: 0.765 ± 0.033	0.857PheAsn: 0.857 ± 0.035	1.463PhePro: 1.463 ± 0.044	1.026PheGln: 1.026 ± 0.033	2.17PheArg: 2.17 ± 0.049	1.586PheSer: 1.586 ± 0.046	1.583PheThr: 1.583 ± 0.051	2.643PheVal: 2.643 ± 0.052	0.443PheTrp: 0.443 ± 0.022	0.947PheTyr: 0.947 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	10.218GlyAla: 10.218 ± 0.129	0.891GlyCys: 0.891 ± 0.036	4.304GlyAsp: 4.304 ± 0.075	5.892GlyGlu: 5.892 ± 0.096	3.061GlyPhe: 3.061 ± 0.056	7.56GlyGly: 7.56 ± 0.139	2.085GlyHis: 2.085 ± 0.054	3.734GlyIle: 3.734 ± 0.073	2.261GlyLys: 2.261 ± 0.061	9.181GlyLeu: 9.181 ± 0.113	2.23GlyMet: 2.23 ± 0.067	1.837GlyAsn: 1.837 ± 0.075	3.366GlyPro: 3.366 ± 0.07	2.786GlyGln: 2.786 ± 0.069	7.083GlyArg: 7.083 ± 0.109	3.811GlySer: 3.811 ± 0.085	4.184GlyThr: 4.184 ± 0.073	6.962GlyVal: 6.962 ± 0.106	1.39GlyTrp: 1.39 ± 0.045	2.562GlyTyr: 2.562 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	3.249HisAla: 3.249 ± 0.069	0.266HisCys: 0.266 ± 0.017	1.292HisAsp: 1.292 ± 0.043	1.432HisGlu: 1.432 ± 0.042	0.921HisPhe: 0.921 ± 0.033	2.448HisGly: 2.448 ± 0.052	0.725HisHis: 0.725 ± 0.025	0.994HisIle: 0.994 ± 0.038	0.535HisLys: 0.535 ± 0.026	2.574HisLeu: 2.574 ± 0.058	0.547HisMet: 0.547 ± 0.028	0.564HisAsn: 0.564 ± 0.028	1.637HisPro: 1.637 ± 0.047	0.759HisGln: 0.759 ± 0.029	1.968HisArg: 1.968 ± 0.056	1.009HisSer: 1.009 ± 0.035	1.179HisThr: 1.179 ± 0.04	1.906HisVal: 1.906 ± 0.05	0.429HisTrp: 0.429 ± 0.025	0.895HisTyr: 0.895 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.144IleAla: 5.144 ± 0.1	0.301IleCys: 0.301 ± 0.019	2.654IleAsp: 2.654 ± 0.057	3.151IleGlu: 3.151 ± 0.07	1.116IlePhe: 1.116 ± 0.038	3.796IleGly: 3.796 ± 0.074	0.9IleHis: 0.9 ± 0.036	1.634IleIle: 1.634 ± 0.045	1.159IleLys: 1.159 ± 0.041	3.548IleLeu: 3.548 ± 0.069	0.8IleMet: 0.8 ± 0.025	1.191IleAsn: 1.191 ± 0.037	2.021IlePro: 2.021 ± 0.05	1.115IleGln: 1.115 ± 0.04	2.625IleArg: 2.625 ± 0.056	1.835IleSer: 1.835 ± 0.049	2.238IleThr: 2.238 ± 0.046	3.194IleVal: 3.194 ± 0.066	0.398IleTrp: 0.398 ± 0.021	1.011IleTyr: 1.011 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.631LysAla: 2.631 ± 0.087	0.15LysCys: 0.15 ± 0.015	1.261LysAsp: 1.261 ± 0.04	1.288LysGlu: 1.288 ± 0.048	0.563LysPhe: 0.563 ± 0.029	1.784LysGly: 1.784 ± 0.049	0.552LysHis: 0.552 ± 0.024	0.878LysIle: 0.878 ± 0.037	0.834LysLys: 0.834 ± 0.073	2.289LysLeu: 2.289 ± 0.061	0.465LysMet: 0.465 ± 0.025	0.605LysAsn: 0.605 ± 0.028	1.29LysPro: 1.29 ± 0.04	0.845LysGln: 0.845 ± 0.035	2.002LysArg: 2.002 ± 0.06	1.035LysSer: 1.035 ± 0.035	1.129LysThr: 1.129 ± 0.037	1.83LysVal: 1.83 ± 0.055	0.201LysTrp: 0.201 ± 0.017	0.559LysTyr: 0.559 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.59LeuAla: 15.59 ± 0.184	0.923LeuCys: 0.923 ± 0.031	6.511LeuAsp: 6.511 ± 0.1	7.015LeuGlu: 7.015 ± 0.11	3.445LeuPhe: 3.445 ± 0.074	9.37LeuGly: 9.37 ± 0.111	2.907LeuHis: 2.907 ± 0.062	4.423LeuIle: 4.423 ± 0.078	2.511LeuLys: 2.511 ± 0.056	12.23LeuLeu: 12.23 ± 0.177	2.403LeuMet: 2.403 ± 0.059	2.4LeuAsn: 2.4 ± 0.058	6.095LeuPro: 6.095 ± 0.089	3.717LeuGln: 3.717 ± 0.061	9.449LeuArg: 9.449 ± 0.096	5.288LeuSer: 5.288 ± 0.093	5.346LeuThr: 5.346 ± 0.09	8.666LeuVal: 8.666 ± 0.112	1.458LeuTrp: 1.458 ± 0.046	2.556LeuTyr: 2.556 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.688MetAla: 2.688 ± 0.056	0.127MetCys: 0.127 ± 0.012	1.222MetAsp: 1.222 ± 0.041	1.262MetGlu: 1.262 ± 0.045	0.568MetPhe: 0.568 ± 0.029	1.672MetGly: 1.672 ± 0.059	0.563MetHis: 0.563 ± 0.024	0.863MetIle: 0.863 ± 0.033	0.707MetLys: 0.707 ± 0.031	2.381MetLeu: 2.381 ± 0.05	0.497MetMet: 0.497 ± 0.028	0.658MetAsn: 0.658 ± 0.033	1.237MetPro: 1.237 ± 0.037	0.904MetGln: 0.904 ± 0.031	1.861MetArg: 1.861 ± 0.048	1.391MetSer: 1.391 ± 0.044	1.167MetThr: 1.167 ± 0.036	1.637MetVal: 1.637 ± 0.043	0.209MetTrp: 0.209 ± 0.015	0.387MetTyr: 0.387 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.544AsnAla: 2.544 ± 0.055	0.208AsnCys: 0.208 ± 0.015	1.131AsnAsp: 1.131 ± 0.04	1.183AsnGlu: 1.183 ± 0.033	0.774AsnPhe: 0.774 ± 0.026	1.832AsnGly: 1.832 ± 0.067	0.502AsnHis: 0.502 ± 0.026	1.15AsnIle: 1.15 ± 0.041	0.567AsnLys: 0.567 ± 0.03	2.433AsnLeu: 2.433 ± 0.063	0.507AsnMet: 0.507 ± 0.025	0.563AsnAsn: 0.563 ± 0.026	1.552AsnPro: 1.552 ± 0.045	0.657AsnGln: 0.657 ± 0.03	1.682AsnArg: 1.682 ± 0.048	0.857AsnSer: 0.857 ± 0.04	1.131AsnThr: 1.131 ± 0.041	1.797AsnVal: 1.797 ± 0.052	0.312AsnTrp: 0.312 ± 0.02	0.574AsnTyr: 0.574 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.833ProAla: 6.833 ± 0.111	0.39ProCys: 0.39 ± 0.023	3.504ProAsp: 3.504 ± 0.069	4.161ProGlu: 4.161 ± 0.078	1.672ProPhe: 1.672 ± 0.046	4.726ProGly: 4.726 ± 0.076	1.311ProHis: 1.311 ± 0.036	1.763ProIle: 1.763 ± 0.054	0.97ProLys: 0.97 ± 0.038	5.731ProLeu: 5.731 ± 0.082	1.093ProMet: 1.093 ± 0.037	1.091ProAsn: 1.091 ± 0.035	3.304ProPro: 3.304 ± 0.084	1.944ProGln: 1.944 ± 0.042	3.839ProArg: 3.839 ± 0.077	2.305ProSer: 2.305 ± 0.049	2.408ProThr: 2.408 ± 0.056	4.282ProVal: 4.282 ± 0.079	0.827ProTrp: 0.827 ± 0.032	1.335ProTyr: 1.335 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	5.271GlnAla: 5.271 ± 0.079	0.28GlnCys: 0.28 ± 0.016	1.679GlnAsp: 1.679 ± 0.042	1.971GlnGlu: 1.971 ± 0.054	1.037GlnPhe: 1.037 ± 0.034	3.109GlnGly: 3.109 ± 0.066	0.93GlnHis: 0.93 ± 0.035	1.366GlnIle: 1.366 ± 0.04	0.661GlnLys: 0.661 ± 0.032	3.528GlnLeu: 3.528 ± 0.073	0.741GlnMet: 0.741 ± 0.029	0.671GlnAsn: 0.671 ± 0.029	1.915GlnPro: 1.915 ± 0.052	1.547GlnGln: 1.547 ± 0.053	3.581GlnArg: 3.581 ± 0.067	1.483GlnSer: 1.483 ± 0.037	1.534GlnThr: 1.534 ± 0.042	2.872GlnVal: 2.872 ± 0.062	0.521GlnTrp: 0.521 ± 0.024	0.781GlnTyr: 0.781 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	10.667ArgAla: 10.667 ± 0.142	0.65ArgCys: 0.65 ± 0.028	4.346ArgAsp: 4.346 ± 0.071	6.008ArgGlu: 6.008 ± 0.087	2.982ArgPhe: 2.982 ± 0.06	6.11ArgGly: 6.11 ± 0.086	2.314ArgHis: 2.314 ± 0.057	3.515ArgIle: 3.515 ± 0.065	1.665ArgLys: 1.665 ± 0.049	10.286ArgLeu: 10.286 ± 0.126	1.993ArgMet: 1.993 ± 0.046	1.78ArgAsn: 1.78 ± 0.047	4.188ArgPro: 4.188 ± 0.077	2.704ArgGln: 2.704 ± 0.062	7.482ArgArg: 7.482 ± 0.131	3.272ArgSer: 3.272 ± 0.061	3.426ArgThr: 3.426 ± 0.068	6.726ArgVal: 6.726 ± 0.092	1.349ArgTrp: 1.349 ± 0.049	2.644ArgTyr: 2.644 ± 0.065	0.0ArgXaa: 0.0 ± 0.0
Ser	5.289SerAla: 5.289 ± 0.085	0.392SerCys: 0.392 ± 0.022	2.26SerAsp: 2.26 ± 0.05	2.642SerGlu: 2.642 ± 0.062	1.539SerPhe: 1.539 ± 0.046	4.488SerGly: 4.488 ± 0.084	1.0SerHis: 1.0 ± 0.033	1.787SerIle: 1.787 ± 0.051	0.954SerLys: 0.954 ± 0.033	4.635SerLeu: 4.635 ± 0.084	1.031SerMet: 1.031 ± 0.033	1.051SerAsn: 1.051 ± 0.04	2.246SerPro: 2.246 ± 0.06	1.268SerGln: 1.268 ± 0.044	3.071SerArg: 3.071 ± 0.057	1.971SerSer: 1.971 ± 0.056	2.089SerThr: 2.089 ± 0.051	3.415SerVal: 3.415 ± 0.068	0.572SerTrp: 0.572 ± 0.027	1.189SerTyr: 1.189 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.114ThrAla: 5.114 ± 0.079	0.369ThrCys: 0.369 ± 0.02	2.368ThrAsp: 2.368 ± 0.06	2.381ThrGlu: 2.381 ± 0.061	1.573ThrPhe: 1.573 ± 0.05	4.297ThrGly: 4.297 ± 0.075	1.192ThrHis: 1.192 ± 0.039	1.799ThrIle: 1.799 ± 0.05	0.848ThrLys: 0.848 ± 0.043	6.341ThrLeu: 6.341 ± 0.098	0.808ThrMet: 0.808 ± 0.033	0.937ThrAsn: 0.937 ± 0.038	3.031ThrPro: 3.031 ± 0.064	1.404ThrGln: 1.404 ± 0.045	3.82ThrArg: 3.82 ± 0.072	1.976ThrSer: 1.976 ± 0.051	2.249ThrThr: 2.249 ± 0.058	4.066ThrVal: 4.066 ± 0.081	0.582ThrTrp: 0.582 ± 0.027	1.174ThrTyr: 1.174 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	9.716ValAla: 9.716 ± 0.129	0.686ValCys: 0.686 ± 0.029	4.719ValAsp: 4.719 ± 0.073	5.201ValGlu: 5.201 ± 0.088	2.646ValPhe: 2.646 ± 0.06	6.112ValGly: 6.112 ± 0.103	1.918ValHis: 1.918 ± 0.049	3.343ValIle: 3.343 ± 0.061	1.718ValLys: 1.718 ± 0.054	9.278ValLeu: 9.278 ± 0.117	1.698ValMet: 1.698 ± 0.046	1.923ValAsn: 1.923 ± 0.051	4.144ValPro: 4.144 ± 0.076	2.728ValGln: 2.728 ± 0.058	6.573ValArg: 6.573 ± 0.094	3.819ValSer: 3.819 ± 0.077	3.902ValThr: 3.902 ± 0.082	6.956ValVal: 6.956 ± 0.101	0.979ValTrp: 0.979 ± 0.037	1.962ValTyr: 1.962 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.403TrpAla: 1.403 ± 0.042	0.146TrpCys: 0.146 ± 0.014	0.667TrpAsp: 0.667 ± 0.026	0.734TrpGlu: 0.734 ± 0.031	0.494TrpPhe: 0.494 ± 0.025	0.979TrpGly: 0.979 ± 0.037	0.409TrpHis: 0.409 ± 0.025	0.562TrpIle: 0.562 ± 0.028	0.261TrpLys: 0.261 ± 0.02	2.013TrpLeu: 2.013 ± 0.053	0.365TrpMet: 0.365 ± 0.021	0.335TrpAsn: 0.335 ± 0.019	0.716TrpPro: 0.716 ± 0.032	0.654TrpGln: 0.654 ± 0.028	1.41TrpArg: 1.41 ± 0.043	0.652TrpSer: 0.652 ± 0.027	0.598TrpThr: 0.598 ± 0.027	1.051TrpVal: 1.051 ± 0.034	0.268TrpTrp: 0.268 ± 0.019	0.345TrpTyr: 0.345 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.932TyrAla: 2.932 ± 0.063	0.265TyrCys: 0.265 ± 0.017	1.459TyrAsp: 1.459 ± 0.055	1.471TyrGlu: 1.471 ± 0.044	0.957TyrPhe: 0.957 ± 0.039	2.209TyrGly: 2.209 ± 0.048	0.692TyrHis: 0.692 ± 0.031	0.879TyrIle: 0.879 ± 0.036	0.513TyrLys: 0.513 ± 0.026	2.954TyrLeu: 2.954 ± 0.056	0.481TyrMet: 0.481 ± 0.027	0.661TyrAsn: 0.661 ± 0.027	1.259TyrPro: 1.259 ± 0.04	0.955TyrGln: 0.955 ± 0.038	2.507TyrArg: 2.507 ± 0.059	1.152TyrSer: 1.152 ± 0.035	1.468TyrThr: 1.468 ± 0.046	1.96TyrVal: 1.96 ± 0.062	0.412TyrTrp: 0.412 ± 0.023	0.831TyrTyr: 0.831 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2766 proteins (869014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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