Amino acid dipepetide frequency for Trachipleistophora hominis (Microsporidian parasite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.552AlaAla: 2.552 ± 0.125	0.941AlaCys: 0.941 ± 0.027	2.447AlaAsp: 2.447 ± 0.055	2.982AlaGlu: 2.982 ± 0.086	2.266AlaPhe: 2.266 ± 0.051	2.203AlaGly: 2.203 ± 0.067	1.042AlaHis: 1.042 ± 0.038	2.979AlaIle: 2.979 ± 0.063	3.183AlaLys: 3.183 ± 0.066	4.79AlaLeu: 4.79 ± 0.087	1.2AlaMet: 1.2 ± 0.04	2.293AlaAsn: 2.293 ± 0.045	1.217AlaPro: 1.217 ± 0.037	1.634AlaGln: 1.634 ± 0.053	2.322AlaArg: 2.322 ± 0.06	2.706AlaSer: 2.706 ± 0.061	1.917AlaThr: 1.917 ± 0.047	3.281AlaVal: 3.281 ± 0.065	0.242AlaTrp: 0.242 ± 0.015	1.834AlaTyr: 1.834 ± 0.047	0.008AlaXaa: 0.008 ± 0.003
Cys	1.134CysAla: 1.134 ± 0.039	0.473CysCys: 0.473 ± 0.027	1.314CysAsp: 1.314 ± 0.042	1.362CysGlu: 1.362 ± 0.046	1.08CysPhe: 1.08 ± 0.038	1.177CysGly: 1.177 ± 0.039	0.384CysHis: 0.384 ± 0.021	1.48CysIle: 1.48 ± 0.043	1.518CysLys: 1.518 ± 0.047	1.706CysLeu: 1.706 ± 0.049	0.558CysMet: 0.558 ± 0.027	1.178CysAsn: 1.178 ± 0.036	0.541CysPro: 0.541 ± 0.03	0.493CysGln: 0.493 ± 0.023	1.081CysArg: 1.081 ± 0.032	1.487CysSer: 1.487 ± 0.045	1.344CysThr: 1.344 ± 0.041	1.583CysVal: 1.583 ± 0.04	0.136CysTrp: 0.136 ± 0.012	0.918CysTyr: 0.918 ± 0.03	0.001CysXaa: 0.001 ± 0.001
Asp	2.635AspAla: 2.635 ± 0.062	1.023AspCys: 1.023 ± 0.035	4.17AspAsp: 4.17 ± 0.087	5.769AspGlu: 5.769 ± 0.104	2.574AspPhe: 2.574 ± 0.056	3.407AspGly: 3.407 ± 0.091	1.093AspHis: 1.093 ± 0.032	3.994AspIle: 3.994 ± 0.075	4.598AspLys: 4.598 ± 0.096	4.875AspLeu: 4.875 ± 0.08	1.464AspMet: 1.464 ± 0.043	3.534AspAsn: 3.534 ± 0.078	1.373AspPro: 1.373 ± 0.044	1.516AspGln: 1.516 ± 0.046	3.027AspArg: 3.027 ± 0.067	3.524AspSer: 3.524 ± 0.076	2.851AspThr: 2.851 ± 0.057	4.415AspVal: 4.415 ± 0.074	0.379AspTrp: 0.379 ± 0.02	2.148AspTyr: 2.148 ± 0.049	0.009AspXaa: 0.009 ± 0.003
Glu	2.387GluAla: 2.387 ± 0.06	1.763GluCys: 1.763 ± 0.056	3.904GluAsp: 3.904 ± 0.084	6.129GluGlu: 6.129 ± 0.133	2.625GluPhe: 2.625 ± 0.066	3.103GluGly: 3.103 ± 0.076	1.734GluHis: 1.734 ± 0.042	5.617GluIle: 5.617 ± 0.097	6.715GluLys: 6.715 ± 0.117	6.048GluLeu: 6.048 ± 0.098	2.485GluMet: 2.485 ± 0.055	5.654GluAsn: 5.654 ± 0.088	1.412GluPro: 1.412 ± 0.043	2.569GluGln: 2.569 ± 0.055	4.523GluArg: 4.523 ± 0.098	4.406GluSer: 4.406 ± 0.072	3.0GluThr: 3.0 ± 0.065	3.687GluVal: 3.687 ± 0.076	0.523GluTrp: 0.523 ± 0.023	3.012GluTyr: 3.012 ± 0.064	0.009GluXaa: 0.009 ± 0.003
Phe	1.837PheAla: 1.837 ± 0.046	1.09PheCys: 1.09 ± 0.031	2.912PheAsp: 2.912 ± 0.051	2.946PheGlu: 2.946 ± 0.053	2.846PhePhe: 2.846 ± 0.071	2.051PheGly: 2.051 ± 0.044	0.806PheHis: 0.806 ± 0.028	3.838PheIle: 3.838 ± 0.077	3.457PheLys: 3.457 ± 0.067	5.306PheLeu: 5.306 ± 0.094	1.294PheMet: 1.294 ± 0.043	2.92PheAsn: 2.92 ± 0.059	1.145PhePro: 1.145 ± 0.036	0.973PheGln: 0.973 ± 0.028	1.903PheArg: 1.903 ± 0.044	3.532PheSer: 3.532 ± 0.065	2.424PheThr: 2.424 ± 0.059	3.798PheVal: 3.798 ± 0.071	0.302PheTrp: 0.302 ± 0.018	2.745PheTyr: 2.745 ± 0.067	0.002PheXaa: 0.002 ± 0.001
Gly	2.099GlyAla: 2.099 ± 0.06	1.192GlyCys: 1.192 ± 0.043	2.812GlyAsp: 2.812 ± 0.066	2.923GlyGlu: 2.923 ± 0.057	1.797GlyPhe: 1.797 ± 0.049	2.531GlyGly: 2.531 ± 0.076	0.908GlyHis: 0.908 ± 0.033	3.344GlyIle: 3.344 ± 0.073	3.756GlyLys: 3.756 ± 0.077	3.63GlyLeu: 3.63 ± 0.061	1.513GlyMet: 1.513 ± 0.041	2.846GlyAsn: 2.846 ± 0.062	1.014GlyPro: 1.014 ± 0.036	1.223GlyGln: 1.223 ± 0.04	2.812GlyArg: 2.812 ± 0.075	3.086GlySer: 3.086 ± 0.066	2.869GlyThr: 2.869 ± 0.065	3.392GlyVal: 3.392 ± 0.079	0.357GlyTrp: 0.357 ± 0.02	1.751GlyTyr: 1.751 ± 0.047	0.013GlyXaa: 0.013 ± 0.005
His	1.023HisAla: 1.023 ± 0.035	0.431HisCys: 0.431 ± 0.021	1.069HisAsp: 1.069 ± 0.039	1.337HisGlu: 1.337 ± 0.039	1.148HisPhe: 1.148 ± 0.038	1.084HisGly: 1.084 ± 0.035	0.511HisHis: 0.511 ± 0.025	1.47HisIle: 1.47 ± 0.049	1.612HisLys: 1.612 ± 0.044	1.983HisLeu: 1.983 ± 0.05	0.46HisMet: 0.46 ± 0.022	1.205HisAsn: 1.205 ± 0.038	0.768HisPro: 0.768 ± 0.032	0.53HisGln: 0.53 ± 0.023	1.054HisArg: 1.054 ± 0.035	1.55HisSer: 1.55 ± 0.046	1.13HisThr: 1.13 ± 0.038	1.592HisVal: 1.592 ± 0.044	0.134HisTrp: 0.134 ± 0.012	0.683HisTyr: 0.683 ± 0.027	0.001HisXaa: 0.001 ± 0.001
Ile	3.381IleAla: 3.381 ± 0.065	1.443IleCys: 1.443 ± 0.04	4.669IleAsp: 4.669 ± 0.08	5.025IleGlu: 5.025 ± 0.079	3.869IlePhe: 3.869 ± 0.08	3.167IleGly: 3.167 ± 0.061	1.433IleHis: 1.433 ± 0.041	5.208IleIle: 5.208 ± 0.08	6.135IleLys: 6.135 ± 0.092	6.863IleLeu: 6.863 ± 0.104	1.597IleMet: 1.597 ± 0.04	5.093IleAsn: 5.093 ± 0.094	2.117IlePro: 2.117 ± 0.047	1.853IleGln: 1.853 ± 0.045	3.768IleArg: 3.768 ± 0.07	5.025IleSer: 5.025 ± 0.08	4.032IleThr: 4.032 ± 0.07	4.816IleVal: 4.816 ± 0.074	0.35IleTrp: 0.35 ± 0.018	2.817IleTyr: 2.817 ± 0.062	0.001IleXaa: 0.001 ± 0.001
Lys	3.055LysAla: 3.055 ± 0.068	1.55LysCys: 1.55 ± 0.047	5.078LysAsp: 5.078 ± 0.105	6.894LysGlu: 6.894 ± 0.126	2.924LysPhe: 2.924 ± 0.066	3.401LysGly: 3.401 ± 0.079	1.751LysHis: 1.751 ± 0.047	6.668LysIle: 6.668 ± 0.105	8.341LysLys: 8.341 ± 0.135	6.635LysLeu: 6.635 ± 0.104	2.693LysMet: 2.693 ± 0.058	6.506LysAsn: 6.506 ± 0.092	1.807LysPro: 1.807 ± 0.05	2.421LysGln: 2.421 ± 0.058	4.891LysArg: 4.891 ± 0.075	4.935LysSer: 4.935 ± 0.08	4.367LysThr: 4.367 ± 0.073	4.354LysVal: 4.354 ± 0.078	0.518LysTrp: 0.518 ± 0.024	3.443LysTyr: 3.443 ± 0.064	0.008LysXaa: 0.008 ± 0.003
Leu	3.72LeuAla: 3.72 ± 0.076	2.145LeuCys: 2.145 ± 0.05	4.529LeuAsp: 4.529 ± 0.077	6.16LeuGlu: 6.16 ± 0.095	5.112LeuPhe: 5.112 ± 0.092	3.561LeuGly: 3.561 ± 0.064	1.999LeuHis: 1.999 ± 0.046	6.367LeuIle: 6.367 ± 0.086	8.478LeuLys: 8.478 ± 0.136	8.757LeuLeu: 8.757 ± 0.144	2.221LeuMet: 2.221 ± 0.054	5.792LeuAsn: 5.792 ± 0.082	2.756LeuPro: 2.756 ± 0.056	2.723LeuGln: 2.723 ± 0.056	5.405LeuArg: 5.405 ± 0.086	7.059LeuSer: 7.059 ± 0.099	4.389LeuThr: 4.389 ± 0.079	5.669LeuVal: 5.669 ± 0.081	0.524LeuTrp: 0.524 ± 0.025	3.725LeuTyr: 3.725 ± 0.061	0.008LeuXaa: 0.008 ± 0.003
Met	1.283MetAla: 1.283 ± 0.038	0.596MetCys: 0.596 ± 0.025	1.578MetAsp: 1.578 ± 0.046	1.692MetGlu: 1.692 ± 0.037	1.194MetPhe: 1.194 ± 0.038	1.035MetGly: 1.035 ± 0.037	0.731MetHis: 0.731 ± 0.032	1.84MetIle: 1.84 ± 0.049	2.416MetLys: 2.416 ± 0.057	2.682MetLeu: 2.682 ± 0.053	0.786MetMet: 0.786 ± 0.03	1.941MetAsn: 1.941 ± 0.048	0.928MetPro: 0.928 ± 0.032	0.819MetGln: 0.819 ± 0.032	1.576MetArg: 1.576 ± 0.05	1.867MetSer: 1.867 ± 0.039	1.099MetThr: 1.099 ± 0.034	2.057MetVal: 2.057 ± 0.05	0.165MetTrp: 0.165 ± 0.013	0.938MetTyr: 0.938 ± 0.033	0.002MetXaa: 0.002 ± 0.002
Asn	3.257AsnAla: 3.257 ± 0.072	1.109AsnCys: 1.109 ± 0.039	4.793AsnAsp: 4.793 ± 0.078	5.551AsnGlu: 5.551 ± 0.083	2.958AsnPhe: 2.958 ± 0.065	3.377AsnGly: 3.377 ± 0.075	1.164AsnHis: 1.164 ± 0.037	5.064AsnIle: 5.064 ± 0.099	4.912AsnLys: 4.912 ± 0.1	5.694AsnLeu: 5.694 ± 0.103	1.697AsnMet: 1.697 ± 0.046	4.688AsnAsn: 4.688 ± 0.118	1.589AsnPro: 1.589 ± 0.055	1.522AsnGln: 1.522 ± 0.042	2.874AsnArg: 2.874 ± 0.062	3.897AsnSer: 3.897 ± 0.074	4.164AsnThr: 4.164 ± 0.089	5.04AsnVal: 5.04 ± 0.08	0.309AsnTrp: 0.309 ± 0.02	2.554AsnTyr: 2.554 ± 0.06	0.002AsnXaa: 0.002 ± 0.001
Pro	1.344ProAla: 1.344 ± 0.046	0.604ProCys: 0.604 ± 0.027	1.375ProAsp: 1.375 ± 0.039	1.813ProGlu: 1.813 ± 0.052	1.649ProPhe: 1.649 ± 0.04	1.247ProGly: 1.247 ± 0.038	0.555ProHis: 0.555 ± 0.024	1.854ProIle: 1.854 ± 0.05	1.913ProLys: 1.913 ± 0.052	2.363ProLeu: 2.363 ± 0.054	0.633ProMet: 0.633 ± 0.026	1.584ProAsn: 1.584 ± 0.049	1.09ProPro: 1.09 ± 0.051	0.782ProGln: 0.782 ± 0.031	1.215ProArg: 1.215 ± 0.037	2.335ProSer: 2.335 ± 0.055	1.509ProThr: 1.509 ± 0.051	1.917ProVal: 1.917 ± 0.053	0.169ProTrp: 0.169 ± 0.013	1.121ProTyr: 1.121 ± 0.039	0.008ProXaa: 0.008 ± 0.003
Gln	1.243GlnAla: 1.243 ± 0.046	0.5GlnCys: 0.5 ± 0.022	1.202GlnAsp: 1.202 ± 0.036	1.803GlnGlu: 1.803 ± 0.048	1.257GlnPhe: 1.257 ± 0.041	1.079GlnGly: 1.079 ± 0.038	0.736GlnHis: 0.736 ± 0.026	2.179GlnIle: 2.179 ± 0.052	2.47GlnLys: 2.47 ± 0.054	2.485GlnLeu: 2.485 ± 0.061	0.824GlnMet: 0.824 ± 0.029	2.171GlnAsn: 2.171 ± 0.05	1.067GlnPro: 1.067 ± 0.043	1.096GlnGln: 1.096 ± 0.042	1.664GlnArg: 1.664 ± 0.045	1.897GlnSer: 1.897 ± 0.049	1.323GlnThr: 1.323 ± 0.04	1.486GlnVal: 1.486 ± 0.047	0.146GlnTrp: 0.146 ± 0.012	0.976GlnTyr: 0.976 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.475ArgAla: 2.475 ± 0.061	1.15ArgCys: 1.15 ± 0.042	2.736ArgAsp: 2.736 ± 0.067	3.75ArgGlu: 3.75 ± 0.079	2.193ArgPhe: 2.193 ± 0.05	2.326ArgGly: 2.326 ± 0.063	0.99ArgHis: 0.99 ± 0.034	4.391ArgIle: 4.391 ± 0.068	4.853ArgLys: 4.853 ± 0.086	4.457ArgLeu: 4.457 ± 0.07	2.014ArgMet: 2.014 ± 0.048	3.702ArgAsn: 3.702 ± 0.068	1.344ArgPro: 1.344 ± 0.04	1.306ArgGln: 1.306 ± 0.033	3.487ArgArg: 3.487 ± 0.084	3.301ArgSer: 3.301 ± 0.058	2.919ArgThr: 2.919 ± 0.072	3.434ArgVal: 3.434 ± 0.074	0.372ArgTrp: 0.372 ± 0.02	1.989ArgTyr: 1.989 ± 0.043	0.009ArgXaa: 0.009 ± 0.003
Ser	3.314SerAla: 3.314 ± 0.064	1.292SerCys: 1.292 ± 0.039	3.949SerAsp: 3.949 ± 0.077	4.033SerGlu: 4.033 ± 0.079	3.669SerPhe: 3.669 ± 0.064	3.141SerGly: 3.141 ± 0.069	1.282SerHis: 1.282 ± 0.044	4.965SerIle: 4.965 ± 0.079	4.876SerLys: 4.876 ± 0.077	6.5SerLeu: 6.5 ± 0.098	1.702SerMet: 1.702 ± 0.043	4.339SerAsn: 4.339 ± 0.081	1.877SerPro: 1.877 ± 0.057	1.595SerGln: 1.595 ± 0.042	2.933SerArg: 2.933 ± 0.069	5.339SerSer: 5.339 ± 0.12	4.153SerThr: 4.153 ± 0.075	4.717SerVal: 4.717 ± 0.064	0.379SerTrp: 0.379 ± 0.021	2.582SerTyr: 2.582 ± 0.051	0.008SerXaa: 0.008 ± 0.003
Thr	2.548ThrAla: 2.548 ± 0.061	1.13ThrCys: 1.13 ± 0.036	2.719ThrAsp: 2.719 ± 0.059	3.175ThrGlu: 3.175 ± 0.054	2.538ThrPhe: 2.538 ± 0.059	2.778ThrGly: 2.778 ± 0.067	1.11ThrHis: 1.11 ± 0.036	3.79ThrIle: 3.79 ± 0.072	4.022ThrLys: 4.022 ± 0.068	4.761ThrLeu: 4.761 ± 0.087	1.271ThrMet: 1.271 ± 0.036	3.764ThrAsn: 3.764 ± 0.083	1.736ThrPro: 1.736 ± 0.05	1.307ThrGln: 1.307 ± 0.038	2.648ThrArg: 2.648 ± 0.062	3.615ThrSer: 3.615 ± 0.07	3.028ThrThr: 3.028 ± 0.082	3.358ThrVal: 3.358 ± 0.072	0.302ThrTrp: 0.302 ± 0.017	2.077ThrTyr: 2.077 ± 0.046	0.005ThrXaa: 0.005 ± 0.002
Val	2.681ValAla: 2.681 ± 0.064	1.559ValCys: 1.559 ± 0.037	3.991ValAsp: 3.991 ± 0.062	4.57ValGlu: 4.57 ± 0.081	3.617ValPhe: 3.617 ± 0.069	2.988ValGly: 2.988 ± 0.067	1.585ValHis: 1.585 ± 0.043	4.627ValIle: 4.627 ± 0.08	5.294ValLys: 5.294 ± 0.083	7.075ValLeu: 7.075 ± 0.093	1.687ValMet: 1.687 ± 0.053	3.999ValAsn: 3.999 ± 0.077	2.16ValPro: 2.16 ± 0.059	1.976ValGln: 1.976 ± 0.043	3.605ValArg: 3.605 ± 0.079	4.291ValSer: 4.291 ± 0.078	2.79ValThr: 2.79 ± 0.063	4.981ValVal: 4.981 ± 0.105	0.381ValTrp: 0.381 ± 0.018	2.858ValTyr: 2.858 ± 0.059	0.009ValXaa: 0.009 ± 0.003
Trp	0.208TrpAla: 0.208 ± 0.016	0.182TrpCys: 0.182 ± 0.015	0.31TrpAsp: 0.31 ± 0.021	0.338TrpGlu: 0.338 ± 0.022	0.289TrpPhe: 0.289 ± 0.016	0.231TrpGly: 0.231 ± 0.017	0.141TrpHis: 0.141 ± 0.012	0.443TrpIle: 0.443 ± 0.023	0.486TrpLys: 0.486 ± 0.022	0.627TrpLeu: 0.627 ± 0.029	0.237TrpMet: 0.237 ± 0.018	0.405TrpAsn: 0.405 ± 0.02	0.176TrpPro: 0.176 ± 0.014	0.186TrpGln: 0.186 ± 0.014	0.365TrpArg: 0.365 ± 0.02	0.408TrpSer: 0.408 ± 0.021	0.28TrpThr: 0.28 ± 0.016	0.297TrpVal: 0.297 ± 0.016	0.057TrpTrp: 0.057 ± 0.009	0.288TrpTyr: 0.288 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.855TyrAla: 1.855 ± 0.051	0.771TyrCys: 0.771 ± 0.028	2.817TyrAsp: 2.817 ± 0.05	3.046TyrGlu: 3.046 ± 0.065	2.517TyrPhe: 2.517 ± 0.059	1.973TyrGly: 1.973 ± 0.049	0.824TyrHis: 0.824 ± 0.03	2.544TyrIle: 2.544 ± 0.066	3.193TyrLys: 3.193 ± 0.067	3.859TyrLeu: 3.859 ± 0.079	0.881TyrMet: 0.881 ± 0.029	2.596TyrAsn: 2.596 ± 0.062	0.957TyrPro: 0.957 ± 0.033	1.076TyrGln: 1.076 ± 0.034	2.039TyrArg: 2.039 ± 0.052	2.377TyrSer: 2.377 ± 0.05	2.087TyrThr: 2.087 ± 0.051	2.844TyrVal: 2.844 ± 0.054	0.207TyrTrp: 0.207 ± 0.015	1.8TyrTyr: 1.8 ± 0.051	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.009XaaAla: 0.009 ± 0.003	0.002XaaCys: 0.002 ± 0.001	0.004XaaAsp: 0.004 ± 0.002	0.005XaaGlu: 0.005 ± 0.003	0.003XaaPhe: 0.003 ± 0.002	0.004XaaGly: 0.004 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.003XaaIle: 0.003 ± 0.002	0.01XaaLys: 0.01 ± 0.003	0.003XaaLeu: 0.003 ± 0.002	0.006XaaMet: 0.006 ± 0.002	0.008XaaAsn: 0.008 ± 0.003	0.004XaaPro: 0.004 ± 0.002	0.005XaaGln: 0.005 ± 0.002	0.006XaaArg: 0.006 ± 0.002	0.006XaaSer: 0.006 ± 0.002	0.008XaaThr: 0.008 ± 0.002	0.005XaaVal: 0.005 ± 0.003	0.002XaaTrp: 0.002 ± 0.002	0.005XaaTyr: 0.005 ± 0.003	11.867XaaXaa: 11.867 ± 1.539

Statistics based on 3212 proteins (933265 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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