Amino acid dipepetide frequency for Escherichia virus Lambda_2E9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.651AlaAla: 11.651 ± 1.9
1.053AlaCys: 1.053 ± 0.306
4.773AlaAsp: 4.773 ± 0.52
6.668AlaGlu: 6.668 ± 0.774
3.65AlaPhe: 3.65 ± 0.49
7.51AlaGly: 7.51 ± 0.905
1.404AlaHis: 1.404 ± 0.282
6.106AlaIle: 6.106 ± 0.714
4.281AlaLys: 4.281 ± 0.756
8.563AlaLeu: 8.563 ± 0.765
2.667AlaMet: 2.667 ± 0.414
3.229AlaAsn: 3.229 ± 0.422
2.737AlaPro: 2.737 ± 0.476
4.211AlaGln: 4.211 ± 0.702
6.246AlaArg: 6.246 ± 0.81
6.387AlaSer: 6.387 ± 0.771
4.913AlaThr: 4.913 ± 1.06
5.896AlaVal: 5.896 ± 0.782
1.755AlaTrp: 1.755 ± 0.39
2.456AlaTyr: 2.456 ± 0.391
0.0AlaXaa: 0.0 ± 0.0
Cys
1.334CysAla: 1.334 ± 0.284
0.351CysCys: 0.351 ± 0.149
0.772CysAsp: 0.772 ± 0.254
0.702CysGlu: 0.702 ± 0.23
0.281CysPhe: 0.281 ± 0.126
0.912CysGly: 0.912 ± 0.321
0.351CysHis: 0.351 ± 0.17
0.772CysIle: 0.772 ± 0.244
0.772CysLys: 0.772 ± 0.24
1.193CysLeu: 1.193 ± 0.372
0.351CysMet: 0.351 ± 0.153
0.561CysAsn: 0.561 ± 0.186
0.281CysPro: 0.281 ± 0.135
0.351CysGln: 0.351 ± 0.149
1.123CysArg: 1.123 ± 0.307
1.053CysSer: 1.053 ± 0.318
0.842CysThr: 0.842 ± 0.269
0.772CysVal: 0.772 ± 0.261
0.281CysTrp: 0.281 ± 0.149
0.281CysTyr: 0.281 ± 0.136
0.0CysXaa: 0.0 ± 0.0
Asp
5.264AspAla: 5.264 ± 0.684
0.632AspCys: 0.632 ± 0.236
4.351AspAsp: 4.351 ± 0.563
4.211AspGlu: 4.211 ± 0.604
1.544AspPhe: 1.544 ± 0.248
4.843AspGly: 4.843 ± 0.719
0.491AspHis: 0.491 ± 0.163
4.001AspIle: 4.001 ± 0.59
2.737AspLys: 2.737 ± 0.514
3.93AspLeu: 3.93 ± 0.57
1.684AspMet: 1.684 ± 0.293
2.176AspAsn: 2.176 ± 0.414
2.386AspPro: 2.386 ± 0.658
1.474AspGln: 1.474 ± 0.336
2.807AspArg: 2.807 ± 0.463
3.229AspSer: 3.229 ± 0.606
2.948AspThr: 2.948 ± 0.548
4.281AspVal: 4.281 ± 0.556
1.123AspTrp: 1.123 ± 0.318
1.684AspTyr: 1.684 ± 0.32
0.0AspXaa: 0.0 ± 0.0
Glu
5.896GluAla: 5.896 ± 0.845
0.983GluCys: 0.983 ± 0.328
2.807GluAsp: 2.807 ± 0.437
3.79GluGlu: 3.79 ± 0.646
2.035GluPhe: 2.035 ± 0.503
3.299GluGly: 3.299 ± 0.475
0.912GluHis: 0.912 ± 0.264
3.86GluIle: 3.86 ± 0.538
4.001GluLys: 4.001 ± 0.503
5.334GluLeu: 5.334 ± 0.764
1.755GluMet: 1.755 ± 0.447
2.527GluAsn: 2.527 ± 0.422
2.246GluPro: 2.246 ± 0.27
3.86GluGln: 3.86 ± 0.619
4.702GluArg: 4.702 ± 0.669
3.439GluSer: 3.439 ± 0.423
3.439GluThr: 3.439 ± 0.488
3.088GluVal: 3.088 ± 0.474
1.334GluTrp: 1.334 ± 0.313
1.755GluTyr: 1.755 ± 0.384
0.0GluXaa: 0.0 ± 0.0
Phe
2.176PheAla: 2.176 ± 0.423
0.561PheCys: 0.561 ± 0.187
2.878PheAsp: 2.878 ± 0.484
1.965PheGlu: 1.965 ± 0.341
1.684PhePhe: 1.684 ± 0.477
2.667PheGly: 2.667 ± 0.388
0.842PheHis: 0.842 ± 0.222
1.474PheIle: 1.474 ± 0.331
1.825PheLys: 1.825 ± 0.336
2.878PheLeu: 2.878 ± 0.55
0.842PheMet: 0.842 ± 0.256
1.123PheAsn: 1.123 ± 0.257
1.755PhePro: 1.755 ± 0.338
0.702PheGln: 0.702 ± 0.236
3.018PheArg: 3.018 ± 0.423
3.299PheSer: 3.299 ± 0.478
3.369PheThr: 3.369 ± 0.499
2.807PheVal: 2.807 ± 0.439
0.561PheTrp: 0.561 ± 0.176
1.123PheTyr: 1.123 ± 0.33
0.0PheXaa: 0.0 ± 0.0
Gly
5.966GlyAla: 5.966 ± 0.905
0.842GlyCys: 0.842 ± 0.282
4.281GlyAsp: 4.281 ± 0.453
3.72GlyGlu: 3.72 ± 0.563
2.386GlyPhe: 2.386 ± 0.392
5.334GlyGly: 5.334 ± 0.789
1.123GlyHis: 1.123 ± 0.365
3.72GlyIle: 3.72 ± 0.582
4.773GlyLys: 4.773 ± 0.535
6.246GlyLeu: 6.246 ± 0.783
2.948GlyMet: 2.948 ± 0.453
3.439GlyAsn: 3.439 ± 0.408
1.263GlyPro: 1.263 ± 0.238
3.158GlyGln: 3.158 ± 0.563
3.72GlyArg: 3.72 ± 0.438
4.001GlySer: 4.001 ± 0.535
3.579GlyThr: 3.579 ± 0.578
5.194GlyVal: 5.194 ± 0.487
1.544GlyTrp: 1.544 ± 0.285
2.597GlyTyr: 2.597 ± 0.388
0.0GlyXaa: 0.0 ± 0.0
His
1.334HisAla: 1.334 ± 0.313
0.211HisCys: 0.211 ± 0.115
0.842HisAsp: 0.842 ± 0.242
0.912HisGlu: 0.912 ± 0.295
0.912HisPhe: 0.912 ± 0.295
1.474HisGly: 1.474 ± 0.354
0.281HisHis: 0.281 ± 0.145
1.193HisIle: 1.193 ± 0.274
0.772HisLys: 0.772 ± 0.226
1.825HisLeu: 1.825 ± 0.331
0.561HisMet: 0.561 ± 0.221
0.912HisAsn: 0.912 ± 0.247
0.702HisPro: 0.702 ± 0.263
0.491HisGln: 0.491 ± 0.184
0.983HisArg: 0.983 ± 0.249
1.053HisSer: 1.053 ± 0.315
0.912HisThr: 0.912 ± 0.25
0.983HisVal: 0.983 ± 0.226
0.07HisTrp: 0.07 ± 0.073
1.053HisTyr: 1.053 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
4.913IleAla: 4.913 ± 0.595
1.193IleCys: 1.193 ± 0.281
2.667IleAsp: 2.667 ± 0.463
3.86IleGlu: 3.86 ± 0.663
1.614IlePhe: 1.614 ± 0.353
3.299IleGly: 3.299 ± 0.53
0.702IleHis: 0.702 ± 0.228
3.72IleIle: 3.72 ± 0.644
3.299IleLys: 3.299 ± 0.613
3.79IleLeu: 3.79 ± 0.527
0.772IleMet: 0.772 ± 0.235
2.807IleAsn: 2.807 ± 0.422
2.316IlePro: 2.316 ± 0.393
2.035IleGln: 2.035 ± 0.344
3.088IleArg: 3.088 ± 0.487
4.492IleSer: 4.492 ± 0.522
4.492IleThr: 4.492 ± 0.715
3.72IleVal: 3.72 ± 0.566
0.491IleTrp: 0.491 ± 0.265
1.123IleTyr: 1.123 ± 0.368
0.0IleXaa: 0.0 ± 0.0
Lys
5.334LysAla: 5.334 ± 0.735
0.632LysCys: 0.632 ± 0.292
2.878LysAsp: 2.878 ± 0.467
3.579LysGlu: 3.579 ± 0.617
1.334LysPhe: 1.334 ± 0.3
4.141LysGly: 4.141 ± 0.571
1.193LysHis: 1.193 ± 0.274
2.246LysIle: 2.246 ± 0.482
3.65LysLys: 3.65 ± 0.505
4.001LysLeu: 4.001 ± 0.667
1.965LysMet: 1.965 ± 0.385
2.527LysAsn: 2.527 ± 0.508
2.176LysPro: 2.176 ± 0.425
2.386LysGln: 2.386 ± 0.366
3.65LysArg: 3.65 ± 0.51
2.878LysSer: 2.878 ± 0.373
3.72LysThr: 3.72 ± 0.586
3.088LysVal: 3.088 ± 0.533
1.404LysTrp: 1.404 ± 0.29
1.684LysTyr: 1.684 ± 0.337
0.0LysXaa: 0.0 ± 0.0
Leu
9.405LeuAla: 9.405 ± 0.883
1.193LeuCys: 1.193 ± 0.282
4.632LeuAsp: 4.632 ± 0.537
3.79LeuGlu: 3.79 ± 0.44
3.299LeuPhe: 3.299 ± 0.563
4.632LeuGly: 4.632 ± 0.494
1.684LeuHis: 1.684 ± 0.388
4.001LeuIle: 4.001 ± 0.611
5.825LeuLys: 5.825 ± 0.65
7.51LeuLeu: 7.51 ± 0.92
2.386LeuMet: 2.386 ± 0.504
3.65LeuAsn: 3.65 ± 0.523
3.79LeuPro: 3.79 ± 0.486
3.509LeuGln: 3.509 ± 0.496
4.843LeuArg: 4.843 ± 0.546
6.878LeuSer: 6.878 ± 0.831
5.545LeuThr: 5.545 ± 0.688
4.492LeuVal: 4.492 ± 0.553
1.755LeuTrp: 1.755 ± 0.429
1.825LeuTyr: 1.825 ± 0.286
0.0LeuXaa: 0.0 ± 0.0
Met
3.299MetAla: 3.299 ± 0.506
0.281MetCys: 0.281 ± 0.134
1.684MetAsp: 1.684 ± 0.4
0.842MetGlu: 0.842 ± 0.327
1.123MetPhe: 1.123 ± 0.268
1.474MetGly: 1.474 ± 0.31
0.561MetHis: 0.561 ± 0.198
1.263MetIle: 1.263 ± 0.313
1.755MetLys: 1.755 ± 0.376
3.158MetLeu: 3.158 ± 0.476
0.702MetMet: 0.702 ± 0.232
1.193MetAsn: 1.193 ± 0.244
1.614MetPro: 1.614 ± 0.385
1.193MetGln: 1.193 ± 0.286
1.755MetArg: 1.755 ± 0.321
1.474MetSer: 1.474 ± 0.318
3.018MetThr: 3.018 ± 0.539
2.316MetVal: 2.316 ± 0.401
0.351MetTrp: 0.351 ± 0.146
0.421MetTyr: 0.421 ± 0.185
0.0MetXaa: 0.0 ± 0.0
Asn
4.141AsnAla: 4.141 ± 0.643
0.772AsnCys: 0.772 ± 0.242
1.825AsnAsp: 1.825 ± 0.289
2.597AsnGlu: 2.597 ± 0.4
1.474AsnPhe: 1.474 ± 0.376
3.369AsnGly: 3.369 ± 0.546
0.912AsnHis: 0.912 ± 0.256
2.246AsnIle: 2.246 ± 0.459
2.316AsnLys: 2.316 ± 0.46
2.527AsnLeu: 2.527 ± 0.433
1.053AsnMet: 1.053 ± 0.237
2.176AsnAsn: 2.176 ± 0.463
1.895AsnPro: 1.895 ± 0.327
1.263AsnGln: 1.263 ± 0.299
2.737AsnArg: 2.737 ± 0.627
2.176AsnSer: 2.176 ± 0.409
2.807AsnThr: 2.807 ± 0.392
2.456AsnVal: 2.456 ± 0.403
0.491AsnTrp: 0.491 ± 0.157
1.544AsnTyr: 1.544 ± 0.377
0.0AsnXaa: 0.0 ± 0.0
Pro
3.439ProAla: 3.439 ± 0.515
0.351ProCys: 0.351 ± 0.147
3.509ProAsp: 3.509 ± 0.519
2.667ProGlu: 2.667 ± 0.548
1.684ProPhe: 1.684 ± 0.326
2.948ProGly: 2.948 ± 0.41
0.772ProHis: 0.772 ± 0.226
1.474ProIle: 1.474 ± 0.348
1.474ProLys: 1.474 ± 0.376
2.456ProLeu: 2.456 ± 0.389
0.561ProMet: 0.561 ± 0.163
1.614ProAsn: 1.614 ± 0.337
1.404ProPro: 1.404 ± 0.396
1.474ProGln: 1.474 ± 0.267
1.895ProArg: 1.895 ± 0.409
2.456ProSer: 2.456 ± 0.458
2.456ProThr: 2.456 ± 0.481
3.65ProVal: 3.65 ± 0.53
0.702ProTrp: 0.702 ± 0.247
0.772ProTyr: 0.772 ± 0.24
0.0ProXaa: 0.0 ± 0.0
Gln
4.071GlnAla: 4.071 ± 0.857
0.561GlnCys: 0.561 ± 0.204
1.334GlnAsp: 1.334 ± 0.317
3.018GlnGlu: 3.018 ± 0.473
1.193GlnPhe: 1.193 ± 0.339
2.456GlnGly: 2.456 ± 0.382
0.702GlnHis: 0.702 ± 0.256
2.527GlnIle: 2.527 ± 0.504
2.106GlnLys: 2.106 ± 0.352
3.439GlnLeu: 3.439 ± 0.431
1.474GlnMet: 1.474 ± 0.357
2.106GlnAsn: 2.106 ± 0.347
1.263GlnPro: 1.263 ± 0.288
2.597GlnGln: 2.597 ± 0.503
3.158GlnArg: 3.158 ± 0.421
2.948GlnSer: 2.948 ± 0.423
2.456GlnThr: 2.456 ± 0.482
2.878GlnVal: 2.878 ± 0.511
0.561GlnTrp: 0.561 ± 0.234
1.123GlnTyr: 1.123 ± 0.242
0.0GlnXaa: 0.0 ± 0.0
Arg
4.773ArgAla: 4.773 ± 0.617
0.561ArgCys: 0.561 ± 0.195
3.439ArgAsp: 3.439 ± 0.563
4.562ArgGlu: 4.562 ± 0.553
2.737ArgPhe: 2.737 ± 0.441
3.65ArgGly: 3.65 ± 0.638
1.544ArgHis: 1.544 ± 0.334
3.72ArgIle: 3.72 ± 0.614
3.509ArgLys: 3.509 ± 0.566
5.966ArgLeu: 5.966 ± 0.749
2.597ArgMet: 2.597 ± 0.437
2.737ArgAsn: 2.737 ± 0.586
1.825ArgPro: 1.825 ± 0.339
3.579ArgGln: 3.579 ± 0.505
5.685ArgArg: 5.685 ± 1.031
2.737ArgSer: 2.737 ± 0.465
2.807ArgThr: 2.807 ± 0.457
3.369ArgVal: 3.369 ± 0.574
1.193ArgTrp: 1.193 ± 0.306
2.035ArgTyr: 2.035 ± 0.385
0.0ArgXaa: 0.0 ± 0.0
Ser
6.597SerAla: 6.597 ± 0.675
0.702SerCys: 0.702 ± 0.245
3.509SerAsp: 3.509 ± 0.454
4.492SerGlu: 4.492 ± 0.55
2.456SerPhe: 2.456 ± 0.398
6.387SerGly: 6.387 ± 0.798
1.263SerHis: 1.263 ± 0.276
3.299SerIle: 3.299 ± 0.463
2.527SerLys: 2.527 ± 0.441
4.702SerLeu: 4.702 ± 0.611
2.246SerMet: 2.246 ± 0.357
1.544SerAsn: 1.544 ± 0.331
2.456SerPro: 2.456 ± 0.415
2.878SerGln: 2.878 ± 0.335
4.211SerArg: 4.211 ± 0.594
3.158SerSer: 3.158 ± 0.416
3.79SerThr: 3.79 ± 0.439
5.545SerVal: 5.545 ± 0.476
0.912SerTrp: 0.912 ± 0.249
2.176SerTyr: 2.176 ± 0.412
0.0SerXaa: 0.0 ± 0.0
Thr
6.597ThrAla: 6.597 ± 0.847
0.702ThrCys: 0.702 ± 0.252
3.439ThrAsp: 3.439 ± 0.414
4.422ThrGlu: 4.422 ± 0.44
2.878ThrPhe: 2.878 ± 0.423
4.702ThrGly: 4.702 ± 0.637
1.053ThrHis: 1.053 ± 0.254
2.948ThrIle: 2.948 ± 0.539
2.737ThrLys: 2.737 ± 0.508
6.246ThrLeu: 6.246 ± 0.653
1.404ThrMet: 1.404 ± 0.326
1.684ThrAsn: 1.684 ± 0.486
3.579ThrPro: 3.579 ± 0.699
2.176ThrGln: 2.176 ± 0.406
3.018ThrArg: 3.018 ± 0.395
3.93ThrSer: 3.93 ± 0.51
3.579ThrThr: 3.579 ± 0.592
4.632ThrVal: 4.632 ± 0.823
0.983ThrTrp: 0.983 ± 0.263
2.246ThrTyr: 2.246 ± 0.388
0.0ThrXaa: 0.0 ± 0.0
Val
5.825ValAla: 5.825 ± 0.736
0.912ValCys: 0.912 ± 0.264
3.65ValAsp: 3.65 ± 0.476
2.948ValGlu: 2.948 ± 0.462
3.018ValPhe: 3.018 ± 0.411
3.86ValGly: 3.86 ± 0.478
0.772ValHis: 0.772 ± 0.207
3.229ValIle: 3.229 ± 0.484
4.141ValLys: 4.141 ± 0.535
5.825ValLeu: 5.825 ± 0.701
1.965ValMet: 1.965 ± 0.415
3.65ValAsn: 3.65 ± 0.484
2.246ValPro: 2.246 ± 0.447
2.316ValGln: 2.316 ± 0.512
3.229ValArg: 3.229 ± 0.433
5.545ValSer: 5.545 ± 0.686
5.545ValThr: 5.545 ± 0.661
5.404ValVal: 5.404 ± 0.531
1.263ValTrp: 1.263 ± 0.288
2.035ValTyr: 2.035 ± 0.395
0.0ValXaa: 0.0 ± 0.0
Trp
1.544TrpAla: 1.544 ± 0.3
0.421TrpCys: 0.421 ± 0.161
0.912TrpAsp: 0.912 ± 0.302
0.702TrpGlu: 0.702 ± 0.202
0.561TrpPhe: 0.561 ± 0.182
0.912TrpGly: 0.912 ± 0.244
0.421TrpHis: 0.421 ± 0.186
1.053TrpIle: 1.053 ± 0.305
0.702TrpLys: 0.702 ± 0.271
2.106TrpLeu: 2.106 ± 0.491
0.772TrpMet: 0.772 ± 0.208
0.351TrpAsn: 0.351 ± 0.137
0.702TrpPro: 0.702 ± 0.227
0.772TrpGln: 0.772 ± 0.248
0.983TrpArg: 0.983 ± 0.244
1.123TrpSer: 1.123 ± 0.202
1.193TrpThr: 1.193 ± 0.301
1.263TrpVal: 1.263 ± 0.295
0.281TrpTrp: 0.281 ± 0.173
0.772TrpTyr: 0.772 ± 0.215
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.597TyrAla: 2.597 ± 0.43
0.421TyrCys: 0.421 ± 0.167
1.614TyrAsp: 1.614 ± 0.266
1.614TyrGlu: 1.614 ± 0.329
1.684TyrPhe: 1.684 ± 0.403
2.035TyrGly: 2.035 ± 0.307
0.491TyrHis: 0.491 ± 0.184
1.544TyrIle: 1.544 ± 0.365
1.263TyrLys: 1.263 ± 0.326
2.948TyrLeu: 2.948 ± 0.502
0.702TyrMet: 0.702 ± 0.265
0.772TyrAsn: 0.772 ± 0.228
1.123TyrPro: 1.123 ± 0.301
1.544TyrGln: 1.544 ± 0.32
2.176TyrArg: 2.176 ± 0.412
2.597TyrSer: 2.597 ± 0.436
1.544TyrThr: 1.544 ± 0.294
1.544TyrVal: 1.544 ± 0.399
0.491TyrTrp: 0.491 ± 0.181
0.842TyrTyr: 0.842 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (14249 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski