Amino acid dipepetide frequency for Bacteroides sp. CAG:545

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.839AlaAla: 7.839 ± 0.14	1.036AlaCys: 1.036 ± 0.039	5.156AlaAsp: 5.156 ± 0.08	5.61AlaGlu: 5.61 ± 0.105	3.278AlaPhe: 3.278 ± 0.064	6.404AlaGly: 6.404 ± 0.1	1.231AlaHis: 1.231 ± 0.039	4.453AlaIle: 4.453 ± 0.091	4.597AlaLys: 4.597 ± 0.087	7.38AlaLeu: 7.38 ± 0.117	2.026AlaMet: 2.026 ± 0.055	2.986AlaAsn: 2.986 ± 0.069	2.727AlaPro: 2.727 ± 0.062	2.408AlaGln: 2.408 ± 0.058	3.24AlaArg: 3.24 ± 0.065	5.625AlaSer: 5.625 ± 0.098	3.908AlaThr: 3.908 ± 0.084	6.096AlaVal: 6.096 ± 0.085	0.819AlaTrp: 0.819 ± 0.033	2.785AlaTyr: 2.785 ± 0.068	0.001AlaXaa: 0.001 ± 0.001
Cys	0.93CysAla: 0.93 ± 0.035	0.226CysCys: 0.226 ± 0.019	0.848CysAsp: 0.848 ± 0.034	0.727CysGlu: 0.727 ± 0.033	0.561CysPhe: 0.561 ± 0.026	1.307CysGly: 1.307 ± 0.047	0.298CysHis: 0.298 ± 0.024	0.818CysIle: 0.818 ± 0.037	0.769CysLys: 0.769 ± 0.034	1.037CysLeu: 1.037 ± 0.039	0.263CysMet: 0.263 ± 0.018	0.562CysAsn: 0.562 ± 0.03	0.638CysPro: 0.638 ± 0.032	0.352CysGln: 0.352 ± 0.021	0.811CysArg: 0.811 ± 0.04	1.026CysSer: 1.026 ± 0.038	0.753CysThr: 0.753 ± 0.032	0.794CysVal: 0.794 ± 0.029	0.179CysTrp: 0.179 ± 0.014	0.53CysTyr: 0.53 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.771AspAla: 4.771 ± 0.081	0.821AspCys: 0.821 ± 0.032	3.096AspAsp: 3.096 ± 0.08	3.991AspGlu: 3.991 ± 0.074	3.136AspPhe: 3.136 ± 0.06	5.457AspGly: 5.457 ± 0.099	0.827AspHis: 0.827 ± 0.033	4.361AspIle: 4.361 ± 0.076	4.264AspLys: 4.264 ± 0.078	4.683AspLeu: 4.683 ± 0.083	1.787AspMet: 1.787 ± 0.047	3.056AspAsn: 3.056 ± 0.058	2.22AspPro: 2.22 ± 0.053	1.147AspGln: 1.147 ± 0.037	2.74AspArg: 2.74 ± 0.063	3.917AspSer: 3.917 ± 0.092	2.774AspThr: 2.774 ± 0.066	4.174AspVal: 4.174 ± 0.084	0.939AspTrp: 0.939 ± 0.035	2.933AspTyr: 2.933 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.91GluAla: 4.91 ± 0.098	0.708GluCys: 0.708 ± 0.035	3.667GluAsp: 3.667 ± 0.074	4.154GluGlu: 4.154 ± 0.098	2.74GluPhe: 2.74 ± 0.073	4.383GluGly: 4.383 ± 0.081	1.106GluHis: 1.106 ± 0.037	4.271GluIle: 4.271 ± 0.078	4.9GluLys: 4.9 ± 0.1	5.411GluLeu: 5.411 ± 0.095	1.863GluMet: 1.863 ± 0.049	3.35GluAsn: 3.35 ± 0.066	2.049GluPro: 2.049 ± 0.058	1.906GluGln: 1.906 ± 0.047	2.937GluArg: 2.937 ± 0.071	3.764GluSer: 3.764 ± 0.066	3.393GluThr: 3.393 ± 0.069	3.984GluVal: 3.984 ± 0.07	0.798GluTrp: 0.798 ± 0.026	2.648GluTyr: 2.648 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.45PheAla: 3.45 ± 0.072	0.692PheCys: 0.692 ± 0.027	2.896PheAsp: 2.896 ± 0.057	2.382PheGlu: 2.382 ± 0.078	1.859PhePhe: 1.859 ± 0.052	3.489PheGly: 3.489 ± 0.079	0.726PheHis: 0.726 ± 0.027	2.758PheIle: 2.758 ± 0.062	2.298PheLys: 2.298 ± 0.06	3.369PheLeu: 3.369 ± 0.077	1.141PheMet: 1.141 ± 0.036	2.174PheAsn: 2.174 ± 0.061	1.669PhePro: 1.669 ± 0.049	1.056PheGln: 1.056 ± 0.035	2.414PheArg: 2.414 ± 0.057	3.74PheSer: 3.74 ± 0.073	2.728PheThr: 2.728 ± 0.057	2.984PheVal: 2.984 ± 0.071	0.596PheTrp: 0.596 ± 0.028	1.797PheTyr: 1.797 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.264GlyAla: 5.264 ± 0.098	1.049GlyCys: 1.049 ± 0.036	4.063GlyAsp: 4.063 ± 0.074	4.577GlyGlu: 4.577 ± 0.078	3.325GlyPhe: 3.325 ± 0.065	5.285GlyGly: 5.285 ± 0.101	1.365GlyHis: 1.365 ± 0.043	5.083GlyIle: 5.083 ± 0.09	5.809GlyLys: 5.809 ± 0.084	5.952GlyLeu: 5.952 ± 0.094	1.963GlyMet: 1.963 ± 0.053	3.667GlyAsn: 3.667 ± 0.074	1.62GlyPro: 1.62 ± 0.046	2.116GlyGln: 2.116 ± 0.056	3.384GlyArg: 3.384 ± 0.067	4.926GlySer: 4.926 ± 0.107	4.64GlyThr: 4.64 ± 0.094	5.256GlyVal: 5.256 ± 0.086	1.163GlyTrp: 1.163 ± 0.039	3.476GlyTyr: 3.476 ± 0.077	0.001GlyXaa: 0.001 ± 0.001
His	0.931HisAla: 0.931 ± 0.037	0.314HisCys: 0.314 ± 0.021	0.906HisAsp: 0.906 ± 0.036	0.854HisGlu: 0.854 ± 0.042	0.899HisPhe: 0.899 ± 0.034	1.209HisGly: 1.209 ± 0.045	0.408HisHis: 0.408 ± 0.031	1.316HisIle: 1.316 ± 0.043	0.98HisLys: 0.98 ± 0.035	1.517HisLeu: 1.517 ± 0.048	0.26HisMet: 0.26 ± 0.019	0.862HisAsn: 0.862 ± 0.032	0.88HisPro: 0.88 ± 0.038	0.404HisGln: 0.404 ± 0.023	0.828HisArg: 0.828 ± 0.033	1.042HisSer: 1.042 ± 0.041	0.887HisThr: 0.887 ± 0.031	0.925HisVal: 0.925 ± 0.037	0.199HisTrp: 0.199 ± 0.016	0.833HisTyr: 0.833 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.088IleAla: 5.088 ± 0.101	0.974IleCys: 0.974 ± 0.04	4.677IleAsp: 4.677 ± 0.081	3.704IleGlu: 3.704 ± 0.078	2.571IlePhe: 2.571 ± 0.059	4.372IleGly: 4.372 ± 0.09	0.968IleHis: 0.968 ± 0.036	3.74IleIle: 3.74 ± 0.084	3.304IleLys: 3.304 ± 0.074	5.267IleLeu: 5.267 ± 0.097	1.497IleMet: 1.497 ± 0.043	2.601IleAsn: 2.601 ± 0.065	2.968IlePro: 2.968 ± 0.061	1.549IleGln: 1.549 ± 0.053	3.167IleArg: 3.167 ± 0.069	4.994IleSer: 4.994 ± 0.088	3.606IleThr: 3.606 ± 0.07	4.43IleVal: 4.43 ± 0.073	0.676IleTrp: 0.676 ± 0.033	2.397IleTyr: 2.397 ± 0.065	0.001IleXaa: 0.001 ± 0.001
Lys	5.34LysAla: 5.34 ± 0.1	0.653LysCys: 0.653 ± 0.03	4.063LysAsp: 4.063 ± 0.075	4.592LysGlu: 4.592 ± 0.088	2.623LysPhe: 2.623 ± 0.054	4.364LysGly: 4.364 ± 0.081	0.946LysHis: 0.946 ± 0.035	4.037LysIle: 4.037 ± 0.085	4.304LysLys: 4.304 ± 0.088	4.842LysLeu: 4.842 ± 0.081	2.137LysMet: 2.137 ± 0.046	3.246LysAsn: 3.246 ± 0.069	2.25LysPro: 2.25 ± 0.051	1.628LysGln: 1.628 ± 0.043	2.655LysArg: 2.655 ± 0.06	4.052LysSer: 4.052 ± 0.077	3.674LysThr: 3.674 ± 0.072	4.729LysVal: 4.729 ± 0.082	0.862LysTrp: 0.862 ± 0.034	2.97LysTyr: 2.97 ± 0.073	0.0LysXaa: 0.0 ± 0.0
Leu	6.661LeuAla: 6.661 ± 0.106	1.288LeuCys: 1.288 ± 0.046	5.029LeuAsp: 5.029 ± 0.08	4.889LeuGlu: 4.889 ± 0.087	3.61LeuPhe: 3.61 ± 0.074	5.686LeuGly: 5.686 ± 0.102	1.399LeuHis: 1.399 ± 0.048	4.449LeuIle: 4.449 ± 0.103	5.964LeuLys: 5.964 ± 0.08	6.808LeuLeu: 6.808 ± 0.125	2.445LeuMet: 2.445 ± 0.058	3.871LeuAsn: 3.871 ± 0.08	3.622LeuPro: 3.622 ± 0.072	2.413LeuGln: 2.413 ± 0.064	4.005LeuArg: 4.005 ± 0.07	7.095LeuSer: 7.095 ± 0.114	5.413LeuThr: 5.413 ± 0.084	5.243LeuVal: 5.243 ± 0.078	0.905LeuTrp: 0.905 ± 0.037	3.196LeuTyr: 3.196 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.224MetAla: 2.224 ± 0.05	0.257MetCys: 0.257 ± 0.018	1.538MetAsp: 1.538 ± 0.039	1.669MetGlu: 1.669 ± 0.044	1.098MetPhe: 1.098 ± 0.039	1.578MetGly: 1.578 ± 0.045	0.394MetHis: 0.394 ± 0.019	1.523MetIle: 1.523 ± 0.042	2.269MetLys: 2.269 ± 0.048	2.494MetLeu: 2.494 ± 0.061	0.843MetMet: 0.843 ± 0.031	1.481MetAsn: 1.481 ± 0.044	1.232MetPro: 1.232 ± 0.04	0.724MetGln: 0.724 ± 0.028	1.323MetArg: 1.323 ± 0.043	2.064MetSer: 2.064 ± 0.05	1.739MetThr: 1.739 ± 0.041	1.646MetVal: 1.646 ± 0.047	0.262MetTrp: 0.262 ± 0.018	0.866MetTyr: 0.866 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	4.044AsnAla: 4.044 ± 0.081	0.571AsnCys: 0.571 ± 0.03	2.644AsnAsp: 2.644 ± 0.054	2.534AsnGlu: 2.534 ± 0.059	1.957AsnPhe: 1.957 ± 0.055	3.844AsnGly: 3.844 ± 0.078	0.724AsnHis: 0.724 ± 0.028	3.356AsnIle: 3.356 ± 0.062	2.425AsnLys: 2.425 ± 0.057	3.678AsnLeu: 3.678 ± 0.067	1.204AsnMet: 1.204 ± 0.039	1.958AsnAsn: 1.958 ± 0.055	2.313AsnPro: 2.313 ± 0.06	1.119AsnGln: 1.119 ± 0.036	1.921AsnArg: 1.921 ± 0.054	2.889AsnSer: 2.889 ± 0.072	2.509AsnThr: 2.509 ± 0.058	3.796AsnVal: 3.796 ± 0.076	0.666AsnTrp: 0.666 ± 0.032	2.105AsnTyr: 2.105 ± 0.051	0.002AsnXaa: 0.002 ± 0.002
Pro	3.3ProAla: 3.3 ± 0.077	0.4ProCys: 0.4 ± 0.024	3.047ProAsp: 3.047 ± 0.06	3.856ProGlu: 3.856 ± 0.075	1.734ProPhe: 1.734 ± 0.049	2.796ProGly: 2.796 ± 0.059	0.571ProHis: 0.571 ± 0.027	1.892ProIle: 1.892 ± 0.048	1.963ProLys: 1.963 ± 0.053	2.911ProLeu: 2.911 ± 0.063	0.946ProMet: 0.946 ± 0.033	1.32ProAsn: 1.32 ± 0.043	0.676ProPro: 0.676 ± 0.03	1.273ProGln: 1.273 ± 0.041	1.26ProArg: 1.26 ± 0.04	2.894ProSer: 2.894 ± 0.06	1.661ProThr: 1.661 ± 0.048	3.419ProVal: 3.419 ± 0.068	0.475ProTrp: 0.475 ± 0.026	1.716ProTyr: 1.716 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.068GlnAla: 2.068 ± 0.059	0.325GlnCys: 0.325 ± 0.021	1.524GlnAsp: 1.524 ± 0.044	1.745GlnGlu: 1.745 ± 0.05	1.153GlnPhe: 1.153 ± 0.038	1.68GlnGly: 1.68 ± 0.048	0.444GlnHis: 0.444 ± 0.024	1.954GlnIle: 1.954 ± 0.045	2.005GlnLys: 2.005 ± 0.052	2.114GlnLeu: 2.114 ± 0.052	0.983GlnMet: 0.983 ± 0.035	1.436GlnAsn: 1.436 ± 0.051	1.009GlnPro: 1.009 ± 0.043	0.925GlnGln: 0.925 ± 0.041	1.156GlnArg: 1.156 ± 0.042	1.734GlnSer: 1.734 ± 0.044	1.644GlnThr: 1.644 ± 0.052	1.81GlnVal: 1.81 ± 0.049	0.4GlnTrp: 0.4 ± 0.023	1.242GlnTyr: 1.242 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	3.093ArgAla: 3.093 ± 0.063	0.572ArgCys: 0.572 ± 0.025	2.488ArgAsp: 2.488 ± 0.06	2.81ArgGlu: 2.81 ± 0.064	2.174ArgPhe: 2.174 ± 0.056	2.751ArgGly: 2.751 ± 0.062	0.989ArgHis: 0.989 ± 0.034	3.35ArgIle: 3.35 ± 0.075	3.434ArgLys: 3.434 ± 0.071	4.231ArgLeu: 4.231 ± 0.074	1.423ArgMet: 1.423 ± 0.045	2.34ArgAsn: 2.34 ± 0.056	1.675ArgPro: 1.675 ± 0.051	1.575ArgGln: 1.575 ± 0.047	2.429ArgArg: 2.429 ± 0.059	2.749ArgSer: 2.749 ± 0.057	2.671ArgThr: 2.671 ± 0.061	2.674ArgVal: 2.674 ± 0.055	0.651ArgTrp: 0.651 ± 0.028	2.185ArgTyr: 2.185 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.885SerAla: 5.885 ± 0.105	1.137SerCys: 1.137 ± 0.038	4.404SerAsp: 4.404 ± 0.077	4.327SerGlu: 4.327 ± 0.089	3.366SerPhe: 3.366 ± 0.06	6.099SerGly: 6.099 ± 0.102	1.187SerHis: 1.187 ± 0.036	4.284SerIle: 4.284 ± 0.083	3.696SerLys: 3.696 ± 0.068	6.362SerLeu: 6.362 ± 0.115	1.942SerMet: 1.942 ± 0.045	2.483SerAsn: 2.483 ± 0.07	2.653SerPro: 2.653 ± 0.062	1.954SerGln: 1.954 ± 0.046	3.395SerArg: 3.395 ± 0.069	5.468SerSer: 5.468 ± 0.111	3.424SerThr: 3.424 ± 0.078	5.329SerVal: 5.329 ± 0.086	0.952SerTrp: 0.952 ± 0.036	3.081SerTyr: 3.081 ± 0.07	0.001SerXaa: 0.001 ± 0.001
Thr	4.471ThrAla: 4.471 ± 0.088	0.578ThrCys: 0.578 ± 0.028	3.691ThrAsp: 3.691 ± 0.064	3.345ThrGlu: 3.345 ± 0.071	2.659ThrPhe: 2.659 ± 0.063	4.879ThrGly: 4.879 ± 0.094	0.85ThrHis: 0.85 ± 0.03	3.424ThrIle: 3.424 ± 0.067	2.823ThrLys: 2.823 ± 0.059	5.261ThrLeu: 5.261 ± 0.087	1.304ThrMet: 1.304 ± 0.036	2.073ThrAsn: 2.073 ± 0.054	2.695ThrPro: 2.695 ± 0.06	1.361ThrGln: 1.361 ± 0.037	2.237ThrArg: 2.237 ± 0.048	3.685ThrSer: 3.685 ± 0.074	3.01ThrThr: 3.01 ± 0.084	4.585ThrVal: 4.585 ± 0.09	0.763ThrTrp: 0.763 ± 0.033	2.305ThrTyr: 2.305 ± 0.059	0.001ThrXaa: 0.001 ± 0.001
Val	5.465ValAla: 5.465 ± 0.095	0.98ValCys: 0.98 ± 0.037	3.795ValAsp: 3.795 ± 0.067	4.104ValGlu: 4.104 ± 0.078	2.906ValPhe: 2.906 ± 0.079	4.2ValGly: 4.2 ± 0.095	1.027ValHis: 1.027 ± 0.032	4.348ValIle: 4.348 ± 0.07	4.75ValLys: 4.75 ± 0.085	6.096ValLeu: 6.096 ± 0.089	1.749ValMet: 1.749 ± 0.047	3.877ValAsn: 3.877 ± 0.073	3.057ValPro: 3.057 ± 0.071	1.852ValGln: 1.852 ± 0.047	3.618ValArg: 3.618 ± 0.065	5.643ValSer: 5.643 ± 0.095	4.43ValThr: 4.43 ± 0.086	4.792ValVal: 4.792 ± 0.094	0.784ValTrp: 0.784 ± 0.036	2.593ValTyr: 2.593 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.838TrpAla: 0.838 ± 0.035	0.229TrpCys: 0.229 ± 0.017	0.731TrpAsp: 0.731 ± 0.029	0.698TrpGlu: 0.698 ± 0.032	0.635TrpPhe: 0.635 ± 0.031	0.946TrpGly: 0.946 ± 0.037	0.257TrpHis: 0.257 ± 0.018	0.644TrpIle: 0.644 ± 0.034	0.969TrpLys: 0.969 ± 0.039	1.142TrpLeu: 1.142 ± 0.041	0.358TrpMet: 0.358 ± 0.019	0.821TrpAsn: 0.821 ± 0.031	0.368TrpPro: 0.368 ± 0.022	0.47TrpGln: 0.47 ± 0.025	0.561TrpArg: 0.561 ± 0.029	0.889TrpSer: 0.889 ± 0.034	0.819TrpThr: 0.819 ± 0.036	0.643TrpVal: 0.643 ± 0.034	0.248TrpTrp: 0.248 ± 0.02	0.611TrpTyr: 0.611 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.037TyrAla: 3.037 ± 0.064	0.617TyrCys: 0.617 ± 0.028	2.833TyrAsp: 2.833 ± 0.059	2.373TyrGlu: 2.373 ± 0.055	1.933TyrPhe: 1.933 ± 0.056	3.253TyrGly: 3.253 ± 0.079	0.737TyrHis: 0.737 ± 0.032	2.488TyrIle: 2.488 ± 0.051	2.44TyrLys: 2.44 ± 0.059	3.434TyrLeu: 3.434 ± 0.066	1.09TyrMet: 1.09 ± 0.035	2.095TyrAsn: 2.095 ± 0.058	1.791TyrPro: 1.791 ± 0.046	1.12TyrGln: 1.12 ± 0.041	2.183TyrArg: 2.183 ± 0.057	3.235TyrSer: 3.235 ± 0.071	2.315TyrThr: 2.315 ± 0.062	2.758TyrVal: 2.758 ± 0.064	0.539TyrTrp: 0.539 ± 0.026	1.904TyrTyr: 1.904 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.002XaaMet: 0.002 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.006

Statistics based on 2183 proteins (809031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---