Amino acid dipepetide frequency for Babesia bigemina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.008AlaAla: 8.008 ± 0.093	1.402AlaCys: 1.402 ± 0.028	4.419AlaAsp: 4.419 ± 0.05	5.034AlaGlu: 5.034 ± 0.066	3.001AlaPhe: 3.001 ± 0.036	4.274AlaGly: 4.274 ± 0.056	1.78AlaHis: 1.78 ± 0.029	4.043AlaIle: 4.043 ± 0.049	4.343AlaLys: 4.343 ± 0.055	7.699AlaLeu: 7.699 ± 0.071	1.904AlaMet: 1.904 ± 0.032	3.069AlaAsn: 3.069 ± 0.038	3.818AlaPro: 3.818 ± 0.053	2.665AlaGln: 2.665 ± 0.047	3.817AlaArg: 3.817 ± 0.047	6.29AlaSer: 6.29 ± 0.078	4.675AlaThr: 4.675 ± 0.057	5.65AlaVal: 5.65 ± 0.058	0.566AlaTrp: 0.566 ± 0.018	2.286AlaTyr: 2.286 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.61CysAla: 1.61 ± 0.026	0.619CysCys: 0.619 ± 0.022	1.298CysAsp: 1.298 ± 0.024	1.117CysGlu: 1.117 ± 0.028	0.793CysPhe: 0.793 ± 0.02	1.568CysGly: 1.568 ± 0.028	0.628CysHis: 0.628 ± 0.017	1.182CysIle: 1.182 ± 0.025	1.297CysLys: 1.297 ± 0.029	1.966CysLeu: 1.966 ± 0.036	0.505CysMet: 0.505 ± 0.017	1.028CysAsn: 1.028 ± 0.026	0.892CysPro: 0.892 ± 0.023	0.707CysGln: 0.707 ± 0.019	1.376CysArg: 1.376 ± 0.023	1.74CysSer: 1.74 ± 0.035	1.111CysThr: 1.111 ± 0.022	1.533CysVal: 1.533 ± 0.031	0.202CysTrp: 0.202 ± 0.01	0.651CysTyr: 0.651 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	5.444AspAla: 5.444 ± 0.057	1.15AspCys: 1.15 ± 0.022	4.482AspAsp: 4.482 ± 0.076	4.452AspGlu: 4.452 ± 0.064	2.243AspPhe: 2.243 ± 0.035	4.098AspGly: 4.098 ± 0.048	1.288AspHis: 1.288 ± 0.026	3.458AspIle: 3.458 ± 0.046	2.923AspLys: 2.923 ± 0.042	4.924AspLeu: 4.924 ± 0.051	1.451AspMet: 1.451 ± 0.027	2.26AspAsn: 2.26 ± 0.037	2.746AspPro: 2.746 ± 0.046	1.5AspGln: 1.5 ± 0.027	2.851AspArg: 2.851 ± 0.038	4.579AspSer: 4.579 ± 0.062	3.076AspThr: 3.076 ± 0.046	4.847AspVal: 4.847 ± 0.05	0.608AspTrp: 0.608 ± 0.015	1.807AspTyr: 1.807 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	5.245GluAla: 5.245 ± 0.059	1.286GluCys: 1.286 ± 0.028	3.766GluAsp: 3.766 ± 0.053	4.761GluGlu: 4.761 ± 0.093	2.188GluPhe: 2.188 ± 0.031	3.51GluGly: 3.51 ± 0.049	1.697GluHis: 1.697 ± 0.031	3.167GluIle: 3.167 ± 0.047	3.579GluLys: 3.579 ± 0.061	5.903GluLeu: 5.903 ± 0.068	1.566GluMet: 1.566 ± 0.029	2.574GluAsn: 2.574 ± 0.03	2.556GluPro: 2.556 ± 0.041	2.38GluGln: 2.38 ± 0.037	3.806GluArg: 3.806 ± 0.062	4.859GluSer: 4.859 ± 0.059	3.237GluThr: 3.237 ± 0.047	4.01GluVal: 4.01 ± 0.052	0.601GluTrp: 0.601 ± 0.017	1.929GluTyr: 1.929 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	2.738PheAla: 2.738 ± 0.038	0.863PheCys: 0.863 ± 0.019	2.557PheAsp: 2.557 ± 0.033	2.25PheGlu: 2.25 ± 0.031	1.334PhePhe: 1.334 ± 0.026	2.423PheGly: 2.423 ± 0.051	0.929PheHis: 0.929 ± 0.02	1.747PheIle: 1.747 ± 0.032	2.169PheLys: 2.169 ± 0.035	3.404PheLeu: 3.404 ± 0.04	0.918PheMet: 0.918 ± 0.02	1.729PheAsn: 1.729 ± 0.028	1.253PhePro: 1.253 ± 0.023	1.085PheGln: 1.085 ± 0.024	2.044PheArg: 2.044 ± 0.032	2.702PheSer: 2.702 ± 0.035	2.08PheThr: 2.08 ± 0.03	2.753PheVal: 2.753 ± 0.038	0.43PheTrp: 0.43 ± 0.014	1.403PheTyr: 1.403 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	4.579GlyAla: 4.579 ± 0.054	1.366GlyCys: 1.366 ± 0.03	3.871GlyAsp: 3.871 ± 0.047	3.574GlyGlu: 3.574 ± 0.048	2.539GlyPhe: 2.539 ± 0.037	4.417GlyGly: 4.417 ± 0.073	1.575GlyHis: 1.575 ± 0.031	3.406GlyIle: 3.406 ± 0.044	3.537GlyLys: 3.537 ± 0.044	4.602GlyLeu: 4.602 ± 0.054	1.418GlyMet: 1.418 ± 0.029	2.588GlyAsn: 2.588 ± 0.037	1.973GlyPro: 1.973 ± 0.038	1.856GlyGln: 1.856 ± 0.037	3.557GlyArg: 3.557 ± 0.039	5.206GlySer: 5.206 ± 0.075	3.401GlyThr: 3.401 ± 0.046	4.199GlyVal: 4.199 ± 0.049	0.657GlyTrp: 0.657 ± 0.015	2.054GlyTyr: 2.054 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.809HisAla: 1.809 ± 0.03	0.618HisCys: 0.618 ± 0.017	1.407HisAsp: 1.407 ± 0.027	1.392HisGlu: 1.392 ± 0.025	1.085HisPhe: 1.085 ± 0.023	1.72HisGly: 1.72 ± 0.034	0.777HisHis: 0.777 ± 0.021	1.508HisIle: 1.508 ± 0.027	1.395HisLys: 1.395 ± 0.032	2.604HisLeu: 2.604 ± 0.036	0.68HisMet: 0.68 ± 0.018	1.107HisAsn: 1.107 ± 0.021	1.312HisPro: 1.312 ± 0.027	0.877HisGln: 0.877 ± 0.031	1.656HisArg: 1.656 ± 0.031	1.881HisSer: 1.881 ± 0.03	1.304HisThr: 1.304 ± 0.023	1.936HisVal: 1.936 ± 0.026	0.274HisTrp: 0.274 ± 0.01	0.935HisTyr: 0.935 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.07IleAla: 4.07 ± 0.047	1.243IleCys: 1.243 ± 0.025	3.164IleAsp: 3.164 ± 0.044	3.094IleGlu: 3.094 ± 0.052	1.852IlePhe: 1.852 ± 0.032	2.869IleGly: 2.869 ± 0.04	1.22IleHis: 1.22 ± 0.024	2.357IleIle: 2.357 ± 0.043	3.087IleLys: 3.087 ± 0.045	4.284IleLeu: 4.284 ± 0.051	1.173IleMet: 1.173 ± 0.024	2.169IleAsn: 2.169 ± 0.036	2.359IlePro: 2.359 ± 0.038	1.736IleGln: 1.736 ± 0.03	3.1IleArg: 3.1 ± 0.047	3.934IleSer: 3.934 ± 0.047	2.92IleThr: 2.92 ± 0.044	3.254IleVal: 3.254 ± 0.04	0.464IleTrp: 0.464 ± 0.016	1.628IleTyr: 1.628 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.432LysAla: 4.432 ± 0.07	1.216LysCys: 1.216 ± 0.028	3.016LysAsp: 3.016 ± 0.047	3.582LysGlu: 3.582 ± 0.048	1.893LysPhe: 1.893 ± 0.03	3.191LysGly: 3.191 ± 0.046	1.693LysHis: 1.693 ± 0.029	2.868LysIle: 2.868 ± 0.051	3.539LysLys: 3.539 ± 0.058	5.462LysLeu: 5.462 ± 0.068	1.354LysMet: 1.354 ± 0.025	2.497LysAsn: 2.497 ± 0.043	2.679LysPro: 2.679 ± 0.05	2.327LysGln: 2.327 ± 0.043	3.788LysArg: 3.788 ± 0.048	4.259LysSer: 4.259 ± 0.056	3.063LysThr: 3.063 ± 0.046	3.643LysVal: 3.643 ± 0.045	0.568LysTrp: 0.568 ± 0.018	1.841LysTyr: 1.841 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	6.136LeuAla: 6.136 ± 0.063	2.313LeuCys: 2.313 ± 0.04	5.138LeuAsp: 5.138 ± 0.053	5.697LeuGlu: 5.697 ± 0.069	3.376LeuPhe: 3.376 ± 0.05	4.969LeuGly: 4.969 ± 0.055	2.715LeuHis: 2.715 ± 0.033	3.909LeuIle: 3.909 ± 0.049	5.912LeuLys: 5.912 ± 0.07	9.253LeuLeu: 9.253 ± 0.093	2.208LeuMet: 2.208 ± 0.03	3.98LeuAsn: 3.98 ± 0.048	4.41LeuPro: 4.41 ± 0.052	4.234LeuGln: 4.234 ± 0.045	6.298LeuArg: 6.298 ± 0.056	7.388LeuSer: 7.388 ± 0.061	4.824LeuThr: 4.824 ± 0.052	5.611LeuVal: 5.611 ± 0.054	0.993LeuTrp: 0.993 ± 0.022	3.33LeuTyr: 3.33 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.014MetAla: 2.014 ± 0.03	0.523MetCys: 0.523 ± 0.016	1.434MetAsp: 1.434 ± 0.026	1.562MetGlu: 1.562 ± 0.029	0.825MetPhe: 0.825 ± 0.021	1.481MetGly: 1.481 ± 0.024	0.654MetHis: 0.654 ± 0.019	1.027MetIle: 1.027 ± 0.024	1.357MetLys: 1.357 ± 0.023	2.664MetLeu: 2.664 ± 0.035	0.639MetMet: 0.639 ± 0.017	0.884MetAsn: 0.884 ± 0.023	1.245MetPro: 1.245 ± 0.029	1.103MetGln: 1.103 ± 0.029	1.659MetArg: 1.659 ± 0.029	1.783MetSer: 1.783 ± 0.029	1.174MetThr: 1.174 ± 0.021	1.456MetVal: 1.456 ± 0.027	0.258MetTrp: 0.258 ± 0.011	0.764MetTyr: 0.764 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.682AsnAla: 3.682 ± 0.042	0.969AsnCys: 0.969 ± 0.021	2.494AsnAsp: 2.494 ± 0.035	2.621AsnGlu: 2.621 ± 0.039	1.548AsnPhe: 1.548 ± 0.03	2.74AsnGly: 2.74 ± 0.039	0.994AsnHis: 0.994 ± 0.031	2.403AsnIle: 2.403 ± 0.035	2.268AsnLys: 2.268 ± 0.042	3.567AsnLeu: 3.567 ± 0.043	1.101AsnMet: 1.101 ± 0.02	1.806AsnAsn: 1.806 ± 0.034	1.912AsnPro: 1.912 ± 0.03	1.367AsnGln: 1.367 ± 0.036	2.315AsnArg: 2.315 ± 0.032	2.916AsnSer: 2.916 ± 0.036	2.403AsnThr: 2.403 ± 0.037	3.478AsnVal: 3.478 ± 0.042	0.414AsnTrp: 0.414 ± 0.014	1.274AsnTyr: 1.274 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	3.574ProAla: 3.574 ± 0.064	0.824ProCys: 0.824 ± 0.019	2.491ProAsp: 2.491 ± 0.041	3.059ProGlu: 3.059 ± 0.045	1.62ProPhe: 1.62 ± 0.027	2.632ProGly: 2.632 ± 0.049	1.181ProHis: 1.181 ± 0.028	2.098ProIle: 2.098 ± 0.038	2.585ProLys: 2.585 ± 0.037	3.879ProLeu: 3.879 ± 0.042	1.153ProMet: 1.153 ± 0.029	1.885ProAsn: 1.885 ± 0.029	3.101ProPro: 3.101 ± 0.074	1.892ProGln: 1.892 ± 0.032	2.532ProArg: 2.532 ± 0.051	4.137ProSer: 4.137 ± 0.064	2.687ProThr: 2.687 ± 0.052	3.046ProVal: 3.046 ± 0.043	0.476ProTrp: 0.476 ± 0.013	1.388ProTyr: 1.388 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.457GlnAla: 2.457 ± 0.042	0.903GlnCys: 0.903 ± 0.022	1.605GlnAsp: 1.605 ± 0.028	2.095GlnGlu: 2.095 ± 0.032	1.262GlnPhe: 1.262 ± 0.02	1.88GlnGly: 1.88 ± 0.037	1.093GlnHis: 1.093 ± 0.026	1.765GlnIle: 1.765 ± 0.029	2.128GlnLys: 2.128 ± 0.037	4.024GlnLeu: 4.024 ± 0.053	1.047GlnMet: 1.047 ± 0.031	1.596GlnAsn: 1.596 ± 0.034	1.98GlnPro: 1.98 ± 0.046	2.046GlnGln: 2.046 ± 0.085	2.474GlnArg: 2.474 ± 0.036	2.799GlnSer: 2.799 ± 0.044	1.837GlnThr: 1.837 ± 0.026	2.156GlnVal: 2.156 ± 0.034	0.397GlnTrp: 0.397 ± 0.015	1.118GlnTyr: 1.118 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.836ArgAla: 3.836 ± 0.052	1.477ArgCys: 1.477 ± 0.033	3.355ArgAsp: 3.355 ± 0.042	3.569ArgGlu: 3.569 ± 0.079	2.282ArgPhe: 2.282 ± 0.035	3.426ArgGly: 3.426 ± 0.048	1.769ArgHis: 1.769 ± 0.031	3.183ArgIle: 3.183 ± 0.037	3.355ArgLys: 3.355 ± 0.042	5.725ArgLeu: 5.725 ± 0.05	1.598ArgMet: 1.598 ± 0.027	2.752ArgAsn: 2.752 ± 0.032	2.315ArgPro: 2.315 ± 0.045	2.418ArgGln: 2.418 ± 0.035	4.651ArgArg: 4.651 ± 0.076	4.694ArgSer: 4.694 ± 0.066	2.769ArgThr: 2.769 ± 0.035	3.758ArgVal: 3.758 ± 0.039	0.637ArgTrp: 0.637 ± 0.017	2.014ArgTyr: 2.014 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.286SerAla: 6.286 ± 0.067	1.57SerCys: 1.57 ± 0.03	5.142SerAsp: 5.142 ± 0.059	4.513SerGlu: 4.513 ± 0.052	2.755SerPhe: 2.755 ± 0.04	5.359SerGly: 5.359 ± 0.064	2.174SerHis: 2.174 ± 0.035	3.705SerIle: 3.705 ± 0.043	4.199SerLys: 4.199 ± 0.047	6.843SerLeu: 6.843 ± 0.068	1.781SerMet: 1.781 ± 0.03	3.271SerAsn: 3.271 ± 0.041	3.761SerPro: 3.761 ± 0.065	2.982SerGln: 2.982 ± 0.057	4.513SerArg: 4.513 ± 0.055	7.268SerSer: 7.268 ± 0.11	4.805SerThr: 4.805 ± 0.064	5.221SerVal: 5.221 ± 0.054	0.688SerTrp: 0.688 ± 0.019	2.223SerTyr: 2.223 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	4.487ThrAla: 4.487 ± 0.047	1.146ThrCys: 1.146 ± 0.029	3.041ThrAsp: 3.041 ± 0.038	3.104ThrGlu: 3.104 ± 0.045	2.098ThrPhe: 2.098 ± 0.032	3.393ThrGly: 3.393 ± 0.05	1.348ThrHis: 1.348 ± 0.023	2.697ThrIle: 2.697 ± 0.038	2.923ThrLys: 2.923 ± 0.042	5.463ThrLeu: 5.463 ± 0.053	1.255ThrMet: 1.255 ± 0.022	2.169ThrAsn: 2.169 ± 0.034	3.184ThrPro: 3.184 ± 0.061	1.889ThrGln: 1.889 ± 0.029	2.76ThrArg: 2.76 ± 0.036	4.363ThrSer: 4.363 ± 0.053	3.336ThrThr: 3.336 ± 0.069	3.866ThrVal: 3.866 ± 0.043	0.552ThrTrp: 0.552 ± 0.015	1.76ThrTyr: 1.76 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	5.44ValAla: 5.44 ± 0.056	1.447ValCys: 1.447 ± 0.029	4.703ValAsp: 4.703 ± 0.053	4.708ValGlu: 4.708 ± 0.059	2.497ValPhe: 2.497 ± 0.038	3.888ValGly: 3.888 ± 0.051	1.628ValHis: 1.628 ± 0.028	3.29ValIle: 3.29 ± 0.045	4.102ValLys: 4.102 ± 0.056	6.26ValLeu: 6.26 ± 0.07	1.605ValMet: 1.605 ± 0.03	2.831ValAsn: 2.831 ± 0.036	3.205ValPro: 3.205 ± 0.046	2.215ValGln: 2.215 ± 0.037	3.665ValArg: 3.665 ± 0.044	5.23ValSer: 5.23 ± 0.056	3.913ValThr: 3.913 ± 0.044	4.996ValVal: 4.996 ± 0.055	0.598ValTrp: 0.598 ± 0.018	2.246ValTyr: 2.246 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.573TrpAla: 0.573 ± 0.016	0.212TrpCys: 0.212 ± 0.008	0.622TrpAsp: 0.622 ± 0.015	0.523TrpGlu: 0.523 ± 0.014	0.358TrpPhe: 0.358 ± 0.014	0.432TrpGly: 0.432 ± 0.015	0.293TrpHis: 0.293 ± 0.012	0.532TrpIle: 0.532 ± 0.018	0.558TrpLys: 0.558 ± 0.015	1.184TrpLeu: 1.184 ± 0.024	0.3TrpMet: 0.3 ± 0.012	0.484TrpAsn: 0.484 ± 0.015	0.33TrpPro: 0.33 ± 0.014	0.395TrpGln: 0.395 ± 0.014	0.723TrpArg: 0.723 ± 0.022	0.752TrpSer: 0.752 ± 0.019	0.488TrpThr: 0.488 ± 0.016	0.563TrpVal: 0.563 ± 0.015	0.112TrpTrp: 0.112 ± 0.008	0.347TrpTyr: 0.347 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.321TyrAla: 2.321 ± 0.036	0.678TyrCys: 0.678 ± 0.018	2.18TyrAsp: 2.18 ± 0.032	1.912TyrGlu: 1.912 ± 0.031	1.266TyrPhe: 1.266 ± 0.023	2.105TyrGly: 2.105 ± 0.033	0.84TyrHis: 0.84 ± 0.021	1.633TyrIle: 1.633 ± 0.028	1.651TyrLys: 1.651 ± 0.028	2.983TyrLeu: 2.983 ± 0.044	0.849TyrMet: 0.849 ± 0.021	1.597TyrAsn: 1.597 ± 0.026	1.21TyrPro: 1.21 ± 0.027	0.985TyrGln: 0.985 ± 0.024	2.001TyrArg: 2.001 ± 0.035	2.279TyrSer: 2.279 ± 0.029	1.733TyrThr: 1.733 ± 0.029	2.491TyrVal: 2.491 ± 0.038	0.284TyrTrp: 0.284 ± 0.011	1.182TyrTyr: 1.182 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4432 proteins (2259908 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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