Amino acid dipepetide frequency for Streptomyces thermoautotrophicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.749AlaAla: 19.749 ± 0.206	1.273AlaCys: 1.273 ± 0.034	7.246AlaAsp: 7.246 ± 0.074	9.532AlaGlu: 9.532 ± 0.105	3.448AlaPhe: 3.448 ± 0.06	12.417AlaGly: 12.417 ± 0.126	2.654AlaHis: 2.654 ± 0.053	4.164AlaIle: 4.164 ± 0.066	2.909AlaLys: 2.909 ± 0.055	13.94AlaLeu: 13.94 ± 0.138	2.41AlaMet: 2.41 ± 0.04	1.996AlaAsn: 1.996 ± 0.038	5.991AlaPro: 5.991 ± 0.092	3.883AlaGln: 3.883 ± 0.063	11.67AlaArg: 11.67 ± 0.123	5.05AlaSer: 5.05 ± 0.065	6.415AlaThr: 6.415 ± 0.08	11.605AlaVal: 11.605 ± 0.105	2.121AlaTrp: 2.121 ± 0.045	2.869AlaTyr: 2.869 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.163CysAla: 1.163 ± 0.032	0.142CysCys: 0.142 ± 0.011	0.576CysAsp: 0.576 ± 0.02	0.513CysGlu: 0.513 ± 0.021	0.268CysPhe: 0.268 ± 0.014	1.071CysGly: 1.071 ± 0.029	0.239CysHis: 0.239 ± 0.013	0.16CysIle: 0.16 ± 0.011	0.121CysLys: 0.121 ± 0.01	0.857CysLeu: 0.857 ± 0.026	0.138CysMet: 0.138 ± 0.012	0.138CysAsn: 0.138 ± 0.011	0.598CysPro: 0.598 ± 0.025	0.256CysGln: 0.256 ± 0.014	0.843CysArg: 0.843 ± 0.024	0.473CysSer: 0.473 ± 0.02	0.426CysThr: 0.426 ± 0.02	0.808CysVal: 0.808 ± 0.026	0.156CysTrp: 0.156 ± 0.011	0.198CysTyr: 0.198 ± 0.012	0.001CysXaa: 0.001 ± 0.001
Asp	6.87AspAla: 6.87 ± 0.083	0.443AspCys: 0.443 ± 0.019	3.043AspAsp: 3.043 ± 0.059	3.999AspGlu: 3.999 ± 0.062	1.499AspPhe: 1.499 ± 0.031	5.08AspGly: 5.08 ± 0.072	1.251AspHis: 1.251 ± 0.033	1.767AspIle: 1.767 ± 0.048	1.176AspLys: 1.176 ± 0.037	6.711AspLeu: 6.711 ± 0.081	0.784AspMet: 0.784 ± 0.028	0.824AspAsn: 0.824 ± 0.028	4.832AspPro: 4.832 ± 0.069	1.773AspGln: 1.773 ± 0.039	5.043AspArg: 5.043 ± 0.068	1.95AspSer: 1.95 ± 0.041	2.735AspThr: 2.735 ± 0.049	4.821AspVal: 4.821 ± 0.064	0.904AspTrp: 0.904 ± 0.026	1.144AspTyr: 1.144 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.875GluAla: 7.875 ± 0.099	0.436GluCys: 0.436 ± 0.018	2.96GluAsp: 2.96 ± 0.051	4.379GluGlu: 4.379 ± 0.075	1.733GluPhe: 1.733 ± 0.038	4.003GluGly: 4.003 ± 0.066	1.724GluHis: 1.724 ± 0.037	2.807GluIle: 2.807 ± 0.051	1.583GluLys: 1.583 ± 0.044	7.414GluLeu: 7.414 ± 0.088	0.975GluMet: 0.975 ± 0.028	1.132GluAsn: 1.132 ± 0.026	3.794GluPro: 3.794 ± 0.066	2.633GluGln: 2.633 ± 0.052	6.419GluArg: 6.419 ± 0.084	2.31GluSer: 2.31 ± 0.044	2.926GluThr: 2.926 ± 0.041	5.277GluVal: 5.277 ± 0.077	0.878GluTrp: 0.878 ± 0.024	1.416GluTyr: 1.416 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.668PheAla: 3.668 ± 0.061	0.35PheCys: 0.35 ± 0.018	1.893PheAsp: 1.893 ± 0.041	1.538PheGlu: 1.538 ± 0.038	0.887PhePhe: 0.887 ± 0.028	2.918PheGly: 2.918 ± 0.053	0.652PheHis: 0.652 ± 0.024	0.798PheIle: 0.798 ± 0.028	0.497PheLys: 0.497 ± 0.021	2.707PheLeu: 2.707 ± 0.054	0.352PheMet: 0.352 ± 0.018	0.544PheAsn: 0.544 ± 0.023	1.392PhePro: 1.392 ± 0.036	0.727PheGln: 0.727 ± 0.026	1.996PheArg: 1.996 ± 0.039	1.221PheSer: 1.221 ± 0.027	1.848PheThr: 1.848 ± 0.043	2.347PheVal: 2.347 ± 0.047	0.419PheTrp: 0.419 ± 0.019	0.605PheTyr: 0.605 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.301GlyAla: 9.301 ± 0.092	0.954GlyCys: 0.954 ± 0.028	4.811GlyAsp: 4.811 ± 0.07	5.504GlyGlu: 5.504 ± 0.074	2.777GlyPhe: 2.777 ± 0.052	7.617GlyGly: 7.617 ± 0.122	2.142GlyHis: 2.142 ± 0.044	3.351GlyIle: 3.351 ± 0.053	2.385GlyLys: 2.385 ± 0.046	9.045GlyLeu: 9.045 ± 0.103	1.906GlyMet: 1.906 ± 0.039	1.589GlyAsn: 1.589 ± 0.035	4.812GlyPro: 4.812 ± 0.058	2.824GlyGln: 2.824 ± 0.05	7.799GlyArg: 7.799 ± 0.084	4.371GlySer: 4.371 ± 0.058	4.884GlyThr: 4.884 ± 0.066	7.979GlyVal: 7.979 ± 0.085	1.693GlyTrp: 1.693 ± 0.038	2.338GlyTyr: 2.338 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.911HisAla: 2.911 ± 0.055	0.235HisCys: 0.235 ± 0.012	1.277HisAsp: 1.277 ± 0.037	1.208HisGlu: 1.208 ± 0.031	0.551HisPhe: 0.551 ± 0.021	2.354HisGly: 2.354 ± 0.042	0.667HisHis: 0.667 ± 0.025	0.62HisIle: 0.62 ± 0.023	0.353HisLys: 0.353 ± 0.017	2.419HisLeu: 2.419 ± 0.047	0.28HisMet: 0.28 ± 0.014	0.37HisAsn: 0.37 ± 0.018	1.921HisPro: 1.921 ± 0.042	0.697HisGln: 0.697 ± 0.024	2.043HisArg: 2.043 ± 0.043	0.809HisSer: 0.809 ± 0.023	1.078HisThr: 1.078 ± 0.031	1.867HisVal: 1.867 ± 0.041	0.318HisTrp: 0.318 ± 0.015	0.457HisTyr: 0.457 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.868IleAla: 4.868 ± 0.07	0.361IleCys: 0.361 ± 0.015	2.298IleAsp: 2.298 ± 0.045	2.462IleGlu: 2.462 ± 0.048	0.802IlePhe: 0.802 ± 0.023	3.471IleGly: 3.471 ± 0.051	0.792IleHis: 0.792 ± 0.022	1.129IleIle: 1.129 ± 0.033	0.885IleLys: 0.885 ± 0.032	2.823IleLeu: 2.823 ± 0.048	0.442IleMet: 0.442 ± 0.022	0.746IleAsn: 0.746 ± 0.026	2.071IlePro: 2.071 ± 0.041	0.939IleGln: 0.939 ± 0.027	2.963IleArg: 2.963 ± 0.045	1.639IleSer: 1.639 ± 0.034	2.221IleThr: 2.221 ± 0.041	3.051IleVal: 3.051 ± 0.05	0.405IleTrp: 0.405 ± 0.018	0.587IleTyr: 0.587 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.821LysAla: 2.821 ± 0.055	0.142LysCys: 0.142 ± 0.012	1.146LysAsp: 1.146 ± 0.034	1.212LysGlu: 1.212 ± 0.042	0.436LysPhe: 0.436 ± 0.019	1.637LysGly: 1.637 ± 0.049	0.499LysHis: 0.499 ± 0.02	1.073LysIle: 1.073 ± 0.03	0.721LysLys: 0.721 ± 0.027	2.207LysLeu: 2.207 ± 0.047	0.371LysMet: 0.371 ± 0.018	0.505LysAsn: 0.505 ± 0.024	1.442LysPro: 1.442 ± 0.037	0.692LysGln: 0.692 ± 0.024	1.785LysArg: 1.785 ± 0.037	0.929LysSer: 0.929 ± 0.028	1.361LysThr: 1.361 ± 0.035	1.901LysVal: 1.901 ± 0.048	0.253LysTrp: 0.253 ± 0.014	0.593LysTyr: 0.593 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	16.492LeuAla: 16.492 ± 0.155	0.873LeuCys: 0.873 ± 0.025	6.666LeuAsp: 6.666 ± 0.081	5.629LeuGlu: 5.629 ± 0.074	2.6LeuPhe: 2.6 ± 0.057	9.196LeuGly: 9.196 ± 0.096	2.155LeuHis: 2.155 ± 0.044	3.424LeuIle: 3.424 ± 0.058	2.032LeuLys: 2.032 ± 0.042	11.396LeuLeu: 11.396 ± 0.134	1.415LeuMet: 1.415 ± 0.035	1.654LeuAsn: 1.654 ± 0.039	6.556LeuPro: 6.556 ± 0.08	2.343LeuGln: 2.343 ± 0.048	9.752LeuArg: 9.752 ± 0.104	4.595LeuSer: 4.595 ± 0.06	6.039LeuThr: 6.039 ± 0.066	9.621LeuVal: 9.621 ± 0.114	1.223LeuTrp: 1.223 ± 0.034	1.999LeuTyr: 1.999 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	2.183MetAla: 2.183 ± 0.044	0.128MetCys: 0.128 ± 0.011	0.729MetAsp: 0.729 ± 0.027	0.738MetGlu: 0.738 ± 0.03	0.455MetPhe: 0.455 ± 0.022	1.194MetGly: 1.194 ± 0.034	0.311MetHis: 0.311 ± 0.015	0.686MetIle: 0.686 ± 0.025	0.418MetLys: 0.418 ± 0.019	1.751MetLeu: 1.751 ± 0.037	0.273MetMet: 0.273 ± 0.017	0.399MetAsn: 0.399 ± 0.018	1.146MetPro: 1.146 ± 0.032	0.389MetGln: 0.389 ± 0.018	1.568MetArg: 1.568 ± 0.035	1.133MetSer: 1.133 ± 0.025	1.427MetThr: 1.427 ± 0.032	1.273MetVal: 1.273 ± 0.034	0.185MetTrp: 0.185 ± 0.011	0.303MetTyr: 0.303 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.19AsnAla: 2.19 ± 0.043	0.167AsnCys: 0.167 ± 0.012	0.803AsnAsp: 0.803 ± 0.025	0.861AsnGlu: 0.861 ± 0.025	0.465AsnPhe: 0.465 ± 0.024	1.607AsnGly: 1.607 ± 0.036	0.379AsnHis: 0.379 ± 0.018	0.607AsnIle: 0.607 ± 0.023	0.357AsnLys: 0.357 ± 0.019	1.831AsnLeu: 1.831 ± 0.036	0.279AsnMet: 0.279 ± 0.017	0.385AsnAsn: 0.385 ± 0.02	1.6AsnPro: 1.6 ± 0.036	0.571AsnGln: 0.571 ± 0.022	1.503AsnArg: 1.503 ± 0.032	0.727AsnSer: 0.727 ± 0.026	0.943AsnThr: 0.943 ± 0.031	1.449AsnVal: 1.449 ± 0.036	0.242AsnTrp: 0.242 ± 0.015	0.359AsnTyr: 0.359 ± 0.017	0.001AsnXaa: 0.001 ± 0.001
Pro	8.086ProAla: 8.086 ± 0.114	0.458ProCys: 0.458 ± 0.021	4.558ProAsp: 4.558 ± 0.067	4.641ProGlu: 4.641 ± 0.057	1.534ProPhe: 1.534 ± 0.04	6.709ProGly: 6.709 ± 0.082	1.39ProHis: 1.39 ± 0.032	1.697ProIle: 1.697 ± 0.039	1.313ProLys: 1.313 ± 0.036	5.388ProLeu: 5.388 ± 0.051	0.96ProMet: 0.96 ± 0.026	1.033ProAsn: 1.033 ± 0.027	3.988ProPro: 3.988 ± 0.079	1.739ProGln: 1.739 ± 0.043	4.724ProArg: 4.724 ± 0.062	2.659ProSer: 2.659 ± 0.048	3.252ProThr: 3.252 ± 0.06	5.604ProVal: 5.604 ± 0.072	0.936ProTrp: 0.936 ± 0.023	1.523ProTyr: 1.523 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.28GlnAla: 4.28 ± 0.066	0.206GlnCys: 0.206 ± 0.011	1.345GlnAsp: 1.345 ± 0.032	1.643GlnGlu: 1.643 ± 0.036	0.655GlnPhe: 0.655 ± 0.023	2.2GlnGly: 2.2 ± 0.038	0.692GlnHis: 0.692 ± 0.022	1.259GlnIle: 1.259 ± 0.034	0.546GlnLys: 0.546 ± 0.026	3.236GlnLeu: 3.236 ± 0.049	0.522GlnMet: 0.522 ± 0.021	0.458GlnAsn: 0.458 ± 0.02	2.061GlnPro: 2.061 ± 0.048	1.33GlnGln: 1.33 ± 0.04	3.053GlnArg: 3.053 ± 0.058	0.937GlnSer: 0.937 ± 0.03	1.347GlnThr: 1.347 ± 0.027	2.93GlnVal: 2.93 ± 0.045	0.367GlnTrp: 0.367 ± 0.018	0.623GlnTyr: 0.623 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.806ArgAla: 10.806 ± 0.107	0.806ArgCys: 0.806 ± 0.026	4.945ArgAsp: 4.945 ± 0.055	5.793ArgGlu: 5.793 ± 0.068	2.68ArgPhe: 2.68 ± 0.045	6.247ArgGly: 6.247 ± 0.074	2.239ArgHis: 2.239 ± 0.045	3.613ArgIle: 3.613 ± 0.048	1.952ArgLys: 1.952 ± 0.043	10.281ArgLeu: 10.281 ± 0.118	1.943ArgMet: 1.943 ± 0.039	1.532ArgAsn: 1.532 ± 0.036	5.395ArgPro: 5.395 ± 0.081	2.875ArgGln: 2.875 ± 0.058	9.409ArgArg: 9.409 ± 0.122	3.779ArgSer: 3.779 ± 0.053	4.505ArgThr: 4.505 ± 0.071	7.403ArgVal: 7.403 ± 0.084	1.64ArgTrp: 1.64 ± 0.041	2.41ArgTyr: 2.41 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.274SerAla: 5.274 ± 0.064	0.415SerCys: 0.415 ± 0.021	2.103SerAsp: 2.103 ± 0.043	2.193SerGlu: 2.193 ± 0.045	1.336SerPhe: 1.336 ± 0.035	4.792SerGly: 4.792 ± 0.069	0.824SerHis: 0.824 ± 0.03	1.421SerIle: 1.421 ± 0.039	0.902SerLys: 0.902 ± 0.03	4.152SerLeu: 4.152 ± 0.058	0.95SerMet: 0.95 ± 0.027	0.734SerAsn: 0.734 ± 0.027	2.969SerPro: 2.969 ± 0.048	1.212SerGln: 1.212 ± 0.029	3.71SerArg: 3.71 ± 0.054	2.178SerSer: 2.178 ± 0.044	2.426SerThr: 2.426 ± 0.045	3.619SerVal: 3.619 ± 0.052	0.783SerTrp: 0.783 ± 0.026	1.007SerTyr: 1.007 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.965ThrAla: 6.965 ± 0.077	0.521ThrCys: 0.521 ± 0.021	2.824ThrAsp: 2.824 ± 0.051	2.946ThrGlu: 2.946 ± 0.051	1.507ThrPhe: 1.507 ± 0.033	5.712ThrGly: 5.712 ± 0.071	1.113ThrHis: 1.113 ± 0.029	1.875ThrIle: 1.875 ± 0.042	1.075ThrLys: 1.075 ± 0.032	5.481ThrLeu: 5.481 ± 0.07	0.867ThrMet: 0.867 ± 0.026	0.914ThrAsn: 0.914 ± 0.025	4.009ThrPro: 4.009 ± 0.07	1.273ThrGln: 1.273 ± 0.034	4.456ThrArg: 4.456 ± 0.069	2.476ThrSer: 2.476 ± 0.048	3.047ThrThr: 3.047 ± 0.056	5.262ThrVal: 5.262 ± 0.077	0.961ThrTrp: 0.961 ± 0.032	1.238ThrTyr: 1.238 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	11.443ValAla: 11.443 ± 0.097	0.86ValCys: 0.86 ± 0.025	5.22ValAsp: 5.22 ± 0.058	5.688ValGlu: 5.688 ± 0.074	2.584ValPhe: 2.584 ± 0.05	6.609ValGly: 6.609 ± 0.083	1.837ValHis: 1.837 ± 0.036	3.426ValIle: 3.426 ± 0.052	1.759ValLys: 1.759 ± 0.041	9.567ValLeu: 9.567 ± 0.113	1.323ValMet: 1.323 ± 0.035	1.672ValAsn: 1.672 ± 0.039	5.447ValPro: 5.447 ± 0.068	2.121ValGln: 2.121 ± 0.044	7.679ValArg: 7.679 ± 0.073	4.08ValSer: 4.08 ± 0.057	5.686ValThr: 5.686 ± 0.074	8.693ValVal: 8.693 ± 0.121	1.166ValTrp: 1.166 ± 0.031	1.747ValTyr: 1.747 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.671TrpAla: 1.671 ± 0.035	0.166TrpCys: 0.166 ± 0.011	0.781TrpAsp: 0.781 ± 0.026	0.758TrpGlu: 0.758 ± 0.023	0.483TrpPhe: 0.483 ± 0.019	1.004TrpGly: 1.004 ± 0.03	0.392TrpHis: 0.392 ± 0.017	0.551TrpIle: 0.551 ± 0.023	0.348TrpLys: 0.348 ± 0.019	1.989TrpLeu: 1.989 ± 0.048	0.285TrpMet: 0.285 ± 0.015	0.337TrpAsn: 0.337 ± 0.017	0.882TrpPro: 0.882 ± 0.029	0.572TrpGln: 0.572 ± 0.023	1.598TrpArg: 1.598 ± 0.038	0.798TrpSer: 0.798 ± 0.028	0.835TrpThr: 0.835 ± 0.027	1.198TrpVal: 1.198 ± 0.03	0.372TrpTrp: 0.372 ± 0.02	0.374TrpTyr: 0.374 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.726TyrAla: 2.726 ± 0.048	0.21TyrCys: 0.21 ± 0.012	1.426TyrAsp: 1.426 ± 0.037	1.435TyrGlu: 1.435 ± 0.034	0.658TyrPhe: 0.658 ± 0.024	2.244TyrGly: 2.244 ± 0.046	0.483TyrHis: 0.483 ± 0.02	0.526TyrIle: 0.526 ± 0.023	0.393TyrLys: 0.393 ± 0.018	2.465TyrLeu: 2.465 ± 0.048	0.214TyrMet: 0.214 ± 0.013	0.364TyrAsn: 0.364 ± 0.018	1.285TyrPro: 1.285 ± 0.037	0.842TyrGln: 0.842 ± 0.025	2.239TyrArg: 2.239 ± 0.04	0.886TyrSer: 0.886 ± 0.029	1.121TyrThr: 1.121 ± 0.033	1.9TyrVal: 1.9 ± 0.038	0.372TyrTrp: 0.372 ± 0.017	0.508TyrTyr: 0.508 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4356 proteins (1278468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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