Amino acid dipepetide frequency for Hydrogenophaga sp. A37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.147AlaAla: 16.147 ± 0.144
1.323AlaCys: 1.323 ± 0.027
6.27AlaAsp: 6.27 ± 0.067
6.367AlaGlu: 6.367 ± 0.069
4.124AlaPhe: 4.124 ± 0.058
10.026AlaGly: 10.026 ± 0.086
2.945AlaHis: 2.945 ± 0.043
4.899AlaIle: 4.899 ± 0.063
3.705AlaLys: 3.705 ± 0.07
15.07AlaLeu: 15.07 ± 0.133
3.653AlaMet: 3.653 ± 0.048
2.832AlaAsn: 2.832 ± 0.049
6.156AlaPro: 6.156 ± 0.087
6.013AlaGln: 6.013 ± 0.054
8.178AlaArg: 8.178 ± 0.084
6.826AlaSer: 6.826 ± 0.077
6.196AlaThr: 6.196 ± 0.071
9.076AlaVal: 9.076 ± 0.08
2.085AlaTrp: 2.085 ± 0.037
2.41AlaTyr: 2.41 ± 0.034
0.0AlaXaa: 0.0 ± 0.0
Cys
1.184CysAla: 1.184 ± 0.029
0.114CysCys: 0.114 ± 0.009
0.564CysAsp: 0.564 ± 0.019
0.549CysGlu: 0.549 ± 0.019
0.327CysPhe: 0.327 ± 0.014
1.015CysGly: 1.015 ± 0.027
0.284CysHis: 0.284 ± 0.013
0.398CysIle: 0.398 ± 0.014
0.246CysLys: 0.246 ± 0.011
0.913CysLeu: 0.913 ± 0.027
0.213CysMet: 0.213 ± 0.012
0.231CysAsn: 0.231 ± 0.012
0.521CysPro: 0.521 ± 0.018
0.305CysGln: 0.305 ± 0.013
0.536CysArg: 0.536 ± 0.022
0.549CysSer: 0.549 ± 0.021
0.526CysThr: 0.526 ± 0.017
0.764CysVal: 0.764 ± 0.024
0.137CysTrp: 0.137 ± 0.009
0.212CysTyr: 0.212 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.956AspAla: 6.956 ± 0.067
0.428AspCys: 0.428 ± 0.017
2.753AspAsp: 2.753 ± 0.056
3.082AspGlu: 3.082 ± 0.047
2.016AspPhe: 2.016 ± 0.035
4.599AspGly: 4.599 ± 0.07
1.338AspHis: 1.338 ± 0.028
2.352AspIle: 2.352 ± 0.04
1.701AspLys: 1.701 ± 0.033
5.337AspLeu: 5.337 ± 0.061
1.312AspMet: 1.312 ± 0.03
1.277AspAsn: 1.277 ± 0.032
3.009AspPro: 3.009 ± 0.066
1.816AspGln: 1.816 ± 0.033
3.15AspArg: 3.15 ± 0.052
2.218AspSer: 2.218 ± 0.04
2.858AspThr: 2.858 ± 0.06
3.919AspVal: 3.919 ± 0.052
0.984AspTrp: 0.984 ± 0.023
1.176AspTyr: 1.176 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
6.744GluAla: 6.744 ± 0.08
0.403GluCys: 0.403 ± 0.016
2.15GluAsp: 2.15 ± 0.04
2.233GluGlu: 2.233 ± 0.048
1.67GluPhe: 1.67 ± 0.036
3.89GluGly: 3.89 ± 0.055
1.42GluHis: 1.42 ± 0.031
2.366GluIle: 2.366 ± 0.044
1.838GluLys: 1.838 ± 0.041
5.92GluLeu: 5.92 ± 0.069
1.226GluMet: 1.226 ± 0.028
1.187GluAsn: 1.187 ± 0.028
2.658GluPro: 2.658 ± 0.041
2.691GluGln: 2.691 ± 0.048
4.545GluArg: 4.545 ± 0.061
2.442GluSer: 2.442 ± 0.043
2.555GluThr: 2.555 ± 0.041
4.125GluVal: 4.125 ± 0.05
0.752GluTrp: 0.752 ± 0.022
0.931GluTyr: 0.931 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.064PheAla: 4.064 ± 0.06
0.406PheCys: 0.406 ± 0.017
2.549PheAsp: 2.549 ± 0.042
2.136PheGlu: 2.136 ± 0.034
1.411PhePhe: 1.411 ± 0.032
3.278PheGly: 3.278 ± 0.047
0.776PheHis: 0.776 ± 0.02
1.442PheIle: 1.442 ± 0.029
1.269PheLys: 1.269 ± 0.027
3.013PheLeu: 3.013 ± 0.044
0.902PheMet: 0.902 ± 0.021
1.208PheAsn: 1.208 ± 0.028
1.506PhePro: 1.506 ± 0.032
1.118PheGln: 1.118 ± 0.027
1.798PheArg: 1.798 ± 0.033
2.156PheSer: 2.156 ± 0.042
1.961PheThr: 1.961 ± 0.043
2.808PheVal: 2.808 ± 0.043
0.594PheTrp: 0.594 ± 0.022
0.925PheTyr: 0.925 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.027GlyAla: 9.027 ± 0.087
0.947GlyCys: 0.947 ± 0.025
3.904GlyAsp: 3.904 ± 0.056
4.484GlyGlu: 4.484 ± 0.061
3.417GlyPhe: 3.417 ± 0.045
6.929GlyGly: 6.929 ± 0.095
2.174GlyHis: 2.174 ± 0.04
3.705GlyIle: 3.705 ± 0.057
3.084GlyLys: 3.084 ± 0.057
9.488GlyLeu: 9.488 ± 0.097
2.413GlyMet: 2.413 ± 0.039
2.136GlyAsn: 2.136 ± 0.053
3.291GlyPro: 3.291 ± 0.043
3.786GlyGln: 3.786 ± 0.057
5.126GlyArg: 5.126 ± 0.071
4.613GlySer: 4.613 ± 0.065
4.408GlyThr: 4.408 ± 0.078
6.787GlyVal: 6.787 ± 0.075
1.583GlyTrp: 1.583 ± 0.037
2.115GlyTyr: 2.115 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.923HisAla: 2.923 ± 0.047
0.304HisCys: 0.304 ± 0.014
1.211HisAsp: 1.211 ± 0.032
1.164HisGlu: 1.164 ± 0.029
0.99HisPhe: 0.99 ± 0.023
2.312HisGly: 2.312 ± 0.041
0.763HisHis: 0.763 ± 0.024
1.084HisIle: 1.084 ± 0.027
0.66HisLys: 0.66 ± 0.021
2.542HisLeu: 2.542 ± 0.046
0.571HisMet: 0.571 ± 0.022
0.588HisAsn: 0.588 ± 0.02
1.627HisPro: 1.627 ± 0.033
0.908HisGln: 0.908 ± 0.021
1.704HisArg: 1.704 ± 0.038
1.165HisSer: 1.165 ± 0.028
1.309HisThr: 1.309 ± 0.03
1.672HisVal: 1.672 ± 0.03
0.52HisTrp: 0.52 ± 0.018
0.561HisTyr: 0.561 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.454IleAla: 5.454 ± 0.066
0.425IleCys: 0.425 ± 0.016
2.89IleAsp: 2.89 ± 0.037
3.033IleGlu: 3.033 ± 0.054
1.226IlePhe: 1.226 ± 0.03
4.003IleGly: 4.003 ± 0.057
0.957IleHis: 0.957 ± 0.027
1.322IleIle: 1.322 ± 0.036
1.494IleLys: 1.494 ± 0.032
2.976IleLeu: 2.976 ± 0.051
0.72IleMet: 0.72 ± 0.023
1.408IleAsn: 1.408 ± 0.037
1.995IlePro: 1.995 ± 0.038
1.366IleGln: 1.366 ± 0.026
2.417IleArg: 2.417 ± 0.041
2.231IleSer: 2.231 ± 0.038
2.564IleThr: 2.564 ± 0.051
3.265IleVal: 3.265 ± 0.047
0.515IleTrp: 0.515 ± 0.018
0.911IleTyr: 0.911 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
4.304LysAla: 4.304 ± 0.061
0.19LysCys: 0.19 ± 0.011
1.791LysAsp: 1.791 ± 0.04
1.459LysGlu: 1.459 ± 0.03
0.903LysPhe: 0.903 ± 0.023
2.567LysGly: 2.567 ± 0.046
0.725LysHis: 0.725 ± 0.021
1.371LysIle: 1.371 ± 0.033
1.415LysLys: 1.415 ± 0.042
3.325LysLeu: 3.325 ± 0.055
0.797LysMet: 0.797 ± 0.024
0.945LysAsn: 0.945 ± 0.03
2.022LysPro: 2.022 ± 0.036
1.209LysGln: 1.209 ± 0.026
2.098LysArg: 2.098 ± 0.039
1.638LysSer: 1.638 ± 0.034
2.044LysThr: 2.044 ± 0.037
2.546LysVal: 2.546 ± 0.051
0.338LysTrp: 0.338 ± 0.016
0.637LysTyr: 0.637 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
14.392LeuAla: 14.392 ± 0.123
1.1LeuCys: 1.1 ± 0.03
5.86LeuAsp: 5.86 ± 0.072
5.011LeuGlu: 5.011 ± 0.067
3.489LeuPhe: 3.489 ± 0.055
8.953LeuGly: 8.953 ± 0.081
2.442LeuHis: 2.442 ± 0.038
4.515LeuIle: 4.515 ± 0.06
3.78LeuLys: 3.78 ± 0.053
11.583LeuLeu: 11.583 ± 0.12
2.836LeuMet: 2.836 ± 0.045
3.015LeuAsn: 3.015 ± 0.04
6.354LeuPro: 6.354 ± 0.067
4.571LeuGln: 4.571 ± 0.055
7.566LeuArg: 7.566 ± 0.084
6.566LeuSer: 6.566 ± 0.06
5.628LeuThr: 5.628 ± 0.075
8.0LeuVal: 8.0 ± 0.083
1.498LeuTrp: 1.498 ± 0.036
1.956LeuTyr: 1.956 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.388MetAla: 3.388 ± 0.045
0.182MetCys: 0.182 ± 0.01
1.277MetAsp: 1.277 ± 0.026
1.091MetGlu: 1.091 ± 0.027
0.687MetPhe: 0.687 ± 0.024
2.197MetGly: 2.197 ± 0.035
0.573MetHis: 0.573 ± 0.018
0.894MetIle: 0.894 ± 0.023
1.067MetLys: 1.067 ± 0.028
2.655MetLeu: 2.655 ± 0.043
0.554MetMet: 0.554 ± 0.018
1.006MetAsn: 1.006 ± 0.022
1.498MetPro: 1.498 ± 0.029
1.083MetGln: 1.083 ± 0.03
1.649MetArg: 1.649 ± 0.032
1.652MetSer: 1.652 ± 0.031
1.543MetThr: 1.543 ± 0.033
1.993MetVal: 1.993 ± 0.039
0.242MetTrp: 0.242 ± 0.013
0.363MetTyr: 0.363 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.394AsnAla: 3.394 ± 0.054
0.266AsnCys: 0.266 ± 0.014
1.44AsnAsp: 1.44 ± 0.047
1.274AsnGlu: 1.274 ± 0.026
0.943AsnPhe: 0.943 ± 0.024
2.295AsnGly: 2.295 ± 0.049
0.62AsnHis: 0.62 ± 0.02
1.143AsnIle: 1.143 ± 0.03
0.827AsnLys: 0.827 ± 0.024
2.674AsnLeu: 2.674 ± 0.042
0.601AsnMet: 0.601 ± 0.017
0.802AsnAsn: 0.802 ± 0.031
1.959AsnPro: 1.959 ± 0.041
1.004AsnGln: 1.004 ± 0.026
1.604AsnArg: 1.604 ± 0.036
1.178AsnSer: 1.178 ± 0.029
1.583AsnThr: 1.583 ± 0.042
1.887AsnVal: 1.887 ± 0.036
0.423AsnTrp: 0.423 ± 0.016
0.608AsnTyr: 0.608 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.98ProAla: 6.98 ± 0.079
0.406ProCys: 0.406 ± 0.018
3.209ProAsp: 3.209 ± 0.047
3.414ProGlu: 3.414 ± 0.043
1.849ProPhe: 1.849 ± 0.038
4.767ProGly: 4.767 ± 0.057
1.24ProHis: 1.24 ± 0.032
1.772ProIle: 1.772 ± 0.033
1.592ProLys: 1.592 ± 0.03
5.496ProLeu: 5.496 ± 0.069
1.409ProMet: 1.409 ± 0.029
1.328ProAsn: 1.328 ± 0.031
2.678ProPro: 2.678 ± 0.053
2.125ProGln: 2.125 ± 0.039
2.807ProArg: 2.807 ± 0.042
2.949ProSer: 2.949 ± 0.046
2.905ProThr: 2.905 ± 0.044
4.573ProVal: 4.573 ± 0.079
0.899ProTrp: 0.899 ± 0.028
1.086ProTyr: 1.086 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
5.784GlnAla: 5.784 ± 0.067
0.321GlnCys: 0.321 ± 0.015
1.732GlnAsp: 1.732 ± 0.034
1.495GlnGlu: 1.495 ± 0.031
1.184GlnPhe: 1.184 ± 0.027
3.304GlnGly: 3.304 ± 0.05
1.094GlnHis: 1.094 ± 0.026
1.752GlnIle: 1.752 ± 0.034
1.186GlnLys: 1.186 ± 0.028
4.488GlnLeu: 4.488 ± 0.051
1.036GlnMet: 1.036 ± 0.027
0.902GlnAsn: 0.902 ± 0.029
2.344GlnPro: 2.344 ± 0.041
2.027GlnGln: 2.027 ± 0.033
3.899GlnArg: 3.899 ± 0.06
2.13GlnSer: 2.13 ± 0.038
2.298GlnThr: 2.298 ± 0.039
3.282GlnVal: 3.282 ± 0.05
0.717GlnTrp: 0.717 ± 0.022
0.738GlnTyr: 0.738 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
7.301ArgAla: 7.301 ± 0.079
0.633ArgCys: 0.633 ± 0.02
3.35ArgAsp: 3.35 ± 0.047
4.026ArgGlu: 4.026 ± 0.052
2.847ArgPhe: 2.847 ± 0.045
4.388ArgGly: 4.388 ± 0.059
1.936ArgHis: 1.936 ± 0.04
3.124ArgIle: 3.124 ± 0.04
1.891ArgLys: 1.891 ± 0.035
7.876ArgLeu: 7.876 ± 0.103
1.778ArgMet: 1.778 ± 0.033
1.658ArgAsn: 1.658 ± 0.031
3.16ArgPro: 3.16 ± 0.05
2.955ArgGln: 2.955 ± 0.051
4.564ArgArg: 4.564 ± 0.068
3.64ArgSer: 3.64 ± 0.051
3.047ArgThr: 3.047 ± 0.047
5.011ArgVal: 5.011 ± 0.063
1.321ArgTrp: 1.321 ± 0.036
1.726ArgTyr: 1.726 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.587SerAla: 6.587 ± 0.072
0.459SerCys: 0.459 ± 0.016
2.725SerAsp: 2.725 ± 0.047
2.638SerGlu: 2.638 ± 0.042
2.089SerPhe: 2.089 ± 0.033
5.293SerGly: 5.293 ± 0.064
1.308SerHis: 1.308 ± 0.035
2.186SerIle: 2.186 ± 0.04
1.538SerLys: 1.538 ± 0.036
5.969SerLeu: 5.969 ± 0.069
1.403SerMet: 1.403 ± 0.032
1.391SerAsn: 1.391 ± 0.036
3.065SerPro: 3.065 ± 0.044
2.003SerGln: 2.003 ± 0.035
3.398SerArg: 3.398 ± 0.046
3.051SerSer: 3.051 ± 0.045
3.043SerThr: 3.043 ± 0.046
4.218SerVal: 4.218 ± 0.058
0.706SerTrp: 0.706 ± 0.021
1.139SerTyr: 1.139 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.347ThrAla: 6.347 ± 0.075
0.453ThrCys: 0.453 ± 0.018
2.735ThrAsp: 2.735 ± 0.059
2.649ThrGlu: 2.649 ± 0.043
1.708ThrPhe: 1.708 ± 0.042
4.849ThrGly: 4.849 ± 0.07
1.357ThrHis: 1.357 ± 0.03
1.956ThrIle: 1.956 ± 0.048
1.307ThrLys: 1.307 ± 0.032
6.606ThrLeu: 6.606 ± 0.076
1.166ThrMet: 1.166 ± 0.027
1.224ThrAsn: 1.224 ± 0.031
3.755ThrPro: 3.755 ± 0.06
2.107ThrGln: 2.107 ± 0.042
3.207ThrArg: 3.207 ± 0.051
2.79ThrSer: 2.79 ± 0.047
3.023ThrThr: 3.023 ± 0.048
4.53ThrVal: 4.53 ± 0.072
0.737ThrTrp: 0.737 ± 0.022
1.08ThrTyr: 1.08 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.356ValAla: 9.356 ± 0.079
0.801ValCys: 0.801 ± 0.026
4.13ValAsp: 4.13 ± 0.065
3.989ValGlu: 3.989 ± 0.051
2.962ValPhe: 2.962 ± 0.048
5.843ValGly: 5.843 ± 0.06
1.732ValHis: 1.732 ± 0.033
3.502ValIle: 3.502 ± 0.047
2.591ValLys: 2.591 ± 0.048
8.627ValLeu: 8.627 ± 0.078
2.091ValMet: 2.091 ± 0.038
2.33ValAsn: 2.33 ± 0.045
4.028ValPro: 4.028 ± 0.042
2.973ValGln: 2.973 ± 0.046
5.07ValArg: 5.07 ± 0.064
4.416ValSer: 4.416 ± 0.053
4.068ValThr: 4.068 ± 0.066
6.634ValVal: 6.634 ± 0.066
1.17ValTrp: 1.17 ± 0.026
1.602ValTyr: 1.602 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.611TrpAla: 1.611 ± 0.039
0.191TrpCys: 0.191 ± 0.011
0.681TrpAsp: 0.681 ± 0.02
0.561TrpGlu: 0.561 ± 0.019
0.599TrpPhe: 0.599 ± 0.019
1.088TrpGly: 1.088 ± 0.024
0.424TrpHis: 0.424 ± 0.017
0.637TrpIle: 0.637 ± 0.023
0.487TrpLys: 0.487 ± 0.017
2.254TrpLeu: 2.254 ± 0.048
0.495TrpMet: 0.495 ± 0.016
0.465TrpAsn: 0.465 ± 0.018
0.824TrpPro: 0.824 ± 0.025
0.779TrpGln: 0.779 ± 0.023
1.284TrpArg: 1.284 ± 0.031
0.869TrpSer: 0.869 ± 0.022
0.787TrpThr: 0.787 ± 0.021
1.272TrpVal: 1.272 ± 0.031
0.333TrpTrp: 0.333 ± 0.013
0.292TrpTyr: 0.292 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.355TyrAla: 2.355 ± 0.04
0.236TyrCys: 0.236 ± 0.011
1.06TyrAsp: 1.06 ± 0.03
1.091TyrGlu: 1.091 ± 0.026
0.88TyrPhe: 0.88 ± 0.025
1.821TyrGly: 1.821 ± 0.032
0.467TyrHis: 0.467 ± 0.017
0.751TyrIle: 0.751 ± 0.021
0.646TyrLys: 0.646 ± 0.019
2.304TyrLeu: 2.304 ± 0.036
0.419TyrMet: 0.419 ± 0.014
0.594TyrAsn: 0.594 ± 0.023
1.035TyrPro: 1.035 ± 0.027
0.875TyrGln: 0.875 ± 0.023
1.633TyrArg: 1.633 ± 0.032
1.133TyrSer: 1.133 ± 0.028
1.237TyrThr: 1.237 ± 0.036
1.554TyrVal: 1.554 ± 0.03
0.381TyrTrp: 0.381 ± 0.017
0.489TyrTyr: 0.489 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5133 proteins (1643886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski