Amino acid dipepetide frequency for Cotton leaf curl virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.14AlaAla: 5.14 ± 1.466
0.0AlaCys: 0.0 ± 0.0
1.468AlaAsp: 1.468 ± 0.836
0.734AlaGlu: 0.734 ± 0.691
0.0AlaPhe: 0.0 ± 0.0
2.937AlaGly: 2.937 ± 0.974
0.734AlaHis: 0.734 ± 0.619
0.734AlaIle: 0.734 ± 0.619
1.468AlaLys: 1.468 ± 0.776
5.874AlaLeu: 5.874 ± 2.823
0.0AlaMet: 0.0 ± 0.0
2.937AlaAsn: 2.937 ± 0.884
2.937AlaPro: 2.937 ± 1.368
5.14AlaGln: 5.14 ± 1.46
3.671AlaArg: 3.671 ± 1.978
3.671AlaSer: 3.671 ± 1.855
3.671AlaThr: 3.671 ± 1.488
1.468AlaVal: 1.468 ± 1.116
1.468AlaTrp: 1.468 ± 0.651
4.405AlaTyr: 4.405 ± 1.968
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.468CysCys: 1.468 ± 1.734
1.468CysAsp: 1.468 ± 1.033
0.734CysGlu: 0.734 ± 0.577
0.734CysPhe: 0.734 ± 0.719
2.203CysGly: 2.203 ± 0.839
0.734CysHis: 0.734 ± 0.727
1.468CysIle: 1.468 ± 0.886
1.468CysLys: 1.468 ± 1.154
1.468CysLeu: 1.468 ± 1.381
1.468CysMet: 1.468 ± 1.23
1.468CysAsn: 1.468 ± 0.776
2.203CysPro: 2.203 ± 1.851
0.734CysGln: 0.734 ± 0.619
1.468CysArg: 1.468 ± 0.973
2.937CysSer: 2.937 ± 1.486
0.734CysThr: 0.734 ± 0.727
1.468CysVal: 1.468 ± 1.154
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.937AspAla: 2.937 ± 1.62
0.0AspCys: 0.0 ± 0.0
2.203AspAsp: 2.203 ± 0.839
2.203AspGlu: 2.203 ± 0.804
1.468AspPhe: 1.468 ± 0.651
2.203AspGly: 2.203 ± 1.856
0.734AspHis: 0.734 ± 0.727
3.671AspIle: 3.671 ± 1.081
1.468AspLys: 1.468 ± 0.886
3.671AspLeu: 3.671 ± 1.598
0.0AspMet: 0.0 ± 0.0
1.468AspAsn: 1.468 ± 0.836
2.937AspPro: 2.937 ± 1.787
2.203AspGln: 2.203 ± 0.838
2.937AspArg: 2.937 ± 1.303
3.671AspSer: 3.671 ± 1.411
2.203AspThr: 2.203 ± 1.851
3.671AspVal: 3.671 ± 1.602
2.203AspTrp: 2.203 ± 1.201
0.734AspTyr: 0.734 ± 0.867
0.0AspXaa: 0.0 ± 0.0
Glu
4.405GluAla: 4.405 ± 2.167
0.734GluCys: 0.734 ± 0.727
0.734GluAsp: 0.734 ± 0.619
5.874GluGlu: 5.874 ± 4.305
2.203GluPhe: 2.203 ± 1.382
3.671GluGly: 3.671 ± 2.067
0.734GluHis: 0.734 ± 0.719
0.734GluIle: 0.734 ± 0.719
2.203GluLys: 2.203 ± 1.069
4.405GluLeu: 4.405 ± 2.337
0.0GluMet: 0.0 ± 0.0
2.937GluAsn: 2.937 ± 1.583
2.937GluPro: 2.937 ± 0.775
2.203GluGln: 2.203 ± 1.095
0.0GluArg: 0.0 ± 0.0
3.671GluSer: 3.671 ± 1.165
0.734GluThr: 0.734 ± 0.691
2.203GluVal: 2.203 ± 1.019
1.468GluTrp: 1.468 ± 0.776
0.734GluTyr: 0.734 ± 0.727
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
1.468PheCys: 1.468 ± 0.836
2.203PheAsp: 2.203 ± 1.132
1.468PheGlu: 1.468 ± 0.651
1.468PhePhe: 1.468 ± 0.651
1.468PheGly: 1.468 ± 1.154
1.468PheHis: 1.468 ± 1.238
2.203PheIle: 2.203 ± 1.069
3.671PheLys: 3.671 ± 2.368
4.405PheLeu: 4.405 ± 1.478
0.734PheMet: 0.734 ± 0.619
2.937PheAsn: 2.937 ± 0.849
0.734PhePro: 0.734 ± 0.867
2.203PheGln: 2.203 ± 1.201
2.937PheArg: 2.937 ± 1.372
2.937PheSer: 2.937 ± 1.953
2.937PheThr: 2.937 ± 1.564
1.468PheVal: 1.468 ± 0.651
0.0PheTrp: 0.0 ± 0.0
2.203PheTyr: 2.203 ± 0.83
0.0PheXaa: 0.0 ± 0.0
Gly
2.203GlyAla: 2.203 ± 1.362
1.468GlyCys: 1.468 ± 0.93
1.468GlyAsp: 1.468 ± 1.238
1.468GlyGlu: 1.468 ± 0.908
2.203GlyPhe: 2.203 ± 1.024
4.405GlyGly: 4.405 ± 0.99
1.468GlyHis: 1.468 ± 0.776
2.203GlyIle: 2.203 ± 0.839
4.405GlyLys: 4.405 ± 1.954
5.14GlyLeu: 5.14 ± 2.239
0.734GlyMet: 0.734 ± 0.867
2.937GlyAsn: 2.937 ± 2.853
2.203GlyPro: 2.203 ± 1.132
4.405GlyGln: 4.405 ± 1.772
1.468GlyArg: 1.468 ± 0.654
5.874GlySer: 5.874 ± 2.269
4.405GlyThr: 4.405 ± 1.633
1.468GlyVal: 1.468 ± 0.919
0.0GlyTrp: 0.0 ± 0.0
0.734GlyTyr: 0.734 ± 0.867
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.468HisCys: 1.468 ± 1.078
2.203HisAsp: 2.203 ± 1.567
0.734HisGlu: 0.734 ± 0.619
2.203HisPhe: 2.203 ± 1.382
1.468HisGly: 1.468 ± 1.078
1.468HisHis: 1.468 ± 1.031
2.937HisIle: 2.937 ± 1.516
1.468HisLys: 1.468 ± 1.147
2.937HisLeu: 2.937 ± 1.407
0.734HisMet: 0.734 ± 0.653
2.937HisAsn: 2.937 ± 1.054
2.937HisPro: 2.937 ± 1.838
1.468HisGln: 1.468 ± 1.078
4.405HisArg: 4.405 ± 1.605
1.468HisSer: 1.468 ± 1.031
2.937HisThr: 2.937 ± 1.476
2.203HisVal: 2.203 ± 1.503
0.0HisTrp: 0.0 ± 0.0
1.468HisTyr: 1.468 ± 0.654
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
2.203IleCys: 2.203 ± 1.244
2.203IleAsp: 2.203 ± 1.201
1.468IleGlu: 1.468 ± 1.238
2.203IlePhe: 2.203 ± 1.856
1.468IleGly: 1.468 ± 0.836
2.937IleHis: 2.937 ± 1.327
1.468IleIle: 1.468 ± 0.919
5.874IleLys: 5.874 ± 1.285
4.405IleLeu: 4.405 ± 1.968
1.468IleMet: 1.468 ± 1.313
2.937IleAsn: 2.937 ± 1.564
1.468IlePro: 1.468 ± 0.776
5.14IleGln: 5.14 ± 1.818
5.14IleArg: 5.14 ± 1.178
6.608IleSer: 6.608 ± 1.523
4.405IleThr: 4.405 ± 1.098
3.671IleVal: 3.671 ± 1.315
3.671IleTrp: 3.671 ± 1.802
1.468IleTyr: 1.468 ± 0.93
0.0IleXaa: 0.0 ± 0.0
Lys
2.203LysAla: 2.203 ± 1.498
2.203LysCys: 2.203 ± 1.362
2.203LysAsp: 2.203 ± 1.856
3.671LysGlu: 3.671 ± 2.3
2.203LysPhe: 2.203 ± 0.905
2.203LysGly: 2.203 ± 1.141
2.203LysHis: 2.203 ± 1.194
3.671LysIle: 3.671 ± 1.802
2.937LysLys: 2.937 ± 1.583
2.203LysLeu: 2.203 ± 1.42
0.0LysMet: 0.0 ± 0.0
4.405LysAsn: 4.405 ± 2.264
2.203LysPro: 2.203 ± 1.064
1.468LysGln: 1.468 ± 0.886
3.671LysArg: 3.671 ± 1.112
5.14LysSer: 5.14 ± 1.173
2.937LysThr: 2.937 ± 1.063
3.671LysVal: 3.671 ± 1.932
0.734LysTrp: 0.734 ± 0.577
5.14LysTyr: 5.14 ± 1.14
0.0LysXaa: 0.0 ± 0.0
Leu
1.468LeuAla: 1.468 ± 0.651
2.203LeuCys: 2.203 ± 1.132
5.14LeuAsp: 5.14 ± 2.632
2.203LeuGlu: 2.203 ± 1.141
2.203LeuPhe: 2.203 ± 1.053
4.405LeuGly: 4.405 ± 1.439
2.937LeuHis: 2.937 ± 1.148
7.342LeuIle: 7.342 ± 2.749
5.874LeuLys: 5.874 ± 1.137
3.671LeuLeu: 3.671 ± 1.829
0.734LeuMet: 0.734 ± 0.577
8.811LeuAsn: 8.811 ± 2.356
0.734LeuPro: 0.734 ± 0.691
2.937LeuGln: 2.937 ± 1.094
6.608LeuArg: 6.608 ± 2.078
5.14LeuSer: 5.14 ± 1.908
9.545LeuThr: 9.545 ± 3.039
3.671LeuVal: 3.671 ± 1.687
0.0LeuTrp: 0.0 ± 0.0
1.468LeuTyr: 1.468 ± 1.439
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.734MetCys: 0.734 ± 0.577
2.937MetAsp: 2.937 ± 1.702
0.0MetGlu: 0.0 ± 0.0
2.203MetPhe: 2.203 ± 1.501
2.203MetGly: 2.203 ± 0.925
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.203MetLeu: 2.203 ± 1.059
0.0MetMet: 0.0 ± 0.0
1.468MetAsn: 1.468 ± 0.836
0.734MetPro: 0.734 ± 0.619
0.0MetGln: 0.0 ± 0.0
1.468MetArg: 1.468 ± 0.776
1.468MetSer: 1.468 ± 0.836
0.734MetThr: 0.734 ± 0.952
0.0MetVal: 0.0 ± 0.0
1.468MetTrp: 1.468 ± 0.973
2.937MetTyr: 2.937 ± 1.224
0.0MetXaa: 0.0 ± 0.0
Asn
2.937AsnAla: 2.937 ± 1.704
0.734AsnCys: 0.734 ± 0.727
2.203AsnAsp: 2.203 ± 1.069
1.468AsnGlu: 1.468 ± 0.886
2.203AsnPhe: 2.203 ± 1.316
2.203AsnGly: 2.203 ± 0.835
2.203AsnHis: 2.203 ± 1.366
6.608AsnIle: 6.608 ± 2.919
0.0AsnLys: 0.0 ± 0.0
5.14AsnLeu: 5.14 ± 1.475
3.671AsnMet: 3.671 ± 1.295
1.468AsnAsn: 1.468 ± 0.919
5.874AsnPro: 5.874 ± 1.72
1.468AsnGln: 1.468 ± 0.654
5.14AsnArg: 5.14 ± 1.83
3.671AsnSer: 3.671 ± 1.027
2.203AsnThr: 2.203 ± 0.835
3.671AsnVal: 3.671 ± 0.964
0.734AsnTrp: 0.734 ± 0.619
3.671AsnTyr: 3.671 ± 1.309
0.0AsnXaa: 0.0 ± 0.0
Pro
4.405ProAla: 4.405 ± 1.194
2.937ProCys: 2.937 ± 1.262
2.203ProAsp: 2.203 ± 1.655
0.734ProGlu: 0.734 ± 0.619
1.468ProPhe: 1.468 ± 0.896
1.468ProGly: 1.468 ± 0.654
3.671ProHis: 3.671 ± 2.476
2.937ProIle: 2.937 ± 1.19
2.203ProLys: 2.203 ± 1.856
2.937ProLeu: 2.937 ± 1.895
2.203ProMet: 2.203 ± 1.084
2.937ProAsn: 2.937 ± 1.202
1.468ProPro: 1.468 ± 1.238
4.405ProGln: 4.405 ± 1.895
3.671ProArg: 3.671 ± 1.098
3.671ProSer: 3.671 ± 1.405
3.671ProThr: 3.671 ± 1.868
6.608ProVal: 6.608 ± 3.208
0.0ProTrp: 0.0 ± 0.0
2.937ProTyr: 2.937 ± 1.115
0.0ProXaa: 0.0 ± 0.0
Gln
5.14GlnAla: 5.14 ± 2.109
0.0GlnCys: 0.0 ± 0.0
4.405GlnAsp: 4.405 ± 2.759
3.671GlnGlu: 3.671 ± 1.271
2.937GlnPhe: 2.937 ± 1.917
2.203GlnGly: 2.203 ± 1.069
4.405GlnHis: 4.405 ± 2.4
2.203GlnIle: 2.203 ± 1.201
2.203GlnLys: 2.203 ± 0.981
1.468GlnLeu: 1.468 ± 0.776
0.0GlnMet: 0.0 ± 0.0
1.468GlnAsn: 1.468 ± 0.776
5.874GlnPro: 5.874 ± 2.904
3.671GlnGln: 3.671 ± 1.411
0.734GlnArg: 0.734 ± 0.952
3.671GlnSer: 3.671 ± 1.584
3.671GlnThr: 3.671 ± 1.589
4.405GlnVal: 4.405 ± 1.256
0.0GlnTrp: 0.0 ± 0.0
1.468GlnTyr: 1.468 ± 0.908
0.0GlnXaa: 0.0 ± 0.0
Arg
1.468ArgAla: 1.468 ± 1.154
2.937ArgCys: 2.937 ± 1.742
2.203ArgAsp: 2.203 ± 1.219
3.671ArgGlu: 3.671 ± 1.542
2.203ArgPhe: 2.203 ± 0.598
3.671ArgGly: 3.671 ± 1.112
2.937ArgHis: 2.937 ± 1.746
5.14ArgIle: 5.14 ± 1.541
2.203ArgLys: 2.203 ± 1.34
4.405ArgLeu: 4.405 ± 2.677
1.468ArgMet: 1.468 ± 1.154
4.405ArgAsn: 4.405 ± 1.439
5.14ArgPro: 5.14 ± 1.417
2.203ArgGln: 2.203 ± 1.371
8.076ArgArg: 8.076 ± 3.907
6.608ArgSer: 6.608 ± 1.612
4.405ArgThr: 4.405 ± 1.797
5.874ArgVal: 5.874 ± 0.733
0.0ArgTrp: 0.0 ± 0.0
1.468ArgTyr: 1.468 ± 0.886
0.0ArgXaa: 0.0 ± 0.0
Ser
3.671SerAla: 3.671 ± 1.652
0.734SerCys: 0.734 ± 0.867
2.203SerAsp: 2.203 ± 0.804
5.14SerGlu: 5.14 ± 1.815
2.203SerPhe: 2.203 ± 0.804
2.203SerGly: 2.203 ± 0.839
1.468SerHis: 1.468 ± 0.852
3.671SerIle: 3.671 ± 1.462
6.608SerLys: 6.608 ± 1.553
3.671SerLeu: 3.671 ± 1.289
2.203SerMet: 2.203 ± 0.951
4.405SerAsn: 4.405 ± 1.281
6.608SerPro: 6.608 ± 1.69
2.937SerGln: 2.937 ± 1.117
9.545SerArg: 9.545 ± 1.033
13.95SerSer: 13.95 ± 5.199
8.076SerThr: 8.076 ± 2.523
5.14SerVal: 5.14 ± 2.46
0.0SerTrp: 0.0 ± 0.0
2.203SerTyr: 2.203 ± 1.201
0.0SerXaa: 0.0 ± 0.0
Thr
5.874ThrAla: 5.874 ± 1.328
1.468ThrCys: 1.468 ± 1.033
0.0ThrAsp: 0.0 ± 0.0
2.203ThrGlu: 2.203 ± 1.138
2.203ThrPhe: 2.203 ± 1.121
6.608ThrGly: 6.608 ± 2.038
3.671ThrHis: 3.671 ± 2.375
3.671ThrIle: 3.671 ± 1.156
4.405ThrLys: 4.405 ± 1.195
5.14ThrLeu: 5.14 ± 1.733
1.468ThrMet: 1.468 ± 0.896
5.14ThrAsn: 5.14 ± 1.708
5.14ThrPro: 5.14 ± 1.342
3.671ThrGln: 3.671 ± 1.58
3.671ThrArg: 3.671 ± 1.719
5.14ThrSer: 5.14 ± 2.122
2.937ThrThr: 2.937 ± 1.75
2.203ThrVal: 2.203 ± 1.219
1.468ThrTrp: 1.468 ± 1.033
2.203ThrTyr: 2.203 ± 0.925
0.0ThrXaa: 0.0 ± 0.0
Val
0.734ValAla: 0.734 ± 0.691
1.468ValCys: 1.468 ± 1.381
3.671ValAsp: 3.671 ± 0.748
2.203ValGlu: 2.203 ± 1.902
2.203ValPhe: 2.203 ± 1.017
0.734ValGly: 0.734 ± 0.577
3.671ValHis: 3.671 ± 2.158
6.608ValIle: 6.608 ± 2.19
5.14ValLys: 5.14 ± 1.865
7.342ValLeu: 7.342 ± 2.023
1.468ValMet: 1.468 ± 1.154
1.468ValAsn: 1.468 ± 0.919
2.937ValPro: 2.937 ± 0.849
5.14ValGln: 5.14 ± 1.865
2.203ValArg: 2.203 ± 1.731
2.203ValSer: 2.203 ± 1.454
3.671ValThr: 3.671 ± 2.886
0.734ValVal: 0.734 ± 0.619
0.734ValTrp: 0.734 ± 0.691
2.203ValTyr: 2.203 ± 1.064
0.0ValXaa: 0.0 ± 0.0
Trp
2.203TrpAla: 2.203 ± 1.069
0.0TrpCys: 0.0 ± 0.0
0.734TrpAsp: 0.734 ± 0.867
0.734TrpGlu: 0.734 ± 0.719
0.734TrpPhe: 0.734 ± 0.619
0.734TrpGly: 0.734 ± 0.619
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.734TrpLeu: 0.734 ± 0.577
0.734TrpMet: 0.734 ± 0.577
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.734TrpGln: 0.734 ± 0.619
0.734TrpArg: 0.734 ± 0.727
1.468TrpSer: 1.468 ± 1.179
2.937TrpThr: 2.937 ± 1.486
0.734TrpVal: 0.734 ± 0.619
0.0TrpTrp: 0.0 ± 0.0
0.734TrpTyr: 0.734 ± 0.577
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.671TyrAla: 3.671 ± 1.473
0.0TyrCys: 0.0 ± 0.0
0.734TyrAsp: 0.734 ± 0.577
2.203TyrGlu: 2.203 ± 1.655
3.671TyrPhe: 3.671 ± 1.156
2.203TyrGly: 2.203 ± 0.839
0.0TyrHis: 0.0 ± 0.0
2.937TyrIle: 2.937 ± 1.917
1.468TyrLys: 1.468 ± 0.654
5.874TyrLeu: 5.874 ± 1.526
0.734TyrMet: 0.734 ± 0.691
1.468TyrAsn: 1.468 ± 1.439
1.468TyrPro: 1.468 ± 0.654
1.468TyrGln: 1.468 ± 0.836
2.937TyrArg: 2.937 ± 1.504
3.671TyrSer: 3.671 ± 1.978
1.468TyrThr: 1.468 ± 0.836
2.203TyrVal: 2.203 ± 1.15
0.0TyrTrp: 0.0 ± 0.0
0.734TyrTyr: 0.734 ± 0.727
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (1363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski