Amino acid dipepetide frequency for Klebsiella pneumoniae IS39

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.238AlaAla: 10.238 ± 0.115	1.098AlaCys: 1.098 ± 0.033	5.087AlaAsp: 5.087 ± 0.077	5.893AlaGlu: 5.893 ± 0.088	3.734AlaPhe: 3.734 ± 0.071	7.821AlaGly: 7.821 ± 0.083	1.952AlaHis: 1.952 ± 0.039	6.079AlaIle: 6.079 ± 0.091	4.086AlaLys: 4.086 ± 0.07	11.435AlaLeu: 11.435 ± 0.113	3.097AlaMet: 3.097 ± 0.049	2.981AlaAsn: 2.981 ± 0.054	3.559AlaPro: 3.559 ± 0.056	4.353AlaGln: 4.353 ± 0.069	5.565AlaArg: 5.565 ± 0.079	5.537AlaSer: 5.537 ± 0.067	4.616AlaThr: 4.616 ± 0.065	6.861AlaVal: 6.861 ± 0.086	1.716AlaTrp: 1.716 ± 0.045	2.036AlaTyr: 2.036 ± 0.034	0.001AlaXaa: 0.001 ± 0.001
Cys	1.007CysAla: 1.007 ± 0.032	0.232CysCys: 0.232 ± 0.016	0.584CysAsp: 0.584 ± 0.024	0.573CysGlu: 0.573 ± 0.023	0.483CysPhe: 0.483 ± 0.02	1.052CysGly: 1.052 ± 0.036	0.309CysHis: 0.309 ± 0.017	0.573CysIle: 0.573 ± 0.026	0.354CysLys: 0.354 ± 0.019	1.041CysLeu: 1.041 ± 0.029	0.312CysMet: 0.312 ± 0.016	0.31CysAsn: 0.31 ± 0.017	0.546CysPro: 0.546 ± 0.023	0.466CysGln: 0.466 ± 0.023	0.803CysArg: 0.803 ± 0.027	0.724CysSer: 0.724 ± 0.025	0.515CysThr: 0.515 ± 0.022	0.739CysVal: 0.739 ± 0.023	0.232CysTrp: 0.232 ± 0.017	0.345CysTyr: 0.345 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.987AspAla: 4.987 ± 0.065	0.512AspCys: 0.512 ± 0.019	3.063AspAsp: 3.063 ± 0.056	3.532AspGlu: 3.532 ± 0.061	2.096AspPhe: 2.096 ± 0.045	3.864AspGly: 3.864 ± 0.062	1.071AspHis: 1.071 ± 0.033	3.326AspIle: 3.326 ± 0.063	2.661AspLys: 2.661 ± 0.055	4.665AspLeu: 4.665 ± 0.063	1.347AspMet: 1.347 ± 0.034	2.137AspAsn: 2.137 ± 0.046	2.356AspPro: 2.356 ± 0.054	1.668AspGln: 1.668 ± 0.037	2.885AspArg: 2.885 ± 0.059	2.658AspSer: 2.658 ± 0.054	2.392AspThr: 2.392 ± 0.048	3.596AspVal: 3.596 ± 0.063	0.79AspTrp: 0.79 ± 0.027	1.955AspTyr: 1.955 ± 0.044	0.001AspXaa: 0.001 ± 0.001
Glu	5.464GluAla: 5.464 ± 0.076	0.477GluCys: 0.477 ± 0.022	2.376GluAsp: 2.376 ± 0.061	3.561GluGlu: 3.561 ± 0.066	1.876GluPhe: 1.876 ± 0.042	3.712GluGly: 3.712 ± 0.06	1.378GluHis: 1.378 ± 0.031	3.317GluIle: 3.317 ± 0.052	3.313GluLys: 3.313 ± 0.054	5.712GluLeu: 5.712 ± 0.083	1.89GluMet: 1.89 ± 0.04	2.211GluAsn: 2.211 ± 0.045	2.039GluPro: 2.039 ± 0.042	3.252GluGln: 3.252 ± 0.061	3.633GluArg: 3.633 ± 0.058	2.821GluSer: 2.821 ± 0.056	2.81GluThr: 2.81 ± 0.05	3.76GluVal: 3.76 ± 0.06	0.764GluTrp: 0.764 ± 0.029	1.516GluTyr: 1.516 ± 0.038	0.001GluXaa: 0.001 ± 0.001
Phe	3.87PheAla: 3.87 ± 0.06	0.623PheCys: 0.623 ± 0.025	2.336PheAsp: 2.336 ± 0.043	1.781PheGlu: 1.781 ± 0.04	1.881PhePhe: 1.881 ± 0.05	3.185PheGly: 3.185 ± 0.06	0.902PheHis: 0.902 ± 0.028	2.68PheIle: 2.68 ± 0.05	1.306PheLys: 1.306 ± 0.032	3.485PheLeu: 3.485 ± 0.062	1.103PheMet: 1.103 ± 0.034	1.803PheAsn: 1.803 ± 0.04	1.61PhePro: 1.61 ± 0.038	1.197PheGln: 1.197 ± 0.037	2.046PheArg: 2.046 ± 0.041	3.181PheSer: 3.181 ± 0.056	2.501PheThr: 2.501 ± 0.044	2.679PheVal: 2.679 ± 0.053	0.695PheTrp: 0.695 ± 0.026	1.326PheTyr: 1.326 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.23GlyAla: 6.23 ± 0.084	1.028GlyCys: 1.028 ± 0.031	3.81GlyAsp: 3.81 ± 0.06	4.623GlyGlu: 4.623 ± 0.071	3.432GlyPhe: 3.432 ± 0.059	5.5GlyGly: 5.5 ± 0.088	1.68GlyHis: 1.68 ± 0.041	5.108GlyIle: 5.108 ± 0.069	4.133GlyLys: 4.133 ± 0.075	7.423GlyLeu: 7.423 ± 0.079	2.562GlyMet: 2.562 ± 0.046	2.662GlyAsn: 2.662 ± 0.053	2.094GlyPro: 2.094 ± 0.047	2.894GlyGln: 2.894 ± 0.058	4.025GlyArg: 4.025 ± 0.066	4.094GlySer: 4.094 ± 0.073	3.607GlyThr: 3.607 ± 0.056	5.711GlyVal: 5.711 ± 0.077	1.306GlyTrp: 1.306 ± 0.035	2.666GlyTyr: 2.666 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.914HisAla: 1.914 ± 0.044	0.319HisCys: 0.319 ± 0.017	1.25HisAsp: 1.25 ± 0.035	1.037HisGlu: 1.037 ± 0.031	1.121HisPhe: 1.121 ± 0.029	1.821HisGly: 1.821 ± 0.043	0.931HisHis: 0.931 ± 0.038	1.396HisIle: 1.396 ± 0.035	0.801HisLys: 0.801 ± 0.03	2.303HisLeu: 2.303 ± 0.041	0.581HisMet: 0.581 ± 0.023	0.821HisAsn: 0.821 ± 0.027	1.399HisPro: 1.399 ± 0.034	1.259HisGln: 1.259 ± 0.041	1.459HisArg: 1.459 ± 0.039	1.288HisSer: 1.288 ± 0.037	1.071HisThr: 1.071 ± 0.033	1.277HisVal: 1.277 ± 0.03	0.396HisTrp: 0.396 ± 0.021	0.946HisTyr: 0.946 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.596IleAla: 6.596 ± 0.084	0.741IleCys: 0.741 ± 0.025	3.626IleAsp: 3.626 ± 0.059	3.298IleGlu: 3.298 ± 0.054	2.243IlePhe: 2.243 ± 0.05	4.584IleGly: 4.584 ± 0.072	1.231IleHis: 1.231 ± 0.033	3.548IleIle: 3.548 ± 0.06	2.422IleLys: 2.422 ± 0.046	5.052IleLeu: 5.052 ± 0.07	1.349IleMet: 1.349 ± 0.038	2.628IleAsn: 2.628 ± 0.05	2.822IlePro: 2.822 ± 0.051	1.816IleGln: 1.816 ± 0.041	3.103IleArg: 3.103 ± 0.049	3.686IleSer: 3.686 ± 0.067	3.432IleThr: 3.432 ± 0.056	4.096IleVal: 4.096 ± 0.062	0.684IleTrp: 0.684 ± 0.024	1.636IleTyr: 1.636 ± 0.041	0.001IleXaa: 0.001 ± 0.001
Lys	4.515LysAla: 4.515 ± 0.072	0.298LysCys: 0.298 ± 0.016	2.054LysAsp: 2.054 ± 0.044	2.434LysGlu: 2.434 ± 0.058	1.195LysPhe: 1.195 ± 0.035	3.079LysGly: 3.079 ± 0.052	0.882LysHis: 0.882 ± 0.029	2.432LysIle: 2.432 ± 0.046	2.496LysLys: 2.496 ± 0.059	4.233LysLeu: 4.233 ± 0.064	1.315LysMet: 1.315 ± 0.035	1.777LysAsn: 1.777 ± 0.04	2.125LysPro: 2.125 ± 0.045	1.994LysGln: 1.994 ± 0.051	2.758LysArg: 2.758 ± 0.048	2.39LysSer: 2.39 ± 0.049	2.62LysThr: 2.62 ± 0.046	3.086LysVal: 3.086 ± 0.055	0.483LysTrp: 0.483 ± 0.022	1.226LysTyr: 1.226 ± 0.033	0.003LysXaa: 0.003 ± 0.002
Leu	11.166LeuAla: 11.166 ± 0.118	1.266LeuCys: 1.266 ± 0.036	5.132LeuAsp: 5.132 ± 0.075	5.242LeuGlu: 5.242 ± 0.078	4.378LeuPhe: 4.378 ± 0.082	7.129LeuGly: 7.129 ± 0.078	2.299LeuHis: 2.299 ± 0.045	5.799LeuIle: 5.799 ± 0.071	4.483LeuLys: 4.483 ± 0.062	11.452LeuLeu: 11.452 ± 0.143	2.959LeuMet: 2.959 ± 0.055	4.006LeuAsn: 4.006 ± 0.068	5.451LeuPro: 5.451 ± 0.062	4.279LeuGln: 4.279 ± 0.069	6.181LeuArg: 6.181 ± 0.091	7.045LeuSer: 7.045 ± 0.089	6.089LeuThr: 6.089 ± 0.084	6.909LeuVal: 6.909 ± 0.08	1.399LeuTrp: 1.399 ± 0.037	2.69LeuTyr: 2.69 ± 0.056	0.003LeuXaa: 0.003 ± 0.002
Met	3.121MetAla: 3.121 ± 0.049	0.218MetCys: 0.218 ± 0.015	1.168MetAsp: 1.168 ± 0.034	1.297MetGlu: 1.297 ± 0.037	1.015MetPhe: 1.015 ± 0.03	1.955MetGly: 1.955 ± 0.042	0.584MetHis: 0.584 ± 0.023	1.607MetIle: 1.607 ± 0.038	1.529MetLys: 1.529 ± 0.038	3.299MetLeu: 3.299 ± 0.057	0.958MetMet: 0.958 ± 0.034	1.186MetAsn: 1.186 ± 0.03	1.492MetPro: 1.492 ± 0.035	1.242MetGln: 1.242 ± 0.034	1.641MetArg: 1.641 ± 0.038	1.878MetSer: 1.878 ± 0.039	1.86MetThr: 1.86 ± 0.041	2.103MetVal: 2.103 ± 0.043	0.296MetTrp: 0.296 ± 0.016	0.586MetTyr: 0.586 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.31AsnAla: 3.31 ± 0.067	0.349AsnCys: 0.349 ± 0.017	2.007AsnAsp: 2.007 ± 0.045	1.869AsnGlu: 1.869 ± 0.047	1.389AsnPhe: 1.389 ± 0.036	2.982AsnGly: 2.982 ± 0.062	0.879AsnHis: 0.879 ± 0.029	2.364AsnIle: 2.364 ± 0.054	1.616AsnLys: 1.616 ± 0.042	3.349AsnLeu: 3.349 ± 0.063	0.984AsnMet: 0.984 ± 0.03	1.534AsnAsn: 1.534 ± 0.042	2.058AsnPro: 2.058 ± 0.041	1.53AsnGln: 1.53 ± 0.035	1.959AsnArg: 1.959 ± 0.042	1.9AsnSer: 1.9 ± 0.044	1.863AsnThr: 1.863 ± 0.042	2.502AsnVal: 2.502 ± 0.049	0.571AsnTrp: 0.571 ± 0.024	1.195AsnTyr: 1.195 ± 0.03	0.001AsnXaa: 0.001 ± 0.001
Pro	4.684ProAla: 4.684 ± 0.06	0.391ProCys: 0.391 ± 0.018	2.74ProAsp: 2.74 ± 0.057	3.279ProGlu: 3.279 ± 0.055	1.911ProPhe: 1.911 ± 0.04	3.612ProGly: 3.612 ± 0.058	1.088ProHis: 1.088 ± 0.031	1.898ProIle: 1.898 ± 0.046	1.506ProLys: 1.506 ± 0.037	4.991ProLeu: 4.991 ± 0.071	1.16ProMet: 1.16 ± 0.036	1.26ProAsn: 1.26 ± 0.036	1.743ProPro: 1.743 ± 0.041	2.27ProGln: 2.27 ± 0.046	2.154ProArg: 2.154 ± 0.049	2.235ProSer: 2.235 ± 0.047	2.098ProThr: 2.098 ± 0.046	3.771ProVal: 3.771 ± 0.062	0.764ProTrp: 0.764 ± 0.026	1.228ProTyr: 1.228 ± 0.036	0.001ProXaa: 0.001 ± 0.001
Gln	4.614GlnAla: 4.614 ± 0.086	0.366GlnCys: 0.366 ± 0.019	1.723GlnAsp: 1.723 ± 0.037	2.17GlnGlu: 2.17 ± 0.047	1.534GlnPhe: 1.534 ± 0.041	3.039GlnGly: 3.039 ± 0.044	1.315GlnHis: 1.315 ± 0.038	2.222GlnIle: 2.222 ± 0.043	1.889GlnLys: 1.889 ± 0.045	4.767GlnLeu: 4.767 ± 0.074	1.24GlnMet: 1.24 ± 0.036	1.395GlnAsn: 1.395 ± 0.034	2.156GlnPro: 2.156 ± 0.049	3.25GlnGln: 3.25 ± 0.062	3.246GlnArg: 3.246 ± 0.065	2.209GlnSer: 2.209 ± 0.043	2.105GlnThr: 2.105 ± 0.044	2.959GlnVal: 2.959 ± 0.057	0.652GlnTrp: 0.652 ± 0.026	1.251GlnTyr: 1.251 ± 0.032	0.002GlnXaa: 0.002 ± 0.001
Arg	4.737ArgAla: 4.737 ± 0.064	0.725ArgCys: 0.725 ± 0.026	3.063ArgAsp: 3.063 ± 0.056	3.804ArgGlu: 3.804 ± 0.063	2.723ArgPhe: 2.723 ± 0.056	3.623ArgGly: 3.623 ± 0.061	1.786ArgHis: 1.786 ± 0.047	3.407ArgIle: 3.407 ± 0.057	2.486ArgLys: 2.486 ± 0.046	6.369ArgLeu: 6.369 ± 0.082	1.913ArgMet: 1.913 ± 0.037	2.034ArgAsn: 2.034 ± 0.044	2.45ArgPro: 2.45 ± 0.051	3.261ArgGln: 3.261 ± 0.063	4.325ArgArg: 4.325 ± 0.071	3.07ArgSer: 3.07 ± 0.055	2.411ArgThr: 2.411 ± 0.054	3.774ArgVal: 3.774 ± 0.058	1.068ArgTrp: 1.068 ± 0.033	2.276ArgTyr: 2.276 ± 0.046	0.002ArgXaa: 0.002 ± 0.001
Ser	5.742SerAla: 5.742 ± 0.088	0.631SerCys: 0.631 ± 0.023	3.035SerAsp: 3.035 ± 0.049	3.058SerGlu: 3.058 ± 0.051	2.392SerPhe: 2.392 ± 0.046	5.218SerGly: 5.218 ± 0.072	1.407SerHis: 1.407 ± 0.036	3.073SerIle: 3.073 ± 0.059	2.069SerLys: 2.069 ± 0.041	6.511SerLeu: 6.511 ± 0.084	1.599SerMet: 1.599 ± 0.04	1.744SerAsn: 1.744 ± 0.041	2.745SerPro: 2.745 ± 0.054	2.396SerGln: 2.396 ± 0.059	3.574SerArg: 3.574 ± 0.055	3.532SerSer: 3.532 ± 0.065	2.883SerThr: 2.883 ± 0.054	4.117SerVal: 4.117 ± 0.057	1.046SerTrp: 1.046 ± 0.034	1.634SerTyr: 1.634 ± 0.044	0.001SerXaa: 0.001 ± 0.001
Thr	4.952ThrAla: 4.952 ± 0.072	0.562ThrCys: 0.562 ± 0.024	2.485ThrAsp: 2.485 ± 0.052	2.499ThrGlu: 2.499 ± 0.053	2.12ThrPhe: 2.12 ± 0.045	4.344ThrGly: 4.344 ± 0.074	1.173ThrHis: 1.173 ± 0.033	2.944ThrIle: 2.944 ± 0.057	1.517ThrLys: 1.517 ± 0.039	6.944ThrLeu: 6.944 ± 0.087	1.256ThrMet: 1.256 ± 0.033	1.488ThrAsn: 1.488 ± 0.037	3.038ThrPro: 3.038 ± 0.055	1.915ThrGln: 1.915 ± 0.044	3.069ThrArg: 3.069 ± 0.053	2.911ThrSer: 2.911 ± 0.058	2.815ThrThr: 2.815 ± 0.056	3.788ThrVal: 3.788 ± 0.064	0.846ThrTrp: 0.846 ± 0.025	1.198ThrTyr: 1.198 ± 0.036	0.001ThrXaa: 0.001 ± 0.001
Val	6.941ValAla: 6.941 ± 0.083	0.768ValCys: 0.768 ± 0.026	3.801ValAsp: 3.801 ± 0.063	4.064ValGlu: 4.064 ± 0.072	2.681ValPhe: 2.681 ± 0.054	4.882ValGly: 4.882 ± 0.075	1.266ValHis: 1.266 ± 0.03	4.648ValIle: 4.648 ± 0.085	3.204ValLys: 3.204 ± 0.058	6.939ValLeu: 6.939 ± 0.092	2.223ValMet: 2.223 ± 0.043	2.741ValAsn: 2.741 ± 0.051	2.978ValPro: 2.978 ± 0.048	2.338ValGln: 2.338 ± 0.049	3.642ValArg: 3.642 ± 0.055	4.532ValSer: 4.532 ± 0.067	4.035ValThr: 4.035 ± 0.059	5.566ValVal: 5.566 ± 0.099	0.946ValTrp: 0.946 ± 0.029	1.824ValTyr: 1.824 ± 0.037	0.002ValXaa: 0.002 ± 0.001
Trp	1.027TrpAla: 1.027 ± 0.033	0.199TrpCys: 0.199 ± 0.013	0.628TrpAsp: 0.628 ± 0.023	0.619TrpGlu: 0.619 ± 0.025	0.731TrpPhe: 0.731 ± 0.03	0.953TrpGly: 0.953 ± 0.035	0.452TrpHis: 0.452 ± 0.02	0.753TrpIle: 0.753 ± 0.028	0.539TrpLys: 0.539 ± 0.025	2.312TrpLeu: 2.312 ± 0.046	0.5TrpMet: 0.5 ± 0.02	0.494TrpAsn: 0.494 ± 0.022	0.657TrpPro: 0.657 ± 0.026	1.111TrpGln: 1.111 ± 0.028	1.24TrpArg: 1.24 ± 0.032	0.882TrpSer: 0.882 ± 0.026	0.625TrpThr: 0.625 ± 0.026	0.956TrpVal: 0.956 ± 0.03	0.254TrpTrp: 0.254 ± 0.016	0.436TrpTyr: 0.436 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.629TyrAla: 2.629 ± 0.047	0.398TyrCys: 0.398 ± 0.015	1.592TyrAsp: 1.592 ± 0.042	1.251TyrGlu: 1.251 ± 0.032	1.251TyrPhe: 1.251 ± 0.033	2.233TyrGly: 2.233 ± 0.046	0.805TyrHis: 0.805 ± 0.025	1.419TyrIle: 1.419 ± 0.041	0.984TyrLys: 0.984 ± 0.027	3.072TyrLeu: 3.072 ± 0.046	0.687TyrMet: 0.687 ± 0.03	1.0TyrAsn: 1.0 ± 0.029	1.463TyrPro: 1.463 ± 0.038	1.612TyrGln: 1.612 ± 0.042	1.997TyrArg: 1.997 ± 0.042	1.832TyrSer: 1.832 ± 0.044	1.518TyrThr: 1.518 ± 0.039	1.771TyrVal: 1.771 ± 0.038	0.457TyrTrp: 0.457 ± 0.02	1.009TyrTyr: 1.009 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.005XaaPhe: 0.005 ± 0.002	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 5313 proteins (1108328 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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