Amino acid dipepetide frequency for Bacteroides cellulosilyticus CAG:158

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.463AlaAla: 5.463 ± 0.073	1.035AlaCys: 1.035 ± 0.025	4.168AlaAsp: 4.168 ± 0.047	4.735AlaGlu: 4.735 ± 0.051	3.212AlaPhe: 3.212 ± 0.042	5.036AlaGly: 5.036 ± 0.061	1.186AlaHis: 1.186 ± 0.026	4.505AlaIle: 4.505 ± 0.05	3.781AlaLys: 3.781 ± 0.053	6.517AlaLeu: 6.517 ± 0.076	1.902AlaMet: 1.902 ± 0.034	3.2AlaAsn: 3.2 ± 0.049	2.391AlaPro: 2.391 ± 0.04	2.657AlaGln: 2.657 ± 0.042	3.046AlaArg: 3.046 ± 0.041	4.352AlaSer: 4.352 ± 0.058	3.928AlaThr: 3.928 ± 0.056	4.614AlaVal: 4.614 ± 0.071	0.941AlaTrp: 0.941 ± 0.023	2.997AlaTyr: 2.997 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.746CysAla: 0.746 ± 0.021	0.226CysCys: 0.226 ± 0.012	0.639CysAsp: 0.639 ± 0.019	0.69CysGlu: 0.69 ± 0.022	0.643CysPhe: 0.643 ± 0.018	0.974CysGly: 0.974 ± 0.023	0.279CysHis: 0.279 ± 0.013	0.973CysIle: 0.973 ± 0.027	0.618CysLys: 0.618 ± 0.021	1.125CysLeu: 1.125 ± 0.029	0.324CysMet: 0.324 ± 0.015	0.538CysAsn: 0.538 ± 0.017	0.508CysPro: 0.508 ± 0.02	0.369CysGln: 0.369 ± 0.016	0.631CysArg: 0.631 ± 0.019	0.821CysSer: 0.821 ± 0.021	0.724CysThr: 0.724 ± 0.021	0.728CysVal: 0.728 ± 0.02	0.177CysTrp: 0.177 ± 0.011	0.601CysTyr: 0.601 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.019AspAla: 4.019 ± 0.048	0.63AspCys: 0.63 ± 0.018	2.676AspAsp: 2.676 ± 0.046	3.786AspGlu: 3.786 ± 0.056	2.945AspPhe: 2.945 ± 0.047	4.449AspGly: 4.449 ± 0.061	0.823AspHis: 0.823 ± 0.023	4.066AspIle: 4.066 ± 0.049	4.039AspLys: 4.039 ± 0.058	4.483AspLeu: 4.483 ± 0.056	1.601AspMet: 1.601 ± 0.027	2.9AspAsn: 2.9 ± 0.047	1.923AspPro: 1.923 ± 0.037	1.334AspGln: 1.334 ± 0.027	2.427AspArg: 2.427 ± 0.039	3.05AspSer: 3.05 ± 0.048	2.715AspThr: 2.715 ± 0.039	3.538AspVal: 3.538 ± 0.044	0.987AspTrp: 0.987 ± 0.022	2.916AspTyr: 2.916 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.755GluAla: 4.755 ± 0.059	0.632GluCys: 0.632 ± 0.022	3.374GluAsp: 3.374 ± 0.051	4.902GluGlu: 4.902 ± 0.072	2.408GluPhe: 2.408 ± 0.038	4.296GluGly: 4.296 ± 0.052	1.199GluHis: 1.199 ± 0.023	4.396GluIle: 4.396 ± 0.054	5.144GluLys: 5.144 ± 0.054	6.094GluLeu: 6.094 ± 0.066	2.036GluMet: 2.036 ± 0.034	3.535GluAsn: 3.535 ± 0.047	1.771GluPro: 1.771 ± 0.038	2.596GluGln: 2.596 ± 0.042	3.102GluArg: 3.102 ± 0.046	3.077GluSer: 3.077 ± 0.046	3.42GluThr: 3.42 ± 0.044	4.314GluVal: 4.314 ± 0.056	0.913GluTrp: 0.913 ± 0.023	2.919GluTyr: 2.919 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.892PheAla: 2.892 ± 0.044	0.704PheCys: 0.704 ± 0.02	2.668PheAsp: 2.668 ± 0.037	2.439PheGlu: 2.439 ± 0.038	2.205PhePhe: 2.205 ± 0.043	3.153PheGly: 3.153 ± 0.049	0.894PheHis: 0.894 ± 0.023	3.232PheIle: 3.232 ± 0.053	2.306PheLys: 2.306 ± 0.039	3.988PheLeu: 3.988 ± 0.055	1.243PheMet: 1.243 ± 0.024	2.384PheAsn: 2.384 ± 0.04	1.827PhePro: 1.827 ± 0.036	1.355PheGln: 1.355 ± 0.028	2.252PheArg: 2.252 ± 0.037	3.621PheSer: 3.621 ± 0.051	2.82PheThr: 2.82 ± 0.038	2.766PheVal: 2.766 ± 0.046	0.652PheTrp: 0.652 ± 0.022	2.151PheTyr: 2.151 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.314GlyAla: 4.314 ± 0.064	0.919GlyCys: 0.919 ± 0.029	3.647GlyAsp: 3.647 ± 0.052	4.27GlyGlu: 4.27 ± 0.056	3.097GlyPhe: 3.097 ± 0.047	4.896GlyGly: 4.896 ± 0.078	1.236GlyHis: 1.236 ± 0.033	5.386GlyIle: 5.386 ± 0.058	5.302GlyLys: 5.302 ± 0.057	5.852GlyLeu: 5.852 ± 0.064	2.2GlyMet: 2.2 ± 0.035	3.759GlyAsn: 3.759 ± 0.049	1.376GlyPro: 1.376 ± 0.033	2.155GlyGln: 2.155 ± 0.037	2.88GlyArg: 2.88 ± 0.043	4.101GlySer: 4.101 ± 0.061	4.472GlyThr: 4.472 ± 0.061	4.827GlyVal: 4.827 ± 0.066	1.173GlyTrp: 1.173 ± 0.032	3.582GlyTyr: 3.582 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.229HisAla: 1.229 ± 0.03	0.281HisCys: 0.281 ± 0.016	0.904HisAsp: 0.904 ± 0.022	1.072HisGlu: 1.072 ± 0.025	1.019HisPhe: 1.019 ± 0.025	1.207HisGly: 1.207 ± 0.031	0.468HisHis: 0.468 ± 0.016	1.362HisIle: 1.362 ± 0.03	0.952HisLys: 0.952 ± 0.022	1.702HisLeu: 1.702 ± 0.036	0.374HisMet: 0.374 ± 0.013	0.926HisAsn: 0.926 ± 0.025	1.082HisPro: 1.082 ± 0.028	0.628HisGln: 0.628 ± 0.021	0.864HisArg: 0.864 ± 0.024	1.137HisSer: 1.137 ± 0.029	1.092HisThr: 1.092 ± 0.027	1.025HisVal: 1.025 ± 0.024	0.301HisTrp: 0.301 ± 0.014	0.952HisTyr: 0.952 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.004IleAla: 5.004 ± 0.058	0.972IleCys: 0.972 ± 0.023	4.077IleAsp: 4.077 ± 0.05	4.242IleGlu: 4.242 ± 0.055	2.813IlePhe: 2.813 ± 0.053	4.697IleGly: 4.697 ± 0.061	1.349IleHis: 1.349 ± 0.03	4.368IleIle: 4.368 ± 0.065	3.722IleLys: 3.722 ± 0.051	5.924IleLeu: 5.924 ± 0.076	1.446IleMet: 1.446 ± 0.028	3.399IleAsn: 3.399 ± 0.051	3.126IlePro: 3.126 ± 0.043	2.146IleGln: 2.146 ± 0.039	3.454IleArg: 3.454 ± 0.049	4.679IleSer: 4.679 ± 0.059	4.123IleThr: 4.123 ± 0.053	4.202IleVal: 4.202 ± 0.062	0.879IleTrp: 0.879 ± 0.027	2.979IleTyr: 2.979 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.612LysAla: 4.612 ± 0.058	0.488LysCys: 0.488 ± 0.017	4.083LysAsp: 4.083 ± 0.052	5.607LysGlu: 5.607 ± 0.067	2.078LysPhe: 2.078 ± 0.038	4.443LysGly: 4.443 ± 0.047	1.207LysHis: 1.207 ± 0.026	3.841LysIle: 3.841 ± 0.058	4.728LysLys: 4.728 ± 0.056	5.227LysLeu: 5.227 ± 0.057	2.014LysMet: 2.014 ± 0.033	3.55LysAsn: 3.55 ± 0.053	2.078LysPro: 2.078 ± 0.037	2.563LysGln: 2.563 ± 0.039	2.891LysArg: 2.891 ± 0.045	3.286LysSer: 3.286 ± 0.044	3.25LysThr: 3.25 ± 0.053	4.281LysVal: 4.281 ± 0.052	0.842LysTrp: 0.842 ± 0.022	2.959LysTyr: 2.959 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	6.185LeuAla: 6.185 ± 0.068	1.357LeuCys: 1.357 ± 0.032	4.55LeuAsp: 4.55 ± 0.049	4.945LeuGlu: 4.945 ± 0.054	4.555LeuPhe: 4.555 ± 0.065	5.453LeuGly: 5.453 ± 0.067	1.704LeuHis: 1.704 ± 0.035	5.673LeuIle: 5.673 ± 0.074	6.237LeuLys: 6.237 ± 0.058	9.252LeuLeu: 9.252 ± 0.105	2.375LeuMet: 2.375 ± 0.044	4.758LeuAsn: 4.758 ± 0.057	4.237LeuPro: 4.237 ± 0.054	3.451LeuGln: 3.451 ± 0.046	4.119LeuArg: 4.119 ± 0.054	6.796LeuSer: 6.796 ± 0.077	5.303LeuThr: 5.303 ± 0.061	4.985LeuVal: 4.985 ± 0.056	1.198LeuTrp: 1.198 ± 0.032	3.863LeuTyr: 3.863 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.905MetAla: 1.905 ± 0.039	0.254MetCys: 0.254 ± 0.012	1.504MetAsp: 1.504 ± 0.033	1.833MetGlu: 1.833 ± 0.036	0.994MetPhe: 0.994 ± 0.027	1.837MetGly: 1.837 ± 0.032	0.476MetHis: 0.476 ± 0.015	1.603MetIle: 1.603 ± 0.033	2.626MetLys: 2.626 ± 0.038	2.473MetLeu: 2.473 ± 0.038	0.802MetMet: 0.802 ± 0.024	1.667MetAsn: 1.667 ± 0.033	1.2MetPro: 1.2 ± 0.026	1.115MetGln: 1.115 ± 0.028	1.349MetArg: 1.349 ± 0.027	1.514MetSer: 1.514 ± 0.026	1.442MetThr: 1.442 ± 0.03	1.489MetVal: 1.489 ± 0.03	0.287MetTrp: 0.287 ± 0.015	0.959MetTyr: 0.959 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.472AsnAla: 3.472 ± 0.057	0.544AsnCys: 0.544 ± 0.017	2.61AsnAsp: 2.61 ± 0.038	3.148AsnGlu: 3.148 ± 0.047	2.309AsnPhe: 2.309 ± 0.034	4.077AsnGly: 4.077 ± 0.057	1.012AsnHis: 1.012 ± 0.025	3.828AsnIle: 3.828 ± 0.059	3.082AsnLys: 3.082 ± 0.043	4.532AsnLeu: 4.532 ± 0.055	1.38AsnMet: 1.38 ± 0.034	2.722AsnAsn: 2.722 ± 0.05	2.568AsnPro: 2.568 ± 0.044	1.74AsnGln: 1.74 ± 0.041	2.536AsnArg: 2.536 ± 0.042	3.025AsnSer: 3.025 ± 0.049	2.842AsnThr: 2.842 ± 0.038	3.241AsnVal: 3.241 ± 0.045	0.797AsnTrp: 0.797 ± 0.02	2.605AsnTyr: 2.605 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.816ProAla: 2.816 ± 0.044	0.373ProCys: 0.373 ± 0.016	2.647ProAsp: 2.647 ± 0.039	3.466ProGlu: 3.466 ± 0.045	1.887ProPhe: 1.887 ± 0.038	2.655ProGly: 2.655 ± 0.045	0.707ProHis: 0.707 ± 0.019	2.237ProIle: 2.237 ± 0.045	1.975ProLys: 1.975 ± 0.037	3.349ProLeu: 3.349 ± 0.047	0.943ProMet: 0.943 ± 0.021	1.726ProAsn: 1.726 ± 0.03	0.785ProPro: 0.785 ± 0.022	1.482ProGln: 1.482 ± 0.028	1.362ProArg: 1.362 ± 0.029	2.257ProSer: 2.257 ± 0.035	1.962ProThr: 1.962 ± 0.036	3.121ProVal: 3.121 ± 0.043	0.536ProTrp: 0.536 ± 0.022	1.818ProTyr: 1.818 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.485GlnAla: 2.485 ± 0.035	0.308GlnCys: 0.308 ± 0.013	1.683GlnAsp: 1.683 ± 0.029	2.363GlnGlu: 2.363 ± 0.043	1.326GlnPhe: 1.326 ± 0.03	2.163GlnGly: 2.163 ± 0.037	0.671GlnHis: 0.671 ± 0.022	2.273GlnIle: 2.273 ± 0.04	2.434GlnLys: 2.434 ± 0.041	3.36GlnLeu: 3.36 ± 0.049	1.067GlnMet: 1.067 ± 0.026	1.834GlnAsn: 1.834 ± 0.037	1.368GlnPro: 1.368 ± 0.033	1.567GlnGln: 1.567 ± 0.035	1.622GlnArg: 1.622 ± 0.036	2.073GlnSer: 2.073 ± 0.036	2.079GlnThr: 2.079 ± 0.037	2.183GlnVal: 2.183 ± 0.039	0.527GlnTrp: 0.527 ± 0.017	1.548GlnTyr: 1.548 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.802ArgAla: 2.802 ± 0.044	0.493ArgCys: 0.493 ± 0.017	2.117ArgAsp: 2.117 ± 0.033	2.971ArgGlu: 2.971 ± 0.041	2.3ArgPhe: 2.3 ± 0.039	2.494ArgGly: 2.494 ± 0.043	0.888ArgHis: 0.888 ± 0.023	3.6ArgIle: 3.6 ± 0.052	3.233ArgLys: 3.233 ± 0.05	4.53ArgLeu: 4.53 ± 0.058	1.528ArgMet: 1.528 ± 0.026	2.579ArgAsn: 2.579 ± 0.041	1.618ArgPro: 1.618 ± 0.034	1.709ArgGln: 1.709 ± 0.036	2.173ArgArg: 2.173 ± 0.038	2.402ArgSer: 2.402 ± 0.041	2.565ArgThr: 2.565 ± 0.038	2.536ArgVal: 2.536 ± 0.041	0.73ArgTrp: 0.73 ± 0.021	2.28ArgTyr: 2.28 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.328SerAla: 4.328 ± 0.06	0.84SerCys: 0.84 ± 0.025	3.407SerAsp: 3.407 ± 0.042	3.528SerGlu: 3.528 ± 0.048	3.32SerPhe: 3.32 ± 0.045	4.756SerGly: 4.756 ± 0.06	1.175SerHis: 1.175 ± 0.026	4.43SerIle: 4.43 ± 0.064	3.186SerLys: 3.186 ± 0.044	6.093SerLeu: 6.093 ± 0.078	1.558SerMet: 1.558 ± 0.03	2.84SerAsn: 2.84 ± 0.053	2.362SerPro: 2.362 ± 0.04	1.92SerGln: 1.92 ± 0.033	2.639SerArg: 2.639 ± 0.042	4.044SerSer: 4.044 ± 0.066	3.41SerThr: 3.41 ± 0.043	4.26SerVal: 4.26 ± 0.06	0.923SerTrp: 0.923 ± 0.027	2.944SerTyr: 2.944 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.075ThrAla: 4.075 ± 0.049	0.594ThrCys: 0.594 ± 0.018	3.504ThrAsp: 3.504 ± 0.046	3.491ThrGlu: 3.491 ± 0.042	2.836ThrPhe: 2.836 ± 0.041	4.56ThrGly: 4.56 ± 0.057	0.995ThrHis: 0.995 ± 0.025	3.698ThrIle: 3.698 ± 0.049	2.802ThrLys: 2.802 ± 0.044	5.557ThrLeu: 5.557 ± 0.059	1.181ThrMet: 1.181 ± 0.026	2.649ThrAsn: 2.649 ± 0.042	2.898ThrPro: 2.898 ± 0.044	1.794ThrGln: 1.794 ± 0.033	2.214ThrArg: 2.214 ± 0.038	3.417ThrSer: 3.417 ± 0.048	3.201ThrThr: 3.201 ± 0.055	4.045ThrVal: 4.045 ± 0.064	0.776ThrTrp: 0.776 ± 0.022	2.644ThrTyr: 2.644 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.496ValAla: 4.496 ± 0.054	0.942ValCys: 0.942 ± 0.027	3.622ValAsp: 3.622 ± 0.05	3.955ValGlu: 3.955 ± 0.049	2.763ValPhe: 2.763 ± 0.044	3.99ValGly: 3.99 ± 0.063	1.141ValHis: 1.141 ± 0.027	4.223ValIle: 4.223 ± 0.06	4.073ValLys: 4.073 ± 0.053	5.617ValLeu: 5.617 ± 0.06	1.664ValMet: 1.664 ± 0.037	3.48ValAsn: 3.48 ± 0.049	2.609ValPro: 2.609 ± 0.041	1.995ValGln: 1.995 ± 0.032	2.937ValArg: 2.937 ± 0.038	4.507ValSer: 4.507 ± 0.056	3.895ValThr: 3.895 ± 0.061	4.296ValVal: 4.296 ± 0.063	0.84ValTrp: 0.84 ± 0.023	2.761ValTyr: 2.761 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.899TrpAla: 0.899 ± 0.021	0.173TrpCys: 0.173 ± 0.011	0.83TrpAsp: 0.83 ± 0.023	0.919TrpGlu: 0.919 ± 0.027	0.64TrpPhe: 0.64 ± 0.017	1.175TrpGly: 1.175 ± 0.027	0.279TrpHis: 0.279 ± 0.015	0.94TrpIle: 0.94 ± 0.027	1.034TrpLys: 1.034 ± 0.029	1.234TrpLeu: 1.234 ± 0.028	0.488TrpMet: 0.488 ± 0.015	0.973TrpAsn: 0.973 ± 0.028	0.327TrpPro: 0.327 ± 0.017	0.591TrpGln: 0.591 ± 0.019	0.658TrpArg: 0.658 ± 0.019	0.795TrpSer: 0.795 ± 0.023	0.773TrpThr: 0.773 ± 0.02	0.816TrpVal: 0.816 ± 0.026	0.249TrpTrp: 0.249 ± 0.012	0.647TrpTyr: 0.647 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.168TyrAla: 3.168 ± 0.045	0.568TyrCys: 0.568 ± 0.02	2.599TyrAsp: 2.599 ± 0.044	2.518TyrGlu: 2.518 ± 0.039	2.202TyrPhe: 2.202 ± 0.037	3.135TyrGly: 3.135 ± 0.048	0.887TyrHis: 0.887 ± 0.024	2.97TyrIle: 2.97 ± 0.047	2.751TyrLys: 2.751 ± 0.04	4.089TyrLeu: 4.089 ± 0.06	1.202TyrMet: 1.202 ± 0.024	2.651TyrAsn: 2.651 ± 0.049	2.05TyrPro: 2.05 ± 0.035	1.766TyrGln: 1.766 ± 0.031	2.391TyrArg: 2.391 ± 0.04	3.01TyrSer: 3.01 ± 0.043	2.916TyrThr: 2.916 ± 0.048	2.538TyrVal: 2.538 ± 0.036	0.712TyrTrp: 0.712 ± 0.023	2.357TyrTyr: 2.357 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4369 proteins (1722108 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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