Amino acid dipepetide frequency for Parasphingorhabdus marina DSM 22363

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.546AlaAla: 13.546 ± 0.161	0.957AlaCys: 0.957 ± 0.032	7.054AlaAsp: 7.054 ± 0.082	7.597AlaGlu: 7.597 ± 0.09	3.934AlaPhe: 3.934 ± 0.069	9.808AlaGly: 9.808 ± 0.13	1.907AlaHis: 1.907 ± 0.044	6.591AlaIle: 6.591 ± 0.092	4.162AlaLys: 4.162 ± 0.076	11.078AlaLeu: 11.078 ± 0.125	3.352AlaMet: 3.352 ± 0.053	3.293AlaAsn: 3.293 ± 0.058	4.688AlaPro: 4.688 ± 0.081	3.799AlaGln: 3.799 ± 0.064	6.849AlaArg: 6.849 ± 0.093	6.363AlaSer: 6.363 ± 0.08	5.448AlaThr: 5.448 ± 0.093	7.319AlaVal: 7.319 ± 0.098	1.336AlaTrp: 1.336 ± 0.035	2.252AlaTyr: 2.252 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.869CysAla: 0.869 ± 0.033	0.101CysCys: 0.101 ± 0.011	0.585CysAsp: 0.585 ± 0.023	0.454CysGlu: 0.454 ± 0.018	0.31CysPhe: 0.31 ± 0.016	0.865CysGly: 0.865 ± 0.03	0.258CysHis: 0.258 ± 0.019	0.385CysIle: 0.385 ± 0.022	0.231CysLys: 0.231 ± 0.014	0.767CysLeu: 0.767 ± 0.029	0.163CysMet: 0.163 ± 0.014	0.264CysAsn: 0.264 ± 0.017	0.444CysPro: 0.444 ± 0.022	0.274CysGln: 0.274 ± 0.015	0.53CysArg: 0.53 ± 0.022	0.504CysSer: 0.504 ± 0.022	0.402CysThr: 0.402 ± 0.02	0.526CysVal: 0.526 ± 0.022	0.103CysTrp: 0.103 ± 0.011	0.18CysTyr: 0.18 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.561AspAla: 6.561 ± 0.075	0.52AspCys: 0.52 ± 0.023	3.823AspAsp: 3.823 ± 0.075	3.904AspGlu: 3.904 ± 0.069	2.485AspPhe: 2.485 ± 0.052	5.798AspGly: 5.798 ± 0.098	1.388AspHis: 1.388 ± 0.038	4.015AspIle: 4.015 ± 0.089	2.275AspLys: 2.275 ± 0.052	5.836AspLeu: 5.836 ± 0.084	1.782AspMet: 1.782 ± 0.035	2.004AspAsn: 2.004 ± 0.046	3.599AspPro: 3.599 ± 0.064	2.418AspGln: 2.418 ± 0.054	4.48AspArg: 4.48 ± 0.07	3.202AspSer: 3.202 ± 0.054	2.674AspThr: 2.674 ± 0.049	4.087AspVal: 4.087 ± 0.075	1.073AspTrp: 1.073 ± 0.038	1.699AspTyr: 1.699 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.973GluAla: 6.973 ± 0.106	0.35GluCys: 0.35 ± 0.018	3.597GluAsp: 3.597 ± 0.063	4.186GluGlu: 4.186 ± 0.083	2.102GluPhe: 2.102 ± 0.046	4.401GluGly: 4.401 ± 0.072	1.222GluHis: 1.222 ± 0.037	3.982GluIle: 3.982 ± 0.064	3.165GluLys: 3.165 ± 0.067	5.612GluLeu: 5.612 ± 0.083	1.816GluMet: 1.816 ± 0.043	2.333GluAsn: 2.333 ± 0.05	2.751GluPro: 2.751 ± 0.055	2.701GluGln: 2.701 ± 0.054	4.136GluArg: 4.136 ± 0.072	3.033GluSer: 3.033 ± 0.049	3.675GluThr: 3.675 ± 0.065	3.527GluVal: 3.527 ± 0.073	0.789GluTrp: 0.789 ± 0.026	1.347GluTyr: 1.347 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.683PheAla: 4.683 ± 0.071	0.379PheCys: 0.379 ± 0.017	2.964PheAsp: 2.964 ± 0.059	2.371PheGlu: 2.371 ± 0.05	1.573PhePhe: 1.573 ± 0.048	4.036PheGly: 4.036 ± 0.07	0.745PheHis: 0.745 ± 0.025	1.63PheIle: 1.63 ± 0.038	1.021PheLys: 1.021 ± 0.036	3.548PheLeu: 3.548 ± 0.063	0.885PheMet: 0.885 ± 0.028	1.219PheAsn: 1.219 ± 0.041	1.657PhePro: 1.657 ± 0.043	1.122PheGln: 1.122 ± 0.034	2.297PheArg: 2.297 ± 0.049	2.474PheSer: 2.474 ± 0.048	2.0PheThr: 2.0 ± 0.059	2.805PheVal: 2.805 ± 0.062	0.593PheTrp: 0.593 ± 0.025	1.024PheTyr: 1.024 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.133GlyAla: 8.133 ± 0.115	0.798GlyCys: 0.798 ± 0.028	5.102GlyAsp: 5.102 ± 0.1	5.131GlyGlu: 5.131 ± 0.078	3.734GlyPhe: 3.734 ± 0.072	7.537GlyGly: 7.537 ± 0.149	1.735GlyHis: 1.735 ± 0.042	4.82GlyIle: 4.82 ± 0.108	3.951GlyLys: 3.951 ± 0.065	8.402GlyLeu: 8.402 ± 0.103	2.318GlyMet: 2.318 ± 0.053	2.911GlyAsn: 2.911 ± 0.067	3.45GlyPro: 3.45 ± 0.059	3.291GlyGln: 3.291 ± 0.051	5.002GlyArg: 5.002 ± 0.073	5.237GlySer: 5.237 ± 0.091	4.845GlyThr: 4.845 ± 0.122	5.369GlyVal: 5.369 ± 0.072	1.398GlyTrp: 1.398 ± 0.038	2.402GlyTyr: 2.402 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.881HisAla: 1.881 ± 0.049	0.256HisCys: 0.256 ± 0.015	1.228HisAsp: 1.228 ± 0.039	1.011HisGlu: 1.011 ± 0.032	0.907HisPhe: 0.907 ± 0.033	1.774HisGly: 1.774 ± 0.044	0.553HisHis: 0.553 ± 0.026	1.109HisIle: 1.109 ± 0.033	0.629HisLys: 0.629 ± 0.026	1.786HisLeu: 1.786 ± 0.039	0.503HisMet: 0.503 ± 0.022	0.555HisAsn: 0.555 ± 0.024	1.252HisPro: 1.252 ± 0.04	0.647HisGln: 0.647 ± 0.024	1.21HisArg: 1.21 ± 0.035	1.044HisSer: 1.044 ± 0.034	0.624HisThr: 0.624 ± 0.025	1.424HisVal: 1.424 ± 0.039	0.343HisTrp: 0.343 ± 0.018	0.581HisTyr: 0.581 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.373IleAla: 7.373 ± 0.089	0.574IleCys: 0.574 ± 0.025	3.925IleAsp: 3.925 ± 0.066	3.591IleGlu: 3.591 ± 0.056	2.134IlePhe: 2.134 ± 0.05	5.183IleGly: 5.183 ± 0.073	0.962IleHis: 0.962 ± 0.035	3.082IleIle: 3.082 ± 0.063	1.624IleLys: 1.624 ± 0.04	5.09IleLeu: 5.09 ± 0.085	1.306IleMet: 1.306 ± 0.034	1.884IleAsn: 1.884 ± 0.052	2.687IlePro: 2.687 ± 0.05	1.347IleGln: 1.347 ± 0.04	3.362IleArg: 3.362 ± 0.058	3.879IleSer: 3.879 ± 0.068	3.096IleThr: 3.096 ± 0.084	4.118IleVal: 4.118 ± 0.059	0.835IleTrp: 0.835 ± 0.029	1.311IleTyr: 1.311 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.241LysAla: 4.241 ± 0.08	0.237LysCys: 0.237 ± 0.016	2.125LysAsp: 2.125 ± 0.049	1.931LysGlu: 1.931 ± 0.053	1.202LysPhe: 1.202 ± 0.035	2.793LysGly: 2.793 ± 0.056	0.7LysHis: 0.7 ± 0.029	2.265LysIle: 2.265 ± 0.055	1.977LysLys: 1.977 ± 0.05	3.868LysLeu: 3.868 ± 0.068	1.109LysMet: 1.109 ± 0.039	1.169LysAsn: 1.169 ± 0.035	2.239LysPro: 2.239 ± 0.055	1.288LysGln: 1.288 ± 0.036	2.395LysArg: 2.395 ± 0.058	2.415LysSer: 2.415 ± 0.055	2.187LysThr: 2.187 ± 0.052	2.414LysVal: 2.414 ± 0.046	0.55LysTrp: 0.55 ± 0.02	0.873LysTyr: 0.873 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.482LeuAla: 11.482 ± 0.149	0.808LeuCys: 0.808 ± 0.03	6.112LeuAsp: 6.112 ± 0.084	5.618LeuGlu: 5.618 ± 0.079	3.979LeuPhe: 3.979 ± 0.085	7.458LeuGly: 7.458 ± 0.098	1.717LeuHis: 1.717 ± 0.042	5.306LeuIle: 5.306 ± 0.095	3.6LeuLys: 3.6 ± 0.069	9.049LeuLeu: 9.049 ± 0.164	2.206LeuMet: 2.206 ± 0.044	2.864LeuAsn: 2.864 ± 0.058	4.967LeuPro: 4.967 ± 0.078	2.925LeuGln: 2.925 ± 0.058	5.449LeuArg: 5.449 ± 0.084	6.381LeuSer: 6.381 ± 0.084	5.419LeuThr: 5.419 ± 0.081	6.623LeuVal: 6.623 ± 0.089	1.124LeuTrp: 1.124 ± 0.033	1.902LeuTyr: 1.902 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.188MetAla: 3.188 ± 0.054	0.171MetCys: 0.171 ± 0.013	1.398MetAsp: 1.398 ± 0.04	1.45MetGlu: 1.45 ± 0.038	0.814MetPhe: 0.814 ± 0.028	1.99MetGly: 1.99 ± 0.047	0.478MetHis: 0.478 ± 0.019	1.615MetIle: 1.615 ± 0.043	1.195MetLys: 1.195 ± 0.035	2.541MetLeu: 2.541 ± 0.052	0.801MetMet: 0.801 ± 0.031	0.858MetAsn: 0.858 ± 0.03	1.427MetPro: 1.427 ± 0.036	0.944MetGln: 0.944 ± 0.029	1.667MetArg: 1.667 ± 0.043	1.62MetSer: 1.62 ± 0.041	1.977MetThr: 1.977 ± 0.046	1.679MetVal: 1.679 ± 0.042	0.239MetTrp: 0.239 ± 0.016	0.307MetTyr: 0.307 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.431AsnAla: 3.431 ± 0.071	0.319AsnCys: 0.319 ± 0.02	1.809AsnAsp: 1.809 ± 0.04	1.502AsnGlu: 1.502 ± 0.036	1.363AsnPhe: 1.363 ± 0.042	2.978AsnGly: 2.978 ± 0.071	0.597AsnHis: 0.597 ± 0.026	2.046AsnIle: 2.046 ± 0.056	0.902AsnLys: 0.902 ± 0.032	2.995AsnLeu: 2.995 ± 0.059	0.849AsnMet: 0.849 ± 0.029	1.071AsnAsn: 1.071 ± 0.041	2.061AsnPro: 2.061 ± 0.044	1.056AsnGln: 1.056 ± 0.033	2.236AsnArg: 2.236 ± 0.053	1.878AsnSer: 1.878 ± 0.045	1.368AsnThr: 1.368 ± 0.043	2.196AsnVal: 2.196 ± 0.046	0.556AsnTrp: 0.556 ± 0.024	0.826AsnTyr: 0.826 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.565ProAla: 5.565 ± 0.078	0.275ProCys: 0.275 ± 0.018	4.257ProAsp: 4.257 ± 0.066	4.213ProGlu: 4.213 ± 0.068	1.904ProPhe: 1.904 ± 0.042	4.333ProGly: 4.333 ± 0.064	0.947ProHis: 0.947 ± 0.033	2.329ProIle: 2.329 ± 0.049	1.726ProLys: 1.726 ± 0.042	4.324ProLeu: 4.324 ± 0.074	1.232ProMet: 1.232 ± 0.034	1.406ProAsn: 1.406 ± 0.037	2.295ProPro: 2.295 ± 0.063	1.525ProGln: 1.525 ± 0.04	2.275ProArg: 2.275 ± 0.046	2.436ProSer: 2.436 ± 0.047	2.187ProThr: 2.187 ± 0.056	4.333ProVal: 4.333 ± 0.063	0.624ProTrp: 0.624 ± 0.022	1.031ProTyr: 1.031 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.777GlnAla: 3.777 ± 0.062	0.294GlnCys: 0.294 ± 0.015	1.841GlnAsp: 1.841 ± 0.043	1.778GlnGlu: 1.778 ± 0.04	1.395GlnPhe: 1.395 ± 0.039	2.421GlnGly: 2.421 ± 0.048	0.611GlnHis: 0.611 ± 0.024	2.236GlnIle: 2.236 ± 0.042	1.501GlnLys: 1.501 ± 0.039	3.288GlnLeu: 3.288 ± 0.059	0.968GlnMet: 0.968 ± 0.029	1.195GlnAsn: 1.195 ± 0.037	1.792GlnPro: 1.792 ± 0.043	1.358GlnGln: 1.358 ± 0.036	2.189GlnArg: 2.189 ± 0.043	2.25GlnSer: 2.25 ± 0.043	1.814GlnThr: 1.814 ± 0.041	2.222GlnVal: 2.222 ± 0.045	0.476GlnTrp: 0.476 ± 0.022	0.8GlnTyr: 0.8 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.909ArgAla: 5.909 ± 0.095	0.429ArgCys: 0.429 ± 0.021	3.795ArgAsp: 3.795 ± 0.064	3.904ArgGlu: 3.904 ± 0.071	2.897ArgPhe: 2.897 ± 0.054	3.97ArgGly: 3.97 ± 0.063	1.37ArgHis: 1.37 ± 0.035	3.884ArgIle: 3.884 ± 0.061	2.903ArgLys: 2.903 ± 0.067	6.576ArgLeu: 6.576 ± 0.096	1.771ArgMet: 1.771 ± 0.042	2.307ArgAsn: 2.307 ± 0.046	2.966ArgPro: 2.966 ± 0.056	2.458ArgGln: 2.458 ± 0.052	3.942ArgArg: 3.942 ± 0.077	3.746ArgSer: 3.746 ± 0.066	3.066ArgThr: 3.066 ± 0.058	3.774ArgVal: 3.774 ± 0.063	0.913ArgTrp: 0.913 ± 0.028	1.672ArgTyr: 1.672 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.562SerAla: 6.562 ± 0.088	0.497SerCys: 0.497 ± 0.025	3.837SerAsp: 3.837 ± 0.061	3.576SerGlu: 3.576 ± 0.062	2.529SerPhe: 2.529 ± 0.053	6.356SerGly: 6.356 ± 0.102	1.021SerHis: 1.021 ± 0.03	3.137SerIle: 3.137 ± 0.064	1.922SerLys: 1.922 ± 0.045	5.591SerLeu: 5.591 ± 0.097	1.5SerMet: 1.5 ± 0.035	1.813SerAsn: 1.813 ± 0.044	2.815SerPro: 2.815 ± 0.046	1.94SerGln: 1.94 ± 0.044	3.863SerArg: 3.863 ± 0.068	3.605SerSer: 3.605 ± 0.07	2.81SerThr: 2.81 ± 0.056	4.032SerVal: 4.032 ± 0.07	0.86SerTrp: 0.86 ± 0.03	1.57SerTyr: 1.57 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.888ThrAla: 5.888 ± 0.095	0.393ThrCys: 0.393 ± 0.02	3.263ThrAsp: 3.263 ± 0.064	3.018ThrGlu: 3.018 ± 0.052	1.859ThrPhe: 1.859 ± 0.053	5.648ThrGly: 5.648 ± 0.163	0.934ThrHis: 0.934 ± 0.033	3.224ThrIle: 3.224 ± 0.064	1.552ThrLys: 1.552 ± 0.038	4.973ThrLeu: 4.973 ± 0.068	1.197ThrMet: 1.197 ± 0.031	1.517ThrAsn: 1.517 ± 0.041	2.959ThrPro: 2.959 ± 0.055	1.416ThrGln: 1.416 ± 0.038	3.161ThrArg: 3.161 ± 0.051	3.049ThrSer: 3.049 ± 0.071	2.722ThrThr: 2.722 ± 0.085	3.991ThrVal: 3.991 ± 0.078	0.605ThrTrp: 0.605 ± 0.026	1.169ThrTyr: 1.169 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.656ValAla: 7.656 ± 0.101	0.5ValCys: 0.5 ± 0.027	4.45ValAsp: 4.45 ± 0.07	4.464ValGlu: 4.464 ± 0.077	2.294ValPhe: 2.294 ± 0.05	5.165ValGly: 5.165 ± 0.082	1.3ValHis: 1.3 ± 0.038	3.903ValIle: 3.903 ± 0.069	2.33ValLys: 2.33 ± 0.054	5.87ValLeu: 5.87 ± 0.081	1.743ValMet: 1.743 ± 0.05	2.178ValAsn: 2.178 ± 0.049	3.451ValPro: 3.451 ± 0.051	2.174ValGln: 2.174 ± 0.05	4.359ValArg: 4.359 ± 0.067	4.329ValSer: 4.329 ± 0.064	4.363ValThr: 4.363 ± 0.099	4.452ValVal: 4.452 ± 0.078	0.808ValTrp: 0.808 ± 0.028	1.45ValTyr: 1.45 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.139TrpAla: 1.139 ± 0.034	0.113TrpCys: 0.113 ± 0.009	0.777TrpAsp: 0.777 ± 0.028	0.669TrpGlu: 0.669 ± 0.025	0.584TrpPhe: 0.584 ± 0.023	0.901TrpGly: 0.901 ± 0.027	0.331TrpHis: 0.331 ± 0.019	0.789TrpIle: 0.789 ± 0.028	0.601TrpLys: 0.601 ± 0.024	1.612TrpLeu: 1.612 ± 0.042	0.385TrpMet: 0.385 ± 0.02	0.497TrpAsn: 0.497 ± 0.019	0.656TrpPro: 0.656 ± 0.022	0.668TrpGln: 0.668 ± 0.023	1.034TrpArg: 1.034 ± 0.033	0.939TrpSer: 0.939 ± 0.031	0.839TrpThr: 0.839 ± 0.027	0.809TrpVal: 0.809 ± 0.027	0.212TrpTrp: 0.212 ± 0.016	0.287TrpTyr: 0.287 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.477TyrAla: 2.477 ± 0.045	0.243TyrCys: 0.243 ± 0.014	1.683TyrAsp: 1.683 ± 0.051	1.332TyrGlu: 1.332 ± 0.035	1.026TyrPhe: 1.026 ± 0.037	2.151TyrGly: 2.151 ± 0.049	0.543TyrHis: 0.543 ± 0.022	1.016TyrIle: 1.016 ± 0.037	0.711TyrLys: 0.711 ± 0.026	2.185TyrLeu: 2.185 ± 0.045	0.474TyrMet: 0.474 ± 0.021	0.699TyrAsn: 0.699 ± 0.023	1.061TyrPro: 1.061 ± 0.031	0.853TyrGln: 0.853 ± 0.028	1.814TyrArg: 1.814 ± 0.047	1.452TyrSer: 1.452 ± 0.037	1.021TyrThr: 1.021 ± 0.038	1.538TyrVal: 1.538 ± 0.035	0.403TyrTrp: 0.403 ± 0.021	0.681TyrTyr: 0.681 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3398 proteins (1084313 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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