Amino acid dipepetide frequency for Fretibacterium sp. OH1220_COT-178

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.699AlaAla: 11.699 ± 0.159	1.392AlaCys: 1.392 ± 0.043	4.993AlaAsp: 4.993 ± 0.081	7.142AlaGlu: 7.142 ± 0.123	4.27AlaPhe: 4.27 ± 0.082	8.891AlaGly: 8.891 ± 0.111	1.698AlaHis: 1.698 ± 0.042	4.548AlaIle: 4.548 ± 0.086	3.231AlaLys: 3.231 ± 0.078	13.059AlaLeu: 13.059 ± 0.154	2.856AlaMet: 2.856 ± 0.069	2.101AlaAsn: 2.101 ± 0.056	4.382AlaPro: 4.382 ± 0.076	2.58AlaGln: 2.58 ± 0.055	7.154AlaArg: 7.154 ± 0.105	5.956AlaSer: 5.956 ± 0.096	3.64AlaThr: 3.64 ± 0.077	8.722AlaVal: 8.722 ± 0.11	1.309AlaTrp: 1.309 ± 0.041	2.266AlaTyr: 2.266 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.341CysAla: 1.341 ± 0.041	0.258CysCys: 0.258 ± 0.022	0.65CysAsp: 0.65 ± 0.028	0.633CysGlu: 0.633 ± 0.028	0.568CysPhe: 0.568 ± 0.028	1.539CysGly: 1.539 ± 0.042	0.24CysHis: 0.24 ± 0.017	0.642CysIle: 0.642 ± 0.029	0.297CysLys: 0.297 ± 0.019	1.314CysLeu: 1.314 ± 0.045	0.321CysMet: 0.321 ± 0.024	0.308CysAsn: 0.308 ± 0.018	0.734CysPro: 0.734 ± 0.032	0.208CysGln: 0.208 ± 0.016	1.082CysArg: 1.082 ± 0.039	0.801CysSer: 0.801 ± 0.03	0.653CysThr: 0.653 ± 0.027	1.018CysVal: 1.018 ± 0.036	0.175CysTrp: 0.175 ± 0.014	0.317CysTyr: 0.317 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.658AspAla: 5.658 ± 0.085	0.679AspCys: 0.679 ± 0.028	2.338AspAsp: 2.338 ± 0.068	3.58AspGlu: 3.58 ± 0.068	2.375AspPhe: 2.375 ± 0.06	4.774AspGly: 4.774 ± 0.097	0.765AspHis: 0.765 ± 0.029	2.783AspIle: 2.783 ± 0.061	1.824AspLys: 1.824 ± 0.056	5.647AspLeu: 5.647 ± 0.082	1.291AspMet: 1.291 ± 0.035	1.149AspAsn: 1.149 ± 0.045	3.054AspPro: 3.054 ± 0.07	0.947AspGln: 0.947 ± 0.032	4.287AspArg: 4.287 ± 0.077	2.398AspSer: 2.398 ± 0.056	2.113AspThr: 2.113 ± 0.056	4.479AspVal: 4.479 ± 0.087	0.693AspTrp: 0.693 ± 0.032	1.465AspTyr: 1.465 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	7.538GluAla: 7.538 ± 0.108	0.579GluCys: 0.579 ± 0.026	3.476GluAsp: 3.476 ± 0.067	5.169GluGlu: 5.169 ± 0.097	1.881GluPhe: 1.881 ± 0.046	6.094GluGly: 6.094 ± 0.086	1.22GluHis: 1.22 ± 0.041	3.432GluIle: 3.432 ± 0.071	3.137GluLys: 3.137 ± 0.067	6.765GluLeu: 6.765 ± 0.105	1.863GluMet: 1.863 ± 0.048	2.049GluAsn: 2.049 ± 0.058	2.681GluPro: 2.681 ± 0.06	1.605GluGln: 1.605 ± 0.054	6.526GluArg: 6.526 ± 0.127	3.195GluSer: 3.195 ± 0.073	3.057GluThr: 3.057 ± 0.066	4.701GluVal: 4.701 ± 0.08	0.661GluTrp: 0.661 ± 0.029	1.365GluTyr: 1.365 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.771PheAla: 3.771 ± 0.072	0.712PheCys: 0.712 ± 0.03	2.176PheAsp: 2.176 ± 0.053	2.363PheGlu: 2.363 ± 0.051	2.016PhePhe: 2.016 ± 0.059	3.477PheGly: 3.477 ± 0.064	0.685PheHis: 0.685 ± 0.032	1.844PheIle: 1.844 ± 0.056	1.209PheLys: 1.209 ± 0.039	4.558PheLeu: 4.558 ± 0.105	1.067PheMet: 1.067 ± 0.038	0.98PheAsn: 0.98 ± 0.034	1.85PhePro: 1.85 ± 0.041	0.925PheGln: 0.925 ± 0.032	2.692PheArg: 2.692 ± 0.062	2.885PheSer: 2.885 ± 0.057	1.704PheThr: 1.704 ± 0.043	3.353PheVal: 3.353 ± 0.085	0.572PheTrp: 0.572 ± 0.023	1.073PheTyr: 1.073 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	9.012GlyAla: 9.012 ± 0.128	1.338GlyCys: 1.338 ± 0.039	4.376GlyAsp: 4.376 ± 0.08	5.52GlyGlu: 5.52 ± 0.075	3.356GlyPhe: 3.356 ± 0.066	8.348GlyGly: 8.348 ± 0.134	1.603GlyHis: 1.603 ± 0.046	5.191GlyIle: 5.191 ± 0.112	3.858GlyLys: 3.858 ± 0.076	9.401GlyLeu: 9.401 ± 0.125	2.71GlyMet: 2.71 ± 0.059	2.365GlyAsn: 2.365 ± 0.064	2.967GlyPro: 2.967 ± 0.073	1.956GlyGln: 1.956 ± 0.053	7.183GlyArg: 7.183 ± 0.117	4.99GlySer: 4.99 ± 0.089	5.075GlyThr: 5.075 ± 0.095	6.903GlyVal: 6.903 ± 0.089	1.227GlyTrp: 1.227 ± 0.038	2.576GlyTyr: 2.576 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.618HisAla: 1.618 ± 0.047	0.283HisCys: 0.283 ± 0.016	0.882HisAsp: 0.882 ± 0.032	0.96HisGlu: 0.96 ± 0.037	0.763HisPhe: 0.763 ± 0.032	1.501HisGly: 1.501 ± 0.049	0.341HisHis: 0.341 ± 0.021	0.987HisIle: 0.987 ± 0.033	0.573HisLys: 0.573 ± 0.03	1.767HisLeu: 1.767 ± 0.042	0.405HisMet: 0.405 ± 0.019	0.489HisAsn: 0.489 ± 0.025	1.228HisPro: 1.228 ± 0.038	0.39HisGln: 0.39 ± 0.023	1.265HisArg: 1.265 ± 0.046	0.843HisSer: 0.843 ± 0.035	0.805HisThr: 0.805 ± 0.032	1.224HisVal: 1.224 ± 0.036	0.232HisTrp: 0.232 ± 0.016	0.539HisTyr: 0.539 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.387IleAla: 5.387 ± 0.091	0.61IleCys: 0.61 ± 0.028	2.815IleAsp: 2.815 ± 0.059	3.167IleGlu: 3.167 ± 0.06	1.947IlePhe: 1.947 ± 0.055	4.324IleGly: 4.324 ± 0.089	0.878IleHis: 0.878 ± 0.026	1.841IleIle: 1.841 ± 0.057	1.447IleLys: 1.447 ± 0.05	5.578IleLeu: 5.578 ± 0.095	1.035IleMet: 1.035 ± 0.039	1.193IleAsn: 1.193 ± 0.04	2.916IlePro: 2.916 ± 0.063	1.241IleGln: 1.241 ± 0.042	3.557IleArg: 3.557 ± 0.07	2.79IleSer: 2.79 ± 0.076	2.054IleThr: 2.054 ± 0.055	4.473IleVal: 4.473 ± 0.08	0.486IleTrp: 0.486 ± 0.028	1.206IleTyr: 1.206 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.899LysAla: 3.899 ± 0.091	0.275LysCys: 0.275 ± 0.022	2.218LysAsp: 2.218 ± 0.058	2.608LysGlu: 2.608 ± 0.065	1.094LysPhe: 1.094 ± 0.034	3.785LysGly: 3.785 ± 0.074	0.54LysHis: 0.54 ± 0.025	1.939LysIle: 1.939 ± 0.056	2.259LysLys: 2.259 ± 0.059	3.431LysLeu: 3.431 ± 0.067	0.991LysMet: 0.991 ± 0.035	1.345LysAsn: 1.345 ± 0.045	1.547LysPro: 1.547 ± 0.044	0.805LysGln: 0.805 ± 0.036	2.755LysArg: 2.755 ± 0.06	1.928LysSer: 1.928 ± 0.059	1.888LysThr: 1.888 ± 0.044	2.792LysVal: 2.792 ± 0.064	0.348LysTrp: 0.348 ± 0.021	0.96LysTyr: 0.96 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.08LeuAla: 11.08 ± 0.151	1.712LeuCys: 1.712 ± 0.047	5.829LeuAsp: 5.829 ± 0.086	7.166LeuGlu: 7.166 ± 0.096	4.582LeuPhe: 4.582 ± 0.096	9.094LeuGly: 9.094 ± 0.132	1.898LeuHis: 1.898 ± 0.055	4.837LeuIle: 4.837 ± 0.09	4.532LeuLys: 4.532 ± 0.086	12.337LeuLeu: 12.337 ± 0.167	2.935LeuMet: 2.935 ± 0.069	3.066LeuAsn: 3.066 ± 0.064	5.676LeuPro: 5.676 ± 0.084	2.484LeuGln: 2.484 ± 0.05	8.116LeuArg: 8.116 ± 0.127	8.078LeuSer: 8.078 ± 0.115	5.078LeuThr: 5.078 ± 0.082	7.349LeuVal: 7.349 ± 0.104	1.542LeuTrp: 1.542 ± 0.05	2.621LeuTyr: 2.621 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.822MetAla: 2.822 ± 0.063	0.205MetCys: 0.205 ± 0.015	1.515MetAsp: 1.515 ± 0.043	1.993MetGlu: 1.993 ± 0.043	0.742MetPhe: 0.742 ± 0.033	2.578MetGly: 2.578 ± 0.056	0.359MetHis: 0.359 ± 0.019	1.373MetIle: 1.373 ± 0.043	1.377MetLys: 1.377 ± 0.045	2.586MetLeu: 2.586 ± 0.061	0.677MetMet: 0.677 ± 0.027	0.939MetAsn: 0.939 ± 0.038	1.323MetPro: 1.323 ± 0.043	0.712MetGln: 0.712 ± 0.03	2.02MetArg: 2.02 ± 0.048	1.508MetSer: 1.508 ± 0.042	1.597MetThr: 1.597 ± 0.045	1.811MetVal: 1.811 ± 0.046	0.191MetTrp: 0.191 ± 0.015	0.42MetTyr: 0.42 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.824AsnAla: 2.824 ± 0.064	0.369AsnCys: 0.369 ± 0.027	1.183AsnAsp: 1.183 ± 0.037	1.436AsnGlu: 1.436 ± 0.04	1.087AsnPhe: 1.087 ± 0.038	2.312AsnGly: 2.312 ± 0.059	0.391AsnHis: 0.391 ± 0.021	1.49AsnIle: 1.49 ± 0.04	0.938AsnLys: 0.938 ± 0.042	2.781AsnLeu: 2.781 ± 0.059	0.683AsnMet: 0.683 ± 0.028	0.643AsnAsn: 0.643 ± 0.031	1.897AsnPro: 1.897 ± 0.059	0.533AsnGln: 0.533 ± 0.028	1.855AsnArg: 1.855 ± 0.049	1.233AsnSer: 1.233 ± 0.039	1.224AsnThr: 1.224 ± 0.048	2.332AsnVal: 2.332 ± 0.058	0.359AsnTrp: 0.359 ± 0.02	0.715AsnTyr: 0.715 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.313ProAla: 4.313 ± 0.08	0.592ProCys: 0.592 ± 0.024	3.14ProAsp: 3.14 ± 0.071	4.406ProGlu: 4.406 ± 0.086	2.125ProPhe: 2.125 ± 0.049	4.368ProGly: 4.368 ± 0.076	0.948ProHis: 0.948 ± 0.035	2.054ProIle: 2.054 ± 0.049	1.618ProLys: 1.618 ± 0.048	5.162ProLeu: 5.162 ± 0.078	1.214ProMet: 1.214 ± 0.036	1.152ProAsn: 1.152 ± 0.042	2.09ProPro: 2.09 ± 0.066	1.401ProGln: 1.401 ± 0.046	2.824ProArg: 2.824 ± 0.067	3.068ProSer: 3.068 ± 0.066	1.949ProThr: 1.949 ± 0.051	4.016ProVal: 4.016 ± 0.074	0.68ProTrp: 0.68 ± 0.031	1.234ProTyr: 1.234 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.456GlnAla: 2.456 ± 0.058	0.228GlnCys: 0.228 ± 0.018	1.27GlnAsp: 1.27 ± 0.041	1.804GlnGlu: 1.804 ± 0.055	0.798GlnPhe: 0.798 ± 0.033	2.09GlnGly: 2.09 ± 0.051	0.375GlnHis: 0.375 ± 0.021	1.371GlnIle: 1.371 ± 0.041	1.181GlnLys: 1.181 ± 0.038	1.964GlnLeu: 1.964 ± 0.062	0.712GlnMet: 0.712 ± 0.031	0.779GlnAsn: 0.779 ± 0.034	0.942GlnPro: 0.942 ± 0.042	0.681GlnGln: 0.681 ± 0.033	1.786GlnArg: 1.786 ± 0.055	1.243GlnSer: 1.243 ± 0.036	1.124GlnThr: 1.124 ± 0.039	1.624GlnVal: 1.624 ± 0.039	0.254GlnTrp: 0.254 ± 0.018	0.65GlnTyr: 0.65 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.883ArgAla: 6.883 ± 0.109	0.948ArgCys: 0.948 ± 0.032	3.946ArgAsp: 3.946 ± 0.089	5.779ArgGlu: 5.779 ± 0.108	3.037ArgPhe: 3.037 ± 0.058	5.861ArgGly: 5.861 ± 0.098	1.434ArgHis: 1.434 ± 0.045	4.401ArgIle: 4.401 ± 0.073	2.9ArgLys: 2.9 ± 0.074	7.99ArgLeu: 7.99 ± 0.119	2.378ArgMet: 2.378 ± 0.053	2.117ArgAsn: 2.117 ± 0.052	3.211ArgPro: 3.211 ± 0.063	1.847ArgGln: 1.847 ± 0.051	6.472ArgArg: 6.472 ± 0.107	4.535ArgSer: 4.535 ± 0.088	3.847ArgThr: 3.847 ± 0.076	5.312ArgVal: 5.312 ± 0.1	1.031ArgTrp: 1.031 ± 0.037	2.131ArgTyr: 2.131 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.786SerAla: 5.786 ± 0.093	0.806SerCys: 0.806 ± 0.031	2.869SerAsp: 2.869 ± 0.062	3.343SerGlu: 3.343 ± 0.069	2.592SerPhe: 2.592 ± 0.059	6.323SerGly: 6.323 ± 0.099	0.906SerHis: 0.906 ± 0.031	2.916SerIle: 2.916 ± 0.063	1.746SerLys: 1.746 ± 0.051	6.726SerLeu: 6.726 ± 0.112	1.723SerMet: 1.723 ± 0.046	1.218SerAsn: 1.218 ± 0.039	3.139SerPro: 3.139 ± 0.073	1.299SerGln: 1.299 ± 0.038	4.044SerArg: 4.044 ± 0.072	3.476SerSer: 3.476 ± 0.074	2.419SerThr: 2.419 ± 0.049	5.02SerVal: 5.02 ± 0.077	0.872SerTrp: 0.872 ± 0.031	1.414SerTyr: 1.414 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.836ThrAla: 4.836 ± 0.081	0.528ThrCys: 0.528 ± 0.029	2.415ThrAsp: 2.415 ± 0.054	2.729ThrGlu: 2.729 ± 0.058	1.948ThrPhe: 1.948 ± 0.05	4.438ThrGly: 4.438 ± 0.08	0.894ThrHis: 0.894 ± 0.035	2.315ThrIle: 2.315 ± 0.067	1.287ThrLys: 1.287 ± 0.042	5.632ThrLeu: 5.632 ± 0.091	1.114ThrMet: 1.114 ± 0.04	1.092ThrAsn: 1.092 ± 0.043	2.691ThrPro: 2.691 ± 0.066	1.02ThrGln: 1.02 ± 0.038	2.86ThrArg: 2.86 ± 0.062	2.453ThrSer: 2.453 ± 0.059	2.328ThrThr: 2.328 ± 0.067	4.223ThrVal: 4.223 ± 0.077	0.542ThrTrp: 0.542 ± 0.026	1.062ThrTyr: 1.062 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	7.446ValAla: 7.446 ± 0.102	1.09ValCys: 1.09 ± 0.034	4.007ValAsp: 4.007 ± 0.085	4.949ValGlu: 4.949 ± 0.078	3.135ValPhe: 3.135 ± 0.069	6.276ValGly: 6.276 ± 0.096	1.301ValHis: 1.301 ± 0.044	3.307ValIle: 3.307 ± 0.067	2.681ValLys: 2.681 ± 0.06	9.486ValLeu: 9.486 ± 0.118	1.881ValMet: 1.881 ± 0.052	2.075ValAsn: 2.075 ± 0.059	4.29ValPro: 4.29 ± 0.08	1.815ValGln: 1.815 ± 0.045	6.495ValArg: 6.495 ± 0.102	5.088ValSer: 5.088 ± 0.081	3.959ValThr: 3.959 ± 0.077	6.929ValVal: 6.929 ± 0.114	0.957ValTrp: 0.957 ± 0.038	1.862ValTyr: 1.862 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.038TrpAla: 1.038 ± 0.034	0.155TrpCys: 0.155 ± 0.015	0.643TrpAsp: 0.643 ± 0.032	0.735TrpGlu: 0.735 ± 0.027	0.51TrpPhe: 0.51 ± 0.029	1.422TrpGly: 1.422 ± 0.044	0.216TrpHis: 0.216 ± 0.017	0.555TrpIle: 0.555 ± 0.025	0.492TrpLys: 0.492 ± 0.025	1.37TrpLeu: 1.37 ± 0.037	0.363TrpMet: 0.363 ± 0.021	0.503TrpAsn: 0.503 ± 0.028	0.473TrpPro: 0.473 ± 0.022	0.346TrpGln: 0.346 ± 0.022	1.086TrpArg: 1.086 ± 0.04	0.75TrpSer: 0.75 ± 0.03	0.678TrpThr: 0.678 ± 0.028	0.842TrpVal: 0.842 ± 0.034	0.195TrpTrp: 0.195 ± 0.018	0.287TrpTyr: 0.287 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.484TyrAla: 2.484 ± 0.059	0.341TyrCys: 0.341 ± 0.024	1.557TyrAsp: 1.557 ± 0.053	1.515TyrGlu: 1.515 ± 0.043	1.087TyrPhe: 1.087 ± 0.035	2.46TyrGly: 2.46 ± 0.052	0.404TyrHis: 0.404 ± 0.022	1.115TyrIle: 1.115 ± 0.038	0.818TyrLys: 0.818 ± 0.037	2.457TyrLeu: 2.457 ± 0.06	0.529TyrMet: 0.529 ± 0.028	0.723TyrAsn: 0.723 ± 0.029	1.263TyrPro: 1.263 ± 0.034	0.537TyrGln: 0.537 ± 0.027	1.999TyrArg: 1.999 ± 0.045	1.417TyrSer: 1.417 ± 0.042	1.216TyrThr: 1.216 ± 0.047	1.907TyrVal: 1.907 ± 0.046	0.331TyrTrp: 0.331 ± 0.017	0.723TyrTyr: 0.723 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2505 proteins (840959 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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